Hypothetical_protein_conserved

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQT3_LEIDO

TriTrypDb:

LdBPK_091160.1 , LdCL_090018000 , LDHU3_09.1390

Length:

255

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 30

Expansion

Sequence features

A0A3S7WQT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.622
CLV_PCSK_KEX2_1	122	124	PF00082	0.635
CLV_PCSK_KEX2_1	137	139	PF00082	0.555
CLV_PCSK_KEX2_1	195	197	PF00082	0.599
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.550
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.525
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.597
CLV_PCSK_SKI1_1	108	112	PF00082	0.606
CLV_PCSK_SKI1_1	196	200	PF00082	0.587
DEG_APCC_KENBOX_2	45	49	PF00400	0.544
DEG_SPOP_SBC_1	97	101	PF00917	0.616
DOC_MAPK_gen_1	16	24	PF00069	0.541
DOC_PP2B_LxvP_1	167	170	PF13499	0.579
DOC_USP7_MATH_1	214	218	PF00917	0.605
DOC_USP7_MATH_1	75	79	PF00917	0.533
DOC_USP7_MATH_1	97	101	PF00917	0.592
DOC_USP7_UBL2_3	195	199	PF12436	0.591
DOC_WW_Pin1_4	224	229	PF00397	0.699
DOC_WW_Pin1_4	23	28	PF00397	0.776
LIG_14-3-3_CanoR_1	151	160	PF00244	0.560
LIG_14-3-3_CanoR_1	168	174	PF00244	0.572
LIG_14-3-3_CanoR_1	76	80	PF00244	0.537
LIG_Actin_WH2_2	174	192	PF00022	0.619
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_FHA_1	162	168	PF00498	0.670
LIG_FHA_1	225	231	PF00498	0.590
LIG_FHA_1	39	45	PF00498	0.610
LIG_FHA_1	99	105	PF00498	0.616
LIG_FHA_2	134	140	PF00498	0.601
LIG_LIR_Gen_1	109	118	PF02991	0.498
LIG_LIR_Gen_1	158	167	PF02991	0.549
LIG_LIR_Nem_3	109	114	PF02991	0.527
LIG_LIR_Nem_3	158	163	PF02991	0.557
LIG_MYND_1	187	191	PF01753	0.634
LIG_SH2_CRK	239	243	PF00017	0.557
LIG_SH3_3	21	27	PF00018	0.555
LIG_SH3_3	227	233	PF00018	0.606
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.546
LIG_UBA3_1	245	250	PF00899	0.538
MOD_CK1_1	125	131	PF00069	0.581
MOD_CK1_1	95	101	PF00069	0.620
MOD_CK2_1	133	139	PF00069	0.595
MOD_GlcNHglycan	144	147	PF01048	0.539
MOD_GlcNHglycan	222	225	PF01048	0.597
MOD_GlcNHglycan	27	30	PF01048	0.605
MOD_GSK3_1	142	149	PF00069	0.538
MOD_GSK3_1	169	176	PF00069	0.635
MOD_GSK3_1	216	223	PF00069	0.591
MOD_GSK3_1	23	30	PF00069	0.528
MOD_GSK3_1	240	247	PF00069	0.677
MOD_GSK3_1	3	10	PF00069	0.651
MOD_GSK3_1	71	78	PF00069	0.549
MOD_GSK3_1	91	98	PF00069	0.594
MOD_NEK2_1	142	147	PF00069	0.592
MOD_NEK2_1	173	178	PF00069	0.545
MOD_NEK2_1	216	221	PF00069	0.486
MOD_NEK2_1	51	56	PF00069	0.504
MOD_PIKK_1	151	157	PF00454	0.538
MOD_PIKK_1	85	91	PF00454	0.636
MOD_PKA_1	122	128	PF00069	0.566
MOD_PKA_2	122	128	PF00069	0.519
MOD_PKA_2	75	81	PF00069	0.569
MOD_Plk_1	38	44	PF00069	0.573
MOD_Plk_4	169	175	PF00069	0.551
MOD_Plk_4	216	222	PF00069	0.544
MOD_Plk_4	240	246	PF00069	0.675
MOD_Plk_4	75	81	PF00069	0.459
MOD_ProDKin_1	224	230	PF00069	0.698
MOD_ProDKin_1	23	29	PF00069	0.775
MOD_SUMO_for_1	249	252	PF00179	0.569
TRG_DiLeu_BaEn_1	158	163	PF01217	0.596
TRG_ENDOCYTIC_2	239	242	PF00928	0.560
TRG_NLS_MonoExtC_3	194	199	PF00514	0.589
TRG_NLS_MonoExtN_4	194	199	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA21	Leptomonas seymouri	67%	93%
A0A422MTH2	Trypanosoma rangeli	30%	83%
A4H5T8	Leishmania braziliensis	84%	100%
A4HU32	Leishmania infantum	100%	100%
E9AMW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHR5	Leishmania major	93%	100%