Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WR07_LEIDO

TriTrypDb:

LdBPK_100140.1 , LdCL_100006600 , LDHU3_10.0240

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WR07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.710
CLV_C14_Caspase3-7	426	430	PF00656	0.547
CLV_C14_Caspase3-7	496	500	PF00656	0.651
CLV_NRD_NRD_1	140	142	PF00675	0.576
CLV_NRD_NRD_1	148	150	PF00675	0.562
CLV_NRD_NRD_1	282	284	PF00675	0.571
CLV_NRD_NRD_1	72	74	PF00675	0.524
CLV_NRD_NRD_1	83	85	PF00675	0.441
CLV_NRD_NRD_1	91	93	PF00675	0.339
CLV_PCSK_KEX2_1	140	142	PF00082	0.595
CLV_PCSK_KEX2_1	282	284	PF00082	0.571
CLV_PCSK_KEX2_1	290	292	PF00082	0.547
CLV_PCSK_KEX2_1	72	74	PF00082	0.524
CLV_PCSK_KEX2_1	83	85	PF00082	0.441
CLV_PCSK_KEX2_1	89	91	PF00082	0.381
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.566
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.548
CLV_PCSK_PC7_1	286	292	PF00082	0.492
CLV_PCSK_SKI1_1	125	129	PF00082	0.543
CLV_PCSK_SKI1_1	469	473	PF00082	0.751
DEG_APCC_DBOX_1	52	60	PF00400	0.510
DEG_SPOP_SBC_1	229	233	PF00917	0.731
DEG_SPOP_SBC_1	402	406	PF00917	0.710
DOC_CYCLIN_RxL_1	466	476	PF00134	0.648
DOC_PP2B_LxvP_1	449	452	PF13499	0.672
DOC_PP4_FxxP_1	390	393	PF00568	0.646
DOC_USP7_MATH_1	182	186	PF00917	0.700
DOC_USP7_MATH_1	190	194	PF00917	0.598
DOC_USP7_MATH_1	204	208	PF00917	0.723
DOC_USP7_MATH_1	210	214	PF00917	0.733
DOC_USP7_MATH_1	229	233	PF00917	0.625
DOC_USP7_MATH_1	258	262	PF00917	0.545
DOC_USP7_MATH_1	358	362	PF00917	0.718
DOC_USP7_MATH_1	368	372	PF00917	0.709
DOC_USP7_MATH_1	393	397	PF00917	0.687
DOC_USP7_MATH_1	400	404	PF00917	0.645
DOC_USP7_MATH_1	419	423	PF00917	0.706
DOC_USP7_MATH_1	486	490	PF00917	0.725
DOC_USP7_MATH_1	492	496	PF00917	0.756
DOC_USP7_MATH_1	8	12	PF00917	0.659
DOC_USP7_UBL2_3	121	125	PF12436	0.552
DOC_WW_Pin1_4	194	199	PF00397	0.650
DOC_WW_Pin1_4	347	352	PF00397	0.684
DOC_WW_Pin1_4	364	369	PF00397	0.462
DOC_WW_Pin1_4	444	449	PF00397	0.803
LIG_14-3-3_CanoR_1	114	123	PF00244	0.563
LIG_14-3-3_CanoR_1	329	336	PF00244	0.665
LIG_14-3-3_CanoR_1	362	370	PF00244	0.731
LIG_14-3-3_CanoR_1	442	448	PF00244	0.713
LIG_AP2alpha_2	388	390	PF02296	0.703
LIG_BIR_III_4	499	503	PF00653	0.603
LIG_BRCT_BRCA1_1	332	336	PF00533	0.699
LIG_FHA_1	115	121	PF00498	0.562
LIG_FHA_1	158	164	PF00498	0.591
LIG_FHA_1	195	201	PF00498	0.731
LIG_FHA_1	210	216	PF00498	0.697
LIG_FHA_1	236	242	PF00498	0.721
LIG_FHA_1	244	250	PF00498	0.611
LIG_FHA_1	262	268	PF00498	0.327
LIG_FHA_1	296	302	PF00498	0.587
LIG_FHA_1	348	354	PF00498	0.745
LIG_FHA_1	45	51	PF00498	0.542
LIG_FHA_1	473	479	PF00498	0.700
LIG_FHA_2	235	241	PF00498	0.673
LIG_FHA_2	56	62	PF00498	0.517
LIG_GBD_Chelix_1	134	142	PF00786	0.531
LIG_GBD_Chelix_1	77	85	PF00786	0.495
LIG_LIR_Apic_2	388	393	PF02991	0.641
LIG_PCNA_yPIPBox_3	72	81	PF02747	0.562
LIG_RPA_C_Fungi	79	91	PF08784	0.539
LIG_SH2_STAP1	17	21	PF00017	0.655
LIG_SH2_STAP1	6	10	PF00017	0.607
LIG_SH2_STAT5	251	254	PF00017	0.576
LIG_SH2_STAT5	273	276	PF00017	0.576
LIG_SH3_3	195	201	PF00018	0.701
LIG_SH3_3	367	373	PF00018	0.734
LIG_SH3_3	383	389	PF00018	0.630
LIG_SH3_3	475	481	PF00018	0.785
LIG_TRAF2_1	107	110	PF00917	0.525
LIG_TRAF2_1	155	158	PF00917	0.563
LIG_TRAF2_1	58	61	PF00917	0.613
LIG_UBA3_1	81	89	PF00899	0.518
LIG_WW_1	14	17	PF00397	0.686
MOD_CDK_SPxxK_3	347	354	PF00069	0.704
MOD_CK1_1	108	114	PF00069	0.510
MOD_CK1_1	181	187	PF00069	0.598
MOD_CK1_1	206	212	PF00069	0.713
MOD_CK1_1	225	231	PF00069	0.573
MOD_CK1_1	261	267	PF00069	0.549
MOD_CK1_1	342	348	PF00069	0.626
MOD_CK1_1	403	409	PF00069	0.752
MOD_CK1_1	415	421	PF00069	0.556
MOD_CK1_1	422	428	PF00069	0.776
MOD_CK1_1	444	450	PF00069	0.753
MOD_CK1_1	462	468	PF00069	0.638
MOD_CK1_1	493	499	PF00069	0.758
MOD_CK1_1	55	61	PF00069	0.588
MOD_CK2_1	265	271	PF00069	0.627
MOD_CK2_1	451	457	PF00069	0.736
MOD_CK2_1	55	61	PF00069	0.558
MOD_GlcNHglycan	10	13	PF01048	0.681
MOD_GlcNHglycan	180	183	PF01048	0.666
MOD_GlcNHglycan	184	187	PF01048	0.719
MOD_GlcNHglycan	192	195	PF01048	0.707
MOD_GlcNHglycan	206	209	PF01048	0.736
MOD_GlcNHglycan	212	215	PF01048	0.665
MOD_GlcNHglycan	227	230	PF01048	0.653
MOD_GlcNHglycan	342	345	PF01048	0.654
MOD_GlcNHglycan	356	359	PF01048	0.683
MOD_GlcNHglycan	364	367	PF01048	0.747
MOD_GlcNHglycan	395	398	PF01048	0.743
MOD_GlcNHglycan	414	417	PF01048	0.673
MOD_GlcNHglycan	421	424	PF01048	0.670
MOD_GlcNHglycan	492	495	PF01048	0.688
MOD_GlcNHglycan	6	9	PF01048	0.714
MOD_GSK3_1	178	185	PF00069	0.614
MOD_GSK3_1	188	195	PF00069	0.719
MOD_GSK3_1	204	211	PF00069	0.796
MOD_GSK3_1	221	228	PF00069	0.601
MOD_GSK3_1	229	236	PF00069	0.666
MOD_GSK3_1	261	268	PF00069	0.620
MOD_GSK3_1	339	346	PF00069	0.631
MOD_GSK3_1	354	361	PF00069	0.655
MOD_GSK3_1	364	371	PF00069	0.660
MOD_GSK3_1	4	11	PF00069	0.633
MOD_GSK3_1	415	422	PF00069	0.796
MOD_GSK3_1	451	458	PF00069	0.760
MOD_GSK3_1	486	493	PF00069	0.718
MOD_LATS_1	220	226	PF00433	0.719
MOD_LATS_1	410	416	PF00433	0.664
MOD_N-GLC_1	114	119	PF02516	0.595
MOD_NEK2_1	113	118	PF00069	0.546
MOD_NEK2_1	331	336	PF00069	0.654
MOD_NEK2_1	340	345	PF00069	0.615
MOD_NEK2_1	443	448	PF00069	0.740
MOD_NEK2_1	45	50	PF00069	0.482
MOD_NEK2_1	472	477	PF00069	0.697
MOD_NEK2_1	52	57	PF00069	0.475
MOD_NEK2_1	85	90	PF00069	0.557
MOD_NEK2_2	258	263	PF00069	0.548
MOD_PIKK_1	105	111	PF00454	0.559
MOD_PIKK_1	114	120	PF00454	0.570
MOD_PIKK_1	188	194	PF00454	0.649
MOD_PIKK_1	295	301	PF00454	0.661
MOD_PIKK_1	462	468	PF00454	0.665
MOD_PK_1	73	79	PF00069	0.528
MOD_PKA_1	90	96	PF00069	0.441
MOD_PKA_2	113	119	PF00069	0.562
MOD_PKA_2	221	227	PF00069	0.717
MOD_PKA_2	441	447	PF00069	0.713
MOD_PKA_2	52	58	PF00069	0.533
MOD_PKA_2	90	96	PF00069	0.441
MOD_Plk_1	455	461	PF00069	0.827
MOD_Plk_1	473	479	PF00069	0.501
MOD_Plk_1	487	493	PF00069	0.749
MOD_Plk_4	45	51	PF00069	0.485
MOD_ProDKin_1	194	200	PF00069	0.651
MOD_ProDKin_1	347	353	PF00069	0.688
MOD_ProDKin_1	364	370	PF00069	0.466
MOD_ProDKin_1	444	450	PF00069	0.805
MOD_SUMO_for_1	127	130	PF00179	0.576
MOD_SUMO_rev_2	105	113	PF00179	0.538
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.693
TRG_ENDOCYTIC_2	67	70	PF00928	0.559
TRG_ER_diArg_1	140	142	PF00400	0.560
TRG_ER_diArg_1	282	284	PF00400	0.602
TRG_ER_diArg_1	50	53	PF00400	0.508
TRG_ER_diArg_1	82	84	PF00400	0.498
TRG_ER_diArg_1	90	92	PF00400	0.483
TRG_NLS_Bipartite_1	72	93	PF00514	0.547
TRG_NLS_MonoCore_2	88	93	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X5	Leptomonas seymouri	55%	67%
A0A0S4JC19	Bodo saltans	27%	100%
A0A3R7MLU6	Trypanosoma rangeli	30%	100%
A4H5Z7	Leishmania braziliensis	77%	100%
A4HUC3	Leishmania infantum	99%	100%
E9AN22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QHK4	Leishmania major	92%	100%