Rhodanese-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQW6_LEIDO

TriTrypDb:

LdBPK_091540.1 , LdCL_090021800 , LDHU3_09.1810

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQW6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004792	thiosulfate sulfurtransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016782	transferase activity, transferring sulphur-containing groups	3	7
GO:0016783	sulfurtransferase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.333
CLV_NRD_NRD_1	3	5	PF00675	0.555
CLV_PCSK_KEX2_1	3	5	PF00082	0.488
CLV_PCSK_SKI1_1	19	23	PF00082	0.290
CLV_PCSK_SKI1_1	63	67	PF00082	0.299
DEG_Nend_Nbox_1	1	3	PF02207	0.455
DOC_CKS1_1	132	137	PF01111	0.584
DOC_CKS1_1	145	150	PF01111	0.533
DOC_USP7_MATH_1	135	139	PF00917	0.598
DOC_USP7_MATH_1	23	27	PF00917	0.328
DOC_WW_Pin1_4	131	136	PF00397	0.546
DOC_WW_Pin1_4	144	149	PF00397	0.545
LIG_14-3-3_CanoR_1	10	15	PF00244	0.386
LIG_14-3-3_CanoR_1	3	7	PF00244	0.558
LIG_Actin_WH2_2	48	65	PF00022	0.458
LIG_FHA_1	3	9	PF00498	0.505
LIG_FHA_1	40	46	PF00498	0.421
LIG_FHA_1	89	95	PF00498	0.479
LIG_GBD_Chelix_1	105	113	PF00786	0.241
LIG_LIR_Gen_1	112	121	PF02991	0.510
LIG_LIR_Gen_1	74	84	PF02991	0.505
LIG_LIR_Nem_3	112	118	PF02991	0.520
LIG_LIR_Nem_3	74	80	PF02991	0.502
LIG_Pex14_1	125	129	PF04695	0.418
LIG_Pex14_2	121	125	PF04695	0.411
LIG_Pex14_2	77	81	PF04695	0.398
LIG_SH2_CRK	132	136	PF00017	0.596
LIG_SH2_STAT5	96	99	PF00017	0.426
LIG_SH3_3	54	60	PF00018	0.419
LIG_SUMO_SIM_par_1	35	42	PF11976	0.426
MOD_CDK_SPxK_1	144	150	PF00069	0.463
MOD_CK1_1	144	150	PF00069	0.566
MOD_CK2_1	38	44	PF00069	0.422
MOD_CMANNOS	125	128	PF00535	0.292
MOD_GlcNHglycan	102	105	PF01048	0.259
MOD_GlcNHglycan	121	124	PF01048	0.250
MOD_GlcNHglycan	137	140	PF01048	0.543
MOD_GlcNHglycan	52	55	PF01048	0.342
MOD_GSK3_1	131	138	PF00069	0.602
MOD_N-GLC_1	119	124	PF02516	0.225
MOD_NEK2_1	121	126	PF00069	0.437
MOD_PIKK_1	64	70	PF00454	0.384
MOD_PIKK_1	88	94	PF00454	0.411
MOD_PK_1	10	16	PF00069	0.251
MOD_PKA_2	2	8	PF00069	0.505
MOD_PKA_2	39	45	PF00069	0.413
MOD_ProDKin_1	131	137	PF00069	0.558
MOD_ProDKin_1	144	150	PF00069	0.549
TRG_ER_diArg_1	2	4	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG29	Leptomonas seymouri	61%	100%
A0A1X0NHS7	Trypanosomatidae	38%	100%
A0A1X0NIC3	Trypanosomatidae	35%	100%
A0A1X0NJI4	Trypanosomatidae	27%	100%
A0A1X0NJQ7	Trypanosomatidae	52%	100%
A0A3R7LB88	Trypanosoma rangeli	32%	100%
A0A3R7P0U7	Trypanosoma rangeli	44%	100%
A0A3S7WQX1	Leishmania donovani	35%	100%
A4H5X3	Leishmania braziliensis	85%	100%
A4H5X4	Leishmania braziliensis	35%	100%
A4HU68	Leishmania infantum	99%	100%
A4HU69	Leishmania infantum	35%	100%
D0A9Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AMZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AMZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
P22978	Drosophila melanogaster	35%	100%
Q08742	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q4QHM8	Leishmania major	39%	100%
Q4QHM9	Leishmania major	94%	100%
V5BMN5	Trypanosoma cruzi	48%	100%