Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQU1_LEIDO

TriTrypDb:

LdBPK_091010.1 , LdCL_090015600 , LDHU3_09.1180

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.477
CLV_C14_Caspase3-7	184	188	PF00656	0.733
CLV_C14_Caspase3-7	219	223	PF00656	0.471
CLV_C14_Caspase3-7	391	395	PF00656	0.579
CLV_MEL_PAP_1	417	423	PF00089	0.670
CLV_PCSK_SKI1_1	118	122	PF00082	0.518
CLV_PCSK_SKI1_1	293	297	PF00082	0.631
CLV_PCSK_SKI1_1	327	331	PF00082	0.607
CLV_PCSK_SKI1_1	458	462	PF00082	0.674
CLV_PCSK_SKI1_1	600	604	PF00082	0.589
DEG_ODPH_VHL_1	247	260	PF01847	0.531
DEG_SPOP_SBC_1	515	519	PF00917	0.712
DEG_SPOP_SBC_1	52	56	PF00917	0.756
DOC_MAPK_MEF2A_6	251	260	PF00069	0.595
DOC_MAPK_MEF2A_6	609	616	PF00069	0.616
DOC_PP1_RVXF_1	436	443	PF00149	0.586
DOC_USP7_MATH_1	116	120	PF00917	0.540
DOC_USP7_MATH_1	299	303	PF00917	0.638
DOC_USP7_MATH_1	372	376	PF00917	0.717
DOC_USP7_MATH_1	515	519	PF00917	0.779
DOC_USP7_MATH_1	53	57	PF00917	0.656
DOC_USP7_MATH_1	580	584	PF00917	0.701
DOC_USP7_MATH_1	605	609	PF00917	0.545
DOC_WW_Pin1_4	342	347	PF00397	0.535
DOC_WW_Pin1_4	475	480	PF00397	0.618
DOC_WW_Pin1_4	483	488	PF00397	0.714
DOC_WW_Pin1_4	511	516	PF00397	0.783
DOC_WW_Pin1_4	57	62	PF00397	0.687
LIG_14-3-3_CanoR_1	327	336	PF00244	0.600
LIG_14-3-3_CanoR_1	453	457	PF00244	0.655
LIG_14-3-3_CanoR_1	570	576	PF00244	0.702
LIG_14-3-3_CanoR_1	579	585	PF00244	0.505
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BIR_III_2	187	191	PF00653	0.570
LIG_BRCT_BRCA1_1	230	234	PF00533	0.482
LIG_BRCT_BRCA1_1	35	39	PF00533	0.659
LIG_BRCT_BRCA1_1	485	489	PF00533	0.628
LIG_Clathr_ClatBox_1	103	107	PF01394	0.463
LIG_deltaCOP1_diTrp_1	197	205	PF00928	0.729
LIG_DLG_GKlike_1	420	428	PF00625	0.680
LIG_FHA_1	19	25	PF00498	0.512
LIG_FHA_1	356	362	PF00498	0.607
LIG_FHA_1	375	381	PF00498	0.613
LIG_FHA_1	402	408	PF00498	0.551
LIG_FHA_1	488	494	PF00498	0.684
LIG_FHA_1	495	501	PF00498	0.691
LIG_FHA_1	547	553	PF00498	0.571
LIG_FHA_1	572	578	PF00498	0.673
LIG_FHA_1	98	104	PF00498	0.502
LIG_FHA_2	127	133	PF00498	0.525
LIG_FHA_2	175	181	PF00498	0.755
LIG_FHA_2	182	188	PF00498	0.704
LIG_FHA_2	306	312	PF00498	0.537
LIG_LIR_Nem_3	583	587	PF02991	0.676
LIG_LYPXL_SIV_4	595	603	PF13949	0.622
LIG_MYND_1	576	580	PF01753	0.616
LIG_PDZ_Class_2	611	616	PF00595	0.462
LIG_Pex14_2	234	238	PF04695	0.406
LIG_Pex14_2	542	546	PF04695	0.504
LIG_SH2_CRK	414	418	PF00017	0.742
LIG_SH2_SRC	4	7	PF00017	0.613
LIG_SH2_STAT3	347	350	PF00017	0.596
LIG_SH2_STAT5	273	276	PF00017	0.400
LIG_SH2_STAT5	4	7	PF00017	0.768
LIG_SH2_STAT5	561	564	PF00017	0.538
LIG_SH3_3	574	580	PF00018	0.714
LIG_SH3_3	58	64	PF00018	0.683
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.491
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.389
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.735
LIG_SUMO_SIM_anti_2	549	556	PF11976	0.479
LIG_SUMO_SIM_anti_2	86	97	PF11976	0.506
LIG_SUMO_SIM_par_1	102	107	PF11976	0.544
LIG_SUMO_SIM_par_1	157	162	PF11976	0.379
LIG_SUMO_SIM_par_1	261	268	PF11976	0.367
LIG_SUMO_SIM_par_1	549	556	PF11976	0.481
LIG_TRAF2_1	13	16	PF00917	0.769
LIG_TRAF2_1	177	180	PF00917	0.807
LIG_TRAF2_1	556	559	PF00917	0.435
LIG_TRAF2_2	452	457	PF00917	0.690
LIG_TRFH_1	342	346	PF08558	0.533
LIG_TYR_ITIM	412	417	PF00017	0.657
LIG_WRC_WIRS_1	581	586	PF05994	0.697
MOD_CDC14_SPxK_1	478	481	PF00782	0.578
MOD_CDK_SPxK_1	475	481	PF00069	0.581
MOD_CK1_1	151	157	PF00069	0.477
MOD_CK1_1	174	180	PF00069	0.781
MOD_CK1_1	302	308	PF00069	0.716
MOD_CK1_1	374	380	PF00069	0.521
MOD_CK1_1	416	422	PF00069	0.699
MOD_CK1_1	432	438	PF00069	0.494
MOD_CK1_1	510	516	PF00069	0.748
MOD_CK1_1	519	525	PF00069	0.713
MOD_CK1_1	529	535	PF00069	0.650
MOD_CK1_1	57	63	PF00069	0.687
MOD_CK1_1	571	577	PF00069	0.658
MOD_CK1_1	583	589	PF00069	0.677
MOD_CK1_1	79	85	PF00069	0.601
MOD_CK2_1	116	122	PF00069	0.452
MOD_CK2_1	173	179	PF00069	0.767
MOD_CK2_1	234	240	PF00069	0.505
MOD_CK2_1	305	311	PF00069	0.605
MOD_CK2_1	372	378	PF00069	0.622
MOD_CK2_1	456	462	PF00069	0.639
MOD_CK2_1	553	559	PF00069	0.537
MOD_CK2_1	583	589	PF00069	0.729
MOD_GlcNHglycan	124	127	PF01048	0.542
MOD_GlcNHglycan	150	153	PF01048	0.446
MOD_GlcNHglycan	169	172	PF01048	0.692
MOD_GlcNHglycan	207	210	PF01048	0.665
MOD_GlcNHglycan	267	270	PF01048	0.553
MOD_GlcNHglycan	304	307	PF01048	0.714
MOD_GlcNHglycan	31	34	PF01048	0.712
MOD_GlcNHglycan	311	315	PF01048	0.757
MOD_GlcNHglycan	374	377	PF01048	0.609
MOD_GlcNHglycan	431	434	PF01048	0.594
MOD_GlcNHglycan	457	461	PF01048	0.731
MOD_GlcNHglycan	509	512	PF01048	0.670
MOD_GlcNHglycan	528	531	PF01048	0.644
MOD_GlcNHglycan	539	542	PF01048	0.527
MOD_GlcNHglycan	555	558	PF01048	0.418
MOD_GlcNHglycan	570	573	PF01048	0.550
MOD_GlcNHglycan	70	73	PF01048	0.445
MOD_GSK3_1	118	125	PF00069	0.557
MOD_GSK3_1	167	174	PF00069	0.720
MOD_GSK3_1	199	206	PF00069	0.768
MOD_GSK3_1	29	36	PF00069	0.629
MOD_GSK3_1	298	305	PF00069	0.699
MOD_GSK3_1	318	325	PF00069	0.694
MOD_GSK3_1	372	379	PF00069	0.656
MOD_GSK3_1	416	423	PF00069	0.694
MOD_GSK3_1	452	459	PF00069	0.622
MOD_GSK3_1	475	482	PF00069	0.711
MOD_GSK3_1	483	490	PF00069	0.618
MOD_GSK3_1	507	514	PF00069	0.739
MOD_GSK3_1	515	522	PF00069	0.732
MOD_GSK3_1	53	60	PF00069	0.643
MOD_GSK3_1	79	86	PF00069	0.476
MOD_GSK3_1	93	100	PF00069	0.352
MOD_N-GLC_1	171	176	PF02516	0.716
MOD_NEK2_1	226	231	PF00069	0.516
MOD_NEK2_1	234	239	PF00069	0.342
MOD_NEK2_1	329	334	PF00069	0.727
MOD_NEK2_1	371	376	PF00069	0.610
MOD_NEK2_1	401	406	PF00069	0.591
MOD_NEK2_1	456	461	PF00069	0.695
MOD_NEK2_1	603	608	PF00069	0.571
MOD_PIKK_1	305	311	PF00454	0.629
MOD_PIKK_1	401	407	PF00454	0.527
MOD_PKA_2	167	173	PF00069	0.648
MOD_PKA_2	29	35	PF00069	0.561
MOD_PKA_2	452	458	PF00069	0.604
MOD_Plk_1	116	122	PF00069	0.503
MOD_Plk_1	456	462	PF00069	0.673
MOD_Plk_4	234	240	PF00069	0.539
MOD_Plk_4	583	589	PF00069	0.637
MOD_ProDKin_1	342	348	PF00069	0.539
MOD_ProDKin_1	475	481	PF00069	0.620
MOD_ProDKin_1	483	489	PF00069	0.707
MOD_ProDKin_1	511	517	PF00069	0.785
MOD_ProDKin_1	57	63	PF00069	0.674
TRG_DiLeu_BaEn_1	41	46	PF01217	0.561
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.592
TRG_ENDOCYTIC_2	414	417	PF00928	0.666
TRG_ER_diArg_1	291	294	PF00400	0.494
TRG_NES_CRM1_1	34	49	PF08389	0.641
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H8	Leptomonas seymouri	48%	81%
A0A1X0NMF5	Trypanosomatidae	30%	100%
A4H5S4	Leishmania braziliensis	77%	100%
A4HU17	Leishmania infantum	100%	100%
D0A9I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AMU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHS8	Leishmania major	91%	100%
V5B2B3	Trypanosoma cruzi	32%	100%