Guanosine diphosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WR18_LEIDO

TriTrypDb:

LdBPK_100150.1 , LdCL_100006700 , LDHU3_10.0260

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 4
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7WR18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR18

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009134	nucleoside diphosphate catabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	9
GO:0004382	GDP phosphatase activity	7	5
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017076	purine nucleotide binding	4	8
GO:0017110	nucleoside diphosphate phosphatase activity	6	5
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.338
CLV_C14_Caspase3-7	298	302	PF00656	0.258
CLV_C14_Caspase3-7	464	468	PF00656	0.233
CLV_NRD_NRD_1	132	134	PF00675	0.573
CLV_NRD_NRD_1	154	156	PF00675	0.552
CLV_NRD_NRD_1	76	78	PF00675	0.533
CLV_PCSK_KEX2_1	132	134	PF00082	0.584
CLV_PCSK_KEX2_1	154	156	PF00082	0.552
CLV_PCSK_KEX2_1	472	474	PF00082	0.485
CLV_PCSK_KEX2_1	76	78	PF00082	0.590
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.567
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.394
CLV_PCSK_SKI1_1	410	414	PF00082	0.440
CLV_PCSK_SKI1_1	505	509	PF00082	0.463
CLV_PCSK_SKI1_1	531	535	PF00082	0.418
CLV_PCSK_SKI1_1	97	101	PF00082	0.661
DEG_APCC_DBOX_1	132	140	PF00400	0.557
DEG_APCC_DBOX_1	78	86	PF00400	0.590
DEG_SPOP_SBC_1	433	437	PF00917	0.394
DOC_CYCLIN_yCln2_LP_2	532	538	PF00134	0.433
DOC_MAPK_DCC_7	529	538	PF00069	0.433
DOC_MAPK_gen_1	529	538	PF00069	0.472
DOC_MAPK_gen_1	588	595	PF00069	0.469
DOC_MAPK_gen_1	76	85	PF00069	0.651
DOC_PP1_RVXF_1	408	415	PF00149	0.374
DOC_PP4_MxPP_1	477	480	PF00568	0.374
DOC_PP4_MxPP_1	551	554	PF00568	0.394
DOC_USP7_MATH_1	223	227	PF00917	0.401
DOC_USP7_MATH_1	30	34	PF00917	0.709
DOC_USP7_MATH_1	349	353	PF00917	0.472
DOC_USP7_MATH_1	370	374	PF00917	0.355
DOC_USP7_MATH_1	441	445	PF00917	0.426
DOC_USP7_MATH_1	460	464	PF00917	0.373
DOC_USP7_MATH_1	575	579	PF00917	0.450
DOC_USP7_MATH_1	584	588	PF00917	0.381
DOC_USP7_UBL2_3	189	193	PF12436	0.394
DOC_USP7_UBL2_3	419	423	PF12436	0.406
DOC_USP7_UBL2_3	505	509	PF12436	0.258
DOC_USP7_UBL2_3	590	594	PF12436	0.477
DOC_WW_Pin1_4	143	148	PF00397	0.460
DOC_WW_Pin1_4	437	442	PF00397	0.369
LIG_14-3-3_CanoR_1	125	130	PF00244	0.573
LIG_14-3-3_CanoR_1	154	162	PF00244	0.533
LIG_14-3-3_CanoR_1	383	389	PF00244	0.456
LIG_14-3-3_CanoR_1	391	400	PF00244	0.324
LIG_14-3-3_CanoR_1	92	100	PF00244	0.573
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BRCT_BRCA1_1	1	5	PF00533	0.447
LIG_BRCT_BRCA1_1	111	115	PF00533	0.609
LIG_BRCT_BRCA1_1	194	198	PF00533	0.336
LIG_BRCT_BRCA1_1	565	569	PF00533	0.472
LIG_deltaCOP1_diTrp_1	257	263	PF00928	0.472
LIG_FHA_1	121	127	PF00498	0.654
LIG_FHA_1	283	289	PF00498	0.332
LIG_FHA_1	295	301	PF00498	0.287
LIG_FHA_1	309	315	PF00498	0.419
LIG_FHA_1	351	357	PF00498	0.312
LIG_FHA_1	362	368	PF00498	0.309
LIG_FHA_1	407	413	PF00498	0.418
LIG_FHA_1	557	563	PF00498	0.370
LIG_FHA_2	17	23	PF00498	0.637
LIG_FHA_2	276	282	PF00498	0.418
LIG_FHA_2	598	604	PF00498	0.262
LIG_FHA_2	616	622	PF00498	0.192
LIG_LIR_Gen_1	191	200	PF02991	0.401
LIG_LIR_Gen_1	2	13	PF02991	0.527
LIG_LIR_Gen_1	257	268	PF02991	0.472
LIG_LIR_Gen_1	566	575	PF02991	0.336
LIG_LIR_Gen_1	629	638	PF02991	0.456
LIG_LIR_Nem_3	145	151	PF02991	0.700
LIG_LIR_Nem_3	191	197	PF02991	0.401
LIG_LIR_Nem_3	2	8	PF02991	0.535
LIG_LIR_Nem_3	257	263	PF02991	0.398
LIG_LIR_Nem_3	399	403	PF02991	0.418
LIG_LIR_Nem_3	489	494	PF02991	0.358
LIG_LIR_Nem_3	566	572	PF02991	0.336
LIG_LIR_Nem_3	631	637	PF02991	0.340
LIG_Pex14_2	5	9	PF04695	0.544
LIG_Pex14_2	565	569	PF04695	0.482
LIG_PTB_Apo_2	306	313	PF02174	0.394
LIG_SH2_CRK	194	198	PF00017	0.370
LIG_SH2_CRK	635	639	PF00017	0.425
LIG_SH2_NCK_1	194	198	PF00017	0.370
LIG_SH2_NCK_1	646	650	PF00017	0.452
LIG_SH2_SRC	396	399	PF00017	0.336
LIG_SH2_SRC	498	501	PF00017	0.401
LIG_SH2_SRC	637	640	PF00017	0.401
LIG_SH2_STAP1	194	198	PF00017	0.366
LIG_SH2_STAP1	384	388	PF00017	0.394
LIG_SH2_STAP1	630	634	PF00017	0.414
LIG_SH2_STAP1	635	639	PF00017	0.414
LIG_SH2_STAP1	663	667	PF00017	0.365
LIG_SH2_STAT5	268	271	PF00017	0.345
LIG_SH2_STAT5	338	341	PF00017	0.401
LIG_SH2_STAT5	563	566	PF00017	0.281
LIG_SH2_STAT5	637	640	PF00017	0.345
LIG_SH3_1	472	478	PF00018	0.392
LIG_SH3_3	364	370	PF00018	0.370
LIG_SH3_3	472	478	PF00018	0.422
LIG_SH3_3	512	518	PF00018	0.361
LIG_SH3_3	547	553	PF00018	0.338
LIG_SH3_3	590	596	PF00018	0.452
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.598
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.433
LIG_SUMO_SIM_anti_2	352	358	PF11976	0.402
LIG_SUMO_SIM_par_1	352	358	PF11976	0.399
LIG_SUMO_SIM_par_1	672	677	PF11976	0.438
LIG_SUMO_SIM_par_1	84	89	PF11976	0.642
LIG_TRAF2_1	128	131	PF00917	0.470
LIG_TRAF2_1	325	328	PF00917	0.472
LIG_UBA3_1	166	175	PF00899	0.605
LIG_UBA3_1	237	243	PF00899	0.471
LIG_UBA3_1	290	295	PF00899	0.472
LIG_UBA3_1	412	419	PF00899	0.410
LIG_WRC_WIRS_1	126	131	PF05994	0.335
LIG_WRC_WIRS_1	564	569	PF05994	0.281
LIG_WW_2	480	483	PF00397	0.289
MOD_CK1_1	109	115	PF00069	0.608
MOD_CK1_1	226	232	PF00069	0.394
MOD_CK1_1	344	350	PF00069	0.258
MOD_CK1_1	431	437	PF00069	0.361
MOD_CK1_1	95	101	PF00069	0.576
MOD_CK2_1	125	131	PF00069	0.659
MOD_CK2_1	275	281	PF00069	0.418
MOD_CK2_1	597	603	PF00069	0.398
MOD_CK2_1	615	621	PF00069	0.230
MOD_GlcNHglycan	372	375	PF01048	0.385
MOD_GlcNHglycan	384	387	PF01048	0.407
MOD_GlcNHglycan	393	396	PF01048	0.207
MOD_GlcNHglycan	443	446	PF01048	0.450
MOD_GlcNHglycan	61	64	PF01048	0.572
MOD_GlcNHglycan	94	97	PF01048	0.625
MOD_GSK3_1	138	145	PF00069	0.556
MOD_GSK3_1	188	195	PF00069	0.401
MOD_GSK3_1	387	394	PF00069	0.419
MOD_GSK3_1	425	432	PF00069	0.381
MOD_GSK3_1	433	440	PF00069	0.333
MOD_GSK3_1	665	672	PF00069	0.343
MOD_N-GLC_1	120	125	PF02516	0.576
MOD_N-GLC_1	143	148	PF02516	0.493
MOD_N-GLC_1	308	313	PF02516	0.355
MOD_N-GLC_1	556	561	PF02516	0.430
MOD_N-GLC_1	575	580	PF02516	0.158
MOD_NEK2_1	142	147	PF00069	0.554
MOD_NEK2_1	170	175	PF00069	0.601
MOD_NEK2_1	282	287	PF00069	0.332
MOD_NEK2_1	36	41	PF00069	0.561
MOD_NEK2_1	382	387	PF00069	0.287
MOD_NEK2_1	574	579	PF00069	0.355
MOD_NEK2_1	609	614	PF00069	0.437
MOD_NEK2_1	633	638	PF00069	0.331
MOD_NEK2_1	669	674	PF00069	0.347
MOD_NEK2_2	622	627	PF00069	0.472
MOD_PIKK_1	36	42	PF00454	0.688
MOD_PIKK_1	361	367	PF00454	0.336
MOD_PIKK_1	417	423	PF00454	0.394
MOD_PKA_1	154	160	PF00069	0.527
MOD_PKA_2	153	159	PF00069	0.582
MOD_PKA_2	170	176	PF00069	0.591
MOD_PKA_2	344	350	PF00069	0.412
MOD_PKA_2	382	388	PF00069	0.374
MOD_PKB_1	306	314	PF00069	0.433
MOD_PKB_1	90	98	PF00069	0.669
MOD_Plk_1	109	115	PF00069	0.681
MOD_Plk_1	308	314	PF00069	0.393
MOD_Plk_1	575	581	PF00069	0.472
MOD_Plk_2-3	461	467	PF00069	0.258
MOD_Plk_2-3	597	603	PF00069	0.258
MOD_Plk_4	109	115	PF00069	0.602
MOD_Plk_4	138	144	PF00069	0.558
MOD_Plk_4	192	198	PF00069	0.360
MOD_Plk_4	308	314	PF00069	0.442
MOD_Plk_4	575	581	PF00069	0.449
MOD_Plk_4	633	639	PF00069	0.319
MOD_Plk_4	669	675	PF00069	0.365
MOD_ProDKin_1	143	149	PF00069	0.463
MOD_ProDKin_1	437	443	PF00069	0.369
MOD_SUMO_for_1	626	629	PF00179	0.452
MOD_SUMO_rev_2	55	62	PF00179	0.494
MOD_SUMO_rev_2	587	596	PF00179	0.452
TRG_DiLeu_BaEn_3	80	86	PF01217	0.591
TRG_DiLeu_BaEn_4	235	241	PF01217	0.401
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.472
TRG_ENDOCYTIC_2	194	197	PF00928	0.370
TRG_ENDOCYTIC_2	630	633	PF00928	0.380
TRG_ENDOCYTIC_2	635	638	PF00928	0.347
TRG_ENDOCYTIC_2	639	642	PF00928	0.254
TRG_ER_diArg_1	153	155	PF00400	0.668
TRG_ER_diArg_1	303	306	PF00400	0.382
TRG_ER_diArg_1	75	77	PF00400	0.642
TRG_NES_CRM1_1	105	119	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E8	Leptomonas seymouri	46%	99%
A0A3R7NV38	Trypanosoma rangeli	33%	100%
A4H5Z8	Leishmania braziliensis	70%	100%
A4HUC4	Leishmania infantum	99%	100%
C9ZVG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AN23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
P40009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4QHK3	Leishmania major	90%	100%
Q5MY95	Homo sapiens	24%	100%
Q5REF6	Pongo abelii	21%	100%
Q8TGH6	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	100%
Q9HEM6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
Q9NQZ7	Homo sapiens	21%	100%