Flagellar glycoprotein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum adhesion protein 1

Species:

Leishmania donovani

UniProt:

A0A3S7WR66_LEIDO

TriTrypDb:

LdBPK_100680.1 , LdCL_100013600 , LDHU3_10.1010

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 1
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0016020	membrane	2	6
GO:0031514	motile cilium	5	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A0A3S7WR66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.285
CLV_C14_Caspase3-7	70	74	PF00656	0.354
CLV_NRD_NRD_1	10	12	PF00675	0.808
CLV_NRD_NRD_1	123	125	PF00675	0.615
CLV_NRD_NRD_1	15	17	PF00675	0.773
CLV_PCSK_KEX2_1	10	12	PF00082	0.804
CLV_PCSK_KEX2_1	125	127	PF00082	0.517
CLV_PCSK_KEX2_1	15	17	PF00082	0.747
CLV_PCSK_KEX2_1	516	518	PF00082	0.576
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.517
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.576
CLV_PCSK_PC7_1	11	17	PF00082	0.608
CLV_PCSK_SKI1_1	509	513	PF00082	0.560
CLV_PCSK_SKI1_1	519	523	PF00082	0.542
CLV_PCSK_SKI1_1	545	549	PF00082	0.617
DEG_APCC_DBOX_1	518	526	PF00400	0.297
DOC_CKS1_1	187	192	PF01111	0.336
DOC_CKS1_1	273	278	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.476
DOC_PP2B_LxvP_1	215	218	PF13499	0.343
DOC_PP4_FxxP_1	456	459	PF00568	0.349
DOC_PP4_FxxP_1	495	498	PF00568	0.367
DOC_USP7_MATH_1	299	303	PF00917	0.265
DOC_USP7_MATH_1	309	313	PF00917	0.263
DOC_USP7_MATH_1	365	369	PF00917	0.484
DOC_USP7_MATH_1	43	47	PF00917	0.591
DOC_USP7_MATH_1	568	572	PF00917	0.267
DOC_USP7_MATH_2	365	371	PF00917	0.488
DOC_USP7_UBL2_3	512	516	PF12436	0.311
DOC_WW_Pin1_4	130	135	PF00397	0.300
DOC_WW_Pin1_4	18	23	PF00397	0.592
DOC_WW_Pin1_4	186	191	PF00397	0.333
DOC_WW_Pin1_4	219	224	PF00397	0.375
DOC_WW_Pin1_4	272	277	PF00397	0.452
DOC_WW_Pin1_4	313	318	PF00397	0.371
DOC_WW_Pin1_4	358	363	PF00397	0.358
DOC_WW_Pin1_4	510	515	PF00397	0.314
DOC_WW_Pin1_4	586	591	PF00397	0.506
LIG_14-3-3_CanoR_1	147	152	PF00244	0.344
LIG_14-3-3_CanoR_1	342	350	PF00244	0.373
LIG_APCC_ABBA_1	336	341	PF00400	0.287
LIG_APCC_ABBAyCdc20_2	335	341	PF00400	0.276
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	246	250	PF00533	0.330
LIG_BRCT_BRCA1_1	590	594	PF00533	0.605
LIG_eIF4E_1	505	511	PF01652	0.258
LIG_FHA_1	172	178	PF00498	0.397
LIG_FHA_1	290	296	PF00498	0.291
LIG_FHA_1	327	333	PF00498	0.427
LIG_FHA_1	351	357	PF00498	0.300
LIG_FHA_1	462	468	PF00498	0.468
LIG_FHA_1	487	493	PF00498	0.303
LIG_FHA_1	593	599	PF00498	0.685
LIG_FHA_2	463	469	PF00498	0.313
LIG_GBD_Chelix_1	160	168	PF00786	0.492
LIG_Integrin_RGD_1	126	128	PF01839	0.563
LIG_LIR_Apic_2	231	237	PF02991	0.343
LIG_LIR_Apic_2	262	266	PF02991	0.388
LIG_LIR_Apic_2	455	459	PF02991	0.406
LIG_LIR_Gen_1	209	218	PF02991	0.370
LIG_LIR_Gen_1	352	363	PF02991	0.362
LIG_LIR_Gen_1	433	443	PF02991	0.358
LIG_LIR_Gen_1	55	66	PF02991	0.373
LIG_LIR_Gen_1	591	602	PF02991	0.603
LIG_LIR_Nem_3	135	141	PF02991	0.368
LIG_LIR_Nem_3	209	214	PF02991	0.382
LIG_LIR_Nem_3	280	284	PF02991	0.388
LIG_LIR_Nem_3	344	350	PF02991	0.294
LIG_LIR_Nem_3	352	358	PF02991	0.296
LIG_LIR_Nem_3	55	61	PF02991	0.343
LIG_LIR_Nem_3	591	597	PF02991	0.594
LIG_MYND_1	317	321	PF01753	0.371
LIG_NRBOX	32	38	PF00104	0.509
LIG_Pex14_2	452	456	PF04695	0.280
LIG_PTB_Apo_2	152	159	PF02174	0.360
LIG_PTB_Apo_2	205	212	PF02174	0.283
LIG_PTB_Phospho_1	205	211	PF10480	0.278
LIG_REV1ctd_RIR_1	337	346	PF16727	0.347
LIG_SH2_CRK	211	215	PF00017	0.350
LIG_SH2_CRK	58	62	PF00017	0.372
LIG_SH2_CRK	81	85	PF00017	0.334
LIG_SH2_PTP2	263	266	PF00017	0.356
LIG_SH2_SRC	216	219	PF00017	0.296
LIG_SH2_STAT5	115	118	PF00017	0.346
LIG_SH2_STAT5	159	162	PF00017	0.259
LIG_SH2_STAT5	216	219	PF00017	0.419
LIG_SH2_STAT5	234	237	PF00017	0.201
LIG_SH2_STAT5	259	262	PF00017	0.354
LIG_SH2_STAT5	263	266	PF00017	0.437
LIG_SH2_STAT5	296	299	PF00017	0.352
LIG_SH2_STAT5	348	351	PF00017	0.290
LIG_SH2_STAT5	505	508	PF00017	0.343
LIG_SH3_3	270	276	PF00018	0.362
LIG_SH3_3	359	365	PF00018	0.432
LIG_SH3_3	454	460	PF00018	0.360
LIG_SH3_3	508	514	PF00018	0.267
LIG_SH3_3	547	553	PF00018	0.474
LIG_SH3_3	595	601	PF00018	0.703
LIG_SUMO_SIM_anti_2	489	494	PF11976	0.370
LIG_SUMO_SIM_par_1	323	330	PF11976	0.340
LIG_SUMO_SIM_par_1	583	589	PF11976	0.360
LIG_TYR_ITSM	207	214	PF00017	0.286
LIG_TYR_ITSM	53	60	PF00017	0.320
MOD_CDC14_SPxK_1	513	516	PF00782	0.322
MOD_CDK_SPxK_1	510	516	PF00069	0.324
MOD_CDK_SPxxK_3	510	517	PF00069	0.282
MOD_CK1_1	196	202	PF00069	0.383
MOD_CK1_1	219	225	PF00069	0.390
MOD_CK1_1	244	250	PF00069	0.348
MOD_CK1_1	267	273	PF00069	0.332
MOD_CK1_1	312	318	PF00069	0.373
MOD_CK1_1	368	374	PF00069	0.497
MOD_CK1_1	375	381	PF00069	0.476
MOD_CK1_1	382	388	PF00069	0.424
MOD_CK1_1	389	395	PF00069	0.430
MOD_CK1_1	396	402	PF00069	0.451
MOD_CK1_1	46	52	PF00069	0.349
MOD_CK1_1	524	530	PF00069	0.428
MOD_CK2_1	400	406	PF00069	0.567
MOD_GlcNHglycan	102	105	PF01048	0.537
MOD_GlcNHglycan	198	201	PF01048	0.653
MOD_GlcNHglycan	312	315	PF01048	0.541
MOD_GlcNHglycan	358	361	PF01048	0.611
MOD_GlcNHglycan	370	373	PF01048	0.628
MOD_GlcNHglycan	395	398	PF01048	0.668
MOD_GlcNHglycan	409	412	PF01048	0.652
MOD_GlcNHglycan	527	530	PF01048	0.580
MOD_GlcNHglycan	558	561	PF01048	0.685
MOD_GlcNHglycan	63	66	PF01048	0.607
MOD_GlcNHglycan	75	78	PF01048	0.565
MOD_GSK3_1	143	150	PF00069	0.417
MOD_GSK3_1	168	175	PF00069	0.413
MOD_GSK3_1	189	196	PF00069	0.392
MOD_GSK3_1	200	207	PF00069	0.404
MOD_GSK3_1	267	274	PF00069	0.438
MOD_GSK3_1	285	292	PF00069	0.268
MOD_GSK3_1	295	302	PF00069	0.343
MOD_GSK3_1	309	316	PF00069	0.300
MOD_GSK3_1	366	373	PF00069	0.462
MOD_GSK3_1	374	381	PF00069	0.522
MOD_GSK3_1	382	389	PF00069	0.502
MOD_GSK3_1	391	398	PF00069	0.488
MOD_GSK3_1	426	433	PF00069	0.333
MOD_GSK3_1	458	465	PF00069	0.454
MOD_GSK3_1	478	485	PF00069	0.341
MOD_GSK3_1	521	528	PF00069	0.363
MOD_GSK3_1	539	546	PF00069	0.370
MOD_GSK3_1	588	595	PF00069	0.635
MOD_GSK3_1	69	76	PF00069	0.368
MOD_N-GLC_1	171	176	PF02516	0.570
MOD_N-GLC_1	227	232	PF02516	0.613
MOD_N-GLC_1	252	257	PF02516	0.533
MOD_N-GLC_1	299	304	PF02516	0.616
MOD_N-GLC_1	426	431	PF02516	0.601
MOD_N-GLC_1	461	466	PF02516	0.587
MOD_N-GLC_1	471	476	PF02516	0.503
MOD_N-GLC_1	478	483	PF02516	0.477
MOD_N-GLC_1	525	530	PF02516	0.536
MOD_N-GLC_1	538	543	PF02516	0.566
MOD_NEK2_1	100	105	PF00069	0.381
MOD_NEK2_1	160	165	PF00069	0.265
MOD_NEK2_1	168	173	PF00069	0.264
MOD_NEK2_1	193	198	PF00069	0.330
MOD_NEK2_1	295	300	PF00069	0.402
MOD_NEK2_1	307	312	PF00069	0.287
MOD_NEK2_1	327	332	PF00069	0.213
MOD_NEK2_1	350	355	PF00069	0.338
MOD_NEK2_1	356	361	PF00069	0.312
MOD_NEK2_1	521	526	PF00069	0.301
MOD_NEK2_2	200	205	PF00069	0.250
MOD_PIKK_1	289	295	PF00454	0.305
MOD_PIKK_1	350	356	PF00454	0.302
MOD_PIKK_1	430	436	PF00454	0.311
MOD_PIKK_1	503	509	PF00454	0.364
MOD_PKA_2	168	174	PF00069	0.270
MOD_PKA_2	341	347	PF00069	0.439
MOD_Plk_1	252	258	PF00069	0.330
MOD_Plk_1	327	333	PF00069	0.262
MOD_Plk_1	426	432	PF00069	0.396
MOD_Plk_1	461	467	PF00069	0.367
MOD_Plk_1	471	477	PF00069	0.300
MOD_Plk_4	177	183	PF00069	0.329
MOD_Plk_4	193	199	PF00069	0.264
MOD_Plk_4	200	206	PF00069	0.347
MOD_Plk_4	210	216	PF00069	0.286
MOD_Plk_4	315	321	PF00069	0.451
MOD_Plk_4	327	333	PF00069	0.296
MOD_Plk_4	343	349	PF00069	0.236
MOD_Plk_4	462	468	PF00069	0.482
MOD_Plk_4	52	58	PF00069	0.388
MOD_Plk_4	569	575	PF00069	0.344
MOD_ProDKin_1	130	136	PF00069	0.295
MOD_ProDKin_1	18	24	PF00069	0.588
MOD_ProDKin_1	186	192	PF00069	0.332
MOD_ProDKin_1	219	225	PF00069	0.374
MOD_ProDKin_1	272	278	PF00069	0.455
MOD_ProDKin_1	313	319	PF00069	0.367
MOD_ProDKin_1	358	364	PF00069	0.369
MOD_ProDKin_1	510	516	PF00069	0.319
MOD_ProDKin_1	586	592	PF00069	0.508
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.383
TRG_ENDOCYTIC_2	211	214	PF00928	0.335
TRG_ENDOCYTIC_2	436	439	PF00928	0.328
TRG_ENDOCYTIC_2	57	60	PF00928	0.319
TRG_ENDOCYTIC_2	81	84	PF00928	0.403
TRG_ER_diArg_1	10	12	PF00400	0.573
TRG_ER_diArg_1	14	16	PF00400	0.568
TRG_NLS_MonoExtN_4	514	520	PF00514	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRY9	Trypanosomatidae	31%	100%
A0A422NWX8	Trypanosoma rangeli	30%	100%
A4H655	Leishmania braziliensis	69%	97%
A4HUH5	Leishmania infantum	98%	98%
C9ZVK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AN73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QHF2	Leishmania major	84%	95%
V5BP43	Trypanosoma cruzi	29%	100%