Nucleotid_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQN6_LEIDO

TriTrypDb:

LdBPK_090740.1 , LdCL_090012500 , LDHU3_09.0880

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.545
CLV_NRD_NRD_1	203	205	PF00675	0.484
CLV_PCSK_KEX2_1	203	205	PF00082	0.484
CLV_PCSK_KEX2_1	234	236	PF00082	0.453
CLV_PCSK_KEX2_1	286	288	PF00082	0.467
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.517
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.420
CLV_PCSK_SKI1_1	180	184	PF00082	0.391
CLV_PCSK_SKI1_1	69	73	PF00082	0.310
DEG_APCC_DBOX_1	203	211	PF00400	0.512
DOC_CKS1_1	118	123	PF01111	0.278
DOC_MAPK_MEF2A_6	105	113	PF00069	0.404
DOC_MAPK_MEF2A_6	29	37	PF00069	0.363
DOC_PP4_FxxP_1	269	272	PF00568	0.491
DOC_SPAK_OSR1_1	235	239	PF12202	0.531
DOC_USP7_MATH_1	116	120	PF00917	0.564
DOC_USP7_MATH_1	261	265	PF00917	0.318
DOC_WW_Pin1_4	117	122	PF00397	0.526
DOC_WW_Pin1_4	145	150	PF00397	0.359
DOC_WW_Pin1_4	169	174	PF00397	0.405
DOC_WW_Pin1_4	240	245	PF00397	0.530
LIG_14-3-3_CanoR_1	180	189	PF00244	0.434
LIG_14-3-3_CanoR_1	26	32	PF00244	0.360
LIG_14-3-3_CanoR_1	97	103	PF00244	0.400
LIG_APCC_ABBA_1	253	258	PF00400	0.476
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BRCT_BRCA1_1	185	189	PF00533	0.393
LIG_deltaCOP1_diTrp_1	174	179	PF00928	0.448
LIG_eIF4E_1	216	222	PF01652	0.377
LIG_FHA_1	118	124	PF00498	0.416
LIG_FHA_1	170	176	PF00498	0.456
LIG_FHA_1	265	271	PF00498	0.360
LIG_FHA_1	293	299	PF00498	0.418
LIG_FHA_1	32	38	PF00498	0.428
LIG_FHA_1	54	60	PF00498	0.501
LIG_LIR_Apic_2	267	272	PF02991	0.491
LIG_LIR_Nem_3	157	163	PF02991	0.337
LIG_LIR_Nem_3	75	80	PF02991	0.473
LIG_MLH1_MIPbox_1	185	189	PF16413	0.393
LIG_PCNA_yPIPBox_3	276	289	PF02747	0.316
LIG_Rb_pABgroove_1	57	65	PF01858	0.285
LIG_SH2_CRK	77	81	PF00017	0.458
LIG_SH2_SRC	63	66	PF00017	0.392
LIG_SH2_STAT3	188	191	PF00017	0.384
LIG_SH2_STAT5	167	170	PF00017	0.433
LIG_SH2_STAT5	188	191	PF00017	0.384
LIG_SH2_STAT5	38	41	PF00017	0.435
LIG_SH3_1	134	140	PF00018	0.413
LIG_SH3_3	115	121	PF00018	0.435
LIG_SH3_3	134	140	PF00018	0.327
LIG_SH3_3	269	275	PF00018	0.563
LIG_SH3_3	30	36	PF00018	0.364
LIG_SH3_3	89	95	PF00018	0.438
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.363
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.351
LIG_SUMO_SIM_par_1	129	135	PF11976	0.277
LIG_WW_3	273	277	PF00397	0.448
MOD_CK1_1	119	125	PF00069	0.539
MOD_CK1_1	243	249	PF00069	0.634
MOD_CK1_1	264	270	PF00069	0.305
MOD_CK2_1	168	174	PF00069	0.527
MOD_CK2_1	225	231	PF00069	0.479
MOD_CK2_1	79	85	PF00069	0.498
MOD_GSK3_1	112	119	PF00069	0.514
MOD_GSK3_1	221	228	PF00069	0.420
MOD_GSK3_1	27	34	PF00069	0.515
MOD_GSK3_1	50	57	PF00069	0.519
MOD_NEK2_1	221	226	PF00069	0.331
MOD_NEK2_2	261	266	PF00069	0.326
MOD_NEK2_2	27	32	PF00069	0.354
MOD_PIKK_1	180	186	PF00454	0.502
MOD_PIKK_1	54	60	PF00454	0.570
MOD_PK_1	225	231	PF00069	0.534
MOD_PK_1	234	240	PF00069	0.376
MOD_PKA_1	234	240	PF00069	0.498
MOD_PKA_2	152	158	PF00069	0.451
MOD_PKA_2	234	240	PF00069	0.498
MOD_PKA_2	96	102	PF00069	0.405
MOD_Plk_2-3	190	196	PF00069	0.342
MOD_ProDKin_1	117	123	PF00069	0.515
MOD_ProDKin_1	145	151	PF00069	0.365
MOD_ProDKin_1	169	175	PF00069	0.403
MOD_ProDKin_1	240	246	PF00069	0.533
MOD_SUMO_rev_2	228	236	PF00179	0.507
TRG_DiLeu_BaEn_1	104	109	PF01217	0.346
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.445
TRG_ENDOCYTIC_2	77	80	PF00928	0.423
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.439
TRG_PTS1	303	306	PF00515	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P758	Leptomonas seymouri	65%	94%
A0A0S4J3K3	Bodo saltans	35%	78%
A0A0S4J3X3	Bodo saltans	35%	82%
A0A1X0NMM8	Trypanosomatidae	51%	89%
A0A3R7NP68	Trypanosoma rangeli	51%	92%
A4H5N9	Leishmania braziliensis	86%	100%
A4H5Q0	Leishmania braziliensis	86%	100%
A4HTZ0	Leishmania infantum	100%	100%
D0A8W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	92%
E9AMS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QHV5	Leishmania major	95%	100%
V5BSP2	Trypanosoma cruzi	47%	80%