Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WR67_LEIDO

TriTrypDb:

LdBPK_100720.1 , LdCL_100014000 , LDHU3_10.1050

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7WR67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	37	39	PF00675	0.606
CLV_PCSK_KEX2_1	37	39	PF00082	0.606
CLV_PCSK_SKI1_1	105	109	PF00082	0.407
DOC_CKS1_1	41	46	PF01111	0.702
DOC_MAPK_FxFP_2	13	16	PF00069	0.769
DOC_MAPK_gen_1	11	20	PF00069	0.724
DOC_MAPK_MEF2A_6	11	20	PF00069	0.794
DOC_PP4_FxxP_1	13	16	PF00568	0.797
DOC_USP7_MATH_1	98	102	PF00917	0.800
DOC_USP7_UBL2_3	104	108	PF12436	0.722
DOC_WW_Pin1_4	20	25	PF00397	0.739
DOC_WW_Pin1_4	263	268	PF00397	0.344
DOC_WW_Pin1_4	27	32	PF00397	0.750
DOC_WW_Pin1_4	40	45	PF00397	0.542
LIG_14-3-3_CanoR_1	173	178	PF00244	0.411
LIG_14-3-3_CanoR_1	38	44	PF00244	0.720
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_BIR_III_3	1	5	PF00653	0.696
LIG_Clathr_ClatBox_1	255	259	PF01394	0.449
LIG_deltaCOP1_diTrp_1	158	166	PF00928	0.342
LIG_FHA_1	174	180	PF00498	0.402
LIG_FHA_1	20	26	PF00498	0.793
LIG_FHA_1	41	47	PF00498	0.701
LIG_FHA_2	70	76	PF00498	0.795
LIG_LIR_Gen_1	125	134	PF02991	0.602
LIG_LIR_Gen_1	184	195	PF02991	0.348
LIG_LIR_Nem_3	125	130	PF02991	0.603
LIG_LIR_Nem_3	231	236	PF02991	0.448
LIG_LIR_Nem_3	259	265	PF02991	0.439
LIG_LIR_Nem_3	275	280	PF02991	0.517
LIG_PDZ_Class_1	319	324	PF00595	0.702
LIG_Pex14_1	229	233	PF04695	0.410
LIG_PTB_Apo_2	229	236	PF02174	0.554
LIG_PTB_Phospho_1	229	235	PF10480	0.553
LIG_SH2_CRK	134	138	PF00017	0.581
LIG_SH2_GRB2like	127	130	PF00017	0.689
LIG_SH2_NCK_1	134	138	PF00017	0.476
LIG_SH2_STAP1	192	196	PF00017	0.449
LIG_SH2_STAP1	280	284	PF00017	0.529
LIG_SH2_STAT5	216	219	PF00017	0.328
LIG_SH2_STAT5	233	236	PF00017	0.306
LIG_SH2_STAT5	260	263	PF00017	0.321
LIG_SH2_STAT5	291	294	PF00017	0.566
LIG_WRC_WIRS_1	179	184	PF05994	0.337
LIG_WRC_WIRS_1	271	276	PF05994	0.533
MOD_CK1_1	152	158	PF00069	0.467
MOD_CK1_1	181	187	PF00069	0.449
MOD_CK1_1	23	29	PF00069	0.775
MOD_CK1_1	269	275	PF00069	0.513
MOD_CK1_1	42	48	PF00069	0.579
MOD_CK1_1	94	100	PF00069	0.814
MOD_CK2_1	152	158	PF00069	0.467
MOD_CK2_1	69	75	PF00069	0.722
MOD_CK2_1	78	84	PF00069	0.722
MOD_GlcNHglycan	223	226	PF01048	0.339
MOD_GlcNHglycan	237	240	PF01048	0.566
MOD_GlcNHglycan	274	277	PF01048	0.451
MOD_GlcNHglycan	93	96	PF01048	0.614
MOD_GSK3_1	150	157	PF00069	0.417
MOD_GSK3_1	19	26	PF00069	0.776
MOD_GSK3_1	217	224	PF00069	0.324
MOD_GSK3_1	266	273	PF00069	0.511
MOD_GSK3_1	27	34	PF00069	0.753
MOD_GSK3_1	294	301	PF00069	0.504
MOD_GSK3_1	76	83	PF00069	0.786
MOD_GSK3_1	87	94	PF00069	0.798
MOD_NEK2_1	150	155	PF00069	0.328
MOD_NEK2_1	178	183	PF00069	0.333
MOD_NEK2_1	188	193	PF00069	0.293
MOD_NEK2_1	196	201	PF00069	0.205
MOD_NEK2_1	228	233	PF00069	0.459
MOD_NEK2_1	298	303	PF00069	0.607
MOD_NEK2_1	3	8	PF00069	0.798
MOD_PIKK_1	45	51	PF00454	0.704
MOD_PK_1	14	20	PF00069	0.698
MOD_PKA_1	112	118	PF00069	0.676
MOD_PKA_2	317	323	PF00069	0.653
MOD_PKA_2	39	45	PF00069	0.763
MOD_Plk_1	168	174	PF00069	0.353
MOD_Plk_4	112	118	PF00069	0.694
MOD_Plk_4	178	184	PF00069	0.269
MOD_Plk_4	266	272	PF00069	0.416
MOD_Plk_4	294	300	PF00069	0.522
MOD_Plk_4	31	37	PF00069	0.759
MOD_Plk_4	42	48	PF00069	0.738
MOD_ProDKin_1	20	26	PF00069	0.740
MOD_ProDKin_1	263	269	PF00069	0.344
MOD_ProDKin_1	27	33	PF00069	0.749
MOD_ProDKin_1	40	46	PF00069	0.539
TRG_DiLeu_BaEn_4	158	164	PF01217	0.401
TRG_ENDOCYTIC_2	127	130	PF00928	0.614
TRG_ENDOCYTIC_2	134	137	PF00928	0.541
TRG_ENDOCYTIC_2	192	195	PF00928	0.441
TRG_ENDOCYTIC_2	262	265	PF00928	0.449
TRG_ENDOCYTIC_2	54	57	PF00928	0.731
TRG_ER_diArg_1	36	38	PF00400	0.798
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE4	Leptomonas seymouri	59%	84%
A0A0S4ILW7	Bodo saltans	46%	93%
A0A1X0NQ98	Trypanosomatidae	52%	100%
A0A3S5IS56	Trypanosoma rangeli	56%	100%
A4H659	Leishmania braziliensis	80%	100%
A4HUH9	Leishmania infantum	99%	100%
C9ZVK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AN77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHE8	Leishmania major	92%	100%
V5BP48	Trypanosoma cruzi	54%	100%