Histidine phosphatase superfamily (Branch 1), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQN5_LEIDO

TriTrypDb:

LdBPK_090610.1 , LdCL_090011200 , LDHU3_09.0750

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.464
CLV_C14_Caspase3-7	215	219	PF00656	0.537
CLV_PCSK_KEX2_1	183	185	PF00082	0.557
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.557
CLV_PCSK_SKI1_1	183	187	PF00082	0.555
DOC_CDC14_PxL_1	185	193	PF14671	0.539
DOC_CKS1_1	250	255	PF01111	0.546
DOC_CYCLIN_RxL_1	177	190	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.569
DOC_MAPK_MEF2A_6	141	150	PF00069	0.470
DOC_MAPK_MEF2A_6	90	98	PF00069	0.538
DOC_PP2B_LxvP_1	156	159	PF13499	0.514
DOC_PP2B_LxvP_1	186	189	PF13499	0.544
DOC_PP4_FxxP_1	127	130	PF00568	0.545
DOC_PP4_FxxP_1	221	224	PF00568	0.467
DOC_PP4_FxxP_1	250	253	PF00568	0.547
DOC_USP7_MATH_1	179	183	PF00917	0.436
DOC_USP7_MATH_1	85	89	PF00917	0.534
DOC_USP7_MATH_1	9	13	PF00917	0.413
DOC_WW_Pin1_4	142	147	PF00397	0.520
DOC_WW_Pin1_4	220	225	PF00397	0.545
DOC_WW_Pin1_4	249	254	PF00397	0.529
DOC_WW_Pin1_4	29	34	PF00397	0.451
DOC_WW_Pin1_4	62	67	PF00397	0.431
LIG_14-3-3_CanoR_1	10	18	PF00244	0.475
LIG_14-3-3_CanoR_1	141	146	PF00244	0.524
LIG_14-3-3_CanoR_1	242	246	PF00244	0.557
LIG_14-3-3_CanoR_1	69	78	PF00244	0.409
LIG_Actin_WH2_2	56	71	PF00022	0.452
LIG_APCC_ABBA_1	94	99	PF00400	0.431
LIG_EH_1	151	155	PF12763	0.576
LIG_EVH1_2	158	162	PF00568	0.516
LIG_FHA_1	193	199	PF00498	0.573
LIG_FHA_1	225	231	PF00498	0.442
LIG_FHA_1	250	256	PF00498	0.578
LIG_FHA_1	62	68	PF00498	0.434
LIG_FHA_1	77	83	PF00498	0.398
LIG_FHA_1	91	97	PF00498	0.607
LIG_FHA_2	161	167	PF00498	0.554
LIG_FHA_2	213	219	PF00498	0.578
LIG_GBD_Chelix_1	41	49	PF00786	0.451
LIG_LIR_Apic_2	218	224	PF02991	0.549
LIG_LIR_Apic_2	248	253	PF02991	0.575
LIG_LIR_Apic_2	25	29	PF02991	0.451
LIG_LIR_Nem_3	104	110	PF02991	0.417
LIG_LIR_Nem_3	223	229	PF02991	0.470
LIG_LIR_Nem_3	244	250	PF02991	0.654
LIG_SH2_CRK	226	230	PF00017	0.422
LIG_SH2_CRK	26	30	PF00017	0.457
LIG_SH2_NCK_1	134	138	PF00017	0.546
LIG_SH2_SRC	97	100	PF00017	0.463
LIG_SH2_STAT5	226	229	PF00017	0.480
LIG_SH2_STAT5	48	51	PF00017	0.405
LIG_SH2_STAT5	97	100	PF00017	0.490
LIG_SH3_3	116	122	PF00018	0.575
LIG_SH3_3	152	158	PF00018	0.571
LIG_SH3_3	250	256	PF00018	0.534
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.502
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.450
LIG_SUMO_SIM_par_1	184	190	PF11976	0.552
LIG_SUMO_SIM_par_1	59	65	PF11976	0.451
LIG_TRFH_1	154	158	PF08558	0.492
MOD_CDK_SPxxK_3	62	69	PF00069	0.392
MOD_CK1_1	32	38	PF00069	0.497
MOD_CK2_1	115	121	PF00069	0.684
MOD_CK2_1	170	176	PF00069	0.524
MOD_CK2_1	234	240	PF00069	0.612
MOD_GlcNHglycan	235	239	PF01048	0.742
MOD_GlcNHglycan	87	90	PF01048	0.587
MOD_GSK3_1	220	227	PF00069	0.665
MOD_GSK3_1	230	237	PF00069	0.553
MOD_NEK2_1	169	174	PF00069	0.480
MOD_NEK2_1	22	27	PF00069	0.451
MOD_NEK2_2	160	165	PF00069	0.542
MOD_PKA_2	140	146	PF00069	0.560
MOD_PKA_2	241	247	PF00069	0.539
MOD_PKA_2	9	15	PF00069	0.451
MOD_Plk_1	170	176	PF00069	0.524
MOD_Plk_4	115	121	PF00069	0.563
MOD_Plk_4	192	198	PF00069	0.586
MOD_Plk_4	201	207	PF00069	0.457
MOD_ProDKin_1	142	148	PF00069	0.515
MOD_ProDKin_1	220	226	PF00069	0.533
MOD_ProDKin_1	249	255	PF00069	0.526
MOD_ProDKin_1	29	35	PF00069	0.451
MOD_ProDKin_1	62	68	PF00069	0.431
MOD_SUMO_rev_2	190	196	PF00179	0.536
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.491
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.534
TRG_ENDOCYTIC_2	107	110	PF00928	0.504
TRG_ENDOCYTIC_2	226	229	PF00928	0.437
TRG_ENDOCYTIC_2	247	250	PF00928	0.536
TRG_ER_FFAT_2	216	227	PF00635	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q9	Leptomonas seymouri	61%	100%
A0A0S4JZY4	Bodo saltans	37%	91%
A4H5N3	Leishmania braziliensis	79%	100%
A4HTX7	Leishmania infantum	100%	100%
E9AMQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QHW8	Leishmania major	93%	100%