Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQN7_LEIDO

TriTrypDb:

LdBPK_090750.1 , LdCL_090012900 , LDHU3_09.0900

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.656
CLV_C14_Caspase3-7	490	494	PF00656	0.724
CLV_NRD_NRD_1	198	200	PF00675	0.569
CLV_NRD_NRD_1	236	238	PF00675	0.505
CLV_NRD_NRD_1	243	245	PF00675	0.554
CLV_NRD_NRD_1	257	259	PF00675	0.432
CLV_NRD_NRD_1	356	358	PF00675	0.787
CLV_NRD_NRD_1	416	418	PF00675	0.644
CLV_PCSK_FUR_1	196	200	PF00082	0.635
CLV_PCSK_FUR_1	234	238	PF00082	0.576
CLV_PCSK_KEX2_1	180	182	PF00082	0.650
CLV_PCSK_KEX2_1	198	200	PF00082	0.611
CLV_PCSK_KEX2_1	236	238	PF00082	0.505
CLV_PCSK_KEX2_1	243	245	PF00082	0.554
CLV_PCSK_KEX2_1	256	258	PF00082	0.453
CLV_PCSK_KEX2_1	265	267	PF00082	0.619
CLV_PCSK_KEX2_1	356	358	PF00082	0.776
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.620
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.753
CLV_PCSK_PC7_1	352	358	PF00082	0.747
CLV_PCSK_SKI1_1	275	279	PF00082	0.758
CLV_PCSK_SKI1_1	288	292	PF00082	0.576
DEG_APCC_DBOX_1	35	43	PF00400	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.719
DEG_SPOP_SBC_1	21	25	PF00917	0.704
DEG_SPOP_SBC_1	457	461	PF00917	0.658
DOC_CKS1_1	126	131	PF01111	0.668
DOC_MAPK_gen_1	187	195	PF00069	0.565
DOC_MAPK_gen_1	196	203	PF00069	0.497
DOC_MAPK_gen_1	256	263	PF00069	0.656
DOC_MAPK_gen_1	265	272	PF00069	0.540
DOC_MAPK_MEF2A_6	187	195	PF00069	0.565
DOC_PP2B_LxvP_1	473	476	PF13499	0.681
DOC_PP4_MxPP_1	367	370	PF00568	0.735
DOC_SPAK_OSR1_1	308	312	PF12202	0.751
DOC_USP7_MATH_1	119	123	PF00917	0.751
DOC_USP7_MATH_1	284	288	PF00917	0.705
DOC_USP7_MATH_1	295	299	PF00917	0.603
DOC_USP7_MATH_1	325	329	PF00917	0.784
DOC_USP7_MATH_1	331	335	PF00917	0.737
DOC_USP7_MATH_1	339	343	PF00917	0.629
DOC_USP7_MATH_1	401	405	PF00917	0.750
DOC_USP7_MATH_1	409	413	PF00917	0.650
DOC_USP7_MATH_1	425	429	PF00917	0.545
DOC_USP7_MATH_2	392	398	PF00917	0.611
DOC_WW_Pin1_4	12	17	PF00397	0.610
DOC_WW_Pin1_4	125	130	PF00397	0.664
DOC_WW_Pin1_4	170	175	PF00397	0.629
DOC_WW_Pin1_4	2	7	PF00397	0.718
DOC_WW_Pin1_4	219	224	PF00397	0.754
DOC_WW_Pin1_4	298	303	PF00397	0.746
DOC_WW_Pin1_4	335	340	PF00397	0.797
DOC_WW_Pin1_4	418	423	PF00397	0.754
DOC_WW_Pin1_4	466	471	PF00397	0.711
DOC_WW_Pin1_4	69	74	PF00397	0.797
LIG_14-3-3_CanoR_1	163	167	PF00244	0.769
LIG_14-3-3_CanoR_1	258	264	PF00244	0.548
LIG_14-3-3_CanoR_1	341	345	PF00244	0.834
LIG_14-3-3_CanoR_1	478	482	PF00244	0.785
LIG_BRCT_BRCA1_1	273	277	PF00533	0.720
LIG_BRCT_BRCA1_1	448	452	PF00533	0.659
LIG_CtBP_PxDLS_1	507	511	PF00389	0.682
LIG_FHA_1	280	286	PF00498	0.742
LIG_FHA_1	432	438	PF00498	0.754
LIG_FHA_2	225	231	PF00498	0.629
LIG_FHA_2	431	437	PF00498	0.675
LIG_GBD_Chelix_1	31	39	PF00786	0.638
LIG_LIR_Apic_2	376	381	PF02991	0.706
LIG_LIR_Apic_2	404	408	PF02991	0.609
LIG_LIR_Apic_2	501	507	PF02991	0.703
LIG_LIR_Apic_2	97	101	PF02991	0.742
LIG_LIR_Nem_3	240	245	PF02991	0.491
LIG_LIR_Nem_3	3	7	PF02991	0.678
LIG_LIR_Nem_3	372	378	PF02991	0.791
LIG_SH2_CRK	242	246	PF00017	0.572
LIG_SH2_CRK	379	383	PF00017	0.817
LIG_SH2_CRK	98	102	PF00017	0.742
LIG_SH2_GRB2like	378	381	PF00017	0.698
LIG_SH2_PTP2	405	408	PF00017	0.610
LIG_SH2_PTP2	504	507	PF00017	0.694
LIG_SH2_STAP1	375	379	PF00017	0.738
LIG_SH2_STAT3	155	158	PF00017	0.714
LIG_SH2_STAT5	405	408	PF00017	0.610
LIG_SH2_STAT5	504	507	PF00017	0.694
LIG_SH3_2	6	11	PF14604	0.684
LIG_SH3_3	103	109	PF00018	0.758
LIG_SH3_3	126	132	PF00018	0.653
LIG_SH3_3	3	9	PF00018	0.678
LIG_SH3_3	363	369	PF00018	0.722
LIG_SH3_3	403	409	PF00018	0.620
LIG_SH3_3	416	422	PF00018	0.600
LIG_SH3_3	486	492	PF00018	0.674
LIG_SH3_3	497	503	PF00018	0.543
LIG_SH3_3	80	86	PF00018	0.744
LIG_SUMO_SIM_anti_2	27	34	PF11976	0.502
LIG_SUMO_SIM_anti_2	509	514	PF11976	0.684
LIG_SUMO_SIM_par_1	506	511	PF11976	0.680
LIG_TRAF2_1	227	230	PF00917	0.622
LIG_TRAF2_1	438	441	PF00917	0.637
LIG_WRC_WIRS_1	1	6	PF05994	0.679
LIG_WRC_WIRS_1	252	257	PF05994	0.622
MOD_CDK_SPxK_1	298	304	PF00069	0.650
MOD_CDK_SPxK_1	335	341	PF00069	0.771
MOD_CK1_1	148	154	PF00069	0.752
MOD_CK1_1	161	167	PF00069	0.596
MOD_CK1_1	173	179	PF00069	0.603
MOD_CK1_1	22	28	PF00069	0.683
MOD_CK1_1	298	304	PF00069	0.747
MOD_CK1_1	385	391	PF00069	0.723
MOD_CK1_1	397	403	PF00069	0.578
MOD_CK1_1	412	418	PF00069	0.657
MOD_CK1_1	428	434	PF00069	0.659
MOD_CK1_1	459	465	PF00069	0.665
MOD_CK1_1	84	90	PF00069	0.740
MOD_CK2_1	224	230	PF00069	0.639
MOD_CK2_1	24	30	PF00069	0.642
MOD_CK2_1	430	436	PF00069	0.636
MOD_Cter_Amidation	196	199	PF01082	0.606
MOD_GlcNHglycan	101	104	PF01048	0.705
MOD_GlcNHglycan	115	118	PF01048	0.694
MOD_GlcNHglycan	147	150	PF01048	0.728
MOD_GlcNHglycan	297	300	PF01048	0.759
MOD_GlcNHglycan	319	322	PF01048	0.680
MOD_GlcNHglycan	325	328	PF01048	0.660
MOD_GlcNHglycan	375	378	PF01048	0.614
MOD_GlcNHglycan	384	387	PF01048	0.675
MOD_GlcNHglycan	389	392	PF01048	0.759
MOD_GlcNHglycan	422	425	PF01048	0.755
MOD_GlcNHglycan	448	451	PF01048	0.659
MOD_GlcNHglycan	464	467	PF01048	0.554
MOD_GSK3_1	158	165	PF00069	0.652
MOD_GSK3_1	20	27	PF00069	0.623
MOD_GSK3_1	271	278	PF00069	0.787
MOD_GSK3_1	331	338	PF00069	0.824
MOD_GSK3_1	340	347	PF00069	0.737
MOD_GSK3_1	369	376	PF00069	0.664
MOD_GSK3_1	393	400	PF00069	0.666
MOD_GSK3_1	409	416	PF00069	0.575
MOD_GSK3_1	425	432	PF00069	0.685
MOD_GSK3_1	458	465	PF00069	0.708
MOD_GSK3_1	487	494	PF00069	0.841
MOD_N-GLC_1	119	124	PF02516	0.730
MOD_N-GLC_1	158	163	PF02516	0.766
MOD_N-GLC_1	224	229	PF02516	0.721
MOD_N-GLC_1	25	30	PF02516	0.530
MOD_N-GLC_1	335	340	PF02516	0.847
MOD_N-GLC_1	412	417	PF02516	0.750
MOD_N-GLC_1	466	471	PF02516	0.672
MOD_NEK2_1	110	115	PF00069	0.708
MOD_NEK2_1	20	25	PF00069	0.761
MOD_NEK2_1	382	387	PF00069	0.672
MOD_NEK2_1	508	513	PF00069	0.681
MOD_NEK2_2	119	124	PF00069	0.730
MOD_PIKK_1	459	465	PF00454	0.665
MOD_PIKK_1	498	504	PF00454	0.725
MOD_PKA_2	110	116	PF00069	0.765
MOD_PKA_2	137	143	PF00069	0.771
MOD_PKA_2	145	151	PF00069	0.697
MOD_PKA_2	162	168	PF00069	0.564
MOD_PKA_2	340	346	PF00069	0.861
MOD_PKA_2	35	41	PF00069	0.449
MOD_PKA_2	359	365	PF00069	0.763
MOD_PKA_2	477	483	PF00069	0.688
MOD_Plk_1	119	125	PF00069	0.748
MOD_Plk_1	161	167	PF00069	0.839
MOD_Plk_1	224	230	PF00069	0.716
MOD_Plk_1	25	31	PF00069	0.526
MOD_Plk_1	487	493	PF00069	0.849
MOD_Plk_1	508	514	PF00069	0.686
MOD_Plk_2-3	436	442	PF00069	0.669
MOD_Plk_2-3	487	493	PF00069	0.735
MOD_Plk_4	119	125	PF00069	0.761
MOD_Plk_4	401	407	PF00069	0.611
MOD_Plk_4	508	514	PF00069	0.686
MOD_ProDKin_1	12	18	PF00069	0.610
MOD_ProDKin_1	125	131	PF00069	0.667
MOD_ProDKin_1	170	176	PF00069	0.626
MOD_ProDKin_1	2	8	PF00069	0.717
MOD_ProDKin_1	219	225	PF00069	0.755
MOD_ProDKin_1	298	304	PF00069	0.747
MOD_ProDKin_1	335	341	PF00069	0.798
MOD_ProDKin_1	418	424	PF00069	0.754
MOD_ProDKin_1	466	472	PF00069	0.713
MOD_ProDKin_1	69	75	PF00069	0.797
MOD_SUMO_rev_2	449	457	PF00179	0.620
MOD_SUMO_rev_2	56	64	PF00179	0.667
TRG_DiLeu_BaEn_4	240	246	PF01217	0.569
TRG_ENDOCYTIC_2	242	245	PF00928	0.617
TRG_ENDOCYTIC_2	252	255	PF00928	0.464
TRG_ENDOCYTIC_2	379	382	PF00928	0.818
TRG_ER_diArg_1	195	198	PF00400	0.578
TRG_ER_diArg_1	234	237	PF00400	0.508
TRG_ER_diArg_1	242	244	PF00400	0.546
TRG_ER_diArg_1	255	258	PF00400	0.450
TRG_NLS_MonoCore_2	416	421	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5Q1	Leishmania braziliensis	44%	97%
A4HTZ1	Leishmania infantum	100%	100%
E9AMS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QHV4	Leishmania major	76%	89%