Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQN2_LEIDO

TriTrypDb:

LdBPK_090670.1 , LdCL_090011800 , LDHU3_09.0810

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.720
CLV_C14_Caspase3-7	378	382	PF00656	0.550
CLV_C14_Caspase3-7	648	652	PF00656	0.615
CLV_C14_Caspase3-7	84	88	PF00656	0.715
CLV_NRD_NRD_1	230	232	PF00675	0.680
CLV_NRD_NRD_1	357	359	PF00675	0.425
CLV_NRD_NRD_1	388	390	PF00675	0.514
CLV_NRD_NRD_1	473	475	PF00675	0.572
CLV_NRD_NRD_1	516	518	PF00675	0.602
CLV_NRD_NRD_1	639	641	PF00675	0.660
CLV_NRD_NRD_1	66	68	PF00675	0.733
CLV_PCSK_FUR_1	403	407	PF00082	0.727
CLV_PCSK_KEX2_1	230	232	PF00082	0.680
CLV_PCSK_KEX2_1	28	30	PF00082	0.779
CLV_PCSK_KEX2_1	357	359	PF00082	0.425
CLV_PCSK_KEX2_1	388	390	PF00082	0.516
CLV_PCSK_KEX2_1	405	407	PF00082	0.613
CLV_PCSK_KEX2_1	473	475	PF00082	0.572
CLV_PCSK_KEX2_1	516	518	PF00082	0.602
CLV_PCSK_KEX2_1	641	643	PF00082	0.571
CLV_PCSK_KEX2_1	65	67	PF00082	0.737
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.779
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.731
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.571
CLV_PCSK_SKI1_1	140	144	PF00082	0.459
CLV_PCSK_SKI1_1	329	333	PF00082	0.636
DEG_Nend_UBRbox_3	1	3	PF02207	0.575
DEG_SCF_FBW7_1	19	24	PF00400	0.587
DEG_SPOP_SBC_1	421	425	PF00917	0.721
DOC_ANK_TNKS_1	357	364	PF00023	0.413
DOC_CKS1_1	318	323	PF01111	0.717
DOC_CKS1_1	493	498	PF01111	0.548
DOC_CKS1_1	511	516	PF01111	0.628
DOC_CKS1_1	99	104	PF01111	0.588
DOC_PP1_RVXF_1	639	646	PF00149	0.686
DOC_PP2B_LxvP_1	191	194	PF13499	0.670
DOC_PP4_FxxP_1	613	616	PF00568	0.696
DOC_USP7_MATH_1	222	226	PF00917	0.557
DOC_USP7_MATH_1	302	306	PF00917	0.654
DOC_USP7_MATH_1	421	425	PF00917	0.708
DOC_USP7_MATH_1	520	524	PF00917	0.705
DOC_USP7_UBL2_3	126	130	PF12436	0.561
DOC_WW_Pin1_4	17	22	PF00397	0.755
DOC_WW_Pin1_4	205	210	PF00397	0.662
DOC_WW_Pin1_4	243	248	PF00397	0.656
DOC_WW_Pin1_4	317	322	PF00397	0.666
DOC_WW_Pin1_4	417	422	PF00397	0.754
DOC_WW_Pin1_4	492	497	PF00397	0.546
DOC_WW_Pin1_4	510	515	PF00397	0.629
DOC_WW_Pin1_4	527	532	PF00397	0.488
DOC_WW_Pin1_4	57	62	PF00397	0.641
DOC_WW_Pin1_4	6	11	PF00397	0.744
DOC_WW_Pin1_4	98	103	PF00397	0.591
LIG_14-3-3_CanoR_1	119	125	PF00244	0.607
LIG_14-3-3_CanoR_1	221	228	PF00244	0.640
LIG_14-3-3_CanoR_1	277	286	PF00244	0.597
LIG_14-3-3_CanoR_1	329	336	PF00244	0.609
LIG_14-3-3_CanoR_1	406	415	PF00244	0.765
LIG_14-3-3_CanoR_1	441	447	PF00244	0.644
LIG_14-3-3_CanoR_1	605	609	PF00244	0.671
LIG_Actin_WH2_2	124	142	PF00022	0.554
LIG_Actin_WH2_2	591	607	PF00022	0.565
LIG_BRCT_BRCA1_1	262	266	PF00533	0.473
LIG_BRCT_BRCA1_1	568	572	PF00533	0.739
LIG_Clathr_ClatBox_1	54	58	PF01394	0.653
LIG_deltaCOP1_diTrp_1	584	587	PF00928	0.619
LIG_FHA_1	131	137	PF00498	0.557
LIG_FHA_1	141	147	PF00498	0.458
LIG_FHA_1	260	266	PF00498	0.419
LIG_FHA_1	347	353	PF00498	0.563
LIG_FHA_1	431	437	PF00498	0.677
LIG_FHA_1	476	482	PF00498	0.488
LIG_FHA_1	502	508	PF00498	0.488
LIG_FHA_1	99	105	PF00498	0.641
LIG_FHA_2	168	174	PF00498	0.753
LIG_FHA_2	221	227	PF00498	0.753
LIG_FHA_2	333	339	PF00498	0.403
LIG_FHA_2	82	88	PF00498	0.688
LIG_LIR_Apic_2	612	616	PF02991	0.698
LIG_LIR_Apic_2	96	102	PF02991	0.636
LIG_LIR_Gen_1	100	111	PF02991	0.588
LIG_LIR_Gen_1	246	256	PF02991	0.542
LIG_LIR_Gen_1	263	274	PF02991	0.422
LIG_LIR_Gen_1	370	380	PF02991	0.519
LIG_LIR_Nem_3	100	106	PF02991	0.595
LIG_LIR_Nem_3	246	252	PF02991	0.545
LIG_LIR_Nem_3	263	269	PF02991	0.403
LIG_MYND_3	271	275	PF01753	0.596
LIG_NRP_CendR_1	653	656	PF00754	0.674
LIG_PTB_Apo_2	483	490	PF02174	0.583
LIG_PTB_Phospho_1	483	489	PF10480	0.583
LIG_SH2_CRK	196	200	PF00017	0.554
LIG_SH2_CRK	99	103	PF00017	0.633
LIG_SH2_NCK_1	99	103	PF00017	0.633
LIG_SH2_STAP1	261	265	PF00017	0.413
LIG_SH2_STAP1	368	372	PF00017	0.431
LIG_SH2_STAP1	568	572	PF00017	0.739
LIG_SH2_STAT3	336	339	PF00017	0.419
LIG_SH2_STAT5	261	264	PF00017	0.420
LIG_SH2_STAT5	345	348	PF00017	0.503
LIG_SH2_STAT5	489	492	PF00017	0.586
LIG_SH2_STAT5	518	521	PF00017	0.687
LIG_SH2_STAT5	99	102	PF00017	0.580
LIG_SH3_3	189	195	PF00018	0.613
LIG_SH3_3	285	291	PF00018	0.595
LIG_SH3_3	488	494	PF00018	0.451
LIG_SH3_3	534	540	PF00018	0.581
LIG_SUMO_SIM_anti_2	504	509	PF11976	0.461
LIG_SUMO_SIM_par_1	453	459	PF11976	0.395
LIG_SUMO_SIM_par_1	53	58	PF11976	0.657
LIG_TRAF2_1	335	338	PF00917	0.373
LIG_WRC_WIRS_1	95	100	PF05994	0.596
MOD_CDK_SPK_2	527	532	PF00069	0.561
MOD_CDK_SPxK_1	492	498	PF00069	0.549
MOD_CDK_SPxK_1	510	516	PF00069	0.628
MOD_CDK_SPxxK_3	510	517	PF00069	0.633
MOD_CDK_SPxxK_3	527	534	PF00069	0.499
MOD_CK1_1	154	160	PF00069	0.578
MOD_CK1_1	17	23	PF00069	0.725
MOD_CK1_1	317	323	PF00069	0.729
MOD_CK1_1	424	430	PF00069	0.690
MOD_CK1_1	439	445	PF00069	0.502
MOD_CK1_1	81	87	PF00069	0.694
MOD_CK2_1	220	226	PF00069	0.805
MOD_CK2_1	332	338	PF00069	0.415
MOD_Cter_Amidation	403	406	PF01082	0.732
MOD_GlcNHglycan	156	159	PF01048	0.601
MOD_GlcNHglycan	178	181	PF01048	0.720
MOD_GlcNHglycan	306	309	PF01048	0.643
MOD_GlcNHglycan	312	315	PF01048	0.630
MOD_GlcNHglycan	424	427	PF01048	0.713
MOD_GlcNHglycan	438	441	PF01048	0.582
MOD_GlcNHglycan	573	576	PF01048	0.555
MOD_GlcNHglycan	579	582	PF01048	0.507
MOD_GSK3_1	126	133	PF00069	0.579
MOD_GSK3_1	147	154	PF00069	0.609
MOD_GSK3_1	17	24	PF00069	0.662
MOD_GSK3_1	261	268	PF00069	0.540
MOD_GSK3_1	296	303	PF00069	0.519
MOD_GSK3_1	310	317	PF00069	0.579
MOD_GSK3_1	407	414	PF00069	0.661
MOD_GSK3_1	417	424	PF00069	0.565
MOD_GSK3_1	442	449	PF00069	0.544
MOD_GSK3_1	475	482	PF00069	0.560
MOD_GSK3_1	567	574	PF00069	0.618
MOD_GSK3_1	94	101	PF00069	0.612
MOD_LATS_1	219	225	PF00433	0.699
MOD_NEK2_1	1	6	PF00069	0.792
MOD_NEK2_1	120	125	PF00069	0.603
MOD_NEK2_1	147	152	PF00069	0.622
MOD_NEK2_1	186	191	PF00069	0.729
MOD_NEK2_1	204	209	PF00069	0.628
MOD_NEK2_1	296	301	PF00069	0.528
MOD_NEK2_1	383	388	PF00069	0.634
MOD_NEK2_1	436	441	PF00069	0.657
MOD_NEK2_1	475	480	PF00069	0.500
MOD_NEK2_1	604	609	PF00069	0.673
MOD_NEK2_2	261	266	PF00069	0.451
MOD_NEK2_2	94	99	PF00069	0.601
MOD_PIKK_1	148	154	PF00454	0.584
MOD_PIKK_1	314	320	PF00454	0.738
MOD_PIKK_1	36	42	PF00454	0.580
MOD_PIKK_1	383	389	PF00454	0.600
MOD_PIKK_1	439	445	PF00454	0.649
MOD_PKA_2	120	126	PF00069	0.598
MOD_PKA_2	174	180	PF00069	0.728
MOD_PKA_2	220	226	PF00069	0.646
MOD_PKA_2	436	442	PF00069	0.674
MOD_PKA_2	604	610	PF00069	0.678
MOD_Plk_1	140	146	PF00069	0.303
MOD_Plk_4	261	267	PF00069	0.439
MOD_Plk_4	446	452	PF00069	0.480
MOD_Plk_4	609	615	PF00069	0.693
MOD_Plk_4	94	100	PF00069	0.676
MOD_ProDKin_1	17	23	PF00069	0.756
MOD_ProDKin_1	205	211	PF00069	0.668
MOD_ProDKin_1	243	249	PF00069	0.647
MOD_ProDKin_1	317	323	PF00069	0.663
MOD_ProDKin_1	417	423	PF00069	0.750
MOD_ProDKin_1	492	498	PF00069	0.549
MOD_ProDKin_1	510	516	PF00069	0.628
MOD_ProDKin_1	527	533	PF00069	0.494
MOD_ProDKin_1	57	63	PF00069	0.634
MOD_ProDKin_1	6	12	PF00069	0.745
MOD_ProDKin_1	98	104	PF00069	0.591
TRG_DiLeu_BaEn_1	141	146	PF01217	0.265
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.689
TRG_ENDOCYTIC_2	196	199	PF00928	0.552
TRG_ENDOCYTIC_2	489	492	PF00928	0.586
TRG_ER_diArg_1	119	122	PF00400	0.619
TRG_ER_diArg_1	472	474	PF00400	0.587
TRG_ER_diArg_1	515	517	PF00400	0.587
TRG_ER_diArg_1	531	534	PF00400	0.593
TRG_ER_diArg_1	64	67	PF00400	0.731
TRG_ER_diArg_1	640	643	PF00400	0.666
TRG_NES_CRM1_1	125	137	PF08389	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC90	Leptomonas seymouri	60%	88%
A0A1X0NNC0	Trypanosomatidae	32%	100%
A0A3R7NXN4	Trypanosoma rangeli	34%	100%
A4H5P3	Leishmania braziliensis	81%	100%
A4HTY3	Leishmania infantum	99%	100%
D0A9D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AMR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QHW2	Leishmania major	94%	99%
V5DJH4	Trypanosoma cruzi	35%	100%