Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WR70_LEIDO

TriTrypDb:

LdBPK_100810.1 , LdCL_100014900 , LDHU3_10.1170

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WR70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.523
CLV_C14_Caspase3-7	260	264	PF00656	0.677
CLV_NRD_NRD_1	361	363	PF00675	0.515
CLV_NRD_NRD_1	393	395	PF00675	0.501
CLV_NRD_NRD_1	412	414	PF00675	0.329
CLV_NRD_NRD_1	546	548	PF00675	0.323
CLV_NRD_NRD_1	9	11	PF00675	0.421
CLV_PCSK_KEX2_1	361	363	PF00082	0.509
CLV_PCSK_KEX2_1	393	395	PF00082	0.501
CLV_PCSK_KEX2_1	412	414	PF00082	0.329
CLV_PCSK_KEX2_1	546	548	PF00082	0.318
CLV_PCSK_KEX2_1	9	11	PF00082	0.421
CLV_PCSK_SKI1_1	198	202	PF00082	0.392
CLV_PCSK_SKI1_1	418	422	PF00082	0.455
CLV_PCSK_SKI1_1	465	469	PF00082	0.408
CLV_PCSK_SKI1_1	532	536	PF00082	0.340
CLV_PCSK_SKI1_1	546	550	PF00082	0.297
DEG_COP1_1	321	331	PF00400	0.533
DEG_SPOP_SBC_1	174	178	PF00917	0.590
DOC_CDC14_PxL_1	515	523	PF14671	0.374
DOC_CKS1_1	396	401	PF01111	0.367
DOC_CYCLIN_yClb3_PxF_3	16	24	PF00134	0.396
DOC_MAPK_DCC_7	493	502	PF00069	0.539
DOC_MAPK_gen_1	217	226	PF00069	0.485
DOC_MAPK_gen_1	602	611	PF00069	0.338
DOC_MAPK_MEF2A_6	493	502	PF00069	0.539
DOC_MAPK_MEF2A_6	532	539	PF00069	0.391
DOC_MAPK_MEF2A_6	589	597	PF00069	0.322
DOC_MAPK_NFAT4_5	532	540	PF00069	0.397
DOC_PP2B_LxvP_1	421	424	PF13499	0.508
DOC_PP2B_LxvP_1	521	524	PF13499	0.378
DOC_PP4_FxxP_1	420	423	PF00568	0.450
DOC_PP4_MxPP_1	172	175	PF00568	0.561
DOC_USP7_MATH_1	102	106	PF00917	0.529
DOC_USP7_MATH_1	209	213	PF00917	0.523
DOC_USP7_MATH_1	327	331	PF00917	0.645
DOC_USP7_MATH_1	467	471	PF00917	0.538
DOC_USP7_MATH_1	507	511	PF00917	0.520
DOC_USP7_MATH_1	555	559	PF00917	0.365
DOC_USP7_MATH_1	566	570	PF00917	0.412
DOC_USP7_MATH_1	63	67	PF00917	0.544
DOC_USP7_MATH_1	91	95	PF00917	0.625
DOC_WW_Pin1_4	1	6	PF00397	0.500
DOC_WW_Pin1_4	165	170	PF00397	0.847
DOC_WW_Pin1_4	246	251	PF00397	0.667
DOC_WW_Pin1_4	253	258	PF00397	0.571
DOC_WW_Pin1_4	330	335	PF00397	0.520
DOC_WW_Pin1_4	395	400	PF00397	0.355
DOC_WW_Pin1_4	81	86	PF00397	0.436
LIG_14-3-3_CanoR_1	198	203	PF00244	0.463
LIG_14-3-3_CanoR_1	393	399	PF00244	0.588
LIG_14-3-3_CanoR_1	41	46	PF00244	0.383
LIG_14-3-3_CanoR_1	412	416	PF00244	0.316
LIG_14-3-3_CanoR_1	469	473	PF00244	0.461
LIG_14-3-3_CanoR_1	564	574	PF00244	0.426
LIG_14-3-3_CanoR_1	604	611	PF00244	0.330
LIG_Actin_WH2_2	345	363	PF00022	0.426
LIG_Actin_WH2_2	454	471	PF00022	0.345
LIG_APCC_ABBA_1	18	23	PF00400	0.393
LIG_APCC_ABBA_1	572	577	PF00400	0.376
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BIR_III_4	620	624	PF00653	0.368
LIG_BRCT_BRCA1_1	341	345	PF00533	0.435
LIG_BRCT_BRCA1_1	43	47	PF00533	0.380
LIG_BRCT_BRCA1_1	541	545	PF00533	0.376
LIG_BRCT_BRCA1_1	83	87	PF00533	0.448
LIG_eIF4E_2	401	407	PF01652	0.400
LIG_FHA_1	15	21	PF00498	0.361
LIG_FHA_1	175	181	PF00498	0.806
LIG_FHA_1	186	192	PF00498	0.480
LIG_FHA_1	2	8	PF00498	0.505
LIG_FHA_1	446	452	PF00498	0.371
LIG_FHA_1	592	598	PF00498	0.365
LIG_FHA_2	203	209	PF00498	0.495
LIG_FHA_2	364	370	PF00498	0.427
LIG_FHA_2	412	418	PF00498	0.404
LIG_FHA_2	99	105	PF00498	0.571
LIG_Integrin_RGD_1	227	229	PF01839	0.524
LIG_LIR_Apic_2	398	404	PF02991	0.395
LIG_LIR_Apic_2	417	423	PF02991	0.331
LIG_LIR_Gen_1	256	265	PF02991	0.406
LIG_LIR_Gen_1	383	392	PF02991	0.329
LIG_LIR_Gen_1	44	55	PF02991	0.422
LIG_LIR_Gen_1	455	464	PF02991	0.365
LIG_LIR_LC3C_4	514	517	PF02991	0.331
LIG_LIR_Nem_3	256	261	PF02991	0.424
LIG_LIR_Nem_3	383	389	PF02991	0.374
LIG_LIR_Nem_3	44	50	PF02991	0.393
LIG_LIR_Nem_3	455	461	PF02991	0.372
LIG_LIR_Nem_3	81	86	PF02991	0.406
LIG_MLH1_MIPbox_1	83	87	PF16413	0.448
LIG_PTAP_UEV_1	540	545	PF05743	0.330
LIG_RPA_C_Fungi	383	395	PF08784	0.353
LIG_SH2_CRK	45	49	PF00017	0.367
LIG_SH2_NCK_1	606	610	PF00017	0.361
LIG_SH2_SRC	575	578	PF00017	0.379
LIG_SH2_STAP1	45	49	PF00017	0.335
LIG_SH2_STAT3	120	123	PF00017	0.405
LIG_SH2_STAT3	233	236	PF00017	0.521
LIG_SH2_STAT5	120	123	PF00017	0.421
LIG_SH2_STAT5	233	236	PF00017	0.537
LIG_SH2_STAT5	258	261	PF00017	0.496
LIG_SH2_STAT5	460	463	PF00017	0.403
LIG_SH2_STAT5	606	609	PF00017	0.362
LIG_SH2_STAT5	86	89	PF00017	0.427
LIG_SH3_1	10	16	PF00018	0.375
LIG_SH3_1	538	544	PF00018	0.393
LIG_SH3_2	541	546	PF14604	0.306
LIG_SH3_3	10	16	PF00018	0.417
LIG_SH3_3	247	253	PF00018	0.736
LIG_SH3_3	367	373	PF00018	0.514
LIG_SH3_3	45	51	PF00018	0.403
LIG_SH3_3	513	519	PF00018	0.458
LIG_SH3_3	538	544	PF00018	0.393
LIG_SH3_3	69	75	PF00018	0.444
LIG_SUMO_SIM_anti_2	514	519	PF11976	0.428
LIG_SUMO_SIM_anti_2	594	600	PF11976	0.437
LIG_SUMO_SIM_par_1	131	136	PF11976	0.411
LIG_SUMO_SIM_par_1	588	594	PF11976	0.338
MOD_CK1_1	146	152	PF00069	0.699
MOD_CK1_1	168	174	PF00069	0.690
MOD_CK1_1	249	255	PF00069	0.654
MOD_CK1_1	330	336	PF00069	0.665
MOD_CK1_1	374	380	PF00069	0.397
MOD_CK1_1	511	517	PF00069	0.438
MOD_CK1_1	565	571	PF00069	0.499
MOD_CK2_1	374	380	PF00069	0.442
MOD_CK2_1	450	456	PF00069	0.358
MOD_CK2_1	555	561	PF00069	0.415
MOD_CK2_1	98	104	PF00069	0.585
MOD_GlcNHglycan	104	107	PF01048	0.588
MOD_GlcNHglycan	110	114	PF01048	0.437
MOD_GlcNHglycan	148	151	PF01048	0.639
MOD_GlcNHglycan	246	249	PF01048	0.795
MOD_GlcNHglycan	329	332	PF01048	0.554
MOD_GlcNHglycan	439	442	PF01048	0.501
MOD_GlcNHglycan	452	455	PF01048	0.365
MOD_GlcNHglycan	465	468	PF01048	0.407
MOD_GlcNHglycan	470	473	PF01048	0.478
MOD_GlcNHglycan	505	508	PF01048	0.536
MOD_GlcNHglycan	532	535	PF01048	0.451
MOD_GlcNHglycan	541	544	PF01048	0.420
MOD_GlcNHglycan	557	560	PF01048	0.480
MOD_GlcNHglycan	564	567	PF01048	0.443
MOD_GlcNHglycan	611	614	PF01048	0.310
MOD_GlcNHglycan	88	91	PF01048	0.501
MOD_GSK3_1	131	138	PF00069	0.456
MOD_GSK3_1	164	171	PF00069	0.739
MOD_GSK3_1	174	181	PF00069	0.559
MOD_GSK3_1	198	205	PF00069	0.497
MOD_GSK3_1	209	216	PF00069	0.606
MOD_GSK3_1	249	256	PF00069	0.679
MOD_GSK3_1	332	339	PF00069	0.660
MOD_GSK3_1	445	452	PF00069	0.546
MOD_GSK3_1	463	470	PF00069	0.349
MOD_GSK3_1	503	510	PF00069	0.562
MOD_GSK3_1	555	562	PF00069	0.447
MOD_GSK3_1	81	88	PF00069	0.455
MOD_GSK3_1	98	105	PF00069	0.572
MOD_LATS_1	160	166	PF00433	0.642
MOD_N-GLC_1	609	614	PF02516	0.374
MOD_NEK2_1	109	114	PF00069	0.520
MOD_NEK2_1	131	136	PF00069	0.421
MOD_NEK2_1	270	275	PF00069	0.494
MOD_NEK2_1	43	48	PF00069	0.337
MOD_NEK2_1	468	473	PF00069	0.627
MOD_NEK2_1	530	535	PF00069	0.369
MOD_NEK2_2	559	564	PF00069	0.408
MOD_PIKK_1	111	117	PF00454	0.433
MOD_PIKK_1	154	160	PF00454	0.645
MOD_PIKK_1	209	215	PF00454	0.716
MOD_PIKK_1	445	451	PF00454	0.375
MOD_PKA_2	138	144	PF00069	0.609
MOD_PKA_2	411	417	PF00069	0.465
MOD_PKA_2	468	474	PF00069	0.461
MOD_PKB_1	602	610	PF00069	0.341
MOD_Plk_1	609	615	PF00069	0.528
MOD_Plk_2-3	285	291	PF00069	0.489
MOD_Plk_4	116	122	PF00069	0.461
MOD_Plk_4	348	354	PF00069	0.462
MOD_Plk_4	397	403	PF00069	0.430
MOD_Plk_4	43	49	PF00069	0.397
MOD_Plk_4	511	517	PF00069	0.435
MOD_Plk_4	64	70	PF00069	0.365
MOD_Plk_4	73	79	PF00069	0.407
MOD_ProDKin_1	1	7	PF00069	0.487
MOD_ProDKin_1	165	171	PF00069	0.847
MOD_ProDKin_1	246	252	PF00069	0.667
MOD_ProDKin_1	253	259	PF00069	0.569
MOD_ProDKin_1	330	336	PF00069	0.520
MOD_ProDKin_1	395	401	PF00069	0.359
MOD_ProDKin_1	81	87	PF00069	0.437
TRG_AP2beta_CARGO_1	383	393	PF09066	0.334
TRG_ENDOCYTIC_2	258	261	PF00928	0.512
TRG_ENDOCYTIC_2	45	48	PF00928	0.368
TRG_ENDOCYTIC_2	606	609	PF00928	0.362
TRG_ER_diArg_1	235	238	PF00400	0.532
TRG_ER_diArg_1	275	278	PF00400	0.460
TRG_ER_diArg_1	360	362	PF00400	0.454
TRG_ER_diArg_1	392	394	PF00400	0.496
TRG_ER_diArg_1	545	547	PF00400	0.318
TRG_ER_diArg_1	601	604	PF00400	0.393
TRG_ER_diArg_1	8	10	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	28%	93%
A0A0N1PDV8	Leptomonas seymouri	46%	100%
A0A3S5H6G6	Leishmania donovani	31%	100%
A4H664	Leishmania braziliensis	67%	97%
A4HUI8	Leishmania infantum	99%	100%
A4HUI9	Leishmania infantum	30%	97%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4QHD7	Leishmania major	30%	100%
Q4QHD8	Leishmania major	89%	99%