Cdc2-related kinase 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 12

Species:

Leishmania donovani

UniProt:

A0A3S7WQK2_LEIDO

TriTrypDb:

LdBPK_090270.1 , LdCL_090008400 , LDHU3_09.0440

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

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Expansion

Sequence features

A0A3S7WQK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQK2

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016192	vesicle-mediated transport	4	1
GO:0016310	phosphorylation	5	5

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	306	308	PF00675	0.706
CLV_NRD_NRD_1	429	431	PF00675	0.660
CLV_NRD_NRD_1	575	577	PF00675	0.399
CLV_NRD_NRD_1	596	598	PF00675	0.399
CLV_NRD_NRD_1	6	8	PF00675	0.719
CLV_NRD_NRD_1	800	802	PF00675	0.487
CLV_NRD_NRD_1	860	862	PF00675	0.497
CLV_NRD_NRD_1	877	879	PF00675	0.580
CLV_PCSK_KEX2_1	204	206	PF00082	0.717
CLV_PCSK_KEX2_1	429	431	PF00082	0.660

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4H5K5	Leishmania braziliensis	77%	100%
E9AMN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QHZ5	Leishmania major	92%	100%

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