Phospholipid:diacylglycerol acyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipid:diacylglycerol acyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQS8_LEIDO

TriTrypDb:

LdBPK_091100.1 , LdCL_090017600 , LDHU3_09.1340

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7WQS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQS8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008080	N-acetyltransferase activity	6	7
GO:0008374	O-acyltransferase activity	5	12
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0046027	phospholipid:diacylglycerol acyltransferase activity	7	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.722
CLV_NRD_NRD_1	121	123	PF00675	0.350
CLV_NRD_NRD_1	175	177	PF00675	0.502
CLV_NRD_NRD_1	29	31	PF00675	0.535
CLV_NRD_NRD_1	319	321	PF00675	0.520
CLV_NRD_NRD_1	389	391	PF00675	0.523
CLV_NRD_NRD_1	551	553	PF00675	0.495
CLV_NRD_NRD_1	631	633	PF00675	0.635
CLV_NRD_NRD_1	653	655	PF00675	0.591
CLV_NRD_NRD_1	92	94	PF00675	0.444
CLV_PCSK_KEX2_1	120	122	PF00082	0.402
CLV_PCSK_KEX2_1	175	177	PF00082	0.503
CLV_PCSK_KEX2_1	29	31	PF00082	0.569
CLV_PCSK_KEX2_1	321	323	PF00082	0.513
CLV_PCSK_KEX2_1	551	553	PF00082	0.451
CLV_PCSK_KEX2_1	631	633	PF00082	0.635
CLV_PCSK_KEX2_1	92	94	PF00082	0.449
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.516
CLV_PCSK_SKI1_1	203	207	PF00082	0.633
CLV_PCSK_SKI1_1	390	394	PF00082	0.427
CLV_PCSK_SKI1_1	556	560	PF00082	0.427
CLV_PCSK_SKI1_1	658	662	PF00082	0.645
DEG_APCC_DBOX_1	121	129	PF00400	0.471
DEG_APCC_DBOX_1	308	316	PF00400	0.252
DEG_Kelch_Keap1_1	620	625	PF01344	0.524
DEG_SCF_TRCP1_1	251	256	PF00400	0.323
DOC_CDC14_PxL_1	468	476	PF14671	0.252
DOC_CKS1_1	507	512	PF01111	0.200
DOC_CYCLIN_yClb1_LxF_4	309	315	PF00134	0.323
DOC_CYCLIN_yClb5_NLxxxL_5	644	653	PF00134	0.330
DOC_MAPK_gen_1	120	129	PF00069	0.451
DOC_MAPK_gen_1	175	181	PF00069	0.264
DOC_MAPK_gen_1	318	326	PF00069	0.291
DOC_MAPK_gen_1	92	103	PF00069	0.671
DOC_MAPK_HePTP_8	118	130	PF00069	0.511
DOC_MAPK_MEF2A_6	120	129	PF00069	0.440
DOC_MAPK_MEF2A_6	175	182	PF00069	0.346
DOC_PP2B_LxvP_1	101	104	PF13499	0.569
DOC_PP4_FxxP_1	78	81	PF00568	0.645
DOC_USP7_MATH_1	102	106	PF00917	0.619
DOC_USP7_MATH_1	23	27	PF00917	0.720
DOC_USP7_MATH_1	536	540	PF00917	0.271
DOC_USP7_MATH_1	662	666	PF00917	0.424
DOC_USP7_MATH_1	81	85	PF00917	0.706
DOC_USP7_UBL2_3	578	582	PF12436	0.314
DOC_WW_Pin1_4	16	21	PF00397	0.711
DOC_WW_Pin1_4	291	296	PF00397	0.238
DOC_WW_Pin1_4	506	511	PF00397	0.314
DOC_WW_Pin1_4	77	82	PF00397	0.634
LIG_14-3-3_CanoR_1	157	163	PF00244	0.370
LIG_14-3-3_CanoR_1	201	206	PF00244	0.389
LIG_14-3-3_CanoR_1	24	31	PF00244	0.719
LIG_14-3-3_CanoR_1	309	313	PF00244	0.314
LIG_14-3-3_CanoR_1	407	416	PF00244	0.245
LIG_14-3-3_CanoR_1	527	535	PF00244	0.323
LIG_14-3-3_CanoR_1	60	65	PF00244	0.645
LIG_14-3-3_CanoR_1	636	645	PF00244	0.291
LIG_14-3-3_CanoR_1	92	98	PF00244	0.647
LIG_Actin_WH2_2	559	577	PF00022	0.314
LIG_APCC_Cbox_2	351	357	PF00515	0.323
LIG_BIR_III_2	155	159	PF00653	0.362
LIG_BRCT_BRCA1_1	310	314	PF00533	0.314
LIG_BRCT_BRCA1_1	514	518	PF00533	0.314
LIG_BRCT_BRCA1_1	62	66	PF00533	0.658
LIG_EH1_1	123	131	PF00400	0.359
LIG_EH1_1	589	597	PF00400	0.304
LIG_FHA_1	185	191	PF00498	0.307
LIG_FHA_1	331	337	PF00498	0.255
LIG_FHA_1	380	386	PF00498	0.266
LIG_FHA_1	439	445	PF00498	0.331
LIG_FHA_1	507	513	PF00498	0.316
LIG_FHA_1	532	538	PF00498	0.242
LIG_FHA_1	624	630	PF00498	0.484
LIG_FHA_2	149	155	PF00498	0.432
LIG_FHA_2	237	243	PF00498	0.227
LIG_FHA_2	3	9	PF00498	0.684
LIG_FHA_2	465	471	PF00498	0.375
LIG_FHA_2	617	623	PF00498	0.463
LIG_FXI_DFP_1	71	75	PF00024	0.458
LIG_GBD_Chelix_1	125	133	PF00786	0.362
LIG_HP1_1	178	182	PF01393	0.285
LIG_Integrin_RGD_1	168	170	PF01839	0.576
LIG_LIR_Apic_2	256	262	PF02991	0.305
LIG_LIR_Apic_2	75	81	PF02991	0.643
LIG_LIR_Gen_1	251	262	PF02991	0.299
LIG_LIR_Gen_1	406	417	PF02991	0.274
LIG_LIR_Gen_1	56	66	PF02991	0.659
LIG_LIR_Gen_1	635	645	PF02991	0.294
LIG_LIR_Gen_1	69	79	PF02991	0.659
LIG_LIR_Nem_3	161	166	PF02991	0.387
LIG_LIR_Nem_3	204	209	PF02991	0.400
LIG_LIR_Nem_3	251	257	PF02991	0.299
LIG_LIR_Nem_3	302	308	PF02991	0.227
LIG_LIR_Nem_3	406	412	PF02991	0.257
LIG_LIR_Nem_3	421	427	PF02991	0.236
LIG_LIR_Nem_3	56	61	PF02991	0.665
LIG_LIR_Nem_3	635	641	PF02991	0.298
LIG_LIR_Nem_3	69	74	PF02991	0.704
LIG_OCRL_FandH_1	348	360	PF00620	0.323
LIG_Pex14_1	229	233	PF04695	0.323
LIG_Pex14_2	205	209	PF04695	0.367
LIG_Pex14_2	74	78	PF04695	0.731
LIG_REV1ctd_RIR_1	160	169	PF16727	0.395
LIG_REV1ctd_RIR_1	336	344	PF16727	0.323
LIG_SH2_GRB2like	357	360	PF00017	0.314
LIG_SH2_GRB2like	618	621	PF00017	0.426
LIG_SH2_NCK_1	618	622	PF00017	0.427
LIG_SH2_NCK_1	638	642	PF00017	0.226
LIG_SH2_PTP2	357	360	PF00017	0.323
LIG_SH2_SRC	31	34	PF00017	0.707
LIG_SH2_SRC	357	360	PF00017	0.323
LIG_SH2_STAP1	289	293	PF00017	0.227
LIG_SH2_STAT3	279	282	PF00017	0.238
LIG_SH2_STAT5	172	175	PF00017	0.419
LIG_SH2_STAT5	220	223	PF00017	0.290
LIG_SH2_STAT5	259	262	PF00017	0.314
LIG_SH2_STAT5	357	360	PF00017	0.262
LIG_SH2_STAT5	497	500	PF00017	0.230
LIG_SH2_STAT5	511	514	PF00017	0.323
LIG_SH2_STAT5	618	621	PF00017	0.468
LIG_SH3_1	656	662	PF00018	0.412
LIG_SH3_3	133	139	PF00018	0.452
LIG_SH3_3	17	23	PF00018	0.717
LIG_SH3_3	177	183	PF00018	0.329
LIG_SH3_3	469	475	PF00018	0.229
LIG_SH3_3	485	491	PF00018	0.220
LIG_SH3_3	605	611	PF00018	0.501
LIG_SH3_3	656	662	PF00018	0.412
LIG_SUMO_SIM_anti_2	591	597	PF11976	0.304
LIG_SUMO_SIM_par_1	14	19	PF11976	0.757
LIG_UBA3_1	232	238	PF00899	0.252
LIG_UBA3_1	592	598	PF00899	0.282
LIG_WRC_WIRS_1	393	398	PF05994	0.314
LIG_WRC_WIRS_1	461	466	PF05994	0.380
LIG_WRC_WIRS_1	61	66	PF05994	0.618
MOD_CDC14_SPxK_1	294	297	PF00782	0.252
MOD_CDK_SPxK_1	291	297	PF00069	0.252
MOD_CK1_1	204	210	PF00069	0.359
MOD_CK1_1	567	573	PF00069	0.277
MOD_CK1_1	675	681	PF00069	0.512
MOD_CK2_1	148	154	PF00069	0.432
MOD_CK2_1	449	455	PF00069	0.316
MOD_CK2_1	460	466	PF00069	0.300
MOD_GlcNHglycan	206	209	PF01048	0.621
MOD_GlcNHglycan	25	28	PF01048	0.537
MOD_GlcNHglycan	251	254	PF01048	0.477
MOD_GlcNHglycan	346	349	PF01048	0.504
MOD_GlcNHglycan	371	374	PF01048	0.429
MOD_GlcNHglycan	451	454	PF01048	0.502
MOD_GlcNHglycan	48	51	PF01048	0.503
MOD_GlcNHglycan	566	569	PF01048	0.449
MOD_GlcNHglycan	579	582	PF01048	0.410
MOD_GlcNHglycan	600	603	PF01048	0.491
MOD_GlcNHglycan	674	677	PF01048	0.686
MOD_GlcNHglycan	83	86	PF01048	0.514
MOD_GSK3_1	249	256	PF00069	0.292
MOD_GSK3_1	326	333	PF00069	0.270
MOD_GSK3_1	403	410	PF00069	0.323
MOD_GSK3_1	431	438	PF00069	0.344
MOD_GSK3_1	460	467	PF00069	0.349
MOD_GSK3_1	564	571	PF00069	0.322
MOD_GSK3_1	616	623	PF00069	0.461
MOD_GSK3_1	644	651	PF00069	0.325
MOD_GSK3_1	674	681	PF00069	0.493
MOD_GSK3_1	77	84	PF00069	0.647
MOD_GSK3_1	87	94	PF00069	0.651
MOD_LATS_1	634	640	PF00433	0.362
MOD_N-GLC_1	431	436	PF02516	0.508
MOD_N-GLC_1	478	483	PF02516	0.410
MOD_N-GLC_1	513	518	PF02516	0.487
MOD_N-GLC_1	519	524	PF02516	0.502
MOD_N-GLC_1	562	567	PF02516	0.532
MOD_N-GLC_1	616	621	PF02516	0.575
MOD_NEK2_1	392	397	PF00069	0.247
MOD_NEK2_1	405	410	PF00069	0.262
MOD_NEK2_1	48	53	PF00069	0.785
MOD_NEK2_1	562	567	PF00069	0.314
MOD_NEK2_1	616	621	PF00069	0.534
MOD_NEK2_1	672	677	PF00069	0.459
MOD_NEK2_2	158	163	PF00069	0.370
MOD_NEK2_2	513	518	PF00069	0.299
MOD_PIKK_1	395	401	PF00454	0.323
MOD_PIKK_1	87	93	PF00454	0.674
MOD_PKA_2	23	29	PF00069	0.682
MOD_PKA_2	308	314	PF00069	0.314
MOD_PKA_2	344	350	PF00069	0.253
MOD_PKA_2	379	385	PF00069	0.314
MOD_PKA_2	438	444	PF00069	0.336
MOD_PKA_2	526	532	PF00069	0.323
MOD_PKA_2	91	97	PF00069	0.648
MOD_Plk_1	193	199	PF00069	0.376
MOD_Plk_1	3	9	PF00069	0.674
MOD_Plk_1	478	484	PF00069	0.189
MOD_Plk_1	513	519	PF00069	0.287
MOD_Plk_1	531	537	PF00069	0.323
MOD_Plk_1	562	568	PF00069	0.301
MOD_Plk_1	624	630	PF00069	0.413
MOD_Plk_4	102	108	PF00069	0.645
MOD_Plk_4	158	164	PF00069	0.346
MOD_Plk_4	168	174	PF00069	0.405
MOD_Plk_4	201	207	PF00069	0.364
MOD_Plk_4	392	398	PF00069	0.314
MOD_Plk_4	411	417	PF00069	0.298
MOD_Plk_4	425	431	PF00069	0.291
MOD_Plk_4	460	466	PF00069	0.354
MOD_Plk_4	513	519	PF00069	0.323
MOD_ProDKin_1	16	22	PF00069	0.709
MOD_ProDKin_1	291	297	PF00069	0.238
MOD_ProDKin_1	506	512	PF00069	0.314
MOD_ProDKin_1	77	83	PF00069	0.635
MOD_SUMO_rev_2	242	248	PF00179	0.342
TRG_ENDOCYTIC_2	220	223	PF00928	0.266
TRG_ENDOCYTIC_2	357	360	PF00928	0.298
TRG_ENDOCYTIC_2	496	499	PF00928	0.349
TRG_ENDOCYTIC_2	590	593	PF00928	0.303
TRG_ENDOCYTIC_2	638	641	PF00928	0.291
TRG_ER_diArg_1	120	122	PF00400	0.550
TRG_ER_diArg_1	174	176	PF00400	0.325
TRG_ER_diArg_1	209	212	PF00400	0.291
TRG_ER_diArg_1	29	31	PF00400	0.693
TRG_ER_diArg_1	550	552	PF00400	0.295
TRG_ER_diArg_1	59	62	PF00400	0.670
TRG_ER_diArg_1	631	633	PF00400	0.435
TRG_NLS_MonoExtC_3	653	658	PF00514	0.412
TRG_NLS_MonoExtN_4	318	324	PF00514	0.313
TRG_NLS_MonoExtN_4	654	659	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU70	Leptomonas seymouri	67%	90%
A0A0S4J6G5	Bodo saltans	37%	100%
A0A1X0NHY0	Trypanosomatidae	46%	86%
A0A3R7KCW2	Trypanosoma rangeli	43%	100%
A4H5T3	Leishmania braziliensis	85%	100%
A4HU26	Leishmania infantum	100%	100%
D0A9K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AMV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O94680	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P40345	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4QHS0	Leishmania major	95%	100%
V5BDI6	Trypanosoma cruzi	43%	100%