Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQM3_LEIDO

TriTrypDb:

LdBPK_090530.1 , LdCL_090010400 , LDHU3_09.0660

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3S7WQM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQM3

Function

Biological processes
Term	Name	Level	Count
GO:0032879	regulation of localization	3	6
GO:0034762	regulation of transmembrane transport	4	6
GO:0034765	regulation of monoatomic ion transmembrane transport	5	6
GO:0043269	regulation of monoatomic ion transport	5	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051049	regulation of transport	4	6
GO:0065007	biological regulation	1	6
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006813	potassium ion transport	7	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071805	potassium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098657	import into cell	4	1
GO:0098659	inorganic cation import across plasma membrane	5	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:0098739	import across plasma membrane	3	1
GO:0099587	inorganic ion import across plasma membrane	4	1
GO:1990573	potassium ion import across plasma membrane	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0005216	monoatomic ion channel activity	4	6
GO:0005242	inward rectifier potassium channel activity	7	6
GO:0005244	voltage-gated monoatomic ion channel activity	4	6
GO:0005249	voltage-gated potassium channel activity	6	6
GO:0005261	monoatomic cation channel activity	5	6
GO:0005267	potassium channel activity	6	6
GO:0008324	monoatomic cation transmembrane transporter activity	4	6
GO:0015075	monoatomic ion transmembrane transporter activity	3	6
GO:0015079	potassium ion transmembrane transporter activity	6	6
GO:0015267	channel activity	4	6
GO:0015276	ligand-gated monoatomic ion channel activity	5	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022803	passive transmembrane transporter activity	3	6
GO:0022832	voltage-gated channel activity	6	6
GO:0022834	ligand-gated channel activity	6	6
GO:0022836	gated channel activity	5	6
GO:0022843	voltage-gated monoatomic cation channel activity	5	6
GO:0022857	transmembrane transporter activity	2	6
GO:0022890	inorganic cation transmembrane transporter activity	4	6
GO:0046873	metal ion transmembrane transporter activity	5	6
GO:0099094	ligand-gated monoatomic cation channel activity	6	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.657
CLV_C14_Caspase3-7	417	421	PF00656	0.513
CLV_C14_Caspase3-7	516	520	PF00656	0.505
CLV_NRD_NRD_1	399	401	PF00675	0.680
CLV_NRD_NRD_1	423	425	PF00675	0.732
CLV_NRD_NRD_1	498	500	PF00675	0.760
CLV_PCSK_FUR_1	496	500	PF00082	0.696
CLV_PCSK_KEX2_1	357	359	PF00082	0.792
CLV_PCSK_KEX2_1	399	401	PF00082	0.678
CLV_PCSK_KEX2_1	423	425	PF00082	0.743
CLV_PCSK_KEX2_1	498	500	PF00082	0.699
CLV_PCSK_KEX2_1	558	560	PF00082	0.753
CLV_PCSK_KEX2_1	691	693	PF00082	0.621
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.792
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.753
CLV_PCSK_PC1ET2_1	691	693	PF00082	0.621
CLV_PCSK_PC7_1	395	401	PF00082	0.676
CLV_PCSK_SKI1_1	12	16	PF00082	0.566
CLV_PCSK_SKI1_1	239	243	PF00082	0.584
CLV_PCSK_SKI1_1	259	263	PF00082	0.441
CLV_PCSK_SKI1_1	305	309	PF00082	0.746
CLV_PCSK_SKI1_1	358	362	PF00082	0.756
CLV_PCSK_SKI1_1	635	639	PF00082	0.586
CLV_PCSK_SKI1_1	84	88	PF00082	0.500
DEG_Nend_Nbox_1	1	3	PF02207	0.762
DEG_SPOP_SBC_1	491	495	PF00917	0.540
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.642
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.380
DOC_MAPK_gen_1	202	210	PF00069	0.512
DOC_MAPK_gen_1	610	618	PF00069	0.426
DOC_MAPK_HePTP_8	628	640	PF00069	0.413
DOC_MAPK_MEF2A_6	25	33	PF00069	0.688
DOC_MAPK_MEF2A_6	586	595	PF00069	0.430
DOC_MAPK_MEF2A_6	631	640	PF00069	0.414
DOC_PP1_RVXF_1	237	243	PF00149	0.398
DOC_PP1_RVXF_1	257	263	PF00149	0.245
DOC_PP2B_LxvP_1	29	32	PF13499	0.714
DOC_PP2B_LxvP_1	638	641	PF13499	0.435
DOC_PP4_FxxP_1	34	37	PF00568	0.740
DOC_USP7_MATH_1	375	379	PF00917	0.584
DOC_USP7_MATH_1	436	440	PF00917	0.513
DOC_USP7_MATH_1	457	461	PF00917	0.500
DOC_USP7_MATH_1	477	481	PF00917	0.499
DOC_USP7_MATH_1	485	489	PF00917	0.514
DOC_USP7_MATH_1	491	495	PF00917	0.514
DOC_USP7_MATH_1	51	55	PF00917	0.650
DOC_USP7_MATH_1	526	530	PF00917	0.527
DOC_USP7_MATH_1	569	573	PF00917	0.557
DOC_USP7_MATH_1	714	718	PF00917	0.432
DOC_USP7_MATH_1	73	77	PF00917	0.708
DOC_USP7_UBL2_3	357	361	PF12436	0.575
DOC_WW_Pin1_4	418	423	PF00397	0.523
DOC_WW_Pin1_4	506	511	PF00397	0.547
DOC_WW_Pin1_4	52	57	PF00397	0.739
DOC_WW_Pin1_4	557	562	PF00397	0.441
DOC_WW_Pin1_4	576	581	PF00397	0.421
DOC_WW_Pin1_4	629	634	PF00397	0.433
DOC_WW_Pin1_4	71	76	PF00397	0.583
LIG_14-3-3_CanoR_1	106	114	PF00244	0.616
LIG_14-3-3_CanoR_1	118	123	PF00244	0.603
LIG_14-3-3_CanoR_1	202	210	PF00244	0.512
LIG_14-3-3_CanoR_1	239	248	PF00244	0.385
LIG_14-3-3_CanoR_1	3	8	PF00244	0.756
LIG_14-3-3_CanoR_1	302	308	PF00244	0.419
LIG_14-3-3_CanoR_1	365	370	PF00244	0.553
LIG_14-3-3_CanoR_1	426	436	PF00244	0.569
LIG_14-3-3_CanoR_1	448	457	PF00244	0.517
LIG_14-3-3_CanoR_1	599	607	PF00244	0.459
LIG_14-3-3_CanoR_1	613	619	PF00244	0.336
LIG_14-3-3_CanoR_1	81	90	PF00244	0.722
LIG_APCC_ABBA_1	634	639	PF00400	0.431
LIG_APCC_ABBA_1	710	715	PF00400	0.426
LIG_BRCT_BRCA1_1	478	482	PF00533	0.515
LIG_BRCT_BRCA1_1	551	555	PF00533	0.499
LIG_BRCT_BRCA1_1	79	83	PF00533	0.692
LIG_CtBP_PxDLS_1	731	735	PF00389	0.441
LIG_deltaCOP1_diTrp_1	256	262	PF00928	0.367
LIG_EH1_1	143	151	PF00400	0.405
LIG_eIF4E_1	144	150	PF01652	0.405
LIG_FHA_1	107	113	PF00498	0.552
LIG_FHA_1	132	138	PF00498	0.542
LIG_FHA_1	203	209	PF00498	0.546
LIG_FHA_1	231	237	PF00498	0.455
LIG_FHA_1	316	322	PF00498	0.455
LIG_FHA_1	93	99	PF00498	0.694
LIG_FHA_2	190	196	PF00498	0.630
LIG_FHA_2	604	610	PF00498	0.464
LIG_FHA_2	678	684	PF00498	0.432
LIG_FHA_2	693	699	PF00498	0.306
LIG_FHA_2	738	744	PF00498	0.544
LIG_GBD_Chelix_1	141	149	PF00786	0.344
LIG_Integrin_isoDGR_2	104	106	PF01839	0.347
LIG_KLC1_Yacidic_2	605	609	PF13176	0.461
LIG_LIR_Gen_1	130	141	PF02991	0.546
LIG_LIR_Gen_1	212	221	PF02991	0.405
LIG_LIR_Gen_1	243	252	PF02991	0.397
LIG_LIR_Gen_1	542	551	PF02991	0.443
LIG_LIR_Gen_1	722	731	PF02991	0.411
LIG_LIR_Nem_3	116	122	PF02991	0.671
LIG_LIR_Nem_3	123	128	PF02991	0.569
LIG_LIR_Nem_3	130	136	PF02991	0.448
LIG_LIR_Nem_3	138	142	PF02991	0.252
LIG_LIR_Nem_3	170	176	PF02991	0.405
LIG_LIR_Nem_3	212	216	PF02991	0.405
LIG_LIR_Nem_3	243	248	PF02991	0.383
LIG_LIR_Nem_3	256	261	PF02991	0.311
LIG_LIR_Nem_3	542	547	PF02991	0.445
LIG_LIR_Nem_3	722	726	PF02991	0.416
LIG_Pex14_1	258	262	PF04695	0.390
LIG_PTB_Apo_2	212	219	PF02174	0.405
LIG_SH2_CRK	139	143	PF00017	0.377
LIG_SH2_GRB2like	213	216	PF00017	0.405
LIG_SH2_GRB2like	694	697	PF00017	0.392
LIG_SH2_GRB2like	725	728	PF00017	0.401
LIG_SH2_PTP2	213	216	PF00017	0.405
LIG_SH2_SRC	144	147	PF00017	0.405
LIG_SH2_SRC	213	216	PF00017	0.405
LIG_SH2_STAP1	139	143	PF00017	0.428
LIG_SH2_STAP1	539	543	PF00017	0.419
LIG_SH2_STAT5	126	129	PF00017	0.603
LIG_SH2_STAT5	144	147	PF00017	0.220
LIG_SH2_STAT5	173	176	PF00017	0.405
LIG_SH2_STAT5	213	216	PF00017	0.405
LIG_SH2_STAT5	232	235	PF00017	0.313
LIG_SH2_STAT5	607	610	PF00017	0.511
LIG_SH2_STAT5	694	697	PF00017	0.383
LIG_SH2_STAT5	725	728	PF00017	0.401
LIG_SH3_1	367	373	PF00018	0.488
LIG_SH3_3	367	373	PF00018	0.557
LIG_SH3_3	50	56	PF00018	0.710
LIG_SH3_3	568	574	PF00018	0.508
LIG_SH3_3	630	636	PF00018	0.434
LIG_SH3_5	99	103	PF00018	0.600
LIG_Sin3_3	223	230	PF02671	0.474
LIG_SUMO_SIM_par_1	133	138	PF11976	0.386
LIG_SUMO_SIM_par_1	146	152	PF11976	0.285
LIG_SUMO_SIM_par_1	205	212	PF11976	0.405
LIG_SUMO_SIM_par_1	672	678	PF11976	0.389
LIG_TRAF2_1	531	534	PF00917	0.496
LIG_TYR_ITIM	137	142	PF00017	0.356
LIG_WRC_WIRS_1	114	119	PF05994	0.576
MOD_CDC14_SPxK_1	421	424	PF00782	0.651
MOD_CDC14_SPxK_1	632	635	PF00782	0.426
MOD_CDK_SPK_2	418	423	PF00069	0.634
MOD_CDK_SPK_2	506	511	PF00069	0.686
MOD_CDK_SPxK_1	418	424	PF00069	0.656
MOD_CDK_SPxK_1	629	635	PF00069	0.451
MOD_CK1_1	313	319	PF00069	0.641
MOD_CK1_1	378	384	PF00069	0.703
MOD_CK1_1	388	394	PF00069	0.569
MOD_CK1_1	430	436	PF00069	0.669
MOD_CK1_1	444	450	PF00069	0.631
MOD_CK1_1	452	458	PF00069	0.664
MOD_CK1_1	460	466	PF00069	0.571
MOD_CK1_1	468	474	PF00069	0.567
MOD_CK1_1	476	482	PF00069	0.558
MOD_CK1_1	484	490	PF00069	0.566
MOD_CK1_1	494	500	PF00069	0.588
MOD_CK1_1	509	515	PF00069	0.611
MOD_CK1_1	528	534	PF00069	0.496
MOD_CK1_1	542	548	PF00069	0.548
MOD_CK1_1	646	652	PF00069	0.624
MOD_CK1_1	686	692	PF00069	0.529
MOD_CK1_1	74	80	PF00069	0.633
MOD_CK2_1	225	231	PF00069	0.432
MOD_CK2_1	528	534	PF00069	0.645
MOD_CK2_1	576	582	PF00069	0.574
MOD_CK2_1	677	683	PF00069	0.509
MOD_CK2_1	735	741	PF00069	0.633
MOD_Cter_Amidation	556	559	PF01082	0.642
MOD_GlcNHglycan	169	172	PF01048	0.468
MOD_GlcNHglycan	315	318	PF01048	0.664
MOD_GlcNHglycan	367	370	PF01048	0.689
MOD_GlcNHglycan	377	380	PF01048	0.745
MOD_GlcNHglycan	385	390	PF01048	0.649
MOD_GlcNHglycan	409	412	PF01048	0.737
MOD_GlcNHglycan	45	48	PF01048	0.641
MOD_GlcNHglycan	451	454	PF01048	0.713
MOD_GlcNHglycan	465	468	PF01048	0.587
MOD_GlcNHglycan	475	478	PF01048	0.599
MOD_GlcNHglycan	483	486	PF01048	0.545
MOD_GlcNHglycan	487	490	PF01048	0.636
MOD_GlcNHglycan	49	52	PF01048	0.614
MOD_GlcNHglycan	515	518	PF01048	0.686
MOD_GlcNHglycan	58	61	PF01048	0.503
MOD_GlcNHglycan	648	651	PF01048	0.640
MOD_GlcNHglycan	652	655	PF01048	0.618
MOD_GlcNHglycan	657	660	PF01048	0.574
MOD_GlcNHglycan	685	688	PF01048	0.484
MOD_GlcNHglycan	84	87	PF01048	0.609
MOD_GSK3_1	127	134	PF00069	0.461
MOD_GSK3_1	240	247	PF00069	0.511
MOD_GSK3_1	311	318	PF00069	0.601
MOD_GSK3_1	35	42	PF00069	0.637
MOD_GSK3_1	361	368	PF00069	0.709
MOD_GSK3_1	409	416	PF00069	0.697
MOD_GSK3_1	43	50	PF00069	0.627
MOD_GSK3_1	451	458	PF00069	0.732
MOD_GSK3_1	459	466	PF00069	0.640
MOD_GSK3_1	468	475	PF00069	0.544
MOD_GSK3_1	477	484	PF00069	0.545
MOD_GSK3_1	485	492	PF00069	0.547
MOD_GSK3_1	509	516	PF00069	0.613
MOD_GSK3_1	52	59	PF00069	0.491
MOD_GSK3_1	525	532	PF00069	0.579
MOD_GSK3_1	557	564	PF00069	0.702
MOD_GSK3_1	646	653	PF00069	0.601
MOD_GSK3_1	655	662	PF00069	0.570
MOD_GSK3_1	67	74	PF00069	0.556
MOD_GSK3_1	677	684	PF00069	0.517
MOD_GSK3_1	686	693	PF00069	0.437
MOD_GSK3_1	735	742	PF00069	0.638
MOD_GSK3_1	88	95	PF00069	0.591
MOD_LATS_1	359	365	PF00433	0.686
MOD_N-GLC_1	526	531	PF02516	0.655
MOD_NEK2_1	1	6	PF00069	0.568
MOD_NEK2_1	127	132	PF00069	0.483
MOD_NEK2_1	149	154	PF00069	0.376
MOD_NEK2_1	209	214	PF00069	0.412
MOD_NEK2_1	225	230	PF00069	0.307
MOD_NEK2_1	24	29	PF00069	0.659
MOD_NEK2_1	301	306	PF00069	0.583
MOD_NEK2_1	310	315	PF00069	0.763
MOD_NEK2_1	407	412	PF00069	0.733
MOD_NEK2_1	473	478	PF00069	0.721
MOD_NEK2_1	483	488	PF00069	0.609
MOD_NEK2_1	598	603	PF00069	0.525
MOD_NEK2_2	113	118	PF00069	0.587
MOD_NEK2_2	539	544	PF00069	0.505
MOD_PIKK_1	127	133	PF00454	0.482
MOD_PIKK_1	509	515	PF00454	0.599
MOD_PIKK_1	529	535	PF00454	0.544
MOD_PKA_2	105	111	PF00069	0.363
MOD_PKA_2	301	307	PF00069	0.585
MOD_PKA_2	458	464	PF00069	0.657
MOD_PKA_2	598	604	PF00069	0.534
MOD_PKA_2	88	94	PF00069	0.588
MOD_PKB_1	118	126	PF00069	0.544
MOD_Plk_1	194	200	PF00069	0.481
MOD_Plk_1	468	474	PF00069	0.674
MOD_Plk_1	526	532	PF00069	0.653
MOD_Plk_2-3	189	195	PF00069	0.476
MOD_Plk_4	120	126	PF00069	0.544
MOD_Plk_4	137	143	PF00069	0.231
MOD_Plk_4	209	215	PF00069	0.405
MOD_Plk_4	24	30	PF00069	0.661
MOD_Plk_4	539	545	PF00069	0.519
MOD_Plk_4	603	609	PF00069	0.583
MOD_Plk_4	614	620	PF00069	0.438
MOD_Plk_4	74	80	PF00069	0.641
MOD_ProDKin_1	418	424	PF00069	0.656
MOD_ProDKin_1	506	512	PF00069	0.684
MOD_ProDKin_1	52	58	PF00069	0.673
MOD_ProDKin_1	557	563	PF00069	0.534
MOD_ProDKin_1	576	582	PF00069	0.509
MOD_ProDKin_1	629	635	PF00069	0.524
MOD_ProDKin_1	71	77	PF00069	0.448
MOD_SUMO_rev_2	19	27	PF00179	0.670
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.622
TRG_ENDOCYTIC_2	139	142	PF00928	0.392
TRG_ENDOCYTIC_2	144	147	PF00928	0.365
TRG_ENDOCYTIC_2	173	176	PF00928	0.405
TRG_ENDOCYTIC_2	213	216	PF00928	0.405
TRG_ER_diArg_1	201	204	PF00400	0.425
TRG_ER_diArg_1	422	424	PF00400	0.634
TRG_ER_diArg_1	496	499	PF00400	0.612
TRG_NLS_MonoExtN_4	354	360	PF00514	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5M5	Leishmania braziliensis	62%	90%
A4HTW2	Leishmania infantum	100%	100%
E9AMP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4QHX6	Leishmania major	89%	99%