Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQW2_LEIDO

TriTrypDb:

LdBPK_091210.1 , LdCL_090018500 , LDHU3_09.1440

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	181	187	PF00089	0.651
CLV_NRD_NRD_1	166	168	PF00675	0.476
CLV_NRD_NRD_1	173	175	PF00675	0.452
CLV_NRD_NRD_1	177	179	PF00675	0.465
CLV_NRD_NRD_1	183	185	PF00675	0.517
CLV_NRD_NRD_1	227	229	PF00675	0.572
CLV_NRD_NRD_1	230	232	PF00675	0.602
CLV_NRD_NRD_1	265	267	PF00675	0.577
CLV_NRD_NRD_1	277	279	PF00675	0.691
CLV_PCSK_FUR_1	228	232	PF00082	0.630
CLV_PCSK_KEX2_1	100	102	PF00082	0.549
CLV_PCSK_KEX2_1	166	168	PF00082	0.471
CLV_PCSK_KEX2_1	173	175	PF00082	0.450
CLV_PCSK_KEX2_1	177	179	PF00082	0.470
CLV_PCSK_KEX2_1	183	185	PF00082	0.505
CLV_PCSK_KEX2_1	229	231	PF00082	0.529
CLV_PCSK_KEX2_1	265	267	PF00082	0.588
CLV_PCSK_KEX2_1	279	281	PF00082	0.682
CLV_PCSK_KEX2_1	48	50	PF00082	0.560
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.561
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.672
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.702
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.594
CLV_PCSK_PC7_1	173	179	PF00082	0.477
CLV_PCSK_PC7_1	275	281	PF00082	0.800
CLV_PCSK_PC7_1	96	102	PF00082	0.493
CLV_PCSK_SKI1_1	53	57	PF00082	0.548
CLV_Separin_Metazoa	252	256	PF03568	0.524
DEG_SCF_SKP2-CKS1_1	185	192	PF00560	0.533
DOC_USP7_MATH_1	128	132	PF00917	0.632
DOC_USP7_MATH_1	3	7	PF00917	0.544
DOC_USP7_MATH_1	36	40	PF00917	0.634
DOC_USP7_MATH_1	75	79	PF00917	0.663
DOC_USP7_UBL2_3	14	18	PF12436	0.677
DOC_WW_Pin1_4	186	191	PF00397	0.549
LIG_14-3-3_CanoR_1	145	152	PF00244	0.539
LIG_deltaCOP1_diTrp_1	88	94	PF00928	0.453
LIG_FHA_1	201	207	PF00498	0.491
LIG_FHA_1	7	13	PF00498	0.523
LIG_FHA_1	71	77	PF00498	0.519
LIG_FHA_2	145	151	PF00498	0.502
LIG_FHA_2	80	86	PF00498	0.518
LIG_LIR_Nem_3	88	94	PF02991	0.481
LIG_PDZ_Class_3	280	285	PF00595	0.665
LIG_SH2_STAP1	123	127	PF00017	0.617
LIG_SH2_STAP1	256	260	PF00017	0.492
LIG_SH2_STAP1	70	74	PF00017	0.506
LIG_SH2_STAT5	70	73	PF00017	0.627
LIG_SH3_3	182	188	PF00018	0.655
LIG_SH3_3	243	249	PF00018	0.488
LIG_TRAF2_1	249	252	PF00917	0.516
LIG_TRAF2_1	82	85	PF00917	0.514
MOD_CDK_SPxK_1	186	192	PF00069	0.536
MOD_CK1_1	155	161	PF00069	0.543
MOD_CK1_1	6	12	PF00069	0.519
MOD_CK2_1	144	150	PF00069	0.482
MOD_CK2_1	79	85	PF00069	0.524
MOD_Cter_Amidation	276	279	PF01082	0.742
MOD_Cter_Amidation	98	101	PF01082	0.501
MOD_GlcNHglycan	157	160	PF01048	0.507
MOD_GlcNHglycan	193	196	PF01048	0.546
MOD_GlcNHglycan	200	203	PF01048	0.507
MOD_GlcNHglycan	242	245	PF01048	0.667
MOD_GSK3_1	75	82	PF00069	0.655
MOD_N-GLC_1	116	121	PF02516	0.533
MOD_N-GLC_1	207	212	PF02516	0.488
MOD_N-GLC_1	240	245	PF02516	0.536
MOD_N-GLC_1	79	84	PF02516	0.504
MOD_NEK2_1	191	196	PF00069	0.559
MOD_NEK2_1	207	212	PF00069	0.510
MOD_NEK2_1	240	245	PF00069	0.511
MOD_PIKK_1	128	134	PF00454	0.517
MOD_PIKK_1	233	239	PF00454	0.593
MOD_PKA_1	231	237	PF00069	0.559
MOD_PKA_2	144	150	PF00069	0.492
MOD_PKA_2	254	260	PF00069	0.582
MOD_PKA_2	6	12	PF00069	0.544
MOD_Plk_1	116	122	PF00069	0.642
MOD_Plk_1	207	213	PF00069	0.487
MOD_Plk_1	79	85	PF00069	0.519
MOD_Plk_2-3	79	85	PF00069	0.502
MOD_Plk_4	37	43	PF00069	0.662
MOD_ProDKin_1	186	192	PF00069	0.555
TRG_ER_diArg_1	105	108	PF00400	0.689
TRG_ER_diArg_1	166	168	PF00400	0.512
TRG_ER_diArg_1	176	178	PF00400	0.501
TRG_ER_diArg_1	182	184	PF00400	0.458
TRG_ER_diArg_1	227	230	PF00400	0.608
TRG_ER_diArg_1	264	266	PF00400	0.547
TRG_ER_KDEL_1	282	285	PF00810	0.667
TRG_NLS_Bipartite_1	265	282	PF00514	0.588
TRG_NLS_MonoCore_2	227	232	PF00514	0.535
TRG_NLS_MonoCore_2	45	50	PF00514	0.677
TRG_NLS_MonoExtC_3	227	232	PF00514	0.683
TRG_NLS_MonoExtC_3	277	282	PF00514	0.736
TRG_NLS_MonoExtC_3	45	51	PF00514	0.677
TRG_NLS_MonoExtN_4	228	233	PF00514	0.707
TRG_NLS_MonoExtN_4	264	270	PF00514	0.596
TRG_NLS_MonoExtN_4	275	282	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W8	Leptomonas seymouri	85%	98%
A0A0S4JUY7	Bodo saltans	54%	100%
A0A1X0NHZ1	Trypanosomatidae	58%	93%
A0A422NZP9	Trypanosoma rangeli	64%	99%
A4H5U3	Leishmania braziliensis	93%	100%
A4HU37	Leishmania infantum	100%	100%
D0A9L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	94%
E9AMW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QHR0	Leishmania major	97%	100%
V5BMM5	Trypanosoma cruzi	63%	99%