LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
Present in the outer mitochondrial membrane proteome 10
Species:
Leishmania donovani
UniProt:
A0A3S7WQS4_LEIDO
TriTrypDb:
LdBPK_091070.1 , LdCL_090016700 , LDHU3_09.1270
Length:
615

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 10 (POMP10)Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005741 mitochondrial outer membrane 5 1
GO:0005929 cilium 4 1
GO:0016020 membrane 2 2
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031514 motile cilium 5 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 1

Phosphorylation

Amastigote: 112

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7WQS4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQS4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 343 347 PF00656 0.600
CLV_NRD_NRD_1 151 153 PF00675 0.422
CLV_NRD_NRD_1 246 248 PF00675 0.421
CLV_NRD_NRD_1 384 386 PF00675 0.504
CLV_NRD_NRD_1 595 597 PF00675 0.404
CLV_PCSK_KEX2_1 138 140 PF00082 0.566
CLV_PCSK_PC1ET2_1 138 140 PF00082 0.566
CLV_PCSK_SKI1_1 258 262 PF00082 0.335
CLV_PCSK_SKI1_1 302 306 PF00082 0.358
CLV_PCSK_SKI1_1 406 410 PF00082 0.327
CLV_PCSK_SKI1_1 434 438 PF00082 0.375
CLV_PCSK_SKI1_1 81 85 PF00082 0.620
DEG_APCC_DBOX_1 170 178 PF00400 0.657
DEG_SCF_FBW7_1 312 319 PF00400 0.628
DEG_SCF_FBW7_2 439 444 PF00400 0.653
DOC_CKS1_1 313 318 PF01111 0.633
DOC_MAPK_gen_1 152 160 PF00069 0.582
DOC_MAPK_gen_1 365 371 PF00069 0.525
DOC_MAPK_gen_1 385 395 PF00069 0.433
DOC_MAPK_gen_1 78 84 PF00069 0.660
DOC_MAPK_MEF2A_6 153 162 PF00069 0.569
DOC_PP4_FxxP_1 41 44 PF00568 0.742
DOC_USP7_MATH_1 109 113 PF00917 0.743
DOC_USP7_MATH_1 126 130 PF00917 0.644
DOC_USP7_MATH_1 316 320 PF00917 0.631
DOC_USP7_MATH_1 435 439 PF00917 0.644
DOC_USP7_MATH_1 44 48 PF00917 0.801
DOC_USP7_MATH_1 63 67 PF00917 0.647
DOC_USP7_MATH_1 73 77 PF00917 0.795
DOC_USP7_UBL2_3 134 138 PF12436 0.775
DOC_USP7_UBL2_3 223 227 PF12436 0.536
DOC_WW_Pin1_4 172 177 PF00397 0.575
DOC_WW_Pin1_4 312 317 PF00397 0.619
DOC_WW_Pin1_4 437 442 PF00397 0.607
DOC_WW_Pin1_4 494 499 PF00397 0.740
DOC_WW_Pin1_4 560 565 PF00397 0.703
LIG_14-3-3_CanoR_1 125 135 PF00244 0.775
LIG_14-3-3_CanoR_1 152 156 PF00244 0.623
LIG_14-3-3_CanoR_1 302 312 PF00244 0.612
LIG_14-3-3_CanoR_1 434 440 PF00244 0.634
LIG_14-3-3_CanoR_1 579 588 PF00244 0.560
LIG_APCC_ABBA_1 267 272 PF00400 0.575
LIG_BRCT_BRCA1_1 320 324 PF00533 0.622
LIG_BRCT_BRCA1_1 607 611 PF00533 0.528
LIG_deltaCOP1_diTrp_1 337 342 PF00928 0.556
LIG_eIF4E_1 410 416 PF01652 0.556
LIG_FHA_1 20 26 PF00498 0.415
LIG_FHA_1 236 242 PF00498 0.651
LIG_FHA_1 327 333 PF00498 0.531
LIG_FHA_1 460 466 PF00498 0.576
LIG_FHA_1 502 508 PF00498 0.585
LIG_FHA_1 524 530 PF00498 0.614
LIG_FHA_1 53 59 PF00498 0.749
LIG_FHA_1 580 586 PF00498 0.534
LIG_FHA_1 8 14 PF00498 0.437
LIG_FHA_2 138 144 PF00498 0.717
LIG_FHA_2 313 319 PF00498 0.620
LIG_FHA_2 368 374 PF00498 0.578
LIG_FHA_2 512 518 PF00498 0.629
LIG_IRF3_LxIS_1 155 161 PF10401 0.614
LIG_LIR_Apic_2 339 345 PF02991 0.541
LIG_LIR_Apic_2 38 44 PF02991 0.744
LIG_LIR_Gen_1 154 162 PF02991 0.604
LIG_LIR_Gen_1 189 198 PF02991 0.673
LIG_LIR_Gen_1 462 471 PF02991 0.639
LIG_LIR_Gen_1 607 615 PF02991 0.619
LIG_LIR_Nem_3 154 158 PF02991 0.557
LIG_LIR_Nem_3 189 193 PF02991 0.636
LIG_LIR_Nem_3 254 260 PF02991 0.615
LIG_LIR_Nem_3 321 327 PF02991 0.599
LIG_LIR_Nem_3 407 413 PF02991 0.560
LIG_LIR_Nem_3 462 466 PF02991 0.634
LIG_LIR_Nem_3 592 598 PF02991 0.602
LIG_LIR_Nem_3 607 612 PF02991 0.518
LIG_PDZ_Class_3 610 615 PF00595 0.637
LIG_Pex14_1 186 190 PF04695 0.637
LIG_Pex14_1 340 344 PF04695 0.550
LIG_Pex14_2 605 609 PF04695 0.561
LIG_PTB_Apo_2 184 191 PF02174 0.638
LIG_REV1ctd_RIR_1 322 330 PF16727 0.626
LIG_SH2_CRK 301 305 PF00017 0.606
LIG_SH2_CRK 413 417 PF00017 0.533
LIG_SH2_STAP1 263 267 PF00017 0.523
LIG_SH2_STAP1 461 465 PF00017 0.616
LIG_SH2_STAP1 598 602 PF00017 0.626
LIG_SH2_STAT3 287 290 PF00017 0.505
LIG_SH2_STAT3 483 486 PF00017 0.613
LIG_SH2_STAT5 287 290 PF00017 0.516
LIG_SH2_STAT5 413 416 PF00017 0.539
LIG_SH2_STAT5 426 429 PF00017 0.522
LIG_SH2_STAT5 461 464 PF00017 0.581
LIG_SH3_2 489 494 PF14604 0.724
LIG_SH3_3 120 126 PF00018 0.782
LIG_SH3_3 182 188 PF00018 0.593
LIG_SH3_3 238 244 PF00018 0.628
LIG_SH3_3 310 316 PF00018 0.623
LIG_SH3_3 413 419 PF00018 0.522
LIG_SH3_3 442 448 PF00018 0.638
LIG_SH3_3 479 485 PF00018 0.583
LIG_SH3_3 486 492 PF00018 0.668
LIG_SH3_3 98 104 PF00018 0.725
LIG_SUMO_SIM_anti_2 22 28 PF11976 0.668
LIG_SUMO_SIM_anti_2 272 277 PF11976 0.569
LIG_SUMO_SIM_anti_2 566 572 PF11976 0.651
LIG_SUMO_SIM_par_1 202 208 PF11976 0.536
LIG_SUMO_SIM_par_1 21 28 PF11976 0.425
LIG_SUMO_SIM_par_1 5 10 PF11976 0.377
LIG_TRAF2_1 129 132 PF00917 0.818
LIG_TRAF2_1 251 254 PF00917 0.611
LIG_TRAF2_1 497 500 PF00917 0.705
LIG_TRAF2_1 521 524 PF00917 0.607
LIG_WRC_WIRS_1 606 611 PF05994 0.567
MOD_CDK_SPK_2 560 565 PF00069 0.703
MOD_CDK_SPxxK_3 560 567 PF00069 0.701
MOD_CK1_1 425 431 PF00069 0.653
MOD_CK1_1 46 52 PF00069 0.792
MOD_CK1_1 490 496 PF00069 0.726
MOD_CK1_1 68 74 PF00069 0.791
MOD_CK2_1 109 115 PF00069 0.715
MOD_CK2_1 126 132 PF00069 0.709
MOD_CK2_1 137 143 PF00069 0.721
MOD_CK2_1 248 254 PF00069 0.604
MOD_CK2_1 367 373 PF00069 0.557
MOD_CK2_1 494 500 PF00069 0.731
MOD_CK2_1 518 524 PF00069 0.576
MOD_CK2_1 560 566 PF00069 0.674
MOD_Cter_Amidation 136 139 PF01082 0.600
MOD_GlcNHglycan 128 131 PF01048 0.584
MOD_GlcNHglycan 15 18 PF01048 0.397
MOD_GlcNHglycan 396 399 PF01048 0.393
MOD_GlcNHglycan 589 592 PF01048 0.407
MOD_GlcNHglycan 67 70 PF01048 0.563
MOD_GSK3_1 126 133 PF00069 0.734
MOD_GSK3_1 223 230 PF00069 0.603
MOD_GSK3_1 25 32 PF00069 0.751
MOD_GSK3_1 312 319 PF00069 0.577
MOD_GSK3_1 326 333 PF00069 0.520
MOD_GSK3_1 336 343 PF00069 0.522
MOD_GSK3_1 435 442 PF00069 0.555
MOD_GSK3_1 44 51 PF00069 0.781
MOD_GSK3_1 466 473 PF00069 0.628
MOD_GSK3_1 490 497 PF00069 0.766
MOD_GSK3_1 587 594 PF00069 0.653
MOD_GSK3_1 59 66 PF00069 0.731
MOD_N-GLC_1 477 482 PF02516 0.439
MOD_N-GLC_1 534 539 PF02516 0.466
MOD_N-GLC_1 579 584 PF02516 0.440
MOD_N-GLC_2 412 414 PF02516 0.365
MOD_NEK2_1 158 163 PF00069 0.551
MOD_NEK2_1 19 24 PF00069 0.282
MOD_NEK2_1 235 240 PF00069 0.562
MOD_NEK2_1 261 266 PF00069 0.545
MOD_NEK2_1 271 276 PF00069 0.511
MOD_NEK2_1 317 322 PF00069 0.582
MOD_NEK2_1 360 365 PF00069 0.551
MOD_NEK2_1 48 53 PF00069 0.798
MOD_NEK2_1 605 610 PF00069 0.536
MOD_NEK2_1 7 12 PF00069 0.480
MOD_NEK2_2 503 508 PF00069 0.565
MOD_PIKK_1 261 267 PF00454 0.574
MOD_PIKK_1 303 309 PF00454 0.631
MOD_PIKK_1 399 405 PF00454 0.643
MOD_PIKK_1 46 52 PF00454 0.792
MOD_PIKK_1 73 79 PF00454 0.804
MOD_PIKK_1 83 89 PF00454 0.764
MOD_PK_1 248 254 PF00069 0.628
MOD_PKA_1 247 253 PF00069 0.639
MOD_PKA_1 30 36 PF00069 0.792
MOD_PKA_1 52 58 PF00069 0.687
MOD_PKA_2 151 157 PF00069 0.629
MOD_PKA_2 63 69 PF00069 0.808
MOD_Plk_1 227 233 PF00069 0.607
MOD_Plk_1 248 254 PF00069 0.604
MOD_Plk_1 271 277 PF00069 0.571
MOD_Plk_1 317 323 PF00069 0.584
MOD_Plk_1 336 342 PF00069 0.397
MOD_Plk_1 367 373 PF00069 0.532
MOD_Plk_1 386 392 PF00069 0.597
MOD_Plk_2-3 367 373 PF00069 0.578
MOD_Plk_4 109 115 PF00069 0.735
MOD_Plk_4 181 187 PF00069 0.568
MOD_Plk_4 19 25 PF00069 0.487
MOD_Plk_4 271 277 PF00069 0.596
MOD_Plk_4 477 483 PF00069 0.611
MOD_Plk_4 550 556 PF00069 0.564
MOD_Plk_4 581 587 PF00069 0.525
MOD_ProDKin_1 172 178 PF00069 0.574
MOD_ProDKin_1 312 318 PF00069 0.627
MOD_ProDKin_1 437 443 PF00069 0.613
MOD_ProDKin_1 494 500 PF00069 0.740
MOD_ProDKin_1 560 566 PF00069 0.702
MOD_SUMO_for_1 364 367 PF00179 0.573
MOD_SUMO_rev_2 129 136 PF00179 0.814
MOD_SUMO_rev_2 148 155 PF00179 0.648
MOD_SUMO_rev_2 400 408 PF00179 0.604
MOD_SUMO_rev_2 94 104 PF00179 0.781
TRG_DiLeu_BaEn_1 215 220 PF01217 0.601
TRG_DiLeu_BaEn_2 549 555 PF01217 0.584
TRG_DiLeu_BaEn_2 606 612 PF01217 0.579
TRG_ENDOCYTIC_2 301 304 PF00928 0.572
TRG_ENDOCYTIC_2 413 416 PF00928 0.521
TRG_NLS_MonoCore_2 77 82 PF00514 0.662
TRG_Pf-PMV_PEXEL_1 258 262 PF00026 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUN6 Leptomonas seymouri 69% 99%
A0A0S4JT82 Bodo saltans 41% 100%
A0A1X0NI07 Trypanosomatidae 49% 100%
A0A3R7MXK0 Trypanosoma rangeli 44% 100%
A4H5S9 Leishmania braziliensis 85% 100%
A4HU23 Leishmania infantum 100% 100%
D0A9K1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9AMV3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QHS3 Leishmania major 95% 100%
V5CK09 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS