Paraflagellar rod component, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQV4_LEIDO

TriTrypDb:

LdBPK_091390.1 , LdCL_090020300 , LDHU3_09.1640

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	35
GO:0031514	motile cilium	5	35
GO:0042995	cell projection	2	35
GO:0043226	organelle	2	35
GO:0043227	membrane-bounded organelle	3	35
GO:0110165	cellular anatomical entity	1	35
GO:0120025	plasma membrane bounded cell projection	3	35
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

A0A3S7WQV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	35
GO:0005515	protein binding	2	35
GO:0005516	calmodulin binding	3	35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.591
CLV_C14_Caspase3-7	457	461	PF00656	0.353
CLV_NRD_NRD_1	329	331	PF00675	0.345
CLV_NRD_NRD_1	372	374	PF00675	0.408
CLV_PCSK_FUR_1	370	374	PF00082	0.216
CLV_PCSK_KEX2_1	226	228	PF00082	0.393
CLV_PCSK_KEX2_1	352	354	PF00082	0.324
CLV_PCSK_KEX2_1	372	374	PF00082	0.307
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.412
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.337
CLV_PCSK_SKI1_1	103	107	PF00082	0.499
CLV_PCSK_SKI1_1	294	298	PF00082	0.414
CLV_PCSK_SKI1_1	337	341	PF00082	0.357
CLV_PCSK_SKI1_1	352	356	PF00082	0.318
CLV_PCSK_SKI1_1	390	394	PF00082	0.424
CLV_PCSK_SKI1_1	540	544	PF00082	0.329
DEG_APCC_DBOX_1	469	477	PF00400	0.265
DEG_Nend_UBRbox_3	1	3	PF02207	0.477
DOC_CYCLIN_RxL_1	121	134	PF00134	0.401
DOC_CYCLIN_RxL_1	223	234	PF00134	0.490
DOC_MAPK_gen_1	421	429	PF00069	0.202
DOC_PP1_RVXF_1	224	231	PF00149	0.470
DOC_PP2B_LxvP_1	140	143	PF13499	0.280
DOC_PP4_FxxP_1	519	522	PF00568	0.326
DOC_USP7_MATH_1	143	147	PF00917	0.360
DOC_USP7_MATH_1	267	271	PF00917	0.395
DOC_USP7_MATH_1	407	411	PF00917	0.400
DOC_USP7_MATH_1	586	590	PF00917	0.629
DOC_USP7_UBL2_3	265	269	PF12436	0.313
DOC_WW_Pin1_4	90	95	PF00397	0.497
LIG_14-3-3_CanoR_1	337	344	PF00244	0.355
LIG_14-3-3_CanoR_1	353	361	PF00244	0.188
LIG_14-3-3_CanoR_1	575	582	PF00244	0.622
LIG_14-3-3_CanoR_1	59	67	PF00244	0.543
LIG_Actin_WH2_2	315	332	PF00022	0.353
LIG_DLG_GKlike_1	455	462	PF00625	0.330
LIG_FHA_1	164	170	PF00498	0.497
LIG_FHA_1	182	188	PF00498	0.460
LIG_FHA_1	338	344	PF00498	0.401
LIG_FHA_1	436	442	PF00498	0.328
LIG_FHA_1	533	539	PF00498	0.388
LIG_FHA_2	117	123	PF00498	0.417
LIG_FHA_2	232	238	PF00498	0.532
LIG_FHA_2	35	41	PF00498	0.375
LIG_FHA_2	353	359	PF00498	0.321
LIG_FHA_2	360	366	PF00498	0.314
LIG_FHA_2	42	48	PF00498	0.406
LIG_FHA_2	508	514	PF00498	0.375
LIG_FHA_2	91	97	PF00498	0.445
LIG_LIR_Apic_2	516	522	PF02991	0.333
LIG_LIR_Gen_1	358	368	PF02991	0.273
LIG_LIR_Gen_1	498	509	PF02991	0.275
LIG_LIR_Nem_3	358	363	PF02991	0.273
LIG_LIR_Nem_3	40	45	PF02991	0.474
LIG_LIR_Nem_3	463	469	PF02991	0.408
LIG_LIR_Nem_3	498	504	PF02991	0.275
LIG_PDZ_Class_2	600	605	PF00595	0.589
LIG_PTB_Apo_2	110	117	PF02174	0.306
LIG_PTB_Phospho_1	110	116	PF10480	0.305
LIG_SH2_SRC	45	48	PF00017	0.532
LIG_SH2_SRC	544	547	PF00017	0.562
LIG_SH2_STAP1	183	187	PF00017	0.471
LIG_SH2_STAP1	194	198	PF00017	0.446
LIG_SH2_STAP1	218	222	PF00017	0.405
LIG_SH2_STAT3	183	186	PF00017	0.314
LIG_SH2_STAT5	128	131	PF00017	0.507
LIG_SH2_STAT5	183	186	PF00017	0.300
LIG_SH2_STAT5	220	223	PF00017	0.418
LIG_SH2_STAT5	224	227	PF00017	0.438
LIG_SH2_STAT5	377	380	PF00017	0.275
LIG_SH2_STAT5	391	394	PF00017	0.261
LIG_SH2_STAT5	544	547	PF00017	0.429
LIG_SH3_2	9	14	PF14604	0.498
LIG_SH3_3	145	151	PF00018	0.522
LIG_SH3_3	594	600	PF00018	0.625
LIG_SH3_3	6	12	PF00018	0.488
LIG_SUMO_SIM_par_1	202	207	PF11976	0.397
LIG_TRAF2_1	165	168	PF00917	0.507
LIG_TRAF2_1	233	236	PF00917	0.626
LIG_TRAF2_1	346	349	PF00917	0.350
LIG_TRAF2_1	356	359	PF00917	0.357
LIG_TRAF2_1	503	506	PF00917	0.285
LIG_TRAF2_1	522	525	PF00917	0.316
LIG_TRAF2_1	93	96	PF00917	0.496
LIG_WW_1	8	11	PF00397	0.519
MOD_CK1_1	307	313	PF00069	0.202
MOD_CK1_1	458	464	PF00069	0.364
MOD_CK2_1	229	235	PF00069	0.427
MOD_CK2_1	307	313	PF00069	0.397
MOD_CK2_1	352	358	PF00069	0.327
MOD_CK2_1	41	47	PF00069	0.558
MOD_CK2_1	500	506	PF00069	0.321
MOD_CK2_1	507	513	PF00069	0.314
MOD_CK2_1	90	96	PF00069	0.479
MOD_GlcNHglycan	107	111	PF01048	0.590
MOD_GlcNHglycan	269	272	PF01048	0.431
MOD_GlcNHglycan	3	6	PF01048	0.603
MOD_GlcNHglycan	577	580	PF01048	0.531
MOD_GSK3_1	171	178	PF00069	0.623
MOD_GSK3_1	231	238	PF00069	0.532
MOD_GSK3_1	431	438	PF00069	0.353
MOD_GSK3_1	454	461	PF00069	0.261
MOD_LATS_1	453	459	PF00433	0.330
MOD_N-GLC_1	1	6	PF02516	0.429
MOD_N-GLC_1	538	543	PF02516	0.346
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	106	111	PF00069	0.509
MOD_NEK2_1	131	136	PF00069	0.456
MOD_NEK2_1	304	309	PF00069	0.440
MOD_NEK2_1	507	512	PF00069	0.419
MOD_NEK2_2	431	436	PF00069	0.298
MOD_PIKK_1	175	181	PF00454	0.362
MOD_PIKK_1	337	343	PF00454	0.383
MOD_PIKK_1	490	496	PF00454	0.261
MOD_PKA_1	352	358	PF00069	0.388
MOD_PKA_2	352	358	PF00069	0.275
MOD_PKA_2	454	460	PF00069	0.274
MOD_PKA_2	58	64	PF00069	0.450
MOD_Plk_1	106	112	PF00069	0.524
MOD_Plk_1	304	310	PF00069	0.393
MOD_Plk_1	431	437	PF00069	0.275
MOD_Plk_1	455	461	PF00069	0.330
MOD_Plk_1	538	544	PF00069	0.285
MOD_Plk_2-3	171	177	PF00069	0.439
MOD_Plk_2-3	359	365	PF00069	0.388
MOD_Plk_4	111	117	PF00069	0.428
MOD_Plk_4	143	149	PF00069	0.538
MOD_Plk_4	220	226	PF00069	0.245
MOD_Plk_4	307	313	PF00069	0.358
MOD_Plk_4	407	413	PF00069	0.195
MOD_ProDKin_1	90	96	PF00069	0.500
MOD_SUMO_for_1	169	172	PF00179	0.559
MOD_SUMO_rev_2	262	267	PF00179	0.334
MOD_SUMO_rev_2	307	316	PF00179	0.440
MOD_SUMO_rev_2	349	354	PF00179	0.200
TRG_DiLeu_BaEn_1	561	566	PF01217	0.376
TRG_DiLeu_BaEn_2	414	420	PF01217	0.256
TRG_DiLeu_BaEn_4	95	101	PF01217	0.351
TRG_ENDOCYTIC_2	128	131	PF00928	0.507
TRG_ENDOCYTIC_2	218	221	PF00928	0.330
TRG_ENDOCYTIC_2	423	426	PF00928	0.317
TRG_ER_diArg_1	124	127	PF00400	0.435
TRG_ER_diArg_1	370	373	PF00400	0.386
TRG_ER_diArg_1	534	537	PF00400	0.293
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P573	Leptomonas seymouri	62%	99%
A0A0N1IFZ5	Leptomonas seymouri	23%	100%
A0A0S4IPM7	Bodo saltans	32%	100%
A0A0S4IZY8	Bodo saltans	23%	100%
A0A0S4JS20	Bodo saltans	21%	100%
A0A1X0NI51	Trypanosomatidae	43%	100%
A0A1X0P0B7	Trypanosomatidae	21%	100%
A0A381MH18	Leishmania infantum	22%	100%
A0A381MN58	Leishmania infantum	21%	100%
A0A3Q8IAP5	Leishmania donovani	22%	100%
A0A3Q8IEH2	Leishmania donovani	21%	100%
A0A3R7KDB9	Trypanosoma rangeli	22%	100%
A0A3R7P0W8	Trypanosoma rangeli	46%	100%
A0A3S5IRI8	Trypanosoma rangeli	21%	100%
A0A3S7X2K1	Leishmania donovani	23%	100%
A4H5W0	Leishmania braziliensis	78%	100%
A4HIY0	Leishmania braziliensis	21%	100%
A4HU55	Leishmania infantum	99%	100%
A4HX40	Leishmania infantum	23%	100%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
D0A9N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AE36	Leishmania major	21%	100%
E9AE37	Leishmania major	21%	100%
E9AHJ2	Leishmania infantum	21%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AMY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	91%
Q4QEM2	Leishmania major	23%	100%
Q4QHP3	Leishmania major	96%	100%
V5BDF9	Trypanosoma cruzi	46%	100%
V5BDW8	Trypanosoma cruzi	21%	100%