Ankyrin repeats (3 copies)/Ankyrin repeat/Ankyrin repeats (Many copies), putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQK8_LEIDO

TriTrypDb:

LdBPK_090340.1 , LdCL_090009100 , LDHU3_09.0510

Length:

210

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.456
CLV_NRD_NRD_1	67	69	PF00675	0.672
CLV_PCSK_KEX2_1	67	69	PF00082	0.574
CLV_PCSK_SKI1_1	148	152	PF00082	0.557
CLV_PCSK_SKI1_1	169	173	PF00082	0.513
CLV_PCSK_SKI1_1	47	51	PF00082	0.655
DEG_SPOP_SBC_1	180	184	PF00917	0.411
DOC_CDC14_PxL_1	150	158	PF14671	0.411
DOC_CYCLIN_RxL_1	164	173	PF00134	0.436
DOC_CYCLIN_RxL_1	44	54	PF00134	0.611
DOC_MAPK_MEF2A_6	195	204	PF00069	0.389
DOC_PP4_FxxP_1	151	154	PF00568	0.469
DOC_USP7_MATH_1	18	22	PF00917	0.724
DOC_USP7_MATH_1	38	42	PF00917	0.332
DOC_USP7_MATH_1	6	10	PF00917	0.709
LIG_14-3-3_CanoR_1	195	204	PF00244	0.521
LIG_14-3-3_CanoR_1	22	31	PF00244	0.658
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_BIR_III_4	130	134	PF00653	0.453
LIG_eIF4E_1	197	203	PF01652	0.436
LIG_EVH1_2	154	158	PF00568	0.411
LIG_FHA_1	181	187	PF00498	0.492
LIG_FHA_2	22	28	PF00498	0.738
LIG_Pex14_2	145	149	PF04695	0.558
LIG_Pex14_2	158	162	PF04695	0.382
LIG_SH2_CRK	197	201	PF00017	0.411
LIG_SH2_STAP1	197	201	PF00017	0.389
LIG_SH2_STAT3	191	194	PF00017	0.436
LIG_SUMO_SIM_anti_2	198	206	PF11976	0.389
LIG_SUMO_SIM_par_1	200	206	PF11976	0.436
LIG_TRAF2_1	58	61	PF00917	0.595
MOD_CK1_1	21	27	PF00069	0.731
MOD_CK2_1	21	27	PF00069	0.745
MOD_CK2_1	38	44	PF00069	0.555
MOD_CK2_1	55	61	PF00069	0.562
MOD_GlcNHglycan	124	127	PF01048	0.591
MOD_GlcNHglycan	197	200	PF01048	0.523
MOD_GlcNHglycan	205	208	PF01048	0.593
MOD_GSK3_1	1	8	PF00069	0.730
MOD_GSK3_1	18	25	PF00069	0.555
MOD_NEK2_1	1	6	PF00069	0.755
MOD_NEK2_1	202	207	PF00069	0.620
MOD_PKA_2	21	27	PF00069	0.675
TRG_DiLeu_BaEn_1	52	57	PF01217	0.630
TRG_DiLeu_BaEn_3	165	171	PF01217	0.383
TRG_DiLeu_BaEn_4	60	66	PF01217	0.571
TRG_ENDOCYTIC_2	140	143	PF00928	0.590
TRG_ENDOCYTIC_2	197	200	PF00928	0.411
TRG_ER_diArg_1	67	69	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ4	Leptomonas seymouri	53%	88%
A4H5L1	Leishmania braziliensis	78%	100%
A4HTV0	Leishmania infantum	100%	100%
E9AMN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QHY8	Leishmania major	95%	100%