4F5_protein_family/Zinc-binding_putative/Pfam:PF0 4419/Pfam:PF12907

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4F5 protein family/Zinc-binding, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WR26_LEIDO

TriTrypDb:

LdBPK_100480.1 , LdCL_100010000 , LDHU3_10.0670

Length:

Annotations

Annotations by Jardim et al.

Metal Binding, 4F5 family/Zinc-binding, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WR26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.277
CLV_NRD_NRD_1	56	58	PF00675	0.304
CLV_PCSK_KEX2_1	12	14	PF00082	0.279
CLV_PCSK_KEX2_1	56	58	PF00082	0.288
CLV_PCSK_PC7_1	8	14	PF00082	0.277
CLV_PCSK_SKI1_1	15	19	PF00082	0.344
CLV_PCSK_SKI1_1	66	70	PF00082	0.286
LIG_FHA_2	26	32	PF00498	0.453
LIG_LIR_Nem_3	75	81	PF02991	0.289
LIG_Pex14_2	74	78	PF04695	0.323
LIG_SH3_3	52	58	PF00018	0.360
MOD_GlcNHglycan	2	5	PF01048	0.294
MOD_GlcNHglycan	21	24	PF01048	0.309
MOD_N-GLC_2	5	7	PF02516	0.257
MOD_SUMO_rev_2	14	20	PF00179	0.525
TRG_ER_diArg_1	55	57	PF00400	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR95	Leptomonas seymouri	84%	100%
A0A0S4JSJ0	Bodo saltans	61%	79%
A0A1X0NRV9	Trypanosomatidae	69%	78%
A4H625	Leishmania braziliensis	85%	100%
A4HUF3	Leishmania infantum	100%	100%
E9AN52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QHH3	Leishmania major	96%	100%