Zinc-binding dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-binding dehydrogenase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WR58_LEIDO

TriTrypDb:

LdBPK_100620.1 , LdCL_100013000 , LDHU3_10.0940

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WR58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR58

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016491	oxidoreductase activity	2	16
GO:0003960	NADPH:quinone reductase activity	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.357
CLV_NRD_NRD_1	355	357	PF00675	0.431
CLV_NRD_NRD_1	439	441	PF00675	0.502
CLV_NRD_NRD_1	60	62	PF00675	0.418
CLV_PCSK_FUR_1	436	440	PF00082	0.595
CLV_PCSK_KEX2_1	355	357	PF00082	0.438
CLV_PCSK_KEX2_1	438	440	PF00082	0.501
CLV_PCSK_KEX2_1	60	62	PF00082	0.520
CLV_PCSK_PC7_1	56	62	PF00082	0.375
CLV_PCSK_SKI1_1	169	173	PF00082	0.370
CLV_PCSK_SKI1_1	247	251	PF00082	0.356
CLV_PCSK_SKI1_1	303	307	PF00082	0.378
CLV_PCSK_SKI1_1	42	46	PF00082	0.527
CLV_PCSK_SKI1_1	421	425	PF00082	0.370
DEG_APCC_DBOX_1	374	382	PF00400	0.459
DOC_MAPK_FxFP_2	122	125	PF00069	0.424
DOC_MAPK_gen_1	162	172	PF00069	0.498
DOC_MAPK_gen_1	436	444	PF00069	0.576
DOC_MAPK_JIP1_4	30	36	PF00069	0.509
DOC_PP1_RVXF_1	167	173	PF00149	0.374
DOC_PP1_RVXF_1	214	221	PF00149	0.453
DOC_PP4_FxxP_1	122	125	PF00568	0.424
DOC_USP7_MATH_1	142	146	PF00917	0.681
DOC_USP7_MATH_1	25	29	PF00917	0.637
DOC_USP7_MATH_1	275	279	PF00917	0.298
DOC_USP7_MATH_1	321	325	PF00917	0.378
DOC_USP7_MATH_1	467	471	PF00917	0.609
DOC_WW_Pin1_4	276	281	PF00397	0.402
DOC_WW_Pin1_4	344	349	PF00397	0.395
LIG_14-3-3_CanoR_1	283	289	PF00244	0.475
LIG_14-3-3_CanoR_1	355	361	PF00244	0.414
LIG_Actin_WH2_2	14	32	PF00022	0.554
LIG_eIF4E_1	312	318	PF01652	0.404
LIG_EVH1_2	120	124	PF00568	0.439
LIG_FHA_1	207	213	PF00498	0.617
LIG_FHA_1	230	236	PF00498	0.360
LIG_FHA_1	341	347	PF00498	0.348
LIG_FHA_1	94	100	PF00498	0.531
LIG_FHA_2	295	301	PF00498	0.315
LIG_FHA_2	305	311	PF00498	0.315
LIG_FHA_2	427	433	PF00498	0.543
LIG_LIR_Apic_2	193	199	PF02991	0.460
LIG_LIR_Gen_1	232	241	PF02991	0.360
LIG_LIR_Gen_1	359	367	PF02991	0.401
LIG_LIR_Nem_3	100	105	PF02991	0.685
LIG_LIR_Nem_3	183	187	PF02991	0.307
LIG_LIR_Nem_3	232	237	PF02991	0.359
LIG_LIR_Nem_3	359	365	PF02991	0.394
LIG_MYND_1	27	31	PF01753	0.615
LIG_NRBOX	341	347	PF00104	0.372
LIG_Pex14_2	172	176	PF04695	0.465
LIG_SH2_NCK_1	187	191	PF00017	0.435
LIG_SH2_NCK_1	296	300	PF00017	0.385
LIG_SH2_NCK_1	445	449	PF00017	0.588
LIG_SH2_PTP2	19	22	PF00017	0.667
LIG_SH2_PTP2	234	237	PF00017	0.348
LIG_SH2_PTP2	362	365	PF00017	0.396
LIG_SH2_SRC	272	275	PF00017	0.313
LIG_SH2_STAP1	308	312	PF00017	0.313
LIG_SH2_STAP1	65	69	PF00017	0.517
LIG_SH2_STAT5	126	129	PF00017	0.393
LIG_SH2_STAT5	19	22	PF00017	0.615
LIG_SH2_STAT5	234	237	PF00017	0.348
LIG_SH2_STAT5	268	271	PF00017	0.344
LIG_SH2_STAT5	272	275	PF00017	0.339
LIG_SH2_STAT5	284	287	PF00017	0.294
LIG_SH2_STAT5	292	295	PF00017	0.348
LIG_SH2_STAT5	296	299	PF00017	0.348
LIG_SH2_STAT5	308	311	PF00017	0.337
LIG_SH2_STAT5	316	319	PF00017	0.291
LIG_SH2_STAT5	362	365	PF00017	0.396
LIG_SH2_STAT5	389	392	PF00017	0.546
LIG_SH3_1	19	25	PF00018	0.569
LIG_SH3_2	118	123	PF14604	0.467
LIG_SH3_3	10	16	PF00018	0.573
LIG_SH3_3	115	121	PF00018	0.561
LIG_SH3_3	19	25	PF00018	0.660
LIG_SH3_3	199	205	PF00018	0.618
LIG_SH3_3	68	74	PF00018	0.368
LIG_SUMO_SIM_anti_2	408	414	PF11976	0.414
LIG_TYR_ITIM	360	365	PF00017	0.412
LIG_WW_1	16	19	PF00397	0.569
MOD_CDK_SPK_2	344	349	PF00069	0.253
MOD_CDK_SPxxK_3	276	283	PF00069	0.313
MOD_CK1_1	108	114	PF00069	0.678
MOD_CK1_1	180	186	PF00069	0.491
MOD_CK1_1	252	258	PF00069	0.320
MOD_CK1_1	276	282	PF00069	0.291
MOD_CK1_1	347	353	PF00069	0.343
MOD_CK1_1	37	43	PF00069	0.487
MOD_CK1_1	7	13	PF00069	0.594
MOD_CK2_1	142	148	PF00069	0.620
MOD_CK2_1	321	327	PF00069	0.368
MOD_CK2_1	64	70	PF00069	0.598
MOD_CK2_1	98	104	PF00069	0.477
MOD_GlcNHglycan	10	13	PF01048	0.677
MOD_GlcNHglycan	107	110	PF01048	0.677
MOD_GlcNHglycan	145	148	PF01048	0.746
MOD_GlcNHglycan	150	154	PF01048	0.561
MOD_GlcNHglycan	157	160	PF01048	0.458
MOD_GlcNHglycan	179	182	PF01048	0.442
MOD_GlcNHglycan	251	254	PF01048	0.362
MOD_GlcNHglycan	259	262	PF01048	0.361
MOD_GlcNHglycan	38	42	PF01048	0.535
MOD_GSK3_1	104	111	PF00069	0.551
MOD_GSK3_1	25	32	PF00069	0.642
MOD_GSK3_1	3	10	PF00069	0.647
MOD_GSK3_1	340	347	PF00069	0.382
MOD_GSK3_1	422	429	PF00069	0.495
MOD_GSK3_1	467	474	PF00069	0.623
MOD_GSK3_1	93	100	PF00069	0.405
MOD_N-GLC_1	4	9	PF02516	0.581
MOD_N-GLC_1	54	59	PF02516	0.387
MOD_NEK2_1	36	41	PF00069	0.496
MOD_NEK2_1	373	378	PF00069	0.448
MOD_NEK2_1	454	459	PF00069	0.542
MOD_PIKK_1	174	180	PF00454	0.462
MOD_PIKK_1	242	248	PF00454	0.381
MOD_PIKK_1	373	379	PF00454	0.449
MOD_PIKK_1	454	460	PF00454	0.460
MOD_PK_1	356	362	PF00069	0.434
MOD_Plk_1	54	60	PF00069	0.543
MOD_Plk_2-3	304	310	PF00069	0.273
MOD_ProDKin_1	276	282	PF00069	0.402
MOD_ProDKin_1	344	350	PF00069	0.395
TRG_DiLeu_BaEn_2	398	404	PF01217	0.475
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.540
TRG_ENDOCYTIC_2	187	190	PF00928	0.376
TRG_ENDOCYTIC_2	234	237	PF00928	0.348
TRG_ENDOCYTIC_2	268	271	PF00928	0.291
TRG_ENDOCYTIC_2	362	365	PF00928	0.396
TRG_ER_diArg_1	354	356	PF00400	0.461
TRG_ER_diArg_1	436	439	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I8	Leptomonas seymouri	46%	100%
A0A0N1I4X2	Leptomonas seymouri	70%	100%
A0A0N1I9E8	Leptomonas seymouri	23%	100%
A0A0N1PDX1	Leptomonas seymouri	23%	100%
A0A0S4ILS9	Bodo saltans	28%	100%
A0A0S4JMB1	Bodo saltans	28%	100%
A0A1X0NRR2	Trypanosomatidae	46%	98%
A0A1X0NZZ5	Trypanosomatidae	23%	100%
A0A3Q8IRG0	Leishmania donovani	27%	100%
A0A3S7WR50	Leishmania donovani	45%	98%
A0A482N9T9	Talaromyces variabilis	23%	100%
A4H648	Leishmania braziliensis	44%	98%
A4H649	Leishmania braziliensis	85%	100%
A4HUG8	Leishmania infantum	45%	98%
A4HUG9	Leishmania infantum	100%	100%
A4IE56	Leishmania infantum	27%	100%
C9ZVI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D7UPN2	Alternaria alternata	27%	100%
E9AN66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	98%
E9AN67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
K4BW79	Solanum lycopersicum	27%	100%
P0DO31	Neonectria sp. (strain DH2)	23%	100%
P42328	Geobacillus stearothermophilus	25%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	25%	100%
P47199	Mus musculus	26%	100%
Q0VC50	Bos taurus	25%	100%
Q4QHF8	Leishmania major	95%	100%
Q4QHF9	Leishmania major	44%	96%
Q4W4Z2	Caenorhabditis elegans	26%	100%
Q5HM44	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5JI69	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	25%	100%
Q7T3C7	Danio rerio	24%	100%
Q8CRJ7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8H0M1	Spinacia oleracea	27%	100%
Q8JFV8	Danio rerio	26%	99%
Q8KQL2	Enterococcus avium	24%	100%
Q8WWV3	Homo sapiens	25%	100%
Q924D0	Mus musculus	25%	100%
Q99536	Homo sapiens	27%	100%
Q9SV68	Arabidopsis thaliana	26%	100%
Q9ZUC1	Arabidopsis thaliana	28%	100%
V5ALK9	Trypanosoma cruzi	48%	100%
V5B1P3	Trypanosoma cruzi	27%	100%