LeishMANIAdb
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Cdc2-related kinase 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cdc2-related kinase 12
Gene product:
cdc2-related kinase 12
Species:
Leishmania donovani
UniProt:
A0A3S7WQK2_LEIDO
TriTrypDb:
LdBPK_090270.1 * , LdCL_090008400 , LDHU3_09.0440
Length:
881

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0016592 mediator complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A0A3S7WQK2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQK2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 5
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016310 phosphorylation 5 5
GO:0019538 protein metabolic process 3 5
GO:0036211 protein modification process 4 5
GO:0043170 macromolecule metabolic process 3 5
GO:0043412 macromolecule modification 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:0006810 transport 3 1
GO:0006897 endocytosis 5 1
GO:0016192 vesicle-mediated transport 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 5
GO:0003824 catalytic activity 1 5
GO:0004672 protein kinase activity 3 5
GO:0005488 binding 1 5
GO:0005524 ATP binding 5 5
GO:0016301 kinase activity 4 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 5
GO:0017076 purine nucleotide binding 4 5
GO:0030554 adenyl nucleotide binding 5 5
GO:0032553 ribonucleotide binding 3 5
GO:0032555 purine ribonucleotide binding 4 5
GO:0032559 adenyl ribonucleotide binding 5 5
GO:0035639 purine ribonucleoside triphosphate binding 4 5
GO:0036094 small molecule binding 2 5
GO:0043167 ion binding 2 5
GO:0043168 anion binding 3 5
GO:0097159 organic cyclic compound binding 2 5
GO:0097367 carbohydrate derivative binding 2 5
GO:0140096 catalytic activity, acting on a protein 2 5
GO:1901265 nucleoside phosphate binding 3 5
GO:1901363 heterocyclic compound binding 2 5
GO:0004674 protein serine/threonine kinase activity 4 1
GO:0004693 cyclin-dependent protein serine/threonine kinase activity 5 1
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 5 1
GO:0097472 cyclin-dependent protein kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 306 308 PF00675 0.706
CLV_NRD_NRD_1 429 431 PF00675 0.660
CLV_NRD_NRD_1 575 577 PF00675 0.399
CLV_NRD_NRD_1 596 598 PF00675 0.399
CLV_NRD_NRD_1 6 8 PF00675 0.719
CLV_NRD_NRD_1 800 802 PF00675 0.487
CLV_NRD_NRD_1 860 862 PF00675 0.497
CLV_NRD_NRD_1 877 879 PF00675 0.580
CLV_PCSK_KEX2_1 204 206 PF00082 0.717
CLV_PCSK_KEX2_1 429 431 PF00082 0.660
CLV_PCSK_KEX2_1 479 481 PF00082 0.399
CLV_PCSK_KEX2_1 488 490 PF00082 0.309
CLV_PCSK_KEX2_1 575 577 PF00082 0.399
CLV_PCSK_KEX2_1 6 8 PF00082 0.719
CLV_PCSK_KEX2_1 800 802 PF00082 0.492
CLV_PCSK_KEX2_1 860 862 PF00082 0.497
CLV_PCSK_KEX2_1 877 879 PF00082 0.580
CLV_PCSK_PC1ET2_1 204 206 PF00082 0.717
CLV_PCSK_PC1ET2_1 479 481 PF00082 0.399
CLV_PCSK_PC1ET2_1 488 490 PF00082 0.309
CLV_PCSK_SKI1_1 413 417 PF00082 0.707
CLV_PCSK_SKI1_1 453 457 PF00082 0.460
CLV_PCSK_SKI1_1 488 492 PF00082 0.399
CLV_PCSK_SKI1_1 590 594 PF00082 0.399
CLV_PCSK_SKI1_1 607 611 PF00082 0.229
CLV_Separin_Metazoa 826 830 PF03568 0.399
DEG_APCC_DBOX_1 206 214 PF00400 0.531
DEG_Nend_UBRbox_3 1 3 PF02207 0.697
DEG_SCF_FBW7_1 356 363 PF00400 0.623
DEG_SCF_FBW7_2 849 856 PF00400 0.558
DEG_SPOP_SBC_1 64 68 PF00917 0.703
DOC_CDC14_PxL_1 836 844 PF14671 0.536
DOC_CKS1_1 119 124 PF01111 0.709
DOC_CKS1_1 185 190 PF01111 0.630
DOC_CKS1_1 317 322 PF01111 0.593
DOC_CKS1_1 645 650 PF01111 0.399
DOC_CKS1_1 850 855 PF01111 0.505
DOC_CYCLIN_RxL_1 237 248 PF00134 0.560
DOC_MAPK_gen_1 238 246 PF00069 0.563
DOC_MAPK_gen_1 429 438 PF00069 0.665
DOC_MAPK_gen_1 479 487 PF00069 0.399
DOC_MAPK_gen_1 554 563 PF00069 0.399
DOC_MAPK_gen_1 590 596 PF00069 0.399
DOC_MAPK_gen_1 597 604 PF00069 0.329
DOC_MAPK_gen_1 607 616 PF00069 0.229
DOC_MAPK_HePTP_8 551 563 PF00069 0.399
DOC_MAPK_MEF2A_6 238 246 PF00069 0.563
DOC_MAPK_MEF2A_6 429 438 PF00069 0.615
DOC_MAPK_MEF2A_6 554 563 PF00069 0.399
DOC_MAPK_RevD_3 585 598 PF00069 0.349
DOC_PP2B_LxvP_1 181 184 PF13499 0.622
DOC_PP2B_LxvP_1 213 216 PF13499 0.526
DOC_PP2B_LxvP_1 242 245 PF13499 0.624
DOC_PP2B_LxvP_1 686 689 PF13499 0.399
DOC_PP2B_LxvP_1 828 831 PF13499 0.399
DOC_USP7_MATH_1 110 114 PF00917 0.587
DOC_USP7_MATH_1 159 163 PF00917 0.655
DOC_USP7_MATH_1 245 249 PF00917 0.655
DOC_USP7_MATH_1 279 283 PF00917 0.652
DOC_USP7_MATH_1 500 504 PF00917 0.399
DOC_USP7_MATH_1 541 545 PF00917 0.399
DOC_USP7_MATH_1 566 570 PF00917 0.399
DOC_USP7_MATH_1 635 639 PF00917 0.390
DOC_USP7_MATH_1 64 68 PF00917 0.703
DOC_USP7_MATH_1 705 709 PF00917 0.399
DOC_USP7_UBL2_3 475 479 PF12436 0.399
DOC_WW_Pin1_4 11 16 PF00397 0.660
DOC_WW_Pin1_4 118 123 PF00397 0.714
DOC_WW_Pin1_4 184 189 PF00397 0.657
DOC_WW_Pin1_4 260 265 PF00397 0.691
DOC_WW_Pin1_4 316 321 PF00397 0.693
DOC_WW_Pin1_4 325 330 PF00397 0.634
DOC_WW_Pin1_4 356 361 PF00397 0.647
DOC_WW_Pin1_4 362 367 PF00397 0.654
DOC_WW_Pin1_4 376 381 PF00397 0.623
DOC_WW_Pin1_4 413 418 PF00397 0.664
DOC_WW_Pin1_4 423 428 PF00397 0.600
DOC_WW_Pin1_4 578 583 PF00397 0.399
DOC_WW_Pin1_4 60 65 PF00397 0.711
DOC_WW_Pin1_4 644 649 PF00397 0.399
DOC_WW_Pin1_4 849 854 PF00397 0.542
LIG_14-3-3_CanoR_1 114 122 PF00244 0.679
LIG_14-3-3_CanoR_1 142 151 PF00244 0.624
LIG_14-3-3_CanoR_1 207 217 PF00244 0.571
LIG_14-3-3_CanoR_1 368 373 PF00244 0.721
LIG_14-3-3_CanoR_1 411 416 PF00244 0.659
LIG_14-3-3_CanoR_1 707 716 PF00244 0.399
LIG_14-3-3_CanoR_1 718 726 PF00244 0.314
LIG_14-3-3_CanoR_1 80 86 PF00244 0.658
LIG_BRCT_BRCA1_1 444 448 PF00533 0.628
LIG_FHA_1 132 138 PF00498 0.717
LIG_FHA_1 143 149 PF00498 0.602
LIG_FHA_1 169 175 PF00498 0.715
LIG_FHA_1 185 191 PF00498 0.549
LIG_FHA_1 229 235 PF00498 0.704
LIG_FHA_1 357 363 PF00498 0.688
LIG_FHA_1 380 386 PF00498 0.735
LIG_FHA_1 535 541 PF00498 0.389
LIG_FHA_1 55 61 PF00498 0.668
LIG_FHA_1 565 571 PF00498 0.399
LIG_FHA_1 645 651 PF00498 0.399
LIG_FHA_1 718 724 PF00498 0.399
LIG_FHA_1 85 91 PF00498 0.626
LIG_FHA_2 307 313 PF00498 0.599
LIG_FHA_2 317 323 PF00498 0.586
LIG_FHA_2 452 458 PF00498 0.517
LIG_FHA_2 467 473 PF00498 0.249
LIG_FHA_2 579 585 PF00498 0.399
LIG_FHA_2 663 669 PF00498 0.399
LIG_FHA_2 709 715 PF00498 0.399
LIG_FHA_2 767 773 PF00498 0.399
LIG_FHA_2 821 827 PF00498 0.372
LIG_FHA_2 832 838 PF00498 0.494
LIG_LIR_Apic_2 196 202 PF02991 0.657
LIG_LIR_Apic_2 642 648 PF02991 0.343
LIG_LIR_Apic_2 652 658 PF02991 0.356
LIG_LIR_Gen_1 18 28 PF02991 0.548
LIG_LIR_Gen_1 406 417 PF02991 0.654
LIG_LIR_Gen_1 445 455 PF02991 0.501
LIG_LIR_Gen_1 774 783 PF02991 0.399
LIG_LIR_Gen_1 844 853 PF02991 0.546
LIG_LIR_Nem_3 18 23 PF02991 0.542
LIG_LIR_Nem_3 406 412 PF02991 0.703
LIG_LIR_Nem_3 445 451 PF02991 0.606
LIG_LIR_Nem_3 467 473 PF02991 0.399
LIG_LIR_Nem_3 774 780 PF02991 0.399
LIG_LIR_Nem_3 844 848 PF02991 0.582
LIG_MYND_1 124 128 PF01753 0.589
LIG_NRBOX 675 681 PF00104 0.399
LIG_PCNA_yPIPBox_3 452 464 PF02747 0.513
LIG_PCNA_yPIPBox_3 501 511 PF02747 0.349
LIG_Pex14_2 771 775 PF04695 0.399
LIG_Pex14_2 783 787 PF04695 0.279
LIG_SH2_CRK 20 24 PF00017 0.548
LIG_SH2_CRK 845 849 PF00017 0.637
LIG_SH2_NCK_1 565 569 PF00017 0.399
LIG_SH2_STAP1 667 671 PF00017 0.399
LIG_SH2_STAT3 552 555 PF00017 0.399
LIG_SH2_STAT5 22 25 PF00017 0.641
LIG_SH2_STAT5 832 835 PF00017 0.496
LIG_SH3_1 150 156 PF00018 0.693
LIG_SH3_1 326 332 PF00018 0.605
LIG_SH3_1 847 853 PF00018 0.542
LIG_SH3_2 850 855 PF14604 0.505
LIG_SH3_3 116 122 PF00018 0.729
LIG_SH3_3 150 156 PF00018 0.693
LIG_SH3_3 182 188 PF00018 0.636
LIG_SH3_3 195 201 PF00018 0.559
LIG_SH3_3 214 220 PF00018 0.554
LIG_SH3_3 326 332 PF00018 0.650
LIG_SH3_3 369 375 PF00018 0.702
LIG_SH3_3 433 439 PF00018 0.662
LIG_SH3_3 722 728 PF00018 0.392
LIG_SH3_3 847 853 PF00018 0.542
LIG_SUMO_SIM_anti_2 558 563 PF11976 0.399
LIG_TRAF2_1 299 302 PF00917 0.737
LIG_TRAF2_1 309 312 PF00917 0.620
LIG_TRFH_1 684 688 PF08558 0.399
LIG_WW_1 688 691 PF00397 0.399
LIG_WW_3 77 81 PF00397 0.657
MOD_CDC14_SPxK_1 426 429 PF00782 0.679
MOD_CDK_SPxK_1 362 368 PF00069 0.642
MOD_CDK_SPxK_1 423 429 PF00069 0.695
MOD_CDK_SPxK_1 849 855 PF00069 0.576
MOD_CDK_SPxxK_3 184 191 PF00069 0.603
MOD_CDK_SPxxK_3 423 430 PF00069 0.692
MOD_CK1_1 113 119 PF00069 0.713
MOD_CK1_1 157 163 PF00069 0.706
MOD_CK1_1 211 217 PF00069 0.648
MOD_CK1_1 303 309 PF00069 0.593
MOD_CK1_1 328 334 PF00069 0.668
MOD_CK1_1 364 370 PF00069 0.707
MOD_CK1_1 379 385 PF00069 0.617
MOD_CK1_1 387 393 PF00069 0.722
MOD_CK1_1 407 413 PF00069 0.677
MOD_CK1_1 466 472 PF00069 0.399
MOD_CK1_1 58 64 PF00069 0.712
MOD_CK1_1 649 655 PF00069 0.283
MOD_CK1_1 69 75 PF00069 0.615
MOD_CK1_1 708 714 PF00069 0.399
MOD_CK1_1 717 723 PF00069 0.309
MOD_CK1_1 9 15 PF00069 0.668
MOD_CK2_1 306 312 PF00069 0.587
MOD_CK2_1 451 457 PF00069 0.489
MOD_CK2_1 466 472 PF00069 0.287
MOD_CK2_1 500 506 PF00069 0.399
MOD_CK2_1 578 584 PF00069 0.399
MOD_CK2_1 615 621 PF00069 0.349
MOD_CK2_1 69 75 PF00069 0.725
MOD_CK2_1 708 714 PF00069 0.349
MOD_CK2_1 766 772 PF00069 0.399
MOD_CK2_1 820 826 PF00069 0.484
MOD_DYRK1A_RPxSP_1 413 417 PF00069 0.707
MOD_GlcNHglycan 161 164 PF01048 0.646
MOD_GlcNHglycan 176 179 PF01048 0.610
MOD_GlcNHglycan 221 224 PF01048 0.742
MOD_GlcNHglycan 285 288 PF01048 0.596
MOD_GlcNHglycan 350 353 PF01048 0.599
MOD_GlcNHglycan 386 389 PF01048 0.784
MOD_GlcNHglycan 397 400 PF01048 0.651
MOD_GlcNHglycan 406 409 PF01048 0.710
MOD_GlcNHglycan 68 71 PF01048 0.716
MOD_GlcNHglycan 706 710 PF01048 0.399
MOD_GlcNHglycan 94 97 PF01048 0.683
MOD_GSK3_1 154 161 PF00069 0.653
MOD_GSK3_1 279 286 PF00069 0.715
MOD_GSK3_1 302 309 PF00069 0.595
MOD_GSK3_1 356 363 PF00069 0.685
MOD_GSK3_1 364 371 PF00069 0.681
MOD_GSK3_1 403 410 PF00069 0.784
MOD_GSK3_1 411 418 PF00069 0.657
MOD_GSK3_1 442 449 PF00069 0.621
MOD_GSK3_1 54 61 PF00069 0.721
MOD_GSK3_1 635 642 PF00069 0.360
MOD_GSK3_1 65 72 PF00069 0.603
MOD_GSK3_1 9 16 PF00069 0.686
MOD_N-GLC_1 283 288 PF02516 0.722
MOD_NEK2_1 229 234 PF00069 0.597
MOD_NEK2_1 361 366 PF00069 0.580
MOD_NEK2_1 381 386 PF00069 0.614
MOD_NEK2_1 404 409 PF00069 0.754
MOD_NEK2_1 492 497 PF00069 0.331
MOD_NEK2_1 65 70 PF00069 0.708
MOD_NEK2_1 661 666 PF00069 0.399
MOD_NEK2_1 791 796 PF00069 0.403
MOD_NEK2_1 841 846 PF00069 0.578
MOD_NEK2_1 92 97 PF00069 0.687
MOD_NEK2_2 500 505 PF00069 0.399
MOD_PIKK_1 100 106 PF00454 0.559
MOD_PIKK_1 387 393 PF00454 0.677
MOD_PIKK_1 420 426 PF00454 0.637
MOD_PIKK_1 541 547 PF00454 0.399
MOD_PIKK_1 800 806 PF00454 0.399
MOD_PIKK_1 872 878 PF00454 0.639
MOD_PK_1 368 374 PF00069 0.670
MOD_PK_1 46 52 PF00069 0.719
MOD_PK_1 646 652 PF00069 0.399
MOD_PKA_1 6 12 PF00069 0.713
MOD_PKA_1 800 806 PF00069 0.447
MOD_PKA_2 113 119 PF00069 0.732
MOD_PKA_2 141 147 PF00069 0.622
MOD_PKA_2 174 180 PF00069 0.600
MOD_PKA_2 306 312 PF00069 0.639
MOD_PKA_2 6 12 PF00069 0.713
MOD_PKA_2 717 723 PF00069 0.399
MOD_PKA_2 800 806 PF00069 0.447
MOD_PKA_2 820 826 PF00069 0.399
MOD_Plk_1 446 452 PF00069 0.523
MOD_Plk_1 541 547 PF00069 0.399
MOD_Plk_4 18 24 PF00069 0.608
MOD_Plk_4 646 652 PF00069 0.354
MOD_Plk_4 727 733 PF00069 0.349
MOD_Plk_4 766 772 PF00069 0.399
MOD_ProDKin_1 11 17 PF00069 0.659
MOD_ProDKin_1 118 124 PF00069 0.708
MOD_ProDKin_1 184 190 PF00069 0.661
MOD_ProDKin_1 260 266 PF00069 0.693
MOD_ProDKin_1 316 322 PF00069 0.695
MOD_ProDKin_1 325 331 PF00069 0.634
MOD_ProDKin_1 356 362 PF00069 0.652
MOD_ProDKin_1 376 382 PF00069 0.625
MOD_ProDKin_1 413 419 PF00069 0.665
MOD_ProDKin_1 423 429 PF00069 0.595
MOD_ProDKin_1 578 584 PF00069 0.399
MOD_ProDKin_1 60 66 PF00069 0.711
MOD_ProDKin_1 644 650 PF00069 0.399
MOD_ProDKin_1 849 855 PF00069 0.535
MOD_SUMO_rev_2 664 671 PF00179 0.399
TRG_DiLeu_BaEn_1 584 589 PF01217 0.399
TRG_DiLeu_BaLyEn_6 121 126 PF01217 0.659
TRG_DiLeu_BaLyEn_6 837 842 PF01217 0.601
TRG_ENDOCYTIC_2 20 23 PF00928 0.544
TRG_ENDOCYTIC_2 470 473 PF00928 0.399
TRG_ENDOCYTIC_2 777 780 PF00928 0.399
TRG_ENDOCYTIC_2 845 848 PF00928 0.642
TRG_ER_diArg_1 172 175 PF00400 0.671
TRG_ER_diArg_1 205 208 PF00400 0.681
TRG_ER_diArg_1 238 241 PF00400 0.568
TRG_ER_diArg_1 428 430 PF00400 0.622
TRG_ER_diArg_1 5 7 PF00400 0.704
TRG_ER_diArg_1 691 694 PF00400 0.399
TRG_ER_diArg_1 800 802 PF00400 0.485
TRG_ER_diArg_1 859 861 PF00400 0.556
TRG_ER_diArg_1 877 879 PF00400 0.571
TRG_NLS_MonoExtC_3 203 208 PF00514 0.707
TRG_NLS_MonoExtN_4 201 208 PF00514 0.698
TRG_Pf-PMV_PEXEL_1 597 601 PF00026 0.399
TRG_Pf-PMV_PEXEL_1 741 745 PF00026 0.399

Homologs

Protein Taxonomy Sequence identity Coverage
A4H5K5 Leishmania braziliensis 77% 100%
E9AMN0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QHZ5 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS