Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQL0_LEIDO

TriTrypDb:

LdBPK_090370.1 , LdCL_090009400 , LDHU3_09.0540

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQL0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.673
CLV_C14_Caspase3-7	307	311	PF00656	0.711
CLV_C14_Caspase3-7	440	444	PF00656	0.734
CLV_NRD_NRD_1	219	221	PF00675	0.663
CLV_NRD_NRD_1	298	300	PF00675	0.728
CLV_NRD_NRD_1	413	415	PF00675	0.536
CLV_NRD_NRD_1	87	89	PF00675	0.607
CLV_PCSK_KEX2_1	219	221	PF00082	0.663
CLV_PCSK_KEX2_1	281	283	PF00082	0.691
CLV_PCSK_KEX2_1	297	299	PF00082	0.589
CLV_PCSK_KEX2_1	413	415	PF00082	0.514
CLV_PCSK_KEX2_1	434	436	PF00082	0.652
CLV_PCSK_KEX2_1	87	89	PF00082	0.607
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.699
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.589
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.652
CLV_PCSK_SKI1_1	173	177	PF00082	0.509
CLV_PCSK_SKI1_1	248	252	PF00082	0.501
CLV_PCSK_SKI1_1	345	349	PF00082	0.504
CLV_PCSK_SKI1_1	356	360	PF00082	0.531
CLV_PCSK_SKI1_1	389	393	PF00082	0.593
CLV_PCSK_SKI1_1	72	76	PF00082	0.434
CLV_PCSK_SKI1_1	90	94	PF00082	0.344
DEG_APCC_DBOX_1	247	255	PF00400	0.511
DEG_SPOP_SBC_1	35	39	PF00917	0.689
DEG_SPOP_SBC_1	47	51	PF00917	0.666
DOC_CKS1_1	446	451	PF01111	0.658
DOC_CYCLIN_RxL_1	342	352	PF00134	0.552
DOC_CYCLIN_RxL_1	69	78	PF00134	0.575
DOC_CYCLIN_RxL_1	87	95	PF00134	0.546
DOC_MAPK_gen_1	130	139	PF00069	0.573
DOC_MAPK_gen_1	245	253	PF00069	0.526
DOC_MAPK_gen_1	368	375	PF00069	0.446
DOC_MAPK_MEF2A_6	173	180	PF00069	0.474
DOC_MAPK_MEF2A_6	245	253	PF00069	0.569
DOC_MAPK_RevD_3	74	88	PF00069	0.487
DOC_PP4_FxxP_1	57	60	PF00568	0.602
DOC_USP7_MATH_1	117	121	PF00917	0.708
DOC_USP7_MATH_1	125	129	PF00917	0.590
DOC_USP7_MATH_1	148	152	PF00917	0.794
DOC_USP7_MATH_1	34	38	PF00917	0.753
DOC_USP7_MATH_1	391	395	PF00917	0.626
DOC_USP7_MATH_1	47	51	PF00917	0.603
DOC_USP7_MATH_1	53	57	PF00917	0.651
DOC_WW_Pin1_4	445	450	PF00397	0.644
LIG_14-3-3_CanoR_1	116	122	PF00244	0.732
LIG_14-3-3_CanoR_1	219	224	PF00244	0.648
LIG_14-3-3_CanoR_1	368	376	PF00244	0.408
LIG_BIR_III_2	114	118	PF00653	0.545
LIG_FHA_1	258	264	PF00498	0.660
LIG_FHA_1	268	274	PF00498	0.540
LIG_FHA_1	53	59	PF00498	0.573
LIG_FHA_2	196	202	PF00498	0.448
LIG_FHA_2	210	216	PF00498	0.516
LIG_FHA_2	446	452	PF00498	0.648
LIG_Integrin_RGD_1	15	17	PF01839	0.491
LIG_LIR_Apic_2	55	60	PF02991	0.609
LIG_LIR_Nem_3	420	425	PF02991	0.471
LIG_MAD2	135	143	PF02301	0.503
LIG_NRBOX	343	349	PF00104	0.498
LIG_PTAP_UEV_1	43	48	PF05743	0.713
LIG_RPA_C_Plants	248	259	PF08784	0.554
LIG_SH2_CRK	422	426	PF00017	0.564
LIG_SH2_STAT5	179	182	PF00017	0.450
LIG_SH2_STAT5	315	318	PF00017	0.671
LIG_SH2_STAT5	98	101	PF00017	0.483
LIG_SH3_3	137	143	PF00018	0.522
LIG_SH3_3	41	47	PF00018	0.712
LIG_SH3_3	443	449	PF00018	0.659
LIG_SH3_3	79	85	PF00018	0.378
LIG_TYR_ITSM	418	425	PF00017	0.567
LIG_UBA3_1	452	460	PF00899	0.611
MOD_CK1_1	208	214	PF00069	0.563
MOD_CK1_1	233	239	PF00069	0.536
MOD_CK1_1	394	400	PF00069	0.604
MOD_CK1_1	442	448	PF00069	0.580
MOD_CK1_1	64	70	PF00069	0.631
MOD_CK2_1	195	201	PF00069	0.441
MOD_CK2_1	209	215	PF00069	0.531
MOD_CK2_1	301	307	PF00069	0.786
MOD_Cter_Amidation	457	460	PF01082	0.439
MOD_GlcNHglycan	154	157	PF01048	0.734
MOD_GlcNHglycan	189	192	PF01048	0.489
MOD_GlcNHglycan	207	210	PF01048	0.355
MOD_GlcNHglycan	232	235	PF01048	0.604
MOD_GlcNHglycan	277	280	PF01048	0.618
MOD_GlcNHglycan	38	41	PF01048	0.659
MOD_GlcNHglycan	50	53	PF01048	0.680
MOD_GSK3_1	148	155	PF00069	0.670
MOD_GSK3_1	205	212	PF00069	0.501
MOD_GSK3_1	215	222	PF00069	0.605
MOD_GSK3_1	236	243	PF00069	0.385
MOD_GSK3_1	297	304	PF00069	0.721
MOD_GSK3_1	30	37	PF00069	0.573
MOD_GSK3_1	42	49	PF00069	0.622
MOD_LATS_1	152	158	PF00433	0.680
MOD_NEK2_1	187	192	PF00069	0.552
MOD_NEK2_1	205	210	PF00069	0.319
MOD_NEK2_1	29	34	PF00069	0.530
MOD_NEK2_1	75	80	PF00069	0.415
MOD_PIKK_1	125	131	PF00454	0.578
MOD_PIKK_1	223	229	PF00454	0.671
MOD_PIKK_1	319	325	PF00454	0.643
MOD_PK_1	219	225	PF00069	0.728
MOD_PK_1	259	265	PF00069	0.494
MOD_PKA_1	219	225	PF00069	0.686
MOD_PKA_1	297	303	PF00069	0.801
MOD_PKA_2	219	225	PF00069	0.686
MOD_PKA_2	275	281	PF00069	0.676
MOD_PKA_2	297	303	PF00069	0.781
MOD_PKA_2	328	334	PF00069	0.606
MOD_PKA_2	394	400	PF00069	0.629
MOD_Plk_1	257	263	PF00069	0.484
MOD_Plk_2-3	195	201	PF00069	0.541
MOD_Plk_4	219	225	PF00069	0.677
MOD_Plk_4	269	275	PF00069	0.454
MOD_Plk_4	311	317	PF00069	0.681
MOD_Plk_4	442	448	PF00069	0.677
MOD_Plk_4	53	59	PF00069	0.681
MOD_Plk_4	61	67	PF00069	0.478
MOD_Plk_4	75	81	PF00069	0.348
MOD_ProDKin_1	445	451	PF00069	0.638
MOD_SUMO_for_1	378	381	PF00179	0.534
MOD_SUMO_rev_2	352	358	PF00179	0.614
MOD_SUMO_rev_2	94	99	PF00179	0.510
TRG_DiLeu_BaEn_2	200	206	PF01217	0.531
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.592
TRG_ENDOCYTIC_2	422	425	PF00928	0.569
TRG_ER_diArg_1	412	414	PF00400	0.562
TRG_ER_diLys_1	459	462	PF00400	0.604
TRG_NLS_Bipartite_1	281	301	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N2	Leptomonas seymouri	56%	98%
A0A1X0NPB5	Trypanosomatidae	23%	100%
A0A3R7K7T1	Trypanosoma rangeli	32%	100%
A4H5L4	Leishmania braziliensis	77%	100%
A4HTV2	Leishmania infantum	99%	78%
D0A9B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AMP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QHY6	Leishmania major	90%	100%