PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WQZ0_LEIDO

TriTrypDb:

LdBPK_100180.1 , LdCL_100007000 , LDHU3_10.0290

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.674
CLV_NRD_NRD_1	278	280	PF00675	0.685
CLV_PCSK_KEX2_1	207	209	PF00082	0.587
CLV_PCSK_SKI1_1	193	197	PF00082	0.660
CLV_PCSK_SKI1_1	211	215	PF00082	0.513
CLV_PCSK_SKI1_1	402	406	PF00082	0.771
CLV_PCSK_SKI1_1	432	436	PF00082	0.834
CLV_PCSK_SKI1_1	636	640	PF00082	0.471
CLV_PCSK_SKI1_1	96	100	PF00082	0.630
DEG_APCC_DBOX_1	154	162	PF00400	0.846
DEG_APCC_DBOX_1	284	292	PF00400	0.736
DEG_APCC_DBOX_1	635	643	PF00400	0.471
DEG_Kelch_actinfilin_1	112	116	PF01344	0.561
DEG_SPOP_SBC_1	132	136	PF00917	0.806
DEG_SPOP_SBC_1	551	555	PF00917	0.666
DOC_ANK_TNKS_1	479	486	PF00023	0.637
DOC_CYCLIN_yClb5_NLxxxL_5	5	14	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	295	298	PF00134	0.730
DOC_MAPK_DCC_7	600	609	PF00069	0.355
DOC_MAPK_MEF2A_6	617	624	PF00069	0.433
DOC_PP2B_LxvP_1	295	298	PF13499	0.730
DOC_USP7_MATH_1	126	130	PF00917	0.704
DOC_USP7_MATH_1	133	137	PF00917	0.654
DOC_USP7_MATH_1	165	169	PF00917	0.865
DOC_USP7_MATH_1	260	264	PF00917	0.616
DOC_USP7_MATH_1	343	347	PF00917	0.828
DOC_USP7_MATH_1	386	390	PF00917	0.846
DOC_USP7_MATH_1	393	397	PF00917	0.722
DOC_USP7_MATH_1	430	434	PF00917	0.838
DOC_USP7_MATH_1	48	52	PF00917	0.710
DOC_USP7_MATH_1	498	502	PF00917	0.763
DOC_USP7_MATH_1	512	516	PF00917	0.675
DOC_USP7_MATH_1	55	59	PF00917	0.672
DOC_USP7_MATH_1	552	556	PF00917	0.652
DOC_USP7_MATH_1	628	632	PF00917	0.452
DOC_USP7_MATH_1	81	85	PF00917	0.797
DOC_USP7_UBL2_3	33	37	PF12436	0.694
DOC_WW_Pin1_4	136	141	PF00397	0.741
DOC_WW_Pin1_4	161	166	PF00397	0.854
DOC_WW_Pin1_4	167	172	PF00397	0.740
DOC_WW_Pin1_4	173	178	PF00397	0.637
DOC_WW_Pin1_4	181	186	PF00397	0.593
DOC_WW_Pin1_4	261	266	PF00397	0.671
DOC_WW_Pin1_4	318	323	PF00397	0.838
DOC_WW_Pin1_4	348	353	PF00397	0.692
DOC_WW_Pin1_4	356	361	PF00397	0.656
DOC_WW_Pin1_4	367	372	PF00397	0.579
DOC_WW_Pin1_4	447	452	PF00397	0.698
DOC_WW_Pin1_4	558	563	PF00397	0.682
DOC_WW_Pin1_4	602	607	PF00397	0.452
DOC_WW_Pin1_4	644	649	PF00397	0.316
DOC_WW_Pin1_4	72	77	PF00397	0.839
DOC_WW_Pin1_4	86	91	PF00397	0.577
LIG_14-3-3_CanoR_1	402	407	PF00244	0.737
LIG_14-3-3_CanoR_1	544	548	PF00244	0.687
LIG_14-3-3_CanoR_1	643	651	PF00244	0.452
LIG_14-3-3_CanoR_1	70	76	PF00244	0.771
LIG_BIR_II_1	1	5	PF00653	0.783
LIG_BIR_III_4	482	486	PF00653	0.677
LIG_BIR_III_4	63	67	PF00653	0.763
LIG_BRCT_BRCA1_1	43	47	PF00533	0.670
LIG_deltaCOP1_diTrp_1	93	98	PF00928	0.721
LIG_Dynein_DLC8_1	641	647	PF01221	0.316
LIG_EH1_1	655	663	PF00400	0.519
LIG_EVH1_1	158	162	PF00568	0.840
LIG_FHA_1	173	179	PF00498	0.772
LIG_FHA_1	373	379	PF00498	0.736
LIG_FHA_1	648	654	PF00498	0.327
LIG_FHA_2	459	465	PF00498	0.793
LIG_FHA_2	655	661	PF00498	0.525
LIG_GBD_Chelix_1	288	296	PF00786	0.755
LIG_Integrin_RGD_1	364	366	PF01839	0.761
LIG_Integrin_RGD_1	617	619	PF01839	0.433
LIG_LIR_Apic_2	341	345	PF02991	0.727
LIG_LIR_Gen_1	545	556	PF02991	0.622
LIG_LIR_Gen_1	660	668	PF02991	0.406
LIG_LIR_Nem_3	545	551	PF02991	0.620
LIG_LIR_Nem_3	660	666	PF02991	0.433
LIG_MYND_1	159	163	PF01753	0.841
LIG_MYND_1	322	326	PF01753	0.707
LIG_PCNA_yPIPBox_3	228	242	PF02747	0.666
LIG_Pex14_1	94	98	PF04695	0.715
LIG_PROFILIN_1	451	457	PF00235	0.623
LIG_SH2_CRK	342	346	PF00017	0.729
LIG_SH2_CRK	548	552	PF00017	0.719
LIG_SH2_NCK_1	342	346	PF00017	0.729
LIG_SH2_STAP1	17	21	PF00017	0.527
LIG_SH2_STAT5	247	250	PF00017	0.525
LIG_SH3_3	156	162	PF00018	0.833
LIG_SH3_3	296	302	PF00018	0.682
LIG_SH3_3	375	381	PF00018	0.786
LIG_SH3_3	445	451	PF00018	0.830
LIG_SH3_3	465	471	PF00018	0.657
LIG_SH3_3	484	490	PF00018	0.667
LIG_SH3_3	556	562	PF00018	0.658
LIG_SH3_3	579	585	PF00018	0.565
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.598
LIG_SUMO_SIM_par_1	647	652	PF11976	0.332
LIG_TRAF2_1	657	660	PF00917	0.574
LIG_TRAF2_2	352	357	PF00917	0.758
LIG_WRC_WIRS_1	95	100	PF05994	0.706
LIG_WW_2	159	162	PF00397	0.839
LIG_WW_2	468	471	PF00397	0.770
MOD_CDK_SPK_2	161	166	PF00069	0.737
MOD_CDK_SPK_2	558	563	PF00069	0.623
MOD_CDK_SPxxK_3	181	188	PF00069	0.765
MOD_CDK_SPxxK_3	72	79	PF00069	0.632
MOD_CK1_1	134	140	PF00069	0.686
MOD_CK1_1	164	170	PF00069	0.684
MOD_CK1_1	263	269	PF00069	0.597
MOD_CK1_1	320	326	PF00069	0.725
MOD_CK1_1	335	341	PF00069	0.589
MOD_CK1_1	400	406	PF00069	0.678
MOD_CK1_1	433	439	PF00069	0.838
MOD_CK1_1	458	464	PF00069	0.628
MOD_CK1_1	521	527	PF00069	0.775
MOD_CK1_1	550	556	PF00069	0.795
MOD_CK1_1	558	564	PF00069	0.695
MOD_CK1_1	58	64	PF00069	0.631
MOD_CK1_1	75	81	PF00069	0.684
MOD_CK1_1	84	90	PF00069	0.737
MOD_CK2_1	16	22	PF00069	0.710
MOD_CK2_1	256	262	PF00069	0.580
MOD_CK2_1	458	464	PF00069	0.793
MOD_CK2_1	498	504	PF00069	0.835
MOD_CK2_1	558	564	PF00069	0.742
MOD_CK2_1	654	660	PF00069	0.521
MOD_Cter_Amidation	205	208	PF01082	0.587
MOD_GlcNHglycan	1	4	PF01048	0.786
MOD_GlcNHglycan	11	14	PF01048	0.701
MOD_GlcNHglycan	128	131	PF01048	0.774
MOD_GlcNHglycan	136	139	PF01048	0.779
MOD_GlcNHglycan	199	202	PF01048	0.646
MOD_GlcNHglycan	258	261	PF01048	0.588
MOD_GlcNHglycan	303	306	PF01048	0.776
MOD_GlcNHglycan	332	335	PF01048	0.801
MOD_GlcNHglycan	337	340	PF01048	0.739
MOD_GlcNHglycan	346	349	PF01048	0.617
MOD_GlcNHglycan	388	391	PF01048	0.857
MOD_GlcNHglycan	395	398	PF01048	0.730
MOD_GlcNHglycan	399	402	PF01048	0.676
MOD_GlcNHglycan	411	415	PF01048	0.552
MOD_GlcNHglycan	441	444	PF01048	0.783
MOD_GlcNHglycan	60	63	PF01048	0.624
MOD_GSK3_1	132	139	PF00069	0.810
MOD_GSK3_1	161	168	PF00069	0.795
MOD_GSK3_1	193	200	PF00069	0.667
MOD_GSK3_1	248	255	PF00069	0.561
MOD_GSK3_1	256	263	PF00069	0.617
MOD_GSK3_1	314	321	PF00069	0.699
MOD_GSK3_1	344	351	PF00069	0.747
MOD_GSK3_1	367	374	PF00069	0.642
MOD_GSK3_1	393	400	PF00069	0.765
MOD_GSK3_1	432	439	PF00069	0.714
MOD_GSK3_1	455	462	PF00069	0.784
MOD_GSK3_1	507	514	PF00069	0.809
MOD_GSK3_1	521	528	PF00069	0.642
MOD_GSK3_1	529	536	PF00069	0.501
MOD_GSK3_1	543	550	PF00069	0.682
MOD_GSK3_1	551	558	PF00069	0.712
MOD_GSK3_1	66	73	PF00069	0.756
MOD_GSK3_1	77	84	PF00069	0.694
MOD_N-GLC_1	126	131	PF02516	0.694
MOD_N-GLC_1	462	467	PF02516	0.745
MOD_N-GLC_1	533	538	PF02516	0.699
MOD_N-GLC_2	540	542	PF02516	0.729
MOD_NEK2_1	197	202	PF00069	0.719
MOD_NEK2_1	248	253	PF00069	0.591
MOD_NEK2_1	332	337	PF00069	0.732
MOD_NEK2_1	372	377	PF00069	0.654
MOD_NEK2_1	518	523	PF00069	0.724
MOD_NEK2_1	543	548	PF00069	0.628
MOD_NEK2_2	512	517	PF00069	0.632
MOD_PIKK_1	642	648	PF00454	0.530
MOD_PK_1	600	606	PF00069	0.530
MOD_PKA_2	165	171	PF00069	0.841
MOD_PKA_2	238	244	PF00069	0.671
MOD_PKA_2	317	323	PF00069	0.632
MOD_PKA_2	436	442	PF00069	0.845
MOD_PKA_2	507	513	PF00069	0.854
MOD_PKA_2	543	549	PF00069	0.687
MOD_PKA_2	642	648	PF00069	0.483
MOD_PKA_2	654	660	PF00069	0.486
MOD_Plk_1	143	149	PF00069	0.770
MOD_Plk_1	193	199	PF00069	0.633
MOD_Plk_4	193	199	PF00069	0.663
MOD_Plk_4	455	461	PF00069	0.628
MOD_Plk_4	543	549	PF00069	0.730
MOD_ProDKin_1	136	142	PF00069	0.744
MOD_ProDKin_1	161	167	PF00069	0.856
MOD_ProDKin_1	173	179	PF00069	0.635
MOD_ProDKin_1	181	187	PF00069	0.665
MOD_ProDKin_1	261	267	PF00069	0.663
MOD_ProDKin_1	318	324	PF00069	0.837
MOD_ProDKin_1	348	354	PF00069	0.693
MOD_ProDKin_1	356	362	PF00069	0.656
MOD_ProDKin_1	367	373	PF00069	0.580
MOD_ProDKin_1	447	453	PF00069	0.695
MOD_ProDKin_1	558	564	PF00069	0.684
MOD_ProDKin_1	602	608	PF00069	0.452
MOD_ProDKin_1	644	650	PF00069	0.316
MOD_ProDKin_1	72	78	PF00069	0.840
MOD_ProDKin_1	86	92	PF00069	0.567
MOD_SUMO_rev_2	273	281	PF00179	0.621
MOD_SUMO_rev_2	28	34	PF00179	0.685
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.722
TRG_ENDOCYTIC_2	548	551	PF00928	0.722
TRG_ER_diArg_1	207	210	PF00400	0.689
TRG_ER_diArg_1	242	245	PF00400	0.681
TRG_ER_diArg_1	284	287	PF00400	0.737
TRG_ER_diArg_1	478	481	PF00400	0.738
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H600	Leishmania braziliensis	59%	98%
A4HUC6	Leishmania infantum	99%	100%
E9AN26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4QHK0	Leishmania major	89%	100%