Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WR08_LEIDO

TriTrypDb:

LdBPK_100230.1 , LdCL_100007600 , LDHU3_10.0360

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WR08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.565
CLV_NRD_NRD_1	230	232	PF00675	0.633
CLV_NRD_NRD_1	234	236	PF00675	0.704
CLV_NRD_NRD_1	4	6	PF00675	0.679
CLV_PCSK_KEX2_1	230	232	PF00082	0.628
CLV_PCSK_KEX2_1	234	236	PF00082	0.704
CLV_PCSK_PC7_1	230	236	PF00082	0.611
CLV_PCSK_SKI1_1	120	124	PF00082	0.765
CLV_PCSK_SKI1_1	5	9	PF00082	0.769
DEG_SCF_FBW7_1	62	69	PF00400	0.566
DOC_CKS1_1	123	128	PF01111	0.568
DOC_PP4_FxxP_1	123	126	PF00568	0.581
DOC_USP7_MATH_1	161	165	PF00917	0.567
DOC_USP7_MATH_1	214	218	PF00917	0.759
DOC_USP7_MATH_1	39	43	PF00917	0.517
DOC_WW_Pin1_4	122	127	PF00397	0.524
DOC_WW_Pin1_4	164	169	PF00397	0.625
DOC_WW_Pin1_4	212	217	PF00397	0.777
DOC_WW_Pin1_4	62	67	PF00397	0.594
LIG_14-3-3_CanoR_1	131	135	PF00244	0.577
LIG_14-3-3_CanoR_1	144	148	PF00244	0.473
LIG_14-3-3_CanoR_1	183	190	PF00244	0.652
LIG_14-3-3_CanoR_1	5	14	PF00244	0.614
LIG_14-3-3_CanoR_1	57	63	PF00244	0.461
LIG_FHA_1	107	113	PF00498	0.626
LIG_FHA_1	15	21	PF00498	0.753
LIG_FHA_1	185	191	PF00498	0.571
LIG_FHA_1	200	206	PF00498	0.536
LIG_FHA_1	57	63	PF00498	0.488
LIG_FHA_2	218	224	PF00498	0.815
LIG_LIR_Apic_2	121	126	PF02991	0.571
LIG_LIR_Gen_1	220	226	PF02991	0.796
LIG_LIR_Nem_3	146	151	PF02991	0.556
LIG_LIR_Nem_3	90	96	PF02991	0.492
LIG_PTAP_UEV_1	167	172	PF05743	0.700
LIG_PTB_Apo_2	246	253	PF02174	0.830
LIG_PTB_Phospho_1	246	252	PF10480	0.830
LIG_SH2_CRK	97	101	PF00017	0.484
LIG_SH2_NCK_1	45	49	PF00017	0.518
LIG_SH2_STAP1	222	226	PF00017	0.753
LIG_SH2_STAP1	45	49	PF00017	0.535
LIG_SH2_STAP1	97	101	PF00017	0.497
LIG_SH3_2	126	131	PF14604	0.593
LIG_SH3_3	123	129	PF00018	0.570
LIG_SH3_3	165	171	PF00018	0.686
LIG_SH3_3	33	39	PF00018	0.591
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.633
LIG_SUMO_SIM_par_1	17	24	PF11976	0.768
MOD_CDK_SPxxK_3	212	219	PF00069	0.778
MOD_CK1_1	150	156	PF00069	0.534
MOD_CK1_1	164	170	PF00069	0.516
MOD_CK1_1	217	223	PF00069	0.764
MOD_CK1_1	80	86	PF00069	0.541
MOD_CK2_1	217	223	PF00069	0.814
MOD_CK2_1	263	269	PF00069	0.780
MOD_GlcNHglycan	168	171	PF01048	0.841
MOD_GlcNHglycan	23	26	PF01048	0.804
MOD_GlcNHglycan	81	85	PF01048	0.719
MOD_GSK3_1	143	150	PF00069	0.565
MOD_GSK3_1	162	169	PF00069	0.638
MOD_GSK3_1	184	191	PF00069	0.590
MOD_GSK3_1	214	221	PF00069	0.775
MOD_GSK3_1	259	266	PF00069	0.773
MOD_GSK3_1	39	46	PF00069	0.581
MOD_GSK3_1	58	65	PF00069	0.437
MOD_GSK3_1	76	83	PF00069	0.385
MOD_N-GLC_1	107	112	PF02516	0.743
MOD_N-GLC_1	156	161	PF02516	0.831
MOD_N-GLC_1	62	67	PF02516	0.766
MOD_N-GLC_2	249	251	PF02516	0.632
MOD_NEK2_1	104	109	PF00069	0.532
MOD_NEK2_1	184	189	PF00069	0.570
MOD_NEK2_1	20	25	PF00069	0.798
MOD_NEK2_2	143	148	PF00069	0.538
MOD_OFUCOSY	155	160	PF10250	0.748
MOD_PIKK_1	162	168	PF00454	0.573
MOD_PKA_1	5	11	PF00069	0.542
MOD_PKA_2	130	136	PF00069	0.511
MOD_PKA_2	143	149	PF00069	0.461
MOD_PKA_2	56	62	PF00069	0.501
MOD_Plk_4	130	136	PF00069	0.529
MOD_Plk_4	14	20	PF00069	0.648
MOD_Plk_4	143	149	PF00069	0.449
MOD_ProDKin_1	122	128	PF00069	0.527
MOD_ProDKin_1	164	170	PF00069	0.630
MOD_ProDKin_1	212	218	PF00069	0.777
MOD_ProDKin_1	62	68	PF00069	0.596
MOD_SUMO_rev_2	150	156	PF00179	0.445
MOD_SUMO_rev_2	257	266	PF00179	0.759
TRG_ENDOCYTIC_2	222	225	PF00928	0.855
TRG_ENDOCYTIC_2	97	100	PF00928	0.502
TRG_ER_diArg_1	233	235	PF00400	0.809
TRG_NLS_MonoExtC_3	230	235	PF00514	0.806
TRG_NLS_MonoExtN_4	230	235	PF00514	0.806

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT1	Leptomonas seymouri	54%	87%
A4H604	Leishmania braziliensis	68%	100%
A4HUD1	Leishmania infantum	100%	100%
E9AN31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QHJ5	Leishmania major	91%	100%