Prefoldin_subunit_2_putative/GeneDB:LmjF.09.0670

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prefoldin subunit 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQR3_LEIDO

TriTrypDb:

LdBPK_090720.1 , LdCL_090012300 , LDHU3_09.0860

Length:

138

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, prefoldin subunit 2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WQR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQR3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051082	unfolded protein binding	3	11
GO:0044183	protein folding chaperone	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	134	138	PF00082	0.580
CLV_PCSK_SKI1_1	89	93	PF00082	0.301
DEG_APCC_DBOX_1	88	96	PF00400	0.538
DOC_USP7_MATH_1	30	34	PF00917	0.506
DOC_USP7_MATH_1	7	11	PF00917	0.695
LIG_Actin_WH2_2	81	98	PF00022	0.488
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_FHA_2	71	77	PF00498	0.452
LIG_PDZ_Class_2	133	138	PF00595	0.554
LIG_SUMO_SIM_par_1	68	73	PF11976	0.553
MOD_CK1_1	10	16	PF00069	0.551
MOD_CK1_1	2	8	PF00069	0.653
MOD_CK2_1	3	9	PF00069	0.639
MOD_CK2_1	70	76	PF00069	0.483
MOD_GlcNHglycan	27	31	PF01048	0.331
MOD_GlcNHglycan	5	8	PF01048	0.673
MOD_GSK3_1	26	33	PF00069	0.533
MOD_GSK3_1	3	10	PF00069	0.642
MOD_N-GLC_1	3	8	PF02516	0.617
MOD_N-GLC_1	39	44	PF02516	0.338
MOD_Plk_1	26	32	PF00069	0.499
MOD_Plk_1	70	76	PF00069	0.440
MOD_Plk_1	8	14	PF00069	0.719
TRG_ENDOCYTIC_2	21	24	PF00928	0.454
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J2	Leptomonas seymouri	91%	99%
A0A0S4JE59	Bodo saltans	47%	97%
A0A1X0NMS2	Trypanosomatidae	52%	93%
A0A422NV63	Trypanosoma rangeli	47%	94%
A1A4P5	Bos taurus	38%	90%
A4HTY8	Leishmania infantum	100%	100%
A8WVJ9	Caenorhabditis briggsae	32%	97%
B0BN18	Rattus norvegicus	40%	90%
D0A9E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	95%
E9AMR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O70591	Mus musculus	42%	90%
P40005	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4QHV7	Leishmania major	96%	100%
Q55GN3	Dictyostelium discoideum	41%	100%
Q9LJ98	Arabidopsis thaliana	35%	93%
Q9N5M2	Caenorhabditis elegans	32%	98%
Q9UHV9	Homo sapiens	39%	90%
Q9UTC9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9VTE5	Drosophila melanogaster	31%	97%
V5DJI3	Trypanosoma cruzi	58%	93%