Mitochondrial_RNA_binding_protein_2/GeneDB:LmjF.0 9.1120

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein 2

Species:

Leishmania donovani

UniProt:

A0A3S7WQT7_LEIDO

TriTrypDb:

LdBPK_091180.1 , LdCL_090018200 , LDHU3_09.1410

Length:

242

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Mitochondrial RNA binding 2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WQT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQT7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.663
CLV_NRD_NRD_1	74	76	PF00675	0.351
CLV_PCSK_FUR_1	72	76	PF00082	0.325
CLV_PCSK_KEX2_1	74	76	PF00082	0.351
CLV_PCSK_SKI1_1	115	119	PF00082	0.352
CLV_PCSK_SKI1_1	136	140	PF00082	0.494
CLV_PCSK_SKI1_1	226	230	PF00082	0.325
DEG_Nend_Nbox_1	1	3	PF02207	0.549
DOC_CDC14_PxL_1	2	10	PF14671	0.533
DOC_MAPK_gen_1	133	142	PF00069	0.314
DOC_MAPK_MEF2A_6	133	142	PF00069	0.307
DOC_USP7_MATH_1	218	222	PF00917	0.385
DOC_WW_Pin1_4	170	175	PF00397	0.406
DOC_WW_Pin1_4	35	40	PF00397	0.668
LIG_14-3-3_CanoR_1	136	141	PF00244	0.341
LIG_14-3-3_CanoR_1	14	23	PF00244	0.596
LIG_14-3-3_CanoR_1	186	191	PF00244	0.376
LIG_14-3-3_CanoR_1	226	234	PF00244	0.292
LIG_14-3-3_CanoR_1	44	53	PF00244	0.652
LIG_BIR_III_2	76	80	PF00653	0.304
LIG_deltaCOP1_diTrp_1	211	216	PF00928	0.325
LIG_FHA_1	116	122	PF00498	0.487
LIG_FHA_1	137	143	PF00498	0.453
LIG_FHA_1	192	198	PF00498	0.481
LIG_FHA_1	227	233	PF00498	0.370
LIG_Integrin_isoDGR_2	62	64	PF01839	0.236
LIG_LIR_Gen_1	104	111	PF02991	0.333
LIG_LIR_Nem_3	104	109	PF02991	0.333
LIG_MAD2	136	144	PF02301	0.437
LIG_Pex14_1	212	216	PF04695	0.325
LIG_PTB_Apo_2	166	173	PF02174	0.285
LIG_SH2_STAT3	111	114	PF00017	0.292
LIG_SH2_STAT5	146	149	PF00017	0.274
LIG_SH2_STAT5	183	186	PF00017	0.440
LIG_SH3_3	137	143	PF00018	0.292
LIG_SUMO_SIM_par_1	135	141	PF11976	0.437
LIG_WW_1	143	146	PF00397	0.437
MOD_CK1_1	165	171	PF00069	0.297
MOD_CK1_1	27	33	PF00069	0.640
MOD_CK2_1	156	162	PF00069	0.461
MOD_Cter_Amidation	72	75	PF01082	0.356
MOD_GlcNHglycan	26	29	PF01048	0.626
MOD_GSK3_1	181	188	PF00069	0.334
MOD_GSK3_1	206	213	PF00069	0.366
MOD_GSK3_1	63	70	PF00069	0.385
MOD_N-GLC_1	168	173	PF02516	0.412
MOD_NEK2_1	185	190	PF00069	0.324
MOD_PIKK_1	226	232	PF00454	0.292
MOD_PIKK_1	67	73	PF00454	0.339
MOD_PKA_2	156	162	PF00069	0.342
MOD_PKA_2	165	171	PF00069	0.268
MOD_PKA_2	185	191	PF00069	0.376
MOD_PKA_2	63	69	PF00069	0.320
MOD_PKB_1	113	121	PF00069	0.356
MOD_Plk_1	168	174	PF00069	0.419
MOD_Plk_1	206	212	PF00069	0.345
MOD_Plk_4	218	224	PF00069	0.292
MOD_Plk_4	4	10	PF00069	0.619
MOD_ProDKin_1	170	176	PF00069	0.406
MOD_ProDKin_1	35	41	PF00069	0.666
TRG_AP2beta_CARGO_1	104	113	PF09066	0.325
TRG_ER_diArg_1	11	14	PF00400	0.568
TRG_ER_diArg_1	72	75	PF00400	0.348
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W9	Leptomonas seymouri	63%	100%
A0A0S4JSM9	Bodo saltans	36%	100%
A0A1X0NIK6	Trypanosomatidae	52%	100%
A0A3R7KW77	Trypanosoma rangeli	51%	100%
A4H5U0	Leishmania braziliensis	81%	100%
A4HU34	Leishmania infantum	100%	100%
D0A9L2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AMW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QHR3	Leishmania major	95%	100%
V5AY48	Trypanosoma cruzi	50%	100%