Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQU3_LEIDO

TriTrypDb:

LdBPK_091290.1 , LdCL_090019300 , LDHU3_09.1530

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQU3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.553
CLV_C14_Caspase3-7	128	132	PF00656	0.446
CLV_C14_Caspase3-7	191	195	PF00656	0.532
CLV_MEL_PAP_1	330	336	PF00089	0.680
CLV_NRD_NRD_1	285	287	PF00675	0.638
CLV_NRD_NRD_1	294	296	PF00675	0.668
CLV_NRD_NRD_1	332	334	PF00675	0.683
CLV_PCSK_KEX2_1	123	125	PF00082	0.742
CLV_PCSK_KEX2_1	285	287	PF00082	0.674
CLV_PCSK_KEX2_1	294	296	PF00082	0.702
CLV_PCSK_KEX2_1	332	334	PF00082	0.683
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.742
CLV_PCSK_SKI1_1	161	165	PF00082	0.653
CLV_PCSK_SKI1_1	286	290	PF00082	0.661
DEG_SCF_TRCP1_1	243	249	PF00400	0.439
DEG_SPOP_SBC_1	349	353	PF00917	0.477
DOC_ANK_TNKS_1	294	301	PF00023	0.510
DOC_ANK_TNKS_1	365	372	PF00023	0.478
DOC_CDC14_PxL_1	198	206	PF14671	0.569
DOC_CYCLIN_yCln2_LP_2	200	203	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.494
DOC_MAPK_gen_1	332	339	PF00069	0.491
DOC_MAPK_gen_1	77	87	PF00069	0.657
DOC_MAPK_MEF2A_6	154	162	PF00069	0.505
DOC_MAPK_MEF2A_6	80	89	PF00069	0.556
DOC_PP2B_LxvP_1	200	203	PF13499	0.518
DOC_PP2B_LxvP_1	36	39	PF13499	0.734
DOC_PP2B_LxvP_1	60	63	PF13499	0.757
DOC_PP4_FxxP_1	16	19	PF00568	0.723
DOC_PP4_FxxP_1	99	102	PF00568	0.598
DOC_SPAK_OSR1_1	333	337	PF12202	0.492
DOC_USP7_MATH_1	246	250	PF00917	0.522
DOC_USP7_MATH_1	308	312	PF00917	0.514
DOC_USP7_MATH_1	378	382	PF00917	0.504
DOC_USP7_MATH_1	430	434	PF00917	0.492
DOC_USP7_MATH_1	47	51	PF00917	0.834
DOC_WW_Pin1_4	264	269	PF00397	0.491
DOC_WW_Pin1_4	43	48	PF00397	0.719
LIG_14-3-3_CanoR_1	124	130	PF00244	0.562
LIG_14-3-3_CanoR_1	341	346	PF00244	0.438
LIG_14-3-3_CanoR_1	7	12	PF00244	0.796
LIG_APCC_ABBA_1	160	165	PF00400	0.519
LIG_BIR_III_4	111	115	PF00653	0.574
LIG_BRCT_BRCA1_1	91	95	PF00533	0.424
LIG_eIF4E_1	276	282	PF01652	0.479
LIG_EVH1_1	201	205	PF00568	0.560
LIG_EVH1_1	60	64	PF00568	0.715
LIG_EVH1_2	12	16	PF00568	0.665
LIG_FHA_1	114	120	PF00498	0.500
LIG_FHA_1	144	150	PF00498	0.448
LIG_FHA_1	151	157	PF00498	0.450
LIG_FHA_1	259	265	PF00498	0.509
LIG_FHA_1	345	351	PF00498	0.479
LIG_FHA_1	399	405	PF00498	0.526
LIG_FHA_1	88	94	PF00498	0.435
LIG_FHA_2	177	183	PF00498	0.483
LIG_FHA_2	81	87	PF00498	0.510
LIG_GBD_Chelix_1	24	32	PF00786	0.477
LIG_LIR_Apic_2	14	19	PF02991	0.726
LIG_LIR_Apic_2	165	170	PF02991	0.525
LIG_LIR_Apic_2	342	346	PF02991	0.428
LIG_LIR_Gen_1	267	277	PF02991	0.499
LIG_LIR_Gen_1	90	99	PF02991	0.390
LIG_LIR_Nem_3	267	272	PF02991	0.475
LIG_LIR_Nem_3	274	279	PF02991	0.486
LIG_LIR_Nem_3	412	418	PF02991	0.583
LIG_LIR_Nem_3	90	94	PF02991	0.444
LIG_LYPXL_yS_3	309	312	PF13949	0.493
LIG_MLH1_MIPbox_1	91	95	PF16413	0.424
LIG_MYND_1	199	203	PF01753	0.499
LIG_PCNA_yPIPBox_3	324	333	PF02747	0.460
LIG_Pex14_1	219	223	PF04695	0.438
LIG_Pex14_2	163	167	PF04695	0.502
LIG_Pex14_2	94	98	PF04695	0.432
LIG_Pex14_2	99	103	PF04695	0.594
LIG_PTAP_UEV_1	345	350	PF05743	0.462
LIG_PTB_Apo_2	263	270	PF02174	0.503
LIG_SH2_CRK	152	156	PF00017	0.506
LIG_SH2_CRK	276	280	PF00017	0.480
LIG_SH2_NCK_1	343	347	PF00017	0.523
LIG_SH2_STAP1	152	156	PF00017	0.506
LIG_SH2_STAP1	321	325	PF00017	0.448
LIG_SH2_STAP1	81	85	PF00017	0.534
LIG_SH2_STAP1	91	95	PF00017	0.341
LIG_SH2_STAT3	321	324	PF00017	0.446
LIG_SH2_STAT5	152	155	PF00017	0.461
LIG_SH2_STAT5	343	346	PF00017	0.458
LIG_SH2_STAT5	355	358	PF00017	0.414
LIG_SH3_1	343	349	PF00018	0.466
LIG_SH3_2	2	7	PF14604	0.678
LIG_SH3_2	310	315	PF14604	0.465
LIG_SH3_3	15	21	PF00018	0.746
LIG_SH3_3	152	158	PF00018	0.451
LIG_SH3_3	196	202	PF00018	0.540
LIG_SH3_3	307	313	PF00018	0.471
LIG_SH3_3	343	349	PF00018	0.451
LIG_SH3_3	55	61	PF00018	0.767
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.450
LIG_TRAF2_1	433	436	PF00917	0.473
LIG_TRAF2_1	50	53	PF00917	0.782
LIG_UBA3_1	280	289	PF00899	0.441
LIG_WW_2	202	205	PF00397	0.558
MOD_CK1_1	183	189	PF00069	0.517
MOD_CK1_1	46	52	PF00069	0.708
MOD_CK2_1	176	182	PF00069	0.477
MOD_CK2_1	430	436	PF00069	0.541
MOD_CK2_1	47	53	PF00069	0.835
MOD_CK2_1	80	86	PF00069	0.579
MOD_GlcNHglycan	182	185	PF01048	0.742
MOD_GlcNHglycan	236	239	PF01048	0.778
MOD_GlcNHglycan	243	246	PF01048	0.752
MOD_GlcNHglycan	419	422	PF01048	0.722
MOD_GlcNHglycan	49	52	PF01048	0.614
MOD_GlcNHglycan	9	12	PF01048	0.537
MOD_GSK3_1	176	183	PF00069	0.580
MOD_GSK3_1	335	342	PF00069	0.494
MOD_GSK3_1	344	351	PF00069	0.401
MOD_GSK3_1	378	385	PF00069	0.475
MOD_GSK3_1	43	50	PF00069	0.757
MOD_GSK3_1	7	14	PF00069	0.783
MOD_N-GLC_1	264	269	PF02516	0.760
MOD_NEK2_1	339	344	PF00069	0.525
MOD_NEK2_1	417	422	PF00069	0.573
MOD_NEK2_1	89	94	PF00069	0.478
MOD_PIKK_1	143	149	PF00454	0.408
MOD_PKA_2	225	231	PF00069	0.502
MOD_PKA_2	378	384	PF00069	0.500
MOD_PKA_2	6	12	PF00069	0.775
MOD_Plk_2-3	431	437	PF00069	0.536
MOD_Plk_4	12	18	PF00069	0.730
MOD_Plk_4	323	329	PF00069	0.454
MOD_Plk_4	350	356	PF00069	0.524
MOD_Plk_4	89	95	PF00069	0.410
MOD_ProDKin_1	264	270	PF00069	0.490
MOD_ProDKin_1	43	49	PF00069	0.722
MOD_SUMO_for_1	367	370	PF00179	0.490
MOD_SUMO_rev_2	118	125	PF00179	0.483
TRG_DiLeu_BaEn_1	275	280	PF01217	0.442
TRG_DiLeu_BaEn_2	29	35	PF01217	0.722
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.513
TRG_ENDOCYTIC_2	152	155	PF00928	0.461
TRG_ENDOCYTIC_2	276	279	PF00928	0.479
TRG_ENDOCYTIC_2	309	312	PF00928	0.493
TRG_ENDOCYTIC_2	91	94	PF00928	0.397
TRG_ER_diArg_1	284	286	PF00400	0.480
TRG_ER_diArg_1	331	333	PF00400	0.477
TRG_ER_diArg_1	376	379	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.678
TRG_PTS1	436	439	PF00515	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P570	Leptomonas seymouri	43%	100%
A0A0S4JNP6	Bodo saltans	22%	100%
A4H5V1	Leishmania braziliensis	65%	99%
A4HU45	Leishmania infantum	99%	100%
E9AMX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QHQ2	Leishmania major	91%	100%