Pteridine transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WR10_LEIDO

TriTrypDb:

LdBPK_100360.1 , LdCL_100008900 , LDHU3_10.0510

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 67
NetGPI	no	yes: 0, no: 67

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	68
GO:0110165	cellular anatomical entity	1	68
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3S7WR10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR10

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.608
CLV_C14_Caspase3-7	285	289	PF00656	0.459
CLV_C14_Caspase3-7	379	383	PF00656	0.602
CLV_C14_Caspase3-7	48	52	PF00656	0.687
CLV_NRD_NRD_1	115	117	PF00675	0.189
CLV_NRD_NRD_1	213	215	PF00675	0.227
CLV_NRD_NRD_1	741	743	PF00675	0.380
CLV_PCSK_KEX2_1	115	117	PF00082	0.264
CLV_PCSK_KEX2_1	155	157	PF00082	0.300
CLV_PCSK_KEX2_1	213	215	PF00082	0.256
CLV_PCSK_KEX2_1	741	743	PF00082	0.385
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.300
CLV_PCSK_SKI1_1	287	291	PF00082	0.288
CLV_PCSK_SKI1_1	341	345	PF00082	0.257
CLV_PCSK_SKI1_1	413	417	PF00082	0.301
CLV_PCSK_SKI1_1	60	64	PF00082	0.319
CLV_Separin_Metazoa	693	697	PF03568	0.527
DEG_APCC_DBOX_1	690	698	PF00400	0.529
DOC_ANK_TNKS_1	46	53	PF00023	0.557
DOC_CYCLIN_yCln2_LP_2	656	662	PF00134	0.393
DOC_MAPK_gen_1	155	161	PF00069	0.520
DOC_MAPK_gen_1	672	681	PF00069	0.583
DOC_MAPK_MEF2A_6	249	256	PF00069	0.346
DOC_MAPK_MEF2A_6	301	309	PF00069	0.405
DOC_MAPK_MEF2A_6	691	699	PF00069	0.543
DOC_PP2B_LxvP_1	391	394	PF13499	0.392
DOC_PP2B_LxvP_1	478	481	PF13499	0.357
DOC_PP2B_LxvP_1	661	664	PF13499	0.369
DOC_PP2B_LxvP_1	668	671	PF13499	0.342
DOC_PP4_FxxP_1	457	460	PF00568	0.334
DOC_USP7_MATH_1	178	182	PF00917	0.261
DOC_USP7_MATH_1	221	225	PF00917	0.326
DOC_USP7_MATH_1	31	35	PF00917	0.671
DOC_USP7_MATH_1	370	374	PF00917	0.470
DOC_USP7_MATH_1	378	382	PF00917	0.471
DOC_USP7_MATH_1	483	487	PF00917	0.309
DOC_USP7_MATH_1	490	494	PF00917	0.285
DOC_USP7_MATH_1	546	550	PF00917	0.330
DOC_USP7_MATH_1	599	603	PF00917	0.490
DOC_USP7_MATH_1	608	612	PF00917	0.344
DOC_USP7_MATH_1	623	627	PF00917	0.373
DOC_USP7_MATH_1	725	729	PF00917	0.747
DOC_USP7_UBL2_3	295	299	PF12436	0.523
DOC_WW_Pin1_4	301	306	PF00397	0.498
LIG_14-3-3_CanoR_1	367	375	PF00244	0.391
LIG_14-3-3_CanoR_1	696	704	PF00244	0.665
LIG_14-3-3_CanoR_1	726	730	PF00244	0.804
LIG_14-3-3_CanoR_1	85	91	PF00244	0.508
LIG_BIR_II_1	1	5	PF00653	0.774
LIG_BRCT_BRCA1_1	394	398	PF00533	0.459
LIG_BRCT_BRCA1_1	501	505	PF00533	0.307
LIG_CaM_NSCaTE_8	412	419	PF13499	0.392
LIG_EH1_1	578	586	PF00400	0.352
LIG_FHA_1	230	236	PF00498	0.367
LIG_FHA_1	334	340	PF00498	0.397
LIG_FHA_1	403	409	PF00498	0.587
LIG_FHA_1	420	426	PF00498	0.339
LIG_FHA_1	535	541	PF00498	0.505
LIG_FHA_1	635	641	PF00498	0.412
LIG_FHA_1	651	657	PF00498	0.468
LIG_FHA_2	384	390	PF00498	0.577
LIG_FHA_2	434	440	PF00498	0.214
LIG_FHA_2	46	52	PF00498	0.655
LIG_FHA_2	704	710	PF00498	0.649
LIG_LIR_Gen_1	122	130	PF02991	0.490
LIG_LIR_Gen_1	145	153	PF02991	0.533
LIG_LIR_Gen_1	170	180	PF02991	0.308
LIG_LIR_Gen_1	205	216	PF02991	0.521
LIG_LIR_Gen_1	224	235	PF02991	0.503
LIG_LIR_Gen_1	342	351	PF02991	0.452
LIG_LIR_Gen_1	436	446	PF02991	0.284
LIG_LIR_Gen_1	474	484	PF02991	0.344
LIG_LIR_Gen_1	526	536	PF02991	0.355
LIG_LIR_Gen_1	549	556	PF02991	0.344
LIG_LIR_Gen_1	604	613	PF02991	0.525
LIG_LIR_Gen_1	643	652	PF02991	0.284
LIG_LIR_Gen_1	666	675	PF02991	0.269
LIG_LIR_Nem_3	122	127	PF02991	0.472
LIG_LIR_Nem_3	147	153	PF02991	0.499
LIG_LIR_Nem_3	154	160	PF02991	0.498
LIG_LIR_Nem_3	170	176	PF02991	0.335
LIG_LIR_Nem_3	205	211	PF02991	0.531
LIG_LIR_Nem_3	224	230	PF02991	0.324
LIG_LIR_Nem_3	342	346	PF02991	0.389
LIG_LIR_Nem_3	395	401	PF02991	0.528
LIG_LIR_Nem_3	439	445	PF02991	0.276
LIG_LIR_Nem_3	474	480	PF02991	0.323
LIG_LIR_Nem_3	502	506	PF02991	0.306
LIG_LIR_Nem_3	549	554	PF02991	0.351
LIG_LIR_Nem_3	557	562	PF02991	0.295
LIG_LIR_Nem_3	643	647	PF02991	0.279
LIG_LIR_Nem_3	666	670	PF02991	0.269
LIG_NRBOX	471	477	PF00104	0.226
LIG_PCNA_yPIPBox_3	737	745	PF02747	0.578
LIG_Pex14_1	227	231	PF04695	0.364
LIG_Pex14_1	438	442	PF04695	0.275
LIG_Pex14_2	268	272	PF04695	0.292
LIG_Pex14_2	501	505	PF04695	0.300
LIG_Pex14_2	525	529	PF04695	0.382
LIG_SH2_CRK	124	128	PF00017	0.501
LIG_SH2_CRK	158	162	PF00017	0.366
LIG_SH2_CRK	173	177	PF00017	0.361
LIG_SH2_CRK	208	212	PF00017	0.529
LIG_SH2_CRK	417	421	PF00017	0.351
LIG_SH2_CRK	442	446	PF00017	0.338
LIG_SH2_CRK	506	510	PF00017	0.314
LIG_SH2_CRK	562	566	PF00017	0.192
LIG_SH2_GRB2like	471	474	PF00017	0.365
LIG_SH2_NCK_1	506	510	PF00017	0.312
LIG_SH2_SRC	471	474	PF00017	0.509
LIG_SH2_STAP1	153	157	PF00017	0.507
LIG_SH2_STAP1	208	212	PF00017	0.493
LIG_SH2_STAP1	417	421	PF00017	0.377
LIG_SH2_STAT5	153	156	PF00017	0.508
LIG_SH2_STAT5	471	474	PF00017	0.354
LIG_SH2_STAT5	477	480	PF00017	0.359
LIG_SH2_STAT5	488	491	PF00017	0.308
LIG_SH2_STAT5	503	506	PF00017	0.279
LIG_SH2_STAT5	571	574	PF00017	0.293
LIG_SH2_STAT5	94	97	PF00017	0.517
LIG_SH3_3	174	180	PF00018	0.287
LIG_SH3_3	25	31	PF00018	0.654
LIG_SH3_3	493	499	PF00018	0.293
LIG_SUMO_SIM_anti_2	198	205	PF11976	0.404
LIG_SUMO_SIM_anti_2	424	430	PF11976	0.248
LIG_SUMO_SIM_anti_2	541	546	PF11976	0.302
LIG_SUMO_SIM_par_1	347	355	PF11976	0.389
LIG_SUMO_SIM_par_1	552	557	PF11976	0.424
LIG_TRAF2_1	377	380	PF00917	0.447
LIG_TRAF2_2	730	735	PF00917	0.592
LIG_TRFH_1	173	177	PF08558	0.345
LIG_TRFH_1	457	461	PF08558	0.192
LIG_TRFH_1	667	671	PF08558	0.304
LIG_TYR_ITIM	171	176	PF00017	0.399
LIG_TYR_ITIM	415	420	PF00017	0.264
LIG_TYR_ITIM	440	445	PF00017	0.357
LIG_TYR_ITIM	475	480	PF00017	0.357
LIG_TYR_ITIM	504	509	PF00017	0.321
LIG_UBA3_1	524	531	PF00899	0.401
LIG_WRC_WIRS_1	484	489	PF05994	0.326
MOD_CK1_1	229	235	PF00069	0.380
MOD_CK1_1	23	29	PF00069	0.603
MOD_CK1_1	424	430	PF00069	0.359
MOD_CK1_1	45	51	PF00069	0.517
MOD_CK1_1	530	536	PF00069	0.382
MOD_CK1_1	583	589	PF00069	0.427
MOD_CK1_1	611	617	PF00069	0.309
MOD_CK2_1	383	389	PF00069	0.276
MOD_CK2_1	433	439	PF00069	0.206
MOD_GlcNHglycan	181	184	PF01048	0.340
MOD_GlcNHglycan	246	249	PF01048	0.406
MOD_GlcNHglycan	25	28	PF01048	0.686
MOD_GlcNHglycan	256	259	PF01048	0.396
MOD_GlcNHglycan	33	36	PF01048	0.683
MOD_GlcNHglycan	368	371	PF01048	0.451
MOD_GlcNHglycan	509	512	PF01048	0.416
MOD_GlcNHglycan	6	9	PF01048	0.721
MOD_GlcNHglycan	610	613	PF01048	0.372
MOD_GSK3_1	191	198	PF00069	0.257
MOD_GSK3_1	297	304	PF00069	0.348
MOD_GSK3_1	366	373	PF00069	0.263
MOD_GSK3_1	415	422	PF00069	0.374
MOD_GSK3_1	429	436	PF00069	0.318
MOD_GSK3_1	441	448	PF00069	0.265
MOD_GSK3_1	507	514	PF00069	0.346
MOD_GSK3_1	523	530	PF00069	0.370
MOD_GSK3_1	534	541	PF00069	0.375
MOD_GSK3_1	580	587	PF00069	0.229
MOD_GSK3_1	588	595	PF00069	0.216
MOD_GSK3_1	619	626	PF00069	0.393
MOD_N-GLC_1	323	328	PF02516	0.204
MOD_N-GLC_2	580	582	PF02516	0.196
MOD_NEK2_1	119	124	PF00069	0.322
MOD_NEK2_1	144	149	PF00069	0.350
MOD_NEK2_1	151	156	PF00069	0.333
MOD_NEK2_1	159	164	PF00069	0.350
MOD_NEK2_1	191	196	PF00069	0.359
MOD_NEK2_1	235	240	PF00069	0.338
MOD_NEK2_1	244	249	PF00069	0.380
MOD_NEK2_1	339	344	PF00069	0.310
MOD_NEK2_1	351	356	PF00069	0.287
MOD_NEK2_1	4	9	PF00069	0.644
MOD_NEK2_1	416	421	PF00069	0.380
MOD_NEK2_1	441	446	PF00069	0.339
MOD_NEK2_1	505	510	PF00069	0.356
MOD_NEK2_1	538	543	PF00069	0.378
MOD_NEK2_1	584	589	PF00069	0.421
MOD_NEK2_1	616	621	PF00069	0.366
MOD_NEK2_1	628	633	PF00069	0.380
MOD_NEK2_1	650	655	PF00069	0.447
MOD_NEK2_1	86	91	PF00069	0.457
MOD_NEK2_2	133	138	PF00069	0.196
MOD_NEK2_2	483	488	PF00069	0.320
MOD_NEK2_2	546	551	PF00069	0.352
MOD_PIKK_1	39	45	PF00454	0.686
MOD_PKA_2	366	372	PF00069	0.297
MOD_PKA_2	599	605	PF00069	0.339
MOD_PKA_2	702	708	PF00069	0.631
MOD_PKA_2	725	731	PF00069	0.627
MOD_Plk_1	119	125	PF00069	0.301
MOD_Plk_1	323	329	PF00069	0.195
MOD_Plk_1	383	389	PF00069	0.255
MOD_Plk_1	490	496	PF00069	0.430
MOD_Plk_4	226	232	PF00069	0.347
MOD_Plk_4	235	241	PF00069	0.327
MOD_Plk_4	416	422	PF00069	0.346
MOD_Plk_4	424	430	PF00069	0.335
MOD_Plk_4	471	477	PF00069	0.356
MOD_Plk_4	483	489	PF00069	0.323
MOD_Plk_4	540	546	PF00069	0.315
MOD_Plk_4	58	64	PF00069	0.508
MOD_Plk_4	580	586	PF00069	0.332
MOD_Plk_4	588	594	PF00069	0.330
MOD_Plk_4	601	607	PF00069	0.377
MOD_Plk_4	623	629	PF00069	0.322
MOD_Plk_4	663	669	PF00069	0.365
MOD_ProDKin_1	301	307	PF00069	0.344
MOD_SUMO_rev_2	285	292	PF00179	0.238
MOD_SUMO_rev_2	304	312	PF00179	0.216
MOD_SUMO_rev_2	34	40	PF00179	0.729
TRG_DiLeu_BaLyEn_6	656	661	PF01217	0.333
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.244
TRG_ENDOCYTIC_2	124	127	PF00928	0.337
TRG_ENDOCYTIC_2	158	161	PF00928	0.365
TRG_ENDOCYTIC_2	173	176	PF00928	0.340
TRG_ENDOCYTIC_2	208	211	PF00928	0.353
TRG_ENDOCYTIC_2	417	420	PF00928	0.352
TRG_ENDOCYTIC_2	442	445	PF00928	0.341
TRG_ENDOCYTIC_2	477	480	PF00928	0.377
TRG_ENDOCYTIC_2	506	509	PF00928	0.362
TRG_ENDOCYTIC_2	562	565	PF00928	0.475
TRG_ENDOCYTIC_2	607	610	PF00928	0.358
TRG_ER_diArg_1	114	116	PF00400	0.236
TRG_ER_diArg_1	212	214	PF00400	0.267
TRG_ER_diArg_1	671	674	PF00400	0.329
TRG_ER_diArg_1	740	742	PF00400	0.461
TRG_NES_CRM1_1	479	491	PF08389	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	58%	100%
A0A0N1HY49	Leptomonas seymouri	49%	100%
A0A0N1HZ06	Leptomonas seymouri	41%	100%
A0A0N1IHL1	Leptomonas seymouri	43%	100%
A0A0N1PAY4	Leptomonas seymouri	39%	85%
A0A0N1PB77	Leptomonas seymouri	41%	100%
A0A0N1PBZ2	Leptomonas seymouri	44%	100%
A0A0N1PCC1	Leptomonas seymouri	41%	100%
A0A381MBI0	Leishmania infantum	40%	100%
A0A3Q8I8X7	Leishmania donovani	40%	100%
A0A3Q8IAZ0	Leishmania donovani	41%	95%
A0A3Q8IH50	Leishmania donovani	49%	100%
A0A3Q8IVN0	Leishmania donovani	40%	96%
A0A3R7M4J1	Trypanosoma rangeli	42%	100%
A0A3S5H5P4	Leishmania donovani	46%	100%
A0A3S5H5V2	Leishmania donovani	45%	97%
A0A3S5H6F6	Leishmania donovani	42%	100%
A0A3S5H763	Leishmania donovani	47%	100%
A0A3S7WR14	Leishmania donovani	45%	100%
A0A3S7WR15	Leishmania donovani	42%	88%
A0A3S7WR24	Leishmania donovani	43%	100%
A4H4T8	Leishmania braziliensis	45%	96%
A4H5Y4	Leishmania braziliensis	41%	100%
A4H617	Leishmania braziliensis	44%	100%
A4H618	Leishmania braziliensis	44%	100%
A4H619	Leishmania braziliensis	44%	100%
A4H620	Leishmania braziliensis	51%	100%
A4H6C3	Leishmania braziliensis	41%	100%
A4HNH7	Leishmania braziliensis	39%	98%
A4HSS2	Leishmania infantum	46%	100%
A4HUE4	Leishmania infantum	100%	100%
A4HUE5	Leishmania infantum	42%	100%
A4HUE6	Leishmania infantum	43%	100%
A4HUE7	Leishmania infantum	41%	95%
A4HUE8	Leishmania infantum	43%	100%
A4HUF4	Leishmania infantum	42%	100%
A4HUF5	Leishmania infantum	49%	96%
A4HYA9	Leishmania infantum	48%	100%
A4IC33	Leishmania infantum	39%	92%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AG72	Leishmania infantum	45%	97%
E9AI40	Leishmania braziliensis	44%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	92%
Q4QDC4	Leishmania major	48%	100%
Q4QH81	Leishmania major	41%	100%
Q4QHH7	Leishmania major	48%	100%
Q4QHH8	Leishmania major	42%	100%
Q4QHH9	Leishmania major	42%	100%
Q4QHI0	Leishmania major	43%	100%
Q4QHI1	Leishmania major	43%	96%
Q4QHI2	Leishmania major	43%	100%
Q4QIU9	Leishmania major	44%	97%
Q4QJ48	Leishmania major	45%	100%
Q7KIP2	Leishmania major	39%	93%