Dual specificity phosphatase 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQX0_LEIDO

TriTrypDb:

LdBPK_091310.1 , LdCL_090019500 , LDHU3_09.1560

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQX0

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.593
CLV_PCSK_KEX2_1	70	72	PF00082	0.593
CLV_PCSK_SKI1_1	65	69	PF00082	0.500
DEG_Nend_UBRbox_2	1	3	PF02207	0.702
DOC_CKS1_1	153	158	PF01111	0.396
DOC_PP4_FxxP_1	99	102	PF00568	0.346
DOC_USP7_MATH_1	115	119	PF00917	0.525
DOC_USP7_MATH_1	25	29	PF00917	0.617
DOC_USP7_MATH_1	74	78	PF00917	0.598
DOC_WW_Pin1_4	102	107	PF00397	0.420
DOC_WW_Pin1_4	152	157	PF00397	0.399
DOC_WW_Pin1_4	169	174	PF00397	0.509
DOC_WW_Pin1_4	179	184	PF00397	0.577
LIG_14-3-3_CanoR_1	159	169	PF00244	0.489
LIG_FHA_1	103	109	PF00498	0.556
LIG_FHA_2	28	34	PF00498	0.631
LIG_LIR_Apic_2	96	102	PF02991	0.358
LIG_SH2_STAT5	128	131	PF00017	0.374
LIG_SH3_3	118	124	PF00018	0.589
LIG_SH3_3	53	59	PF00018	0.493
LIG_SUMO_SIM_par_1	166	172	PF11976	0.360
MOD_CDK_SPxxK_3	152	159	PF00069	0.392
MOD_CK1_1	146	152	PF00069	0.370
MOD_CK2_1	87	93	PF00069	0.574
MOD_GlcNHglycan	117	120	PF01048	0.466
MOD_GlcNHglycan	162	165	PF01048	0.357
MOD_GlcNHglycan	174	177	PF01048	0.602
MOD_GlcNHglycan	4	7	PF01048	0.678
MOD_GlcNHglycan	85	88	PF01048	0.649
MOD_GlcNHglycan	89	92	PF01048	0.575
MOD_GSK3_1	139	146	PF00069	0.388
MOD_GSK3_1	25	32	PF00069	0.508
MOD_GSK3_1	83	90	PF00069	0.622
MOD_N-GLC_1	115	120	PF02516	0.569
MOD_N-GLC_1	63	68	PF02516	0.619
MOD_NEK2_1	94	99	PF00069	0.426
MOD_NEK2_2	63	68	PF00069	0.667
MOD_PIKK_1	143	149	PF00454	0.402
MOD_Plk_1	63	69	PF00069	0.626
MOD_Plk_4	123	129	PF00069	0.415
MOD_Plk_4	94	100	PF00069	0.371
MOD_ProDKin_1	102	108	PF00069	0.417
MOD_ProDKin_1	152	158	PF00069	0.393
MOD_ProDKin_1	169	175	PF00069	0.518
TRG_ER_diArg_1	132	135	PF00400	0.505
TRG_ER_diArg_1	45	48	PF00400	0.378
TRG_ER_diArg_1	69	71	PF00400	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S9	Leptomonas seymouri	62%	100%
A0A0S4JFW8	Bodo saltans	44%	100%
A0A1X0NI01	Trypanosomatidae	52%	100%
A0A422NZK2	Trypanosoma rangeli	53%	100%
A4H5V3	Leishmania braziliensis	75%	100%
A4HU47	Leishmania infantum	100%	100%
D0A9M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	93%
E9AMX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QHQ0	Leishmania major	91%	100%
Q570P7	Arabidopsis thaliana	29%	100%
V5BMP4	Trypanosoma cruzi	50%	100%