Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WR67_LEIDO

TriTrypDb:

LdBPK_100720.1 , LdCL_100014000 , LDHU3_10.1050

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S7WR67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR67

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	37	39	PF00675	0.606
CLV_PCSK_KEX2_1	37	39	PF00082	0.606
CLV_PCSK_SKI1_1	105	109	PF00082	0.407
DOC_CKS1_1	41	46	PF01111	0.702
DOC_MAPK_FxFP_2	13	16	PF00069	0.769
DOC_MAPK_gen_1	11	20	PF00069	0.724
DOC_MAPK_MEF2A_6	11	20	PF00069	0.794
DOC_PP4_FxxP_1	13	16	PF00568	0.797
DOC_USP7_MATH_1	98	102	PF00917	0.800
DOC_USP7_UBL2_3	104	108	PF12436	0.722

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE4	Leptomonas seymouri	59%	84%
A0A0S4ILW7	Bodo saltans	46%	93%
A0A1X0NQ98	Trypanosomatidae	52%	100%
A0A3S5IS56	Trypanosoma rangeli	56%	100%
A4H659	Leishmania braziliensis	80%	100%
A4HUH9	Leishmania infantum	99%	100%
C9ZVK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AN77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHE8	Leishmania major	92%	100%
V5BP48	Trypanosoma cruzi	54%	100%

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