4a-hydroxytetrahydrobiopterin dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pterin 4 alpha carbinolamine dehydratase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WR02_LEIDO

TriTrypDb:

LdBPK_100270.1 , LdCL_100008000 , LDHU3_10.0400

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WR02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WR02

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006729	tetrahydrobiopterin biosynthetic process	6	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019751	polyol metabolic process	4	11
GO:0034311	diol metabolic process	5	11
GO:0034312	diol biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0042558	pteridine-containing compound metabolic process	4	11
GO:0042559	pteridine-containing compound biosynthetic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046146	tetrahydrobiopterin metabolic process	5	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	5	11
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0016836	hydro-lyase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.550
CLV_C14_Caspase3-7	245	249	PF00656	0.680
CLV_C14_Caspase3-7	74	78	PF00656	0.603
CLV_NRD_NRD_1	179	181	PF00675	0.464
CLV_NRD_NRD_1	187	189	PF00675	0.484
CLV_NRD_NRD_1	213	215	PF00675	0.413
CLV_NRD_NRD_1	51	53	PF00675	0.426
CLV_PCSK_KEX2_1	163	165	PF00082	0.297
CLV_PCSK_KEX2_1	187	189	PF00082	0.438
CLV_PCSK_KEX2_1	213	215	PF00082	0.434
CLV_PCSK_KEX2_1	51	53	PF00082	0.426
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.297
CLV_PCSK_PC7_1	159	165	PF00082	0.297
CLV_PCSK_SKI1_1	214	218	PF00082	0.566
CLV_PCSK_SKI1_1	63	67	PF00082	0.418
DEG_Nend_UBRbox_1	1	4	PF02207	0.540
DEG_SPOP_SBC_1	84	88	PF00917	0.727
DOC_ANK_TNKS_1	186	193	PF00023	0.516
DOC_USP7_MATH_1	250	254	PF00917	0.621
DOC_USP7_MATH_1	84	88	PF00917	0.727
DOC_WW_Pin1_4	152	157	PF00397	0.252
DOC_WW_Pin1_4	235	240	PF00397	0.612
LIG_14-3-3_CanoR_1	195	203	PF00244	0.459
LIG_14-3-3_CanoR_1	2	8	PF00244	0.713
LIG_14-3-3_CanoR_1	230	240	PF00244	0.677
LIG_Actin_WH2_2	165	182	PF00022	0.362
LIG_Actin_WH2_2	204	220	PF00022	0.504
LIG_BRCT_BRCA1_1	154	158	PF00533	0.311
LIG_FHA_1	148	154	PF00498	0.305
LIG_FHA_1	217	223	PF00498	0.614
LIG_FHA_2	116	122	PF00498	0.294
LIG_FHA_2	195	201	PF00498	0.523
LIG_LIR_Gen_1	113	124	PF02991	0.294
LIG_LIR_Gen_1	29	40	PF02991	0.531
LIG_LIR_Gen_1	5	15	PF02991	0.596
LIG_LIR_Nem_3	113	119	PF02991	0.279
LIG_LIR_Nem_3	136	142	PF02991	0.287
LIG_LIR_Nem_3	155	161	PF02991	0.311
LIG_LIR_Nem_3	174	179	PF02991	0.363
LIG_LIR_Nem_3	29	35	PF02991	0.543
LIG_LIR_Nem_3	5	10	PF02991	0.634
LIG_LYPXL_yS_3	139	142	PF13949	0.258
LIG_PCNA_yPIPBox_3	195	203	PF02747	0.508
LIG_Pex14_1	130	134	PF04695	0.297
LIG_Pex14_1	68	72	PF04695	0.488
LIG_PTB_Apo_2	170	177	PF02174	0.368
LIG_PTB_Phospho_1	170	176	PF10480	0.297
LIG_SH2_CRK	176	180	PF00017	0.397
LIG_SH2_NCK_1	72	76	PF00017	0.600
LIG_SH2_SRC	152	155	PF00017	0.297
LIG_SH2_SRC	72	75	PF00017	0.500
LIG_SH2_STAP1	72	76	PF00017	0.600
LIG_SH2_STAT5	123	126	PF00017	0.294
LIG_SH2_STAT5	152	155	PF00017	0.337
LIG_SH3_3	94	100	PF00018	0.686
LIG_TRAF2_1	198	201	PF00917	0.454
LIG_TRAF2_1	221	224	PF00917	0.549
LIG_ULM_U2AF65_1	180	185	PF00076	0.470
LIG_WRC_WIRS_1	111	116	PF05994	0.371
MOD_CDC14_SPxK_1	238	241	PF00782	0.544
MOD_CDK_SPxK_1	235	241	PF00069	0.524
MOD_CDK_SPxxK_3	152	159	PF00069	0.252
MOD_CK1_1	231	237	PF00069	0.567
MOD_CK1_1	242	248	PF00069	0.708
MOD_CK1_1	5	11	PF00069	0.685
MOD_CK1_1	86	92	PF00069	0.737
MOD_CK2_1	115	121	PF00069	0.334
MOD_CK2_1	159	165	PF00069	0.279
MOD_CK2_1	194	200	PF00069	0.473
MOD_CK2_1	90	96	PF00069	0.597
MOD_GlcNHglycan	11	14	PF01048	0.655
MOD_GlcNHglycan	233	236	PF01048	0.580
MOD_GlcNHglycan	244	247	PF01048	0.677
MOD_GlcNHglycan	90	93	PF01048	0.658
MOD_GSK3_1	140	147	PF00069	0.338
MOD_GSK3_1	2	9	PF00069	0.710
MOD_GSK3_1	231	238	PF00069	0.622
MOD_GSK3_1	83	90	PF00069	0.756
MOD_NEK2_1	16	21	PF00069	0.574
MOD_NEK2_1	179	184	PF00069	0.392
MOD_NEK2_1	35	40	PF00069	0.510
MOD_NEK2_1	61	66	PF00069	0.387
MOD_PIKK_1	19	25	PF00454	0.612
MOD_PKA_2	179	185	PF00069	0.466
MOD_PKA_2	194	200	PF00069	0.523
MOD_PKA_2	3	9	PF00069	0.610
MOD_Plk_1	16	22	PF00069	0.550
MOD_ProDKin_1	152	158	PF00069	0.252
MOD_ProDKin_1	235	241	PF00069	0.618
TRG_DiLeu_BaEn_2	120	126	PF01217	0.410
TRG_DiLeu_BaEn_2	56	62	PF01217	0.406
TRG_ENDOCYTIC_2	123	126	PF00928	0.279
TRG_ENDOCYTIC_2	139	142	PF00928	0.279
TRG_ENDOCYTIC_2	176	179	PF00928	0.382
TRG_ENDOCYTIC_2	72	75	PF00928	0.627
TRG_ER_diArg_1	1	4	PF00400	0.559
TRG_ER_diArg_1	187	189	PF00400	0.537
TRG_ER_diArg_1	51	54	PF00400	0.428
TRG_NLS_Bipartite_1	163	184	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W5	Leptomonas seymouri	70%	97%
A0A0S4IXY6	Bodo saltans	41%	100%
A0A1X0NQ34	Trypanosomatidae	57%	100%
A4H608	Leishmania braziliensis	78%	100%
A4HUD5	Leishmania infantum	100%	100%
C9ZVG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	81%
E9AN35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	97%
Q4QHJ1	Leishmania major	94%	100%
V5BIH1	Trypanosoma cruzi	64%	100%