Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WR77_LEIDO

TriTrypDb:

LdBPK_100690.1 , LdCL_100013700 , LDHU3_10.1020

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WR77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR77

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.504
CLV_NRD_NRD_1	19	21	PF00675	0.646
CLV_PCSK_KEX2_1	176	178	PF00082	0.504
CLV_PCSK_KEX2_1	18	20	PF00082	0.623
DOC_CKS1_1	213	218	PF01111	0.507
DOC_USP7_MATH_1	137	141	PF00917	0.720
DOC_USP7_MATH_1	189	193	PF00917	0.669
DOC_WW_Pin1_4	135	140	PF00397	0.538
DOC_WW_Pin1_4	154	159	PF00397	0.601
DOC_WW_Pin1_4	212	217	PF00397	0.515
DOC_WW_Pin1_4	30	35	PF00397	0.538
DOC_WW_Pin1_4	49	54	PF00397	0.583
DOC_WW_Pin1_4	67	72	PF00397	0.580
LIG_14-3-3_CterR_2	239	243	PF00244	0.611
LIG_Actin_WH2_2	53	70	PF00022	0.613
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_EVH1_1	152	156	PF00568	0.564
LIG_FHA_1	196	202	PF00498	0.696
LIG_FHA_2	100	106	PF00498	0.658
LIG_FHA_2	226	232	PF00498	0.441
LIG_LIR_Gen_1	54	62	PF02991	0.559
LIG_LIR_Nem_3	54	60	PF02991	0.594
LIG_LIR_Nem_3	80	84	PF02991	0.465
LIG_LIR_Nem_3	86	91	PF02991	0.532
LIG_MYND_1	150	154	PF01753	0.580
LIG_NRBOX	126	132	PF00104	0.662
LIG_PTB_Apo_2	181	188	PF02174	0.586
LIG_PTB_Phospho_1	181	187	PF10480	0.582
LIG_SH2_CRK	48	52	PF00017	0.515
LIG_SH2_NCK_1	57	61	PF00017	0.579
LIG_SH2_STAT5	27	30	PF00017	0.516
LIG_SH2_STAT5	48	51	PF00017	0.568
LIG_SH3_3	147	153	PF00018	0.612
LIG_SH3_3	155	161	PF00018	0.509
LIG_SH3_3	7	13	PF00018	0.647
LIG_WRC_WIRS_1	101	106	PF05994	0.637
LIG_WW_2	150	153	PF00397	0.633
MOD_CK1_1	123	129	PF00069	0.730
MOD_CK1_1	141	147	PF00069	0.580
MOD_CK1_1	193	199	PF00069	0.547
MOD_CK2_1	99	105	PF00069	0.663
MOD_GlcNHglycan	114	117	PF01048	0.729
MOD_GlcNHglycan	118	121	PF01048	0.649
MOD_GlcNHglycan	122	125	PF01048	0.599
MOD_GlcNHglycan	131	134	PF01048	0.518
MOD_GlcNHglycan	135	138	PF01048	0.556
MOD_GlcNHglycan	143	146	PF01048	0.510
MOD_GlcNHglycan	206	209	PF01048	0.666
MOD_GSK3_1	112	119	PF00069	0.731
MOD_GSK3_1	125	132	PF00069	0.776
MOD_GSK3_1	133	140	PF00069	0.672
MOD_GSK3_1	189	196	PF00069	0.759
MOD_GSK3_1	63	70	PF00069	0.620
MOD_N-GLC_1	116	121	PF02516	0.612
MOD_N-GLC_1	190	195	PF02516	0.618
MOD_N-GLC_1	30	35	PF02516	0.546
MOD_NEK2_1	1	6	PF00069	0.638
MOD_NEK2_1	131	136	PF00069	0.763
MOD_Plk_1	182	188	PF00069	0.654
MOD_Plk_1	63	69	PF00069	0.615
MOD_Plk_4	126	132	PF00069	0.688
MOD_Plk_4	182	188	PF00069	0.632
MOD_ProDKin_1	135	141	PF00069	0.538
MOD_ProDKin_1	154	160	PF00069	0.595
MOD_ProDKin_1	212	218	PF00069	0.508
MOD_ProDKin_1	30	36	PF00069	0.532
MOD_ProDKin_1	49	55	PF00069	0.580
MOD_ProDKin_1	67	73	PF00069	0.576
MOD_SUMO_rev_2	103	109	PF00179	0.601
TRG_ENDOCYTIC_2	48	51	PF00928	0.512
TRG_ENDOCYTIC_2	57	60	PF00928	0.493
TRG_ENDOCYTIC_2	88	91	PF00928	0.540
TRG_ER_diArg_1	175	177	PF00400	0.524
TRG_ER_diArg_1	18	20	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD67	Leptomonas seymouri	63%	99%
A0A0S4J8D0	Bodo saltans	28%	100%
A4H656	Leishmania braziliensis	79%	100%
A4HUH6	Leishmania infantum	100%	100%
C9ZVJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AN74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QHF1	Leishmania major	95%	100%