UEV domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UEV domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQU2_LEIDO

TriTrypDb:

LdCL_090016600 , LDHU3_09.1260

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQU2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006810	transport	3	8
GO:0008104	protein localization	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0015031	protein transport	4	8
GO:0019538	protein metabolic process	3	8
GO:0033036	macromolecule localization	2	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044238	primary metabolic process	2	8
GO:0045184	establishment of protein localization	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0070727	cellular macromolecule localization	3	8
GO:0071702	organic substance transport	4	8
GO:0071704	organic substance metabolic process	2	8
GO:0071705	nitrogen compound transport	4	8
GO:1901564	organonitrogen compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.309
CLV_NRD_NRD_1	37	39	PF00675	0.326
CLV_PCSK_KEX2_1	21	23	PF00082	0.283
CLV_PCSK_SKI1_1	197	201	PF00082	0.459
CLV_PCSK_SKI1_1	38	42	PF00082	0.431
CLV_Separin_Metazoa	18	22	PF03568	0.414
DEG_Nend_UBRbox_3	1	3	PF02207	0.395
DEG_SPOP_SBC_1	150	154	PF00917	0.351
DOC_MAPK_gen_1	168	176	PF00069	0.427
DOC_MAPK_gen_1	21	27	PF00069	0.324
DOC_MAPK_gen_1	214	220	PF00069	0.321
DOC_PP4_FxxP_1	84	87	PF00568	0.413
DOC_USP7_MATH_1	150	154	PF00917	0.351
DOC_USP7_MATH_1	186	190	PF00917	0.469
DOC_WW_Pin1_4	181	186	PF00397	0.471
LIG_14-3-3_CanoR_1	109	117	PF00244	0.371
LIG_14-3-3_CanoR_1	38	44	PF00244	0.347
LIG_14-3-3_CanoR_1	7	17	PF00244	0.514
LIG_Actin_WH2_2	113	128	PF00022	0.371
LIG_APCC_ABBAyCdc20_2	171	177	PF00400	0.317
LIG_BRCT_BRCA1_1	153	157	PF00533	0.371
LIG_BRCT_BRCA1_1	32	36	PF00533	0.394
LIG_BRCT_BRCA1_1	92	96	PF00533	0.455
LIG_FHA_1	120	126	PF00498	0.501
LIG_FHA_1	150	156	PF00498	0.379
LIG_FHA_1	215	221	PF00498	0.245
LIG_LIR_Apic_2	83	87	PF02991	0.192
LIG_LIR_Gen_1	99	107	PF02991	0.455
LIG_LIR_Nem_3	135	139	PF02991	0.477
LIG_LIR_Nem_3	60	64	PF02991	0.345
LIG_LIR_Nem_3	99	105	PF02991	0.455
LIG_PCNA_yPIPBox_3	2	16	PF02747	0.351
LIG_SH2_CRK	54	58	PF00017	0.240
LIG_SH2_STAT3	175	178	PF00017	0.362
LIG_SH2_STAT5	104	107	PF00017	0.480
LIG_SH2_STAT5	175	178	PF00017	0.520
LIG_SH3_3	215	221	PF00018	0.176
LIG_SH3_3	56	62	PF00018	0.409
LIG_SH3_3	94	100	PF00018	0.351
MOD_CK1_1	10	16	PF00069	0.489
MOD_CK1_1	111	117	PF00069	0.371
MOD_CK1_1	119	125	PF00069	0.334
MOD_CK1_1	151	157	PF00069	0.390
MOD_CK1_1	74	80	PF00069	0.533
MOD_GlcNHglycan	167	171	PF01048	0.470
MOD_GlcNHglycan	72	76	PF01048	0.551
MOD_GSK3_1	107	114	PF00069	0.371
MOD_GSK3_1	116	123	PF00069	0.334
MOD_GSK3_1	151	158	PF00069	0.417
MOD_GSK3_1	193	200	PF00069	0.557
MOD_GSK3_1	26	33	PF00069	0.347
MOD_GSK3_1	34	41	PF00069	0.374
MOD_N-GLC_1	120	125	PF02516	0.305
MOD_NEK2_1	105	110	PF00069	0.371
MOD_NEK2_1	166	171	PF00069	0.551
MOD_NEK2_1	34	39	PF00069	0.318
MOD_NEK2_1	8	13	PF00069	0.313
MOD_OFUCOSY	226	231	PF10250	0.265
MOD_PKA_1	214	220	PF00069	0.321
MOD_PKA_1	38	44	PF00069	0.423
MOD_PKA_2	108	114	PF00069	0.455
MOD_Plk_1	111	117	PF00069	0.488
MOD_Plk_1	120	126	PF00069	0.413
MOD_Plk_4	120	126	PF00069	0.455
MOD_Plk_4	214	220	PF00069	0.176
MOD_Plk_4	80	86	PF00069	0.413
MOD_ProDKin_1	181	187	PF00069	0.473
MOD_SUMO_rev_2	144	151	PF00179	0.371
MOD_SUMO_rev_2	207	217	PF00179	0.347
TRG_AP2beta_CARGO_1	99	109	PF09066	0.455
TRG_ENDOCYTIC_2	54	57	PF00928	0.229
TRG_ER_diArg_1	20	22	PF00400	0.317
TRG_ER_diArg_1	247	250	PF00400	0.274
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E1	Leptomonas seymouri	66%	100%
A0A0S4JX55	Bodo saltans	37%	100%
A0A1X0NHS1	Trypanosomatidae	40%	100%
D0A9J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q94HV7	Arabidopsis thaliana	26%	75%
V5B2G1	Trypanosoma cruzi	35%	86%
V5BCE4	Trypanosoma cruzi	36%	97%