Glycerol-3-phosphate dehydrogenase [NAD(+)]

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate dehydrogenase [NAD+], glycosomal

Species:

Leishmania donovani

UniProt:

A0A3S7WR51_LEIDO

TriTrypDb:

LdBPK_100560.1 , LdCL_100012300 , LDHU3_10.0880

Length:

367

Annotations

Annotations by Jardim et al.

Glycolysis Proteins, Glycerol-3-phosphate dehydrogenase [NAD(+)] GPD

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	10
GO:0020015	glycosome	7	1
GO:0032991	protein-containing complex	1	10
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WR51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR51

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	10
GO:0006072	glycerol-3-phosphate metabolic process	5	10
GO:0006116	NADH oxidation	3	1
GO:0006734	NADH metabolic process	2	1
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009987	cellular process	1	10
GO:0019637	organophosphate metabolic process	3	10

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	3
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	10
GO:0036094	small molecule binding	2	10
GO:0042802	identical protein binding	3	3
GO:0042803	protein homodimerization activity	4	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.482
CLV_PCSK_KEX2_1	180	182	PF00082	0.468
CLV_PCSK_KEX2_1	5	7	PF00082	0.656
CLV_PCSK_KEX2_1	58	60	PF00082	0.336
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.653
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.336
CLV_PCSK_SKI1_1	100	104	PF00082	0.258
CLV_PCSK_SKI1_1	184	188	PF00082	0.343
CLV_PCSK_SKI1_1	211	215	PF00082	0.254
CLV_PCSK_SKI1_1	231	235	PF00082	0.213

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWM8	Leptomonas seymouri	68%	100%
A0A0S4JNL8	Bodo saltans	48%	100%
A0A1X0NQ93	Trypanosomatidae	61%	100%
A0AK48	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	34%	100%
A0KF08	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	35%	100%
A0KR80	Shewanella sp. (strain ANA-3)	34%	100%
A0LLR7	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	39%	100%
A0Q4Y5	Francisella tularensis subsp. novicida (strain U112)	36%	100%
A0QLB8	Mycobacterium avium (strain 104)	36%	100%
A0RBW0	Bacillus thuringiensis (strain Al Hakam)	36%	100%

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