Leucine-rich repeat protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQP1_LEIDO

TriTrypDb:

LdBPK_090580.1 , LdCL_090010900 , LDHU3_09.0710

Length:

997

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0000151	ubiquitin ligase complex	3	1
GO:0005930	axoneme	2	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7WQP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQP1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.566
CLV_C14_Caspase3-7	282	286	PF00656	0.394
CLV_C14_Caspase3-7	721	725	PF00656	0.582
CLV_C14_Caspase3-7	780	784	PF00656	0.619
CLV_NRD_NRD_1	131	133	PF00675	0.589
CLV_NRD_NRD_1	522	524	PF00675	0.501
CLV_NRD_NRD_1	874	876	PF00675	0.647
CLV_PCSK_KEX2_1	131	133	PF00082	0.670
CLV_PCSK_KEX2_1	522	524	PF00082	0.501
CLV_PCSK_KEX2_1	585	587	PF00082	0.495
CLV_PCSK_KEX2_1	874	876	PF00082	0.647
CLV_PCSK_KEX2_1	934	936	PF00082	0.684
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.495
CLV_PCSK_PC1ET2_1	934	936	PF00082	0.684
CLV_PCSK_SKI1_1	147	151	PF00082	0.661
CLV_PCSK_SKI1_1	234	238	PF00082	0.451
CLV_PCSK_SKI1_1	495	499	PF00082	0.467
CLV_PCSK_SKI1_1	603	607	PF00082	0.477
CLV_PCSK_SKI1_1	611	615	PF00082	0.390
CLV_PCSK_SKI1_1	698	702	PF00082	0.644
CLV_PCSK_SKI1_1	730	734	PF00082	0.566
CLV_Separin_Metazoa	519	523	PF03568	0.441
DEG_APCC_DBOX_1	460	468	PF00400	0.454
DEG_APCC_DBOX_1	494	502	PF00400	0.479
DEG_APCC_DBOX_1	697	705	PF00400	0.565
DEG_SIAH_1	40	48	PF03145	0.544
DOC_CDC14_PxL_1	288	296	PF14671	0.455
DOC_CKS1_1	830	835	PF01111	0.585
DOC_CYCLIN_RxL_1	319	328	PF00134	0.470
DOC_CYCLIN_RxL_1	446	454	PF00134	0.398
DOC_CYCLIN_RxL_1	734	747	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	400	403	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	830	836	PF00134	0.670
DOC_CYCLIN_yCln2_LP_2	869	872	PF00134	0.633
DOC_MAPK_DCC_7	322	331	PF00069	0.457
DOC_MAPK_DCC_7	483	492	PF00069	0.474
DOC_MAPK_gen_1	418	427	PF00069	0.439
DOC_MAPK_gen_1	483	492	PF00069	0.472
DOC_MAPK_HePTP_8	480	492	PF00069	0.466
DOC_MAPK_MEF2A_6	322	331	PF00069	0.457
DOC_MAPK_MEF2A_6	483	492	PF00069	0.426
DOC_PP2B_LxvP_1	324	327	PF13499	0.382
DOC_PP2B_LxvP_1	399	402	PF13499	0.423
DOC_PP2B_LxvP_1	488	491	PF13499	0.454
DOC_PP2B_LxvP_1	501	504	PF13499	0.459
DOC_PP2B_LxvP_1	825	828	PF13499	0.643
DOC_PP2B_LxvP_1	869	872	PF13499	0.633
DOC_PP4_FxxP_1	991	994	PF00568	0.579
DOC_USP7_MATH_1	210	214	PF00917	0.551
DOC_USP7_MATH_1	227	231	PF00917	0.304
DOC_USP7_MATH_1	278	282	PF00917	0.415
DOC_USP7_MATH_1	359	363	PF00917	0.667
DOC_USP7_MATH_1	364	368	PF00917	0.659
DOC_USP7_MATH_1	479	483	PF00917	0.410
DOC_USP7_MATH_1	687	691	PF00917	0.654
DOC_USP7_MATH_1	710	714	PF00917	0.613
DOC_USP7_MATH_1	761	765	PF00917	0.812
DOC_USP7_MATH_1	853	857	PF00917	0.651
DOC_USP7_MATH_1	929	933	PF00917	0.756
DOC_USP7_MATH_1	943	947	PF00917	0.535
DOC_USP7_MATH_1	948	952	PF00917	0.497
DOC_WW_Pin1_4	236	241	PF00397	0.537
DOC_WW_Pin1_4	34	39	PF00397	0.793
DOC_WW_Pin1_4	829	834	PF00397	0.585
DOC_WW_Pin1_4	859	864	PF00397	0.651
DOC_WW_Pin1_4	874	879	PF00397	0.801
DOC_WW_Pin1_4	890	895	PF00397	0.579
DOC_WW_Pin1_4	901	906	PF00397	0.686
LIG_14-3-3_CanoR_1	10	18	PF00244	0.596
LIG_14-3-3_CanoR_1	107	111	PF00244	0.420
LIG_14-3-3_CanoR_1	191	199	PF00244	0.683
LIG_14-3-3_CanoR_1	234	243	PF00244	0.483
LIG_14-3-3_CanoR_1	267	272	PF00244	0.420
LIG_14-3-3_CanoR_1	406	412	PF00244	0.523
LIG_14-3-3_CanoR_1	421	426	PF00244	0.439
LIG_14-3-3_CanoR_1	432	440	PF00244	0.240
LIG_14-3-3_CanoR_1	495	504	PF00244	0.441
LIG_14-3-3_CanoR_1	505	511	PF00244	0.388
LIG_14-3-3_CanoR_1	539	544	PF00244	0.446
LIG_14-3-3_CanoR_1	603	610	PF00244	0.470
LIG_14-3-3_CanoR_1	643	650	PF00244	0.317
LIG_14-3-3_CanoR_1	874	878	PF00244	0.635
LIG_14-3-3_CanoR_1	95	104	PF00244	0.557
LIG_14-3-3_CanoR_1	958	966	PF00244	0.723
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BIR_III_4	848	852	PF00653	0.625
LIG_BRCT_BRCA1_1	167	171	PF00533	0.537
LIG_BRCT_BRCA1_1	269	273	PF00533	0.427
LIG_BRCT_BRCA1_1	541	545	PF00533	0.415
LIG_BRCT_BRCA1_1	801	805	PF00533	0.651
LIG_BRCT_BRCA1_1	855	859	PF00533	0.551
LIG_BRCT_BRCA1_1	945	949	PF00533	0.620
LIG_FAT_LD_1	467	475	PF03623	0.404
LIG_FHA_1	266	272	PF00498	0.437
LIG_FHA_1	310	316	PF00498	0.412
LIG_FHA_1	352	358	PF00498	0.606
LIG_FHA_1	372	378	PF00498	0.446
LIG_FHA_1	406	412	PF00498	0.435
LIG_FHA_1	422	428	PF00498	0.352
LIG_FHA_1	594	600	PF00498	0.428
LIG_FHA_1	659	665	PF00498	0.476
LIG_FHA_1	704	710	PF00498	0.510
LIG_FHA_1	822	828	PF00498	0.627
LIG_FHA_2	280	286	PF00498	0.387
LIG_FHA_2	542	548	PF00498	0.539
LIG_FHA_2	602	608	PF00498	0.475
LIG_FHA_2	778	784	PF00498	0.621
LIG_FHA_2	875	881	PF00498	0.830
LIG_GBD_Chelix_1	664	672	PF00786	0.418
LIG_Integrin_isoDGR_2	525	527	PF01839	0.541
LIG_LIR_Apic_2	989	994	PF02991	0.579
LIG_LIR_LC3C_4	328	331	PF02991	0.409
LIG_LIR_Nem_3	274	280	PF02991	0.587
LIG_LIR_Nem_3	553	559	PF02991	0.447
LIG_LIR_Nem_3	946	952	PF02991	0.625
LIG_MAD2	449	457	PF02301	0.376
LIG_NRBOX	231	237	PF00104	0.475
LIG_NRBOX	338	344	PF00104	0.447
LIG_PCNA_yPIPBox_3	183	191	PF02747	0.544
LIG_Pex14_2	269	273	PF04695	0.427
LIG_Pex14_2	991	995	PF04695	0.581
LIG_SH2_CRK	277	281	PF00017	0.405
LIG_SH2_STAT3	916	919	PF00017	0.641
LIG_SH2_STAT5	189	192	PF00017	0.449
LIG_SH2_STAT5	195	198	PF00017	0.497
LIG_SH2_STAT5	916	919	PF00017	0.665
LIG_SH3_1	875	881	PF00018	0.656
LIG_SH3_3	193	199	PF00018	0.527
LIG_SH3_3	35	41	PF00018	0.743
LIG_SH3_3	58	64	PF00018	0.599
LIG_SH3_3	657	663	PF00018	0.501
LIG_SH3_3	704	710	PF00018	0.543
LIG_SH3_3	830	836	PF00018	0.668
LIG_SH3_3	857	863	PF00018	0.602
LIG_SH3_3	875	881	PF00018	0.536
LIG_SUMO_SIM_anti_2	122	129	PF11976	0.575
LIG_SUMO_SIM_anti_2	395	400	PF11976	0.381
LIG_SUMO_SIM_anti_2	465	473	PF11976	0.455
LIG_SUMO_SIM_anti_2	596	601	PF11976	0.433
LIG_SUMO_SIM_par_1	122	129	PF11976	0.601
LIG_SUMO_SIM_par_1	373	378	PF11976	0.433
LIG_SUMO_SIM_par_1	423	428	PF11976	0.355
LIG_SUMO_SIM_par_1	449	454	PF11976	0.446
LIG_SUMO_SIM_par_1	705	711	PF11976	0.480
LIG_SUMO_SIM_par_1	823	829	PF11976	0.636
LIG_TRAF2_1	920	923	PF00917	0.788
LIG_TRAF2_1	994	997	PF00917	0.698
LIG_WRC_WIRS_1	266	271	PF05994	0.426
MOD_CK1_1	11	17	PF00069	0.617
MOD_CK1_1	281	287	PF00069	0.414
MOD_CK1_1	290	296	PF00069	0.416
MOD_CK1_1	507	513	PF00069	0.590
MOD_CK1_1	546	552	PF00069	0.482
MOD_CK1_1	631	637	PF00069	0.473
MOD_CK1_1	713	719	PF00069	0.569
MOD_CK1_1	775	781	PF00069	0.644
MOD_CK1_1	820	826	PF00069	0.660
MOD_CK1_1	829	835	PF00069	0.624
MOD_CK1_1	904	910	PF00069	0.663
MOD_CK1_1	911	917	PF00069	0.627
MOD_CK1_1	960	966	PF00069	0.697
MOD_CK1_1	967	973	PF00069	0.586
MOD_CK2_1	209	215	PF00069	0.541
MOD_CK2_1	322	328	PF00069	0.385
MOD_CK2_1	541	547	PF00069	0.545
MOD_CK2_1	720	726	PF00069	0.552
MOD_CK2_1	874	880	PF00069	0.644
MOD_CK2_1	917	923	PF00069	0.750
MOD_GlcNHglycan	212	215	PF01048	0.666
MOD_GlcNHglycan	254	258	PF01048	0.542
MOD_GlcNHglycan	376	380	PF01048	0.399
MOD_GlcNHglycan	426	430	PF01048	0.444
MOD_GlcNHglycan	442	445	PF01048	0.488
MOD_GlcNHglycan	527	530	PF01048	0.550
MOD_GlcNHglycan	578	581	PF01048	0.385
MOD_GlcNHglycan	710	713	PF01048	0.590
MOD_GlcNHglycan	746	749	PF01048	0.607
MOD_GlcNHglycan	787	791	PF01048	0.689
MOD_GlcNHglycan	819	822	PF01048	0.642
MOD_GlcNHglycan	910	913	PF01048	0.595
MOD_GlcNHglycan	945	948	PF01048	0.742
MOD_GSK3_1	165	172	PF00069	0.579
MOD_GSK3_1	253	260	PF00069	0.521
MOD_GSK3_1	371	378	PF00069	0.462
MOD_GSK3_1	4	11	PF00069	0.613
MOD_GSK3_1	401	408	PF00069	0.515
MOD_GSK3_1	421	428	PF00069	0.372
MOD_GSK3_1	539	546	PF00069	0.474
MOD_GSK3_1	708	715	PF00069	0.657
MOD_GSK3_1	716	723	PF00069	0.499
MOD_GSK3_1	817	824	PF00069	0.594
MOD_GSK3_1	903	910	PF00069	0.706
MOD_GSK3_1	914	921	PF00069	0.656
MOD_GSK3_1	929	936	PF00069	0.543
MOD_GSK3_1	957	964	PF00069	0.689
MOD_LATS_1	265	271	PF00433	0.441
MOD_LATS_1	573	579	PF00433	0.471
MOD_N-GLC_1	4	9	PF02516	0.516
MOD_NEK2_1	106	111	PF00069	0.508
MOD_NEK2_1	209	214	PF00069	0.486
MOD_NEK2_1	287	292	PF00069	0.440
MOD_NEK2_1	345	350	PF00069	0.389
MOD_NEK2_1	375	380	PF00069	0.357
MOD_NEK2_1	4	9	PF00069	0.716
MOD_NEK2_1	407	412	PF00069	0.388
MOD_NEK2_1	425	430	PF00069	0.410
MOD_NEK2_1	440	445	PF00069	0.424
MOD_NEK2_1	470	475	PF00069	0.382
MOD_NEK2_1	559	564	PF00069	0.412
MOD_NEK2_1	777	782	PF00069	0.695
MOD_NEK2_1	933	938	PF00069	0.805
MOD_NEK2_2	929	934	PF00069	0.672
MOD_PIKK_1	165	171	PF00454	0.536
MOD_PIKK_1	234	240	PF00454	0.576
MOD_PIKK_1	316	322	PF00454	0.472
MOD_PIKK_1	504	510	PF00454	0.466
MOD_PIKK_1	559	565	PF00454	0.449
MOD_PIKK_1	611	617	PF00454	0.416
MOD_PIKK_1	914	920	PF00454	0.684
MOD_PK_1	267	273	PF00069	0.444
MOD_PK_1	539	545	PF00069	0.442
MOD_PKA_2	106	112	PF00069	0.457
MOD_PKA_2	190	196	PF00069	0.667
MOD_PKA_2	345	351	PF00069	0.486
MOD_PKA_2	405	411	PF00069	0.535
MOD_PKA_2	431	437	PF00069	0.485
MOD_PKA_2	504	510	PF00069	0.530
MOD_PKA_2	538	544	PF00069	0.401
MOD_PKA_2	642	648	PF00069	0.328
MOD_PKA_2	761	767	PF00069	0.690
MOD_PKA_2	873	879	PF00069	0.637
MOD_PKA_2	9	15	PF00069	0.658
MOD_PKA_2	94	100	PF00069	0.448
MOD_PKA_2	957	963	PF00069	0.723
MOD_PKA_2	964	970	PF00069	0.817
MOD_Plk_1	253	259	PF00069	0.464
MOD_Plk_1	322	328	PF00069	0.441
MOD_Plk_1	546	552	PF00069	0.380
MOD_Plk_1	634	640	PF00069	0.460
MOD_Plk_4	227	233	PF00069	0.574
MOD_Plk_4	4	10	PF00069	0.577
MOD_Plk_4	407	413	PF00069	0.447
MOD_Plk_4	470	476	PF00069	0.366
MOD_Plk_4	497	503	PF00069	0.468
MOD_Plk_4	546	552	PF00069	0.408
MOD_Plk_4	567	573	PF00069	0.523
MOD_Plk_4	772	778	PF00069	0.745
MOD_ProDKin_1	236	242	PF00069	0.543
MOD_ProDKin_1	34	40	PF00069	0.790
MOD_ProDKin_1	829	835	PF00069	0.584
MOD_ProDKin_1	859	865	PF00069	0.651
MOD_ProDKin_1	874	880	PF00069	0.802
MOD_ProDKin_1	890	896	PF00069	0.578
MOD_ProDKin_1	901	907	PF00069	0.684
MOD_SUMO_for_1	70	73	PF00179	0.515
TRG_DiLeu_BaEn_1	122	127	PF01217	0.572
TRG_DiLeu_BaEn_4	122	128	PF01217	0.576
TRG_DiLeu_BaEn_4	535	541	PF01217	0.428
TRG_DiLeu_BaEn_4	73	79	PF01217	0.453
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.474
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.390
TRG_ENDOCYTIC_2	277	280	PF00928	0.574
TRG_ER_diArg_1	131	134	PF00400	0.581
TRG_ER_diArg_1	521	523	PF00400	0.601
TRG_ER_diArg_1	873	875	PF00400	0.647
TRG_NES_CRM1_1	646	658	PF08389	0.498
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	449	454	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	611	615	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	739	744	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	935	939	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422NV64	Trypanosoma rangeli	27%	92%
A4H5N0	Leishmania braziliensis	71%	98%
A4HTW7	Leishmania infantum	100%	100%
D0A9D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
E9AMQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QHX1	Leishmania major	92%	100%