Paraflagellar rod component, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQV4_LEIDO

TriTrypDb:

LdBPK_091390.1 , LdCL_090020300 , LDHU3_09.1640

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005929	cilium	4	35
GO:0031514	motile cilium	5	35
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0042995	cell projection	2	35
GO:0043226	organelle	2	35
GO:0043227	membrane-bounded organelle	3	35
GO:0043233	organelle lumen	3	3

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Expansion

Sequence features

A0A3S7WQV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQV4

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	35
GO:0005515	protein binding	2	35
GO:0005516	calmodulin binding	3	35

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.591
CLV_C14_Caspase3-7	457	461	PF00656	0.353
CLV_NRD_NRD_1	329	331	PF00675	0.345
CLV_NRD_NRD_1	372	374	PF00675	0.408
CLV_PCSK_FUR_1	370	374	PF00082	0.216
CLV_PCSK_KEX2_1	226	228	PF00082	0.393
CLV_PCSK_KEX2_1	352	354	PF00082	0.324
CLV_PCSK_KEX2_1	372	374	PF00082	0.307
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.412
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.337

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P573	Leptomonas seymouri	62%	99%
A0A0N1IFZ5	Leptomonas seymouri	23%	100%
A0A0S4IPM7	Bodo saltans	32%	100%
A0A0S4IZY8	Bodo saltans	23%	100%
A0A0S4JS20	Bodo saltans	21%	100%
A0A1X0NI51	Trypanosomatidae	43%	100%
A0A1X0P0B7	Trypanosomatidae	21%	100%
A0A381MH18	Leishmania infantum	22%	100%
A0A381MN58	Leishmania infantum	21%	100%
A0A3Q8IAP5	Leishmania donovani	22%	100%

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