LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WR65_LEIDO
TriTrypDb:
LdBPK_100570.1 * , LdCL_100012500 , LDHU3_10.0890
Length:
906

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WR65
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR65

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 396 400 PF00656 0.672
CLV_C14_Caspase3-7 841 845 PF00656 0.642
CLV_NRD_NRD_1 13 15 PF00675 0.559
CLV_NRD_NRD_1 131 133 PF00675 0.473
CLV_NRD_NRD_1 202 204 PF00675 0.608
CLV_NRD_NRD_1 214 216 PF00675 0.621
CLV_NRD_NRD_1 287 289 PF00675 0.533
CLV_NRD_NRD_1 29 31 PF00675 0.378
CLV_NRD_NRD_1 331 333 PF00675 0.562
CLV_NRD_NRD_1 386 388 PF00675 0.713
CLV_NRD_NRD_1 397 399 PF00675 0.583
CLV_NRD_NRD_1 453 455 PF00675 0.593
CLV_NRD_NRD_1 644 646 PF00675 0.567
CLV_NRD_NRD_1 653 655 PF00675 0.375
CLV_NRD_NRD_1 693 695 PF00675 0.509
CLV_NRD_NRD_1 902 904 PF00675 0.610
CLV_NRD_NRD_1 92 94 PF00675 0.445
CLV_PCSK_FUR_1 900 904 PF00082 0.599
CLV_PCSK_KEX2_1 13 15 PF00082 0.559
CLV_PCSK_KEX2_1 131 133 PF00082 0.473
CLV_PCSK_KEX2_1 204 206 PF00082 0.660
CLV_PCSK_KEX2_1 287 289 PF00082 0.533
CLV_PCSK_KEX2_1 29 31 PF00082 0.378
CLV_PCSK_KEX2_1 331 333 PF00082 0.562
CLV_PCSK_KEX2_1 386 388 PF00082 0.713
CLV_PCSK_KEX2_1 397 399 PF00082 0.583
CLV_PCSK_KEX2_1 653 655 PF00082 0.387
CLV_PCSK_KEX2_1 680 682 PF00082 0.471
CLV_PCSK_KEX2_1 693 695 PF00082 0.432
CLV_PCSK_KEX2_1 902 904 PF00082 0.610
CLV_PCSK_KEX2_1 92 94 PF00082 0.445
CLV_PCSK_PC1ET2_1 204 206 PF00082 0.637
CLV_PCSK_PC1ET2_1 680 682 PF00082 0.471
CLV_PCSK_SKI1_1 159 163 PF00082 0.666
CLV_PCSK_SKI1_1 296 300 PF00082 0.413
CLV_PCSK_SKI1_1 3 7 PF00082 0.459
CLV_PCSK_SKI1_1 429 433 PF00082 0.573
CLV_PCSK_SKI1_1 531 535 PF00082 0.602
CLV_PCSK_SKI1_1 579 583 PF00082 0.401
CLV_PCSK_SKI1_1 681 685 PF00082 0.504
CLV_PCSK_SKI1_1 707 711 PF00082 0.450
CLV_PCSK_SKI1_1 779 783 PF00082 0.478
CLV_PCSK_SKI1_1 80 84 PF00082 0.403
CLV_Separin_Metazoa 26 30 PF03568 0.424
CLV_Separin_Metazoa 342 346 PF03568 0.397
DEG_APCC_DBOX_1 113 121 PF00400 0.380
DEG_APCC_DBOX_1 2 10 PF00400 0.524
DEG_APCC_DBOX_1 656 664 PF00400 0.417
DEG_APCC_DBOX_1 680 688 PF00400 0.417
DEG_APCC_DBOX_1 782 790 PF00400 0.442
DEG_COP1_1 478 489 PF00400 0.558
DEG_Nend_Nbox_1 1 3 PF02207 0.490
DEG_SPOP_SBC_1 440 444 PF00917 0.586
DEG_SPOP_SBC_1 845 849 PF00917 0.570
DOC_CKS1_1 596 601 PF01111 0.537
DOC_CYCLIN_RxL_1 426 436 PF00134 0.579
DOC_CYCLIN_RxL_1 704 713 PF00134 0.451
DOC_CYCLIN_yCln2_LP_2 745 751 PF00134 0.487
DOC_CYCLIN_yCln2_LP_2 802 808 PF00134 0.606
DOC_CYCLIN_yCln2_LP_2 825 831 PF00134 0.615
DOC_MAPK_gen_1 427 434 PF00069 0.578
DOC_MAPK_gen_1 653 663 PF00069 0.367
DOC_MAPK_gen_1 680 686 PF00069 0.460
DOC_MAPK_MEF2A_6 821 829 PF00069 0.663
DOC_MAPK_MEF2A_6 93 102 PF00069 0.508
DOC_PP1_RVXF_1 529 536 PF00149 0.394
DOC_PP2B_LxvP_1 432 435 PF13499 0.596
DOC_PP2B_LxvP_1 688 691 PF13499 0.367
DOC_PP2B_LxvP_1 825 828 PF13499 0.616
DOC_PP2B_LxvP_1 829 832 PF13499 0.579
DOC_PP4_FxxP_1 534 537 PF00568 0.383
DOC_PP4_FxxP_1 712 715 PF00568 0.424
DOC_USP7_MATH_1 146 150 PF00917 0.611
DOC_USP7_MATH_1 170 174 PF00917 0.522
DOC_USP7_MATH_1 310 314 PF00917 0.536
DOC_USP7_MATH_1 388 392 PF00917 0.757
DOC_USP7_MATH_1 39 43 PF00917 0.504
DOC_USP7_MATH_1 393 397 PF00917 0.852
DOC_USP7_MATH_1 440 444 PF00917 0.786
DOC_USP7_MATH_1 485 489 PF00917 0.627
DOC_USP7_MATH_1 50 54 PF00917 0.563
DOC_USP7_MATH_1 512 516 PF00917 0.532
DOC_USP7_MATH_1 591 595 PF00917 0.561
DOC_USP7_MATH_1 809 813 PF00917 0.692
DOC_USP7_MATH_1 843 847 PF00917 0.717
DOC_USP7_UBL2_3 216 220 PF12436 0.599
DOC_WW_Pin1_4 115 120 PF00397 0.411
DOC_WW_Pin1_4 331 336 PF00397 0.491
DOC_WW_Pin1_4 369 374 PF00397 0.683
DOC_WW_Pin1_4 411 416 PF00397 0.836
DOC_WW_Pin1_4 479 484 PF00397 0.583
DOC_WW_Pin1_4 489 494 PF00397 0.707
DOC_WW_Pin1_4 595 600 PF00397 0.553
DOC_WW_Pin1_4 62 67 PF00397 0.649
DOC_WW_Pin1_4 667 672 PF00397 0.455
DOC_WW_Pin1_4 673 678 PF00397 0.395
DOC_WW_Pin1_4 744 749 PF00397 0.462
DOC_WW_Pin1_4 871 876 PF00397 0.648
DOC_WW_Pin1_4 901 906 PF00397 0.618
DOC_WW_Pin1_4 94 99 PF00397 0.527
LIG_14-3-3_CanoR_1 147 153 PF00244 0.600
LIG_14-3-3_CanoR_1 29 39 PF00244 0.466
LIG_14-3-3_CanoR_1 302 307 PF00244 0.339
LIG_14-3-3_CanoR_1 309 315 PF00244 0.324
LIG_14-3-3_CanoR_1 345 353 PF00244 0.402
LIG_14-3-3_CanoR_1 365 373 PF00244 0.621
LIG_14-3-3_CanoR_1 418 423 PF00244 0.651
LIG_14-3-3_CanoR_1 433 439 PF00244 0.513
LIG_14-3-3_CanoR_1 454 460 PF00244 0.558
LIG_14-3-3_CanoR_1 539 544 PF00244 0.493
LIG_14-3-3_CanoR_1 645 651 PF00244 0.430
LIG_14-3-3_CanoR_1 790 797 PF00244 0.525
LIG_14-3-3_CanoR_1 821 826 PF00244 0.647
LIG_14-3-3_CanoR_1 878 888 PF00244 0.594
LIG_Actin_WH2_2 767 785 PF00022 0.462
LIG_ActinCP_TwfCPI_2 712 720 PF01115 0.468
LIG_BRCT_BRCA1_1 221 225 PF00533 0.496
LIG_BRCT_BRCA1_1 688 692 PF00533 0.491
LIG_CSL_BTD_1 437 440 PF09270 0.595
LIG_DCNL_PONY_1 1 4 PF03556 0.547
LIG_deltaCOP1_diTrp_1 238 244 PF00928 0.465
LIG_eIF4E_1 338 344 PF01652 0.506
LIG_FHA_1 120 126 PF00498 0.455
LIG_FHA_1 249 255 PF00498 0.389
LIG_FHA_1 476 482 PF00498 0.554
LIG_FHA_1 518 524 PF00498 0.503
LIG_FHA_1 564 570 PF00498 0.393
LIG_FHA_1 674 680 PF00498 0.563
LIG_FHA_1 723 729 PF00498 0.735
LIG_FHA_1 741 747 PF00498 0.406
LIG_FHA_1 756 762 PF00498 0.699
LIG_FHA_1 820 826 PF00498 0.669
LIG_FHA_1 894 900 PF00498 0.565
LIG_FHA_1 97 103 PF00498 0.499
LIG_FHA_2 224 230 PF00498 0.480
LIG_FHA_2 68 74 PF00498 0.601
LIG_FHA_2 711 717 PF00498 0.515
LIG_FHA_2 773 779 PF00498 0.649
LIG_FHA_2 791 797 PF00498 0.585
LIG_FHA_2 99 105 PF00498 0.472
LIG_GBD_Chelix_1 109 117 PF00786 0.383
LIG_LIR_Apic_2 334 340 PF02991 0.543
LIG_LIR_Apic_2 532 537 PF02991 0.367
LIG_LIR_Gen_1 504 514 PF02991 0.437
LIG_LIR_Nem_3 238 244 PF02991 0.400
LIG_LIR_Nem_3 504 510 PF02991 0.395
LIG_PCNA_yPIPBox_3 567 579 PF02747 0.303
LIG_SH2_CRK 658 662 PF00017 0.351
LIG_SH2_STAP1 477 481 PF00017 0.480
LIG_SH2_STAT3 338 341 PF00017 0.534
LIG_SH2_STAT3 898 901 PF00017 0.598
LIG_SH2_STAT5 469 472 PF00017 0.429
LIG_SH2_STAT5 477 480 PF00017 0.555
LIG_SH2_STAT5 898 901 PF00017 0.598
LIG_SH3_3 382 388 PF00018 0.685
LIG_SH3_3 420 426 PF00018 0.615
LIG_SH3_3 478 484 PF00018 0.639
LIG_SH3_3 557 563 PF00018 0.421
LIG_SH3_3 593 599 PF00018 0.560
LIG_SH3_3 803 809 PF00018 0.612
LIG_SUMO_SIM_anti_2 259 266 PF11976 0.419
LIG_SUMO_SIM_par_1 310 316 PF11976 0.415
LIG_SUMO_SIM_par_1 351 357 PF11976 0.488
LIG_SUMO_SIM_par_1 96 104 PF11976 0.498
LIG_TRAF2_1 316 319 PF00917 0.527
LIG_TRAF2_1 785 788 PF00917 0.465
LIG_TRAF2_1 881 884 PF00917 0.582
LIG_UBA3_1 152 159 PF00899 0.590
MOD_CDK_SPK_2 871 876 PF00069 0.648
MOD_CDK_SPxxK_3 411 418 PF00069 0.668
MOD_CDK_SPxxK_3 673 680 PF00069 0.476
MOD_CDK_SPxxK_3 871 878 PF00069 0.648
MOD_CK1_1 219 225 PF00069 0.516
MOD_CK1_1 313 319 PF00069 0.455
MOD_CK1_1 34 40 PF00069 0.499
MOD_CK1_1 364 370 PF00069 0.711
MOD_CK1_1 405 411 PF00069 0.726
MOD_CK1_1 442 448 PF00069 0.599
MOD_CK1_1 479 485 PF00069 0.602
MOD_CK1_1 516 522 PF00069 0.510
MOD_CK1_1 846 852 PF00069 0.710
MOD_CK1_1 861 867 PF00069 0.557
MOD_CK1_1 96 102 PF00069 0.467
MOD_CK2_1 313 319 PF00069 0.499
MOD_CK2_1 327 333 PF00069 0.494
MOD_CK2_1 369 375 PF00069 0.763
MOD_CK2_1 644 650 PF00069 0.542
MOD_CK2_1 67 73 PF00069 0.649
MOD_CK2_1 710 716 PF00069 0.493
MOD_CK2_1 772 778 PF00069 0.518
MOD_CK2_1 790 796 PF00069 0.472
MOD_CK2_1 807 813 PF00069 0.714
MOD_GlcNHglycan 141 144 PF01048 0.724
MOD_GlcNHglycan 207 210 PF01048 0.608
MOD_GlcNHglycan 270 273 PF01048 0.553
MOD_GlcNHglycan 367 370 PF01048 0.645
MOD_GlcNHglycan 390 393 PF01048 0.755
MOD_GlcNHglycan 579 582 PF01048 0.443
MOD_GlcNHglycan 593 596 PF01048 0.453
MOD_GlcNHglycan 688 691 PF01048 0.498
MOD_GlcNHglycan 766 769 PF01048 0.675
MOD_GlcNHglycan 775 778 PF01048 0.543
MOD_GlcNHglycan 783 786 PF01048 0.359
MOD_GlcNHglycan 809 812 PF01048 0.621
MOD_GlcNHglycan 841 844 PF01048 0.625
MOD_GlcNHglycan 860 863 PF01048 0.693
MOD_GSK3_1 115 122 PF00069 0.465
MOD_GSK3_1 134 141 PF00069 0.418
MOD_GSK3_1 199 206 PF00069 0.519
MOD_GSK3_1 219 226 PF00069 0.467
MOD_GSK3_1 263 270 PF00069 0.418
MOD_GSK3_1 287 294 PF00069 0.581
MOD_GSK3_1 30 37 PF00069 0.454
MOD_GSK3_1 327 334 PF00069 0.588
MOD_GSK3_1 361 368 PF00069 0.632
MOD_GSK3_1 388 395 PF00069 0.652
MOD_GSK3_1 400 407 PF00069 0.653
MOD_GSK3_1 475 482 PF00069 0.539
MOD_GSK3_1 485 492 PF00069 0.594
MOD_GSK3_1 512 519 PF00069 0.460
MOD_GSK3_1 587 594 PF00069 0.595
MOD_GSK3_1 632 639 PF00069 0.487
MOD_GSK3_1 641 648 PF00069 0.451
MOD_GSK3_1 667 674 PF00069 0.465
MOD_GSK3_1 740 747 PF00069 0.601
MOD_GSK3_1 827 834 PF00069 0.598
MOD_GSK3_1 839 846 PF00069 0.601
MOD_GSK3_1 861 868 PF00069 0.593
MOD_GSK3_1 887 894 PF00069 0.544
MOD_GSK3_1 94 101 PF00069 0.514
MOD_NEK2_1 155 160 PF00069 0.551
MOD_NEK2_1 199 204 PF00069 0.552
MOD_NEK2_1 263 268 PF00069 0.398
MOD_NEK2_1 282 287 PF00069 0.544
MOD_NEK2_1 31 36 PF00069 0.442
MOD_NEK2_1 404 409 PF00069 0.694
MOD_NEK2_1 475 480 PF00069 0.666
MOD_NEK2_1 577 582 PF00069 0.394
MOD_NEK2_1 601 606 PF00069 0.477
MOD_NEK2_1 614 619 PF00069 0.327
MOD_NEK2_1 630 635 PF00069 0.390
MOD_NEK2_1 686 691 PF00069 0.478
MOD_NEK2_1 710 715 PF00069 0.468
MOD_NEK2_1 781 786 PF00069 0.491
MOD_NEK2_2 615 620 PF00069 0.395
MOD_NEK2_2 623 628 PF00069 0.416
MOD_NEK2_2 67 72 PF00069 0.600
MOD_PIKK_1 119 125 PF00454 0.465
MOD_PIKK_1 313 319 PF00454 0.551
MOD_PIKK_1 344 350 PF00454 0.594
MOD_PIKK_1 563 569 PF00454 0.376
MOD_PIKK_1 632 638 PF00454 0.485
MOD_PIKK_1 722 728 PF00454 0.616
MOD_PIKK_1 790 796 PF00454 0.550
MOD_PKA_1 203 209 PF00069 0.636
MOD_PKA_1 287 293 PF00069 0.585
MOD_PKA_1 645 651 PF00069 0.430
MOD_PKA_2 146 152 PF00069 0.676
MOD_PKA_2 204 210 PF00069 0.758
MOD_PKA_2 287 293 PF00069 0.585
MOD_PKA_2 344 350 PF00069 0.485
MOD_PKA_2 361 367 PF00069 0.560
MOD_PKA_2 393 399 PF00069 0.703
MOD_PKA_2 453 459 PF00069 0.707
MOD_PKA_2 644 650 PF00069 0.546
MOD_PKA_2 879 885 PF00069 0.601
MOD_PKB_1 201 209 PF00069 0.570
MOD_PKB_1 865 873 PF00069 0.608
MOD_Plk_1 374 380 PF00069 0.651
MOD_Plk_1 740 746 PF00069 0.483
MOD_Plk_4 177 183 PF00069 0.419
MOD_Plk_4 434 440 PF00069 0.511
MOD_Plk_4 565 571 PF00069 0.511
MOD_ProDKin_1 115 121 PF00069 0.404
MOD_ProDKin_1 331 337 PF00069 0.488
MOD_ProDKin_1 369 375 PF00069 0.685
MOD_ProDKin_1 411 417 PF00069 0.837
MOD_ProDKin_1 479 485 PF00069 0.585
MOD_ProDKin_1 489 495 PF00069 0.695
MOD_ProDKin_1 595 601 PF00069 0.539
MOD_ProDKin_1 62 68 PF00069 0.646
MOD_ProDKin_1 667 673 PF00069 0.454
MOD_ProDKin_1 744 750 PF00069 0.466
MOD_ProDKin_1 871 877 PF00069 0.648
MOD_ProDKin_1 94 100 PF00069 0.517
TRG_DiLeu_BaEn_1 548 553 PF01217 0.376
TRG_DiLeu_BaEn_1 741 746 PF01217 0.413
TRG_DiLeu_BaEn_1 883 888 PF01217 0.522
TRG_DiLeu_BaLyEn_6 348 353 PF01217 0.429
TRG_DiLeu_BaLyEn_6 83 88 PF01217 0.384
TRG_ENDOCYTIC_2 658 661 PF00928 0.351
TRG_ER_diArg_1 13 15 PF00400 0.543
TRG_ER_diArg_1 131 133 PF00400 0.473
TRG_ER_diArg_1 28 30 PF00400 0.379
TRG_ER_diArg_1 286 288 PF00400 0.548
TRG_ER_diArg_1 385 387 PF00400 0.711
TRG_ER_diArg_1 460 463 PF00400 0.497
TRG_ER_diArg_1 692 694 PF00400 0.463
TRG_ER_diArg_1 875 878 PF00400 0.711
TRG_ER_diArg_1 899 902 PF00400 0.611
TRG_ER_diArg_1 91 93 PF00400 0.440
TRG_NES_CRM1_1 174 186 PF08389 0.434
TRG_NES_CRM1_1 341 354 PF08389 0.429
TRG_NLS_MonoExtN_4 201 207 PF00514 0.566
TRG_Pf-PMV_PEXEL_1 13 17 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 296 300 PF00026 0.412
TRG_Pf-PMV_PEXEL_1 3 7 PF00026 0.495
TRG_Pf-PMV_PEXEL_1 541 545 PF00026 0.593
TRG_Pf-PMV_PEXEL_1 681 685 PF00026 0.548
TRG_Pf-PMV_PEXEL_1 800 804 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 897 901 PF00026 0.552

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE49 Leptomonas seymouri 45% 94%
A4H644 Leishmania braziliensis 76% 100%
A4HUG4 Leishmania infantum 99% 100%
E9AN62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QHG3 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS