Acyl-CoA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQP7_LEIDO

TriTrypDb:

LdBPK_090800.1 , LdCL_090013400 , LDHU3_09.0950

Length:

998

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQP7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	9
GO:0000166	nucleotide binding	3	9
GO:0005488	binding	1	9
GO:0008289	lipid binding	2	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0033218	amide binding	2	9
GO:0036094	small molecule binding	2	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0120227	acyl-CoA binding	3	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:1901567	fatty acid derivative binding	3	9
GO:1901681	sulfur compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.690
CLV_C14_Caspase3-7	174	178	PF00656	0.706
CLV_C14_Caspase3-7	686	690	PF00656	0.731
CLV_C14_Caspase3-7	736	740	PF00656	0.705
CLV_C14_Caspase3-7	975	979	PF00656	0.520
CLV_NRD_NRD_1	19	21	PF00675	0.433
CLV_NRD_NRD_1	226	228	PF00675	0.537
CLV_NRD_NRD_1	321	323	PF00675	0.468
CLV_NRD_NRD_1	527	529	PF00675	0.685
CLV_NRD_NRD_1	702	704	PF00675	0.522
CLV_NRD_NRD_1	878	880	PF00675	0.516
CLV_NRD_NRD_1	993	995	PF00675	0.363
CLV_NRD_NRD_1	996	998	PF00675	0.423
CLV_PCSK_FUR_1	525	529	PF00082	0.686
CLV_PCSK_KEX2_1	320	322	PF00082	0.478
CLV_PCSK_KEX2_1	525	527	PF00082	0.720
CLV_PCSK_KEX2_1	702	704	PF00082	0.487
CLV_PCSK_KEX2_1	878	880	PF00082	0.516
CLV_PCSK_KEX2_1	980	982	PF00082	0.279
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.462
CLV_PCSK_PC1ET2_1	980	982	PF00082	0.320
CLV_PCSK_SKI1_1	309	313	PF00082	0.392
CLV_PCSK_SKI1_1	503	507	PF00082	0.601
CLV_PCSK_SKI1_1	703	707	PF00082	0.497
CLV_PCSK_SKI1_1	83	87	PF00082	0.392
CLV_PCSK_SKI1_1	878	882	PF00082	0.497
CLV_PCSK_SKI1_1	942	946	PF00082	0.253
DEG_APCC_DBOX_1	308	316	PF00400	0.596
DEG_APCC_DBOX_1	82	90	PF00400	0.584
DEG_SPOP_SBC_1	244	248	PF00917	0.701
DOC_CKS1_1	231	236	PF01111	0.714
DOC_CYCLIN_RxL_1	306	314	PF00134	0.658
DOC_CYCLIN_RxL_1	655	665	PF00134	0.680
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.626
DOC_MAPK_gen_1	525	532	PF00069	0.488
DOC_MAPK_gen_1	702	713	PF00069	0.709
DOC_MAPK_MEF2A_6	503	511	PF00069	0.450
DOC_MAPK_MEF2A_6	597	606	PF00069	0.278
DOC_MAPK_MEF2A_6	83	91	PF00069	0.538
DOC_MAPK_MEF2A_6	928	937	PF00069	0.520
DOC_PP1_RVXF_1	422	429	PF00149	0.299
DOC_PP1_RVXF_1	501	507	PF00149	0.413
DOC_PP1_RVXF_1	932	938	PF00149	0.520
DOC_PP4_FxxP_1	593	596	PF00568	0.479
DOC_PP4_MxPP_1	823	826	PF00568	0.692
DOC_USP7_MATH_1	176	180	PF00917	0.746
DOC_USP7_MATH_1	244	248	PF00917	0.787
DOC_USP7_MATH_1	255	259	PF00917	0.620
DOC_USP7_MATH_1	437	441	PF00917	0.497
DOC_USP7_MATH_1	472	476	PF00917	0.531
DOC_USP7_MATH_1	744	748	PF00917	0.767
DOC_USP7_MATH_1	753	757	PF00917	0.669
DOC_USP7_MATH_1	806	810	PF00917	0.725
DOC_USP7_MATH_1	896	900	PF00917	0.793
DOC_USP7_MATH_1	907	911	PF00917	0.655
DOC_WW_Pin1_4	146	151	PF00397	0.685
DOC_WW_Pin1_4	161	166	PF00397	0.729
DOC_WW_Pin1_4	190	195	PF00397	0.683
DOC_WW_Pin1_4	230	235	PF00397	0.748
DOC_WW_Pin1_4	236	241	PF00397	0.783
DOC_WW_Pin1_4	245	250	PF00397	0.682
DOC_WW_Pin1_4	346	351	PF00397	0.692
DOC_WW_Pin1_4	441	446	PF00397	0.561
DOC_WW_Pin1_4	453	458	PF00397	0.433
DOC_WW_Pin1_4	592	597	PF00397	0.470
DOC_WW_Pin1_4	639	644	PF00397	0.659
DOC_WW_Pin1_4	749	754	PF00397	0.739
DOC_WW_Pin1_4	782	787	PF00397	0.723
DOC_WW_Pin1_4	821	826	PF00397	0.767
LIG_14-3-3_CanoR_1	217	226	PF00244	0.724
LIG_14-3-3_CanoR_1	322	332	PF00244	0.688
LIG_14-3-3_CanoR_1	411	416	PF00244	0.720
LIG_14-3-3_CanoR_1	537	541	PF00244	0.457
LIG_14-3-3_CanoR_1	651	659	PF00244	0.662
LIG_14-3-3_CanoR_1	805	811	PF00244	0.802
LIG_14-3-3_CanoR_1	858	864	PF00244	0.685
LIG_14-3-3_CanoR_1	981	991	PF00244	0.562
LIG_BIR_III_4	177	181	PF00653	0.745
LIG_BRCT_BRCA1_1	424	428	PF00533	0.281
LIG_BRCT_BRCA1_1	455	459	PF00533	0.484
LIG_BRCT_BRCA1_1	599	603	PF00533	0.383
LIG_CaM_IQ_9	59	75	PF13499	0.534
LIG_CtBP_PxDLS_1	445	449	PF00389	0.483
LIG_deltaCOP1_diTrp_1	783	791	PF00928	0.684
LIG_EVH1_1	487	491	PF00568	0.467
LIG_EVH1_2	488	492	PF00568	0.463
LIG_FHA_1	182	188	PF00498	0.737
LIG_FHA_1	327	333	PF00498	0.746
LIG_FHA_1	347	353	PF00498	0.720
LIG_FHA_1	38	44	PF00498	0.524
LIG_FHA_2	100	106	PF00498	0.660
LIG_FHA_2	380	386	PF00498	0.634
LIG_FHA_2	652	658	PF00498	0.675
LIG_FHA_2	684	690	PF00498	0.719
LIG_FHA_2	729	735	PF00498	0.635
LIG_FHA_2	757	763	PF00498	0.691
LIG_FHA_2	867	873	PF00498	0.699
LIG_FHA_2	943	949	PF00498	0.453
LIG_HCF-1_HBM_1	79	82	PF13415	0.572
LIG_LIR_Gen_1	14	22	PF02991	0.642
LIG_LIR_Gen_1	425	436	PF02991	0.237
LIG_LIR_Gen_1	456	466	PF02991	0.499
LIG_LIR_Gen_1	579	585	PF02991	0.397
LIG_LIR_Gen_1	600	611	PF02991	0.379
LIG_LIR_Gen_1	966	976	PF02991	0.453
LIG_LIR_Nem_3	111	116	PF02991	0.542
LIG_LIR_Nem_3	14	19	PF02991	0.650
LIG_LIR_Nem_3	40	44	PF02991	0.579
LIG_LIR_Nem_3	403	409	PF02991	0.651
LIG_LIR_Nem_3	425	431	PF02991	0.237
LIG_LIR_Nem_3	456	462	PF02991	0.539
LIG_LIR_Nem_3	579	584	PF02991	0.444
LIG_LIR_Nem_3	587	593	PF02991	0.408
LIG_LIR_Nem_3	600	606	PF02991	0.375
LIG_LIR_Nem_3	657	662	PF02991	0.608
LIG_LIR_Nem_3	688	694	PF02991	0.707
LIG_LIR_Nem_3	712	718	PF02991	0.599
LIG_LIR_Nem_3	79	85	PF02991	0.583
LIG_LIR_Nem_3	966	971	PF02991	0.453
LIG_MYND_2	374	378	PF01753	0.659
LIG_Pex14_2	402	406	PF04695	0.610
LIG_Pex14_2	506	510	PF04695	0.399
LIG_Pex14_2	599	603	PF04695	0.383
LIG_Pex14_2	659	663	PF04695	0.611
LIG_Pex14_2	937	941	PF04695	0.505
LIG_SH2_CRK	82	86	PF00017	0.544
LIG_SH2_NCK_1	716	720	PF00017	0.656
LIG_SH2_STAT5	145	148	PF00017	0.612
LIG_SH2_STAT5	299	302	PF00017	0.652
LIG_SH2_STAT5	363	366	PF00017	0.698
LIG_SH2_STAT5	57	60	PF00017	0.593
LIG_SH2_STAT5	581	584	PF00017	0.460
LIG_SH2_STAT5	590	593	PF00017	0.420
LIG_SH2_STAT5	647	650	PF00017	0.637
LIG_SH2_STAT5	983	986	PF00017	0.453
LIG_SH3_1	228	234	PF00018	0.692
LIG_SH3_2	231	236	PF14604	0.696
LIG_SH3_3	163	169	PF00018	0.744
LIG_SH3_3	228	234	PF00018	0.833
LIG_SH3_3	347	353	PF00018	0.660
LIG_SH3_3	368	374	PF00018	0.702
LIG_SH3_3	485	491	PF00018	0.501
LIG_SH3_3	614	620	PF00018	0.690
LIG_SH3_3	635	641	PF00018	0.661
LIG_SH3_3	668	674	PF00018	0.627
LIG_SH3_3	747	753	PF00018	0.661
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.666
LIG_SUMO_SIM_anti_2	709	715	PF11976	0.672
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.618
LIG_SUMO_SIM_par_1	374	379	PF11976	0.687
LIG_SUMO_SIM_par_1	85	90	PF11976	0.593
LIG_TRAF2_1	516	519	PF00917	0.444
LIG_TRAF2_1	725	728	PF00917	0.687
LIG_TRAF2_1	801	804	PF00917	0.719
LIG_TRAF2_1	869	872	PF00917	0.626
LIG_TYR_ITIM	713	718	PF00017	0.668
LIG_UBA3_1	565	570	PF00899	0.415
LIG_UBA3_1	622	629	PF00899	0.660
LIG_UBA3_1	989	998	PF00899	0.624
MOD_CDC14_SPxK_1	642	645	PF00782	0.684
MOD_CDK_SPK_2	592	597	PF00069	0.428
MOD_CDK_SPxK_1	230	236	PF00069	0.817
MOD_CDK_SPxK_1	639	645	PF00069	0.690
MOD_CDK_SPxK_1	782	788	PF00069	0.673
MOD_CK1_1	14	20	PF00069	0.602
MOD_CK1_1	148	154	PF00069	0.684
MOD_CK1_1	263	269	PF00069	0.687
MOD_CK1_1	365	371	PF00069	0.643
MOD_CK1_1	440	446	PF00069	0.554
MOD_CK1_1	467	473	PF00069	0.544
MOD_CK1_1	520	526	PF00069	0.458
MOD_CK1_1	650	656	PF00069	0.677
MOD_CK1_1	756	762	PF00069	0.683
MOD_CK1_1	792	798	PF00069	0.727
MOD_CK1_1	809	815	PF00069	0.606
MOD_CK2_1	651	657	PF00069	0.639
MOD_CK2_1	706	712	PF00069	0.618
MOD_CK2_1	728	734	PF00069	0.703
MOD_CK2_1	756	762	PF00069	0.702
MOD_CK2_1	809	815	PF00069	0.748
MOD_CK2_1	866	872	PF00069	0.702
MOD_CK2_1	906	912	PF00069	0.581
MOD_CMANNOS	965	968	PF00535	0.253
MOD_Cter_Amidation	523	526	PF01082	0.712
MOD_DYRK1A_RPxSP_1	230	234	PF00069	0.725
MOD_GlcNHglycan	150	153	PF01048	0.489
MOD_GlcNHglycan	177	181	PF01048	0.479
MOD_GlcNHglycan	22	25	PF01048	0.347
MOD_GlcNHglycan	222	225	PF01048	0.537
MOD_GlcNHglycan	253	256	PF01048	0.586
MOD_GlcNHglycan	257	260	PF01048	0.601
MOD_GlcNHglycan	354	357	PF01048	0.472
MOD_GlcNHglycan	448	451	PF01048	0.737
MOD_GlcNHglycan	45	49	PF01048	0.449
MOD_GlcNHglycan	465	469	PF01048	0.783
MOD_GlcNHglycan	518	523	PF01048	0.673
MOD_GlcNHglycan	561	564	PF01048	0.622
MOD_GlcNHglycan	599	602	PF01048	0.346
MOD_GlcNHglycan	608	611	PF01048	0.369
MOD_GlcNHglycan	698	701	PF01048	0.489
MOD_GlcNHglycan	746	749	PF01048	0.607
MOD_GlcNHglycan	755	758	PF01048	0.473
MOD_GlcNHglycan	811	814	PF01048	0.638
MOD_GlcNHglycan	898	901	PF01048	0.561
MOD_GlcNHglycan	916	919	PF01048	0.248
MOD_GSK3_1	141	148	PF00069	0.632
MOD_GSK3_1	226	233	PF00069	0.727
MOD_GSK3_1	251	258	PF00069	0.793
MOD_GSK3_1	326	333	PF00069	0.716
MOD_GSK3_1	422	429	PF00069	0.252
MOD_GSK3_1	437	444	PF00069	0.537
MOD_GSK3_1	448	455	PF00069	0.616
MOD_GSK3_1	467	474	PF00069	0.492
MOD_GSK3_1	555	562	PF00069	0.437
MOD_GSK3_1	570	577	PF00069	0.320
MOD_GSK3_1	602	609	PF00069	0.383
MOD_GSK3_1	647	654	PF00069	0.640
MOD_GSK3_1	744	751	PF00069	0.766
MOD_GSK3_1	787	794	PF00069	0.803
MOD_GSK3_1	821	828	PF00069	0.783
MOD_N-GLC_1	438	443	PF02516	0.690
MOD_N-GLC_1	849	854	PF02516	0.489
MOD_NEK2_1	120	125	PF00069	0.603
MOD_NEK2_1	220	225	PF00069	0.775
MOD_NEK2_1	273	278	PF00069	0.692
MOD_NEK2_1	311	316	PF00069	0.636
MOD_NEK2_1	44	49	PF00069	0.584
MOD_NEK2_1	448	453	PF00069	0.560
MOD_NEK2_1	471	476	PF00069	0.588
MOD_NEK2_1	492	497	PF00069	0.432
MOD_NEK2_1	546	551	PF00069	0.473
MOD_NEK2_1	556	561	PF00069	0.444
MOD_NEK2_1	591	596	PF00069	0.506
MOD_NEK2_1	602	607	PF00069	0.333
MOD_NEK2_1	777	782	PF00069	0.740
MOD_NEK2_1	791	796	PF00069	0.674
MOD_NEK2_1	827	832	PF00069	0.811
MOD_NEK2_1	922	927	PF00069	0.494
MOD_NEK2_1	993	998	PF00069	0.641
MOD_PIKK_1	795	801	PF00454	0.761
MOD_PIKK_1	99	105	PF00454	0.647
MOD_PK_1	528	534	PF00069	0.425
MOD_PKA_1	20	26	PF00069	0.628
MOD_PKA_2	218	224	PF00069	0.717
MOD_PKA_2	226	232	PF00069	0.716
MOD_PKA_2	536	542	PF00069	0.464
MOD_PKA_2	650	656	PF00069	0.668
MOD_PKA_2	787	793	PF00069	0.719
MOD_PKA_2	857	863	PF00069	0.658
MOD_PKB_1	217	225	PF00069	0.729
MOD_PKB_1	526	534	PF00069	0.500
MOD_Plk_1	14	20	PF00069	0.644
MOD_Plk_1	438	444	PF00069	0.582
MOD_Plk_1	556	562	PF00069	0.538
MOD_Plk_1	574	580	PF00069	0.409
MOD_Plk_1	87	93	PF00069	0.609
MOD_Plk_2-3	379	385	PF00069	0.640
MOD_Plk_2-3	728	734	PF00069	0.632
MOD_Plk_4	141	147	PF00069	0.658
MOD_Plk_4	183	189	PF00069	0.631
MOD_Plk_4	311	317	PF00069	0.643
MOD_Plk_4	365	371	PF00069	0.721
MOD_Plk_4	379	385	PF00069	0.667
MOD_Plk_4	411	417	PF00069	0.725
MOD_Plk_4	536	542	PF00069	0.493
MOD_Plk_4	556	562	PF00069	0.414
MOD_Plk_4	602	608	PF00069	0.271
MOD_Plk_4	629	635	PF00069	0.672
MOD_Plk_4	87	93	PF00069	0.546
MOD_ProDKin_1	146	152	PF00069	0.689
MOD_ProDKin_1	161	167	PF00069	0.731
MOD_ProDKin_1	190	196	PF00069	0.679
MOD_ProDKin_1	230	236	PF00069	0.751
MOD_ProDKin_1	245	251	PF00069	0.787
MOD_ProDKin_1	346	352	PF00069	0.689
MOD_ProDKin_1	441	447	PF00069	0.562
MOD_ProDKin_1	453	459	PF00069	0.434
MOD_ProDKin_1	592	598	PF00069	0.466
MOD_ProDKin_1	639	645	PF00069	0.661
MOD_ProDKin_1	749	755	PF00069	0.739
MOD_ProDKin_1	782	788	PF00069	0.726
MOD_ProDKin_1	821	827	PF00069	0.769
MOD_SUMO_rev_2	929	935	PF00179	0.481
MOD_SUMO_rev_2	975	982	PF00179	0.520
MOD_SUMO_rev_2	985	990	PF00179	0.583
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.619
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.707
TRG_ENDOCYTIC_2	581	584	PF00928	0.464
TRG_ENDOCYTIC_2	590	593	PF00928	0.411
TRG_ENDOCYTIC_2	715	718	PF00928	0.596
TRG_ENDOCYTIC_2	82	85	PF00928	0.544
TRG_ENDOCYTIC_2	938	941	PF00928	0.505
TRG_ENDOCYTIC_2	987	990	PF00928	0.548
TRG_ER_diArg_1	217	220	PF00400	0.767
TRG_ER_diArg_1	525	528	PF00400	0.511
TRG_ER_diArg_1	702	704	PF00400	0.742
TRG_ER_diArg_1	707	710	PF00400	0.672
TRG_ER_diArg_1	877	879	PF00400	0.711
TRG_NES_CRM1_1	391	403	PF08389	0.544
TRG_NLS_Bipartite_1	980	998	PF00514	0.585
TRG_NLS_MonoExtC_3	226	231	PF00514	0.643
TRG_NLS_MonoExtC_3	993	998	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.702
TRG_Pf-PMV_PEXEL_1	660	665	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G9	Leptomonas seymouri	54%	100%
A0A422N766	Trypanosoma rangeli	28%	100%
A4H5Q6	Leishmania braziliensis	73%	100%
A4HTZ6	Leishmania infantum	99%	100%
D0A9G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AMS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QHU9	Leishmania major	94%	100%