Leucine-rich repeat protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQZ4_LEIDO

TriTrypDb:

LdBPK_100160.1 , LdCL_100006800

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3S7WQZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	151	155	PF00082	0.387
DEG_APCC_DBOX_1	53	61	PF00400	0.561
DOC_CDC14_PxL_1	144	152	PF14671	0.359
DOC_CKS1_1	160	165	PF01111	0.594
DOC_CYCLIN_RxL_1	148	156	PF00134	0.422
DOC_MAPK_gen_1	100	109	PF00069	0.387
DOC_MAPK_gen_1	189	197	PF00069	0.550
DOC_MAPK_MEF2A_6	191	199	PF00069	0.578
DOC_MAPK_MEF2A_6	206	213	PF00069	0.594
DOC_PP2B_LxvP_1	145	148	PF13499	0.313
DOC_USP7_MATH_1	177	181	PF00917	0.556
DOC_WW_Pin1_4	159	164	PF00397	0.582
DOC_WW_Pin1_4	69	74	PF00397	0.663
LIG_14-3-3_CanoR_1	106	110	PF00244	0.378
LIG_14-3-3_CanoR_1	151	156	PF00244	0.422
LIG_14-3-3_CanoR_1	74	81	PF00244	0.629
LIG_Actin_WH2_2	77	94	PF00022	0.675
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	37	41	PF00533	0.715
LIG_CSL_BTD_1	115	118	PF09270	0.422
LIG_FHA_1	17	23	PF00498	0.619
LIG_FHA_2	160	166	PF00498	0.629
LIG_FHA_2	223	229	PF00498	0.637
LIG_LIR_Gen_1	198	203	PF02991	0.573
LIG_LIR_Gen_1	207	214	PF02991	0.654
LIG_LIR_Gen_1	87	94	PF02991	0.545
LIG_LIR_Nem_3	115	119	PF02991	0.398
LIG_LIR_Nem_3	190	196	PF02991	0.569
LIG_LIR_Nem_3	198	202	PF02991	0.488
LIG_LIR_Nem_3	207	213	PF02991	0.653
LIG_LIR_Nem_3	87	91	PF02991	0.527
LIG_MAD2	151	159	PF02301	0.448
LIG_PCNA_yPIPBox_3	103	117	PF02747	0.448
LIG_Pex14_2	37	41	PF04695	0.715
LIG_PTB_Apo_2	155	162	PF02174	0.422
LIG_PTB_Phospho_1	155	161	PF10480	0.448
LIG_SH2_CRK	88	92	PF00017	0.548
LIG_SH2_SRC	174	177	PF00017	0.636
LIG_SH2_STAT5	161	164	PF00017	0.694
LIG_SH2_STAT5	174	177	PF00017	0.605
LIG_SH2_STAT5	36	39	PF00017	0.656
LIG_SH2_STAT5	88	91	PF00017	0.564
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.569
LIG_SUMO_SIM_par_1	151	156	PF11976	0.336
LIG_SxIP_EBH_1	168	179	PF03271	0.518
LIG_TRAF2_1	126	129	PF00917	0.336
LIG_TRAF2_1	162	165	PF00917	0.666
LIG_WRC_WIRS_1	196	201	PF05994	0.558
MOD_CDK_SPK_2	69	74	PF00069	0.663
MOD_CK1_1	87	93	PF00069	0.665
MOD_CK1_1	96	102	PF00069	0.637
MOD_CK2_1	10	16	PF00069	0.571
MOD_CK2_1	159	165	PF00069	0.628
MOD_CK2_1	222	228	PF00069	0.644
MOD_CK2_1	99	105	PF00069	0.570
MOD_GlcNHglycan	182	186	PF01048	0.692
MOD_GSK3_1	177	184	PF00069	0.596
MOD_GSK3_1	31	38	PF00069	0.576
MOD_GSK3_1	69	76	PF00069	0.632
MOD_GSK3_1	90	97	PF00069	0.651
MOD_N-GLC_1	41	46	PF02516	0.698
MOD_N-GLC_1	84	89	PF02516	0.535
MOD_NEK2_1	3	8	PF00069	0.701
MOD_NEK2_1	35	40	PF00069	0.597
MOD_NEK2_1	84	89	PF00069	0.530
MOD_NEK2_2	31	36	PF00069	0.687
MOD_PKA_2	73	79	PF00069	0.640
MOD_PKA_2	99	105	PF00069	0.566
MOD_PKB_1	149	157	PF00069	0.448
MOD_Plk_1	84	90	PF00069	0.535
MOD_Plk_1	94	100	PF00069	0.566
MOD_Plk_4	10	16	PF00069	0.686
MOD_Plk_4	112	118	PF00069	0.448
MOD_Plk_4	170	176	PF00069	0.616
MOD_Plk_4	198	204	PF00069	0.634
MOD_Plk_4	31	37	PF00069	0.615
MOD_ProDKin_1	159	165	PF00069	0.584
MOD_ProDKin_1	69	75	PF00069	0.664
TRG_ENDOCYTIC_2	193	196	PF00928	0.533
TRG_ENDOCYTIC_2	88	91	PF00928	0.529
TRG_ER_diArg_1	148	151	PF00400	0.448
TRG_ER_diArg_1	188	191	PF00400	0.548
TRG_ER_diArg_1	223	226	PF00400	0.620
TRG_NES_CRM1_1	123	133	PF08389	0.312
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B1	Leptomonas seymouri	63%	100%
A0A0S4J897	Bodo saltans	47%	83%
A0A1X0NQ44	Trypanosomatidae	56%	100%
A0A422NRS7	Trypanosoma rangeli	56%	100%
A4H5Z9	Leishmania braziliensis	83%	100%
A4HUC5	Leishmania infantum	99%	100%
C9ZVG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AN24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q32NT4	Xenopus laevis	26%	68%
Q4QHK2	Leishmania major	94%	100%
Q66HD6	Rattus norvegicus	30%	93%
V5BIH6	Trypanosoma cruzi	55%	100%