Dual specificity phosphatase, catalytic domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQM8_LEIDO

TriTrypDb:

LdBPK_090600.1 , LdCL_090011100 , LDHU3_09.0740

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQM8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.742
CLV_NRD_NRD_1	148	150	PF00675	0.653
CLV_NRD_NRD_1	195	197	PF00675	0.606
CLV_NRD_NRD_1	201	203	PF00675	0.708
CLV_NRD_NRD_1	236	238	PF00675	0.701
CLV_NRD_NRD_1	453	455	PF00675	0.711
CLV_NRD_NRD_1	553	555	PF00675	0.481
CLV_NRD_NRD_1	566	568	PF00675	0.496
CLV_PCSK_FUR_1	564	568	PF00082	0.505
CLV_PCSK_KEX2_1	148	150	PF00082	0.653
CLV_PCSK_KEX2_1	195	197	PF00082	0.636
CLV_PCSK_KEX2_1	201	203	PF00082	0.686
CLV_PCSK_KEX2_1	265	267	PF00082	0.496
CLV_PCSK_KEX2_1	453	455	PF00082	0.756
CLV_PCSK_KEX2_1	553	555	PF00082	0.480
CLV_PCSK_KEX2_1	564	566	PF00082	0.493
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.569
CLV_PCSK_SKI1_1	171	175	PF00082	0.577
CLV_PCSK_SKI1_1	432	436	PF00082	0.454
CLV_PCSK_SKI1_1	505	509	PF00082	0.467
DEG_APCC_DBOX_1	406	414	PF00400	0.493
DEG_SCF_FBW7_1	421	428	PF00400	0.510
DEG_SPOP_SBC_1	307	311	PF00917	0.616
DEG_SPOP_SBC_1	338	342	PF00917	0.690
DEG_SPOP_SBC_1	96	100	PF00917	0.767
DOC_MAPK_gen_1	404	412	PF00069	0.577
DOC_MAPK_gen_1	564	574	PF00069	0.494
DOC_MAPK_MEF2A_6	167	176	PF00069	0.520
DOC_MAPK_MEF2A_6	182	191	PF00069	0.485
DOC_MAPK_MEF2A_6	23	31	PF00069	0.515
DOC_MAPK_MEF2A_6	404	412	PF00069	0.577
DOC_MAPK_MEF2A_6	490	497	PF00069	0.411
DOC_MAPK_MEF2A_6	564	572	PF00069	0.492
DOC_PP1_RVXF_1	503	510	PF00149	0.429
DOC_PP2B_LxvP_1	114	117	PF13499	0.791
DOC_PP2B_LxvP_1	408	411	PF13499	0.473
DOC_USP7_MATH_1	165	169	PF00917	0.738
DOC_USP7_MATH_1	212	216	PF00917	0.780
DOC_USP7_MATH_1	233	237	PF00917	0.797
DOC_USP7_MATH_1	256	260	PF00917	0.504
DOC_USP7_MATH_1	289	293	PF00917	0.778
DOC_USP7_MATH_1	305	309	PF00917	0.704
DOC_USP7_MATH_1	332	336	PF00917	0.663
DOC_USP7_MATH_1	338	342	PF00917	0.625
DOC_USP7_MATH_1	425	429	PF00917	0.481
DOC_USP7_MATH_1	463	467	PF00917	0.729
DOC_USP7_MATH_1	50	54	PF00917	0.789
DOC_USP7_MATH_1	501	505	PF00917	0.474
DOC_USP7_MATH_1	58	62	PF00917	0.651
DOC_USP7_MATH_1	97	101	PF00917	0.671
DOC_WW_Pin1_4	324	329	PF00397	0.665
DOC_WW_Pin1_4	334	339	PF00397	0.669
DOC_WW_Pin1_4	371	376	PF00397	0.758
DOC_WW_Pin1_4	412	417	PF00397	0.555
DOC_WW_Pin1_4	421	426	PF00397	0.497
DOC_WW_Pin1_4	458	463	PF00397	0.624
LIG_14-3-3_CanoR_1	148	154	PF00244	0.580
LIG_14-3-3_CanoR_1	167	175	PF00244	0.416
LIG_14-3-3_CanoR_1	202	212	PF00244	0.639
LIG_14-3-3_CanoR_1	393	403	PF00244	0.558
LIG_14-3-3_CanoR_1	407	411	PF00244	0.410
LIG_14-3-3_CanoR_1	432	438	PF00244	0.469
LIG_14-3-3_CanoR_1	505	510	PF00244	0.419
LIG_Actin_WH2_2	136	153	PF00022	0.562
LIG_Actin_WH2_2	178	194	PF00022	0.580
LIG_BRCT_BRCA1_1	505	509	PF00533	0.443
LIG_deltaCOP1_diTrp_1	354	358	PF00928	0.595
LIG_deltaCOP1_diTrp_1	517	521	PF00928	0.447
LIG_EVH1_1	114	118	PF00568	0.717
LIG_EVH1_2	118	122	PF00568	0.716
LIG_FHA_1	139	145	PF00498	0.487
LIG_FHA_1	205	211	PF00498	0.671
LIG_FHA_1	311	317	PF00498	0.485
LIG_FHA_1	398	404	PF00498	0.659
LIG_FHA_1	407	413	PF00498	0.498
LIG_FHA_1	416	422	PF00498	0.437
LIG_FHA_1	425	431	PF00498	0.416
LIG_FHA_1	88	94	PF00498	0.716
LIG_FHA_1	97	103	PF00498	0.572
LIG_FHA_2	272	278	PF00498	0.647
LIG_FHA_2	340	346	PF00498	0.660
LIG_FHA_2	349	355	PF00498	0.520
LIG_FHA_2	434	440	PF00498	0.522
LIG_FHA_2	459	465	PF00498	0.715
LIG_GBD_Chelix_1	27	35	PF00786	0.488
LIG_LIR_Gen_1	135	144	PF02991	0.509
LIG_LIR_Gen_1	352	362	PF02991	0.585
LIG_LIR_Gen_1	578	588	PF02991	0.477
LIG_LIR_LC3C_4	24	29	PF02991	0.521
LIG_LIR_Nem_3	135	139	PF02991	0.500
LIG_LIR_Nem_3	261	267	PF02991	0.483
LIG_LIR_Nem_3	352	358	PF02991	0.587
LIG_LIR_Nem_3	402	408	PF02991	0.498
LIG_PCNA_yPIPBox_3	257	266	PF02747	0.426
LIG_Pex14_1	518	522	PF04695	0.451
LIG_Pex14_2	34	38	PF04695	0.514
LIG_Pex14_2	509	513	PF04695	0.433
LIG_SH2_CRK	264	268	PF00017	0.493
LIG_SH2_STAT5	106	109	PF00017	0.665
LIG_SH2_STAT5	132	135	PF00017	0.476
LIG_SH2_STAT5	299	302	PF00017	0.763
LIG_SH2_STAT5	423	426	PF00017	0.485
LIG_SH2_STAT5	562	565	PF00017	0.493
LIG_SH3_2	115	120	PF14604	0.723
LIG_SH3_3	109	115	PF00018	0.767
LIG_SH3_3	181	187	PF00018	0.452
LIG_SH3_3	322	328	PF00018	0.552
LIG_SH3_CIN85_PxpxPR_1	115	120	PF14604	0.801
LIG_SUMO_SIM_par_1	27	32	PF11976	0.507
LIG_TRAF2_1	436	439	PF00917	0.606
LIG_TYR_ITIM	403	408	PF00017	0.575
LIG_WW_3	110	114	PF00397	0.704
LIG_WW_3	117	121	PF00397	0.633
MOD_CDC14_SPxK_1	331	334	PF00782	0.798
MOD_CDK_SPxK_1	328	334	PF00069	0.771
MOD_CDK_SPxxK_3	412	419	PF00069	0.664
MOD_CK1_1	152	158	PF00069	0.763
MOD_CK1_1	161	167	PF00069	0.514
MOD_CK1_1	280	286	PF00069	0.696
MOD_CK1_1	308	314	PF00069	0.687
MOD_CK1_1	337	343	PF00069	0.655
MOD_CK1_1	348	354	PF00069	0.559
MOD_CK1_1	371	377	PF00069	0.665
MOD_CK1_1	397	403	PF00069	0.535
MOD_CK1_1	415	421	PF00069	0.514
MOD_CK1_1	53	59	PF00069	0.681
MOD_CK1_1	87	93	PF00069	0.750
MOD_CK1_1	95	101	PF00069	0.657
MOD_CK2_1	256	262	PF00069	0.524
MOD_CK2_1	290	296	PF00069	0.671
MOD_CK2_1	433	439	PF00069	0.515
MOD_CMANNOS	518	521	PF00535	0.444
MOD_DYRK1A_RPxSP_1	334	338	PF00069	0.691
MOD_GlcNHglycan	300	303	PF01048	0.661
MOD_GlcNHglycan	313	316	PF01048	0.465
MOD_GlcNHglycan	334	337	PF01048	0.712
MOD_GlcNHglycan	347	350	PF01048	0.508
MOD_GlcNHglycan	351	354	PF01048	0.456
MOD_GlcNHglycan	368	373	PF01048	0.460
MOD_GlcNHglycan	396	399	PF01048	0.728
MOD_GlcNHglycan	52	55	PF01048	0.702
MOD_GlcNHglycan	80	83	PF01048	0.672
MOD_GlcNHglycan	94	97	PF01048	0.514
MOD_GSK3_1	1	8	PF00069	0.844
MOD_GSK3_1	134	141	PF00069	0.493
MOD_GSK3_1	154	161	PF00069	0.524
MOD_GSK3_1	305	312	PF00069	0.734
MOD_GSK3_1	324	331	PF00069	0.567
MOD_GSK3_1	334	341	PF00069	0.598
MOD_GSK3_1	345	352	PF00069	0.491
MOD_GSK3_1	364	371	PF00069	0.504
MOD_GSK3_1	394	401	PF00069	0.660
MOD_GSK3_1	421	428	PF00069	0.588
MOD_GSK3_1	49	56	PF00069	0.698
MOD_GSK3_1	501	508	PF00069	0.439
MOD_GSK3_1	9	16	PF00069	0.603
MOD_GSK3_1	92	99	PF00069	0.782
MOD_N-GLC_1	458	463	PF02516	0.779
MOD_N-GLC_1	9	14	PF02516	0.695
MOD_NEK2_1	191	196	PF00069	0.637
MOD_NEK2_1	555	560	PF00069	0.445
MOD_NEK2_1	78	83	PF00069	0.754
MOD_PIKK_1	166	172	PF00454	0.462
MOD_PIKK_1	225	231	PF00454	0.756
MOD_PIKK_1	575	581	PF00454	0.482
MOD_PK_1	149	155	PF00069	0.595
MOD_PK_1	503	509	PF00069	0.432
MOD_PK_1	547	553	PF00069	0.530
MOD_PKA_2	166	172	PF00069	0.462
MOD_PKA_2	191	197	PF00069	0.515
MOD_PKA_2	203	209	PF00069	0.618
MOD_PKA_2	406	412	PF00069	0.498
MOD_PKB_1	149	157	PF00069	0.653
MOD_PKB_1	202	210	PF00069	0.706
MOD_PKB_1	545	553	PF00069	0.549
MOD_Plk_1	280	286	PF00069	0.684
MOD_Plk_4	13	19	PF00069	0.652
MOD_Plk_4	280	286	PF00069	0.684
MOD_Plk_4	425	431	PF00069	0.456
MOD_Plk_4	505	511	PF00069	0.418
MOD_Plk_4	555	561	PF00069	0.452
MOD_ProDKin_1	324	330	PF00069	0.667
MOD_ProDKin_1	334	340	PF00069	0.664
MOD_ProDKin_1	371	377	PF00069	0.762
MOD_ProDKin_1	412	418	PF00069	0.553
MOD_ProDKin_1	421	427	PF00069	0.491
MOD_ProDKin_1	458	464	PF00069	0.624
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.626
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.573
TRG_ENDOCYTIC_2	264	267	PF00928	0.501
TRG_ENDOCYTIC_2	405	408	PF00928	0.464
TRG_ENDOCYTIC_2	423	426	PF00928	0.485
TRG_ER_diArg_1	148	151	PF00400	0.669
TRG_ER_diArg_1	201	204	PF00400	0.728
TRG_ER_diArg_1	553	555	PF00400	0.480
TRG_ER_diArg_1	563	566	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F1	Leptomonas seymouri	36%	100%
A4H5N2	Leishmania braziliensis	68%	97%
A4HTX6	Leishmania infantum	99%	99%
E9AMQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QHW9	Leishmania major	89%	100%