Kinetoplastid kinetochore protein 4, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 4, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WR22_LEIDO

TriTrypDb:

LdBPK_100320.1 , LdCL_100008500 , LDHU3_10.0460

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WR22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR22

PDB structure(s): 6zpj_A , 6zpj_B

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.569
CLV_C14_Caspase3-7	738	742	PF00656	0.511
CLV_NRD_NRD_1	160	162	PF00675	0.682
CLV_NRD_NRD_1	193	195	PF00675	0.466
CLV_NRD_NRD_1	246	248	PF00675	0.471
CLV_NRD_NRD_1	411	413	PF00675	0.699
CLV_NRD_NRD_1	449	451	PF00675	0.655
CLV_NRD_NRD_1	452	454	PF00675	0.620
CLV_NRD_NRD_1	602	604	PF00675	0.386
CLV_NRD_NRD_1	82	84	PF00675	0.700
CLV_PCSK_FUR_1	450	454	PF00082	0.639
CLV_PCSK_KEX2_1	160	162	PF00082	0.682
CLV_PCSK_KEX2_1	193	195	PF00082	0.466
CLV_PCSK_KEX2_1	352	354	PF00082	0.616
CLV_PCSK_KEX2_1	391	393	PF00082	0.658
CLV_PCSK_KEX2_1	411	413	PF00082	0.590
CLV_PCSK_KEX2_1	451	453	PF00082	0.647
CLV_PCSK_KEX2_1	595	597	PF00082	0.450
CLV_PCSK_KEX2_1	602	604	PF00082	0.386
CLV_PCSK_KEX2_1	734	736	PF00082	0.683
CLV_PCSK_KEX2_1	82	84	PF00082	0.634
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.616
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.658
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.715
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.450
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.613
CLV_PCSK_PC7_1	156	162	PF00082	0.631
CLV_PCSK_PC7_1	387	393	PF00082	0.681
CLV_PCSK_PC7_1	447	453	PF00082	0.632
CLV_PCSK_PC7_1	78	84	PF00082	0.581
CLV_PCSK_SKI1_1	10	14	PF00082	0.521
CLV_PCSK_SKI1_1	172	176	PF00082	0.589
CLV_PCSK_SKI1_1	229	233	PF00082	0.492
CLV_PCSK_SKI1_1	257	261	PF00082	0.454
CLV_PCSK_SKI1_1	392	396	PF00082	0.601
CLV_PCSK_SKI1_1	504	508	PF00082	0.631
CLV_PCSK_SKI1_1	603	607	PF00082	0.388
CLV_PCSK_SKI1_1	653	657	PF00082	0.423
CLV_PCSK_SKI1_1	702	706	PF00082	0.420
CLV_PCSK_SKI1_1	758	762	PF00082	0.406
CLV_Separin_Metazoa	7	11	PF03568	0.597
DEG_APCC_DBOX_1	712	720	PF00400	0.383
DEG_APCC_KENBOX_2	287	291	PF00400	0.577
DEG_SCF_FBW7_1	455	461	PF00400	0.620
DEG_SCF_FBW7_1	492	497	PF00400	0.607
DEG_SPOP_SBC_1	639	643	PF00917	0.446
DOC_CKS1_1	165	170	PF01111	0.604
DOC_CKS1_1	426	431	PF01111	0.675
DOC_CKS1_1	455	460	PF01111	0.624
DOC_CYCLIN_RxL_1	254	262	PF00134	0.464
DOC_CYCLIN_RxL_1	699	708	PF00134	0.467
DOC_MAPK_gen_1	699	707	PF00069	0.583
DOC_PP4_FxxP_1	694	697	PF00568	0.394
DOC_USP7_MATH_1	141	145	PF00917	0.622
DOC_USP7_MATH_1	152	156	PF00917	0.672
DOC_USP7_MATH_1	159	163	PF00917	0.591
DOC_USP7_MATH_1	331	335	PF00917	0.706
DOC_USP7_MATH_1	494	498	PF00917	0.629
DOC_USP7_MATH_1	502	506	PF00917	0.643
DOC_USP7_MATH_1	630	634	PF00917	0.544
DOC_USP7_MATH_1	729	733	PF00917	0.536
DOC_WW_Pin1_4	131	136	PF00397	0.623
DOC_WW_Pin1_4	164	169	PF00397	0.614
DOC_WW_Pin1_4	419	424	PF00397	0.642
DOC_WW_Pin1_4	425	430	PF00397	0.667
DOC_WW_Pin1_4	451	456	PF00397	0.634
DOC_WW_Pin1_4	488	493	PF00397	0.615
DOC_WW_Pin1_4	508	513	PF00397	0.616
DOC_WW_Pin1_4	585	590	PF00397	0.600
DOC_WW_Pin1_4	648	653	PF00397	0.435
DOC_WW_Pin1_4	666	671	PF00397	0.360
LIG_14-3-3_CanoR_1	10	19	PF00244	0.515
LIG_14-3-3_CanoR_1	119	123	PF00244	0.696
LIG_14-3-3_CanoR_1	160	165	PF00244	0.664
LIG_14-3-3_CanoR_1	172	177	PF00244	0.549
LIG_14-3-3_CanoR_1	187	195	PF00244	0.506
LIG_14-3-3_CanoR_1	204	212	PF00244	0.405
LIG_14-3-3_CanoR_1	332	338	PF00244	0.625
LIG_14-3-3_CanoR_1	474	482	PF00244	0.658
LIG_14-3-3_CanoR_1	616	624	PF00244	0.439
LIG_14-3-3_CanoR_1	702	708	PF00244	0.388
LIG_14-3-3_CanoR_1	758	765	PF00244	0.449
LIG_Actin_WH2_2	743	760	PF00022	0.413
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_Clathr_ClatBox_1	704	708	PF01394	0.395
LIG_EVH1_1	556	560	PF00568	0.639
LIG_FHA_1	204	210	PF00498	0.529
LIG_FHA_1	395	401	PF00498	0.642
LIG_FHA_1	435	441	PF00498	0.684
LIG_FHA_1	482	488	PF00498	0.632
LIG_FHA_1	491	497	PF00498	0.607
LIG_FHA_1	575	581	PF00498	0.632
LIG_FHA_1	641	647	PF00498	0.467
LIG_FHA_2	165	171	PF00498	0.652
LIG_FHA_2	173	179	PF00498	0.601
LIG_FHA_2	290	296	PF00498	0.620
LIG_FHA_2	391	397	PF00498	0.621
LIG_FHA_2	415	421	PF00498	0.690
LIG_FHA_2	459	465	PF00498	0.612
LIG_FHA_2	519	525	PF00498	0.655
LIG_FHA_2	68	74	PF00498	0.624
LIG_FHA_2	749	755	PF00498	0.389
LIG_MYND_1	320	324	PF01753	0.654
LIG_NRBOX	255	261	PF00104	0.525
LIG_PDZ_Class_3	760	765	PF00595	0.535
LIG_RPA_C_Fungi	407	419	PF08784	0.648
LIG_RPA_C_Fungi	469	481	PF08784	0.604
LIG_SH2_CRK	241	245	PF00017	0.458
LIG_SH2_STAP1	272	276	PF00017	0.517
LIG_SH2_STAT3	674	677	PF00017	0.444
LIG_SH2_STAT3	759	762	PF00017	0.477
LIG_SH2_STAT5	425	428	PF00017	0.688
LIG_SH2_STAT5	520	523	PF00017	0.697
LIG_SH2_STAT5	672	675	PF00017	0.381
LIG_SH3_1	452	458	PF00018	0.628
LIG_SH3_2	455	460	PF14604	0.649
LIG_SH3_2	557	562	PF14604	0.645
LIG_SH3_2	591	596	PF14604	0.511
LIG_SH3_3	452	458	PF00018	0.628
LIG_SH3_3	554	560	PF00018	0.667
LIG_SH3_3	58	64	PF00018	0.647
LIG_SH3_3	588	594	PF00018	0.547
LIG_SH3_3	704	710	PF00018	0.474
LIG_SUMO_SIM_anti_2	746	752	PF11976	0.404
LIG_SUMO_SIM_par_1	703	708	PF11976	0.387
LIG_SUMO_SIM_par_1	746	752	PF11976	0.404
LIG_UBA3_1	605	610	PF00899	0.486
LIG_WW_3	32	36	PF00397	0.613
LIG_WW_3	62	66	PF00397	0.609
MOD_CDK_SPK_2	451	456	PF00069	0.634
MOD_CDK_SPK_2	648	653	PF00069	0.435
MOD_CDK_SPxK_1	454	460	PF00069	0.648
MOD_CDK_SPxxK_3	427	434	PF00069	0.701
MOD_CK1_1	109	115	PF00069	0.555
MOD_CK1_1	133	139	PF00069	0.681
MOD_CK1_1	163	169	PF00069	0.613
MOD_CK1_1	325	331	PF00069	0.667
MOD_CK1_1	341	347	PF00069	0.570
MOD_CK1_1	37	43	PF00069	0.629
MOD_CK1_1	47	53	PF00069	0.567
MOD_CK1_1	575	581	PF00069	0.631
MOD_CK1_1	641	647	PF00069	0.507
MOD_CK1_1	676	682	PF00069	0.389
MOD_CK1_1	88	94	PF00069	0.775
MOD_CK1_1	99	105	PF00069	0.615
MOD_CK2_1	164	170	PF00069	0.629
MOD_CK2_1	414	420	PF00069	0.626
MOD_CK2_1	458	464	PF00069	0.637
MOD_CK2_1	466	472	PF00069	0.597
MOD_CK2_1	518	524	PF00069	0.655
MOD_Cter_Amidation	409	412	PF01082	0.699
MOD_DYRK1A_RPxSP_1	587	591	PF00069	0.572
MOD_GlcNHglycan	122	125	PF01048	0.636
MOD_GlcNHglycan	267	270	PF01048	0.423
MOD_GlcNHglycan	299	302	PF01048	0.634
MOD_GlcNHglycan	340	343	PF01048	0.654
MOD_GlcNHglycan	348	351	PF01048	0.591
MOD_GlcNHglycan	36	39	PF01048	0.601
MOD_GlcNHglycan	402	405	PF01048	0.653
MOD_GlcNHglycan	447	450	PF01048	0.763
MOD_GlcNHglycan	515	518	PF01048	0.687
MOD_GlcNHglycan	574	577	PF01048	0.668
MOD_GlcNHglycan	581	584	PF01048	0.671
MOD_GlcNHglycan	618	621	PF01048	0.482
MOD_GlcNHglycan	662	665	PF01048	0.426
MOD_GlcNHglycan	678	681	PF01048	0.407
MOD_GlcNHglycan	729	732	PF01048	0.535
MOD_GlcNHglycan	737	740	PF01048	0.623
MOD_GlcNHglycan	751	754	PF01048	0.332
MOD_GlcNHglycan	93	96	PF01048	0.703
MOD_GlcNHglycan	98	101	PF01048	0.647
MOD_GSK3_1	126	133	PF00069	0.656
MOD_GSK3_1	135	142	PF00069	0.600
MOD_GSK3_1	159	166	PF00069	0.648
MOD_GSK3_1	390	397	PF00069	0.681
MOD_GSK3_1	414	421	PF00069	0.650
MOD_GSK3_1	441	448	PF00069	0.726
MOD_GSK3_1	454	461	PF00069	0.768
MOD_GSK3_1	490	497	PF00069	0.632
MOD_GSK3_1	498	505	PF00069	0.678
MOD_GSK3_1	508	515	PF00069	0.551
MOD_GSK3_1	520	527	PF00069	0.556
MOD_GSK3_1	570	577	PF00069	0.672
MOD_GSK3_1	579	586	PF00069	0.758
MOD_GSK3_1	63	70	PF00069	0.574
MOD_GSK3_1	84	91	PF00069	0.644
MOD_GSK3_1	94	101	PF00069	0.618
MOD_LATS_1	76	82	PF00433	0.579
MOD_N-GLC_1	289	294	PF02516	0.604
MOD_NEK2_1	139	144	PF00069	0.699
MOD_NEK2_1	181	186	PF00069	0.496
MOD_NEK2_1	202	207	PF00069	0.456
MOD_NEK2_1	234	239	PF00069	0.483
MOD_NEK2_1	259	264	PF00069	0.447
MOD_NEK2_1	265	270	PF00069	0.430
MOD_NEK2_1	390	395	PF00069	0.740
MOD_NEK2_1	466	471	PF00069	0.748
MOD_NEK2_1	506	511	PF00069	0.663
MOD_NEK2_1	604	609	PF00069	0.399
MOD_NEK2_1	98	103	PF00069	0.645
MOD_NEK2_2	483	488	PF00069	0.635
MOD_PIKK_1	101	107	PF00454	0.678
MOD_PIKK_1	203	209	PF00454	0.448
MOD_PIKK_1	322	328	PF00454	0.658
MOD_PIKK_1	441	447	PF00454	0.622
MOD_PIKK_1	474	480	PF00454	0.743
MOD_PIKK_1	673	679	PF00454	0.452
MOD_PIKK_1	758	764	PF00454	0.506
MOD_PKA_1	160	166	PF00069	0.643
MOD_PKA_2	118	124	PF00069	0.696
MOD_PKA_2	159	165	PF00069	0.636
MOD_PKA_2	186	192	PF00069	0.552
MOD_PKA_2	203	209	PF00069	0.404
MOD_PKA_2	331	337	PF00069	0.619
MOD_PKA_2	34	40	PF00069	0.638
MOD_PKA_2	77	83	PF00069	0.596
MOD_Plk_1	395	401	PF00069	0.660
MOD_Plk_1	502	508	PF00069	0.699
MOD_Plk_2-3	67	73	PF00069	0.580
MOD_Plk_4	106	112	PF00069	0.677
MOD_Plk_4	135	141	PF00069	0.585
MOD_Plk_4	160	166	PF00069	0.643
MOD_ProDKin_1	131	137	PF00069	0.621
MOD_ProDKin_1	164	170	PF00069	0.617
MOD_ProDKin_1	419	425	PF00069	0.644
MOD_ProDKin_1	427	433	PF00069	0.677
MOD_ProDKin_1	451	457	PF00069	0.632
MOD_ProDKin_1	488	494	PF00069	0.612
MOD_ProDKin_1	508	514	PF00069	0.612
MOD_ProDKin_1	585	591	PF00069	0.598
MOD_ProDKin_1	648	654	PF00069	0.429
MOD_ProDKin_1	666	672	PF00069	0.357
MOD_SUMO_for_1	270	273	PF00179	0.514
MOD_SUMO_for_1	487	490	PF00179	0.700
TRG_DiLeu_BaEn_1	613	618	PF01217	0.390
TRG_ENDOCYTIC_2	241	244	PF00928	0.461
TRG_ENDOCYTIC_2	272	275	PF00928	0.536
TRG_ER_diArg_1	159	161	PF00400	0.629
TRG_ER_diArg_1	193	195	PF00400	0.466
TRG_ER_diArg_1	450	453	PF00400	0.644
TRG_ER_diArg_1	601	603	PF00400	0.408
TRG_NLS_MonoCore_2	449	454	PF00514	0.709
TRG_NLS_MonoExtC_3	450	455	PF00514	0.709
TRG_NLS_MonoExtN_4	447	454	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R5	Leptomonas seymouri	52%	100%
A4H613	Leishmania braziliensis	78%	100%
A4HUE0	Leishmania infantum	100%	100%
E9AN40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHI6	Leishmania major	94%	100%