Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQJ7_LEIDO

TriTrypDb:

LdBPK_090210.1 , LdCL_090007200 , LDHU3_09.0290

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7WQJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.444
CLV_NRD_NRD_1	7	9	PF00675	0.462
CLV_PCSK_FUR_1	33	37	PF00082	0.453
CLV_PCSK_KEX2_1	35	37	PF00082	0.444
DEG_SPOP_SBC_1	103	107	PF00917	0.506
DOC_USP7_MATH_1	103	107	PF00917	0.515
DOC_USP7_MATH_1	108	112	PF00917	0.458
DOC_USP7_MATH_1	91	95	PF00917	0.557
DOC_WW_Pin1_4	19	24	PF00397	0.620
DOC_WW_Pin1_4	25	30	PF00397	0.659
DOC_WW_Pin1_4	99	104	PF00397	0.548
LIG_14-3-3_CanoR_1	92	101	PF00244	0.466
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	1	5	PF00533	0.646
LIG_EH1_1	43	51	PF00400	0.347
LIG_FHA_1	12	18	PF00498	0.682
LIG_FHA_2	93	99	PF00498	0.571
LIG_LIR_Nem_3	60	66	PF02991	0.422
LIG_LIR_Nem_3	76	82	PF02991	0.454
LIG_NRBOX	16	22	PF00104	0.617
LIG_PTB_Apo_2	53	60	PF02174	0.458
LIG_PTB_Phospho_1	53	59	PF10480	0.461
LIG_SH2_CRK	63	67	PF00017	0.403
LIG_SH2_STAP1	59	63	PF00017	0.394
LIG_SH2_STAT5	19	22	PF00017	0.661
LIG_SH2_STAT5	39	42	PF00017	0.491
LIG_SH2_STAT5	51	54	PF00017	0.162
LIG_SH2_STAT5	61	64	PF00017	0.272
LIG_SH2_STAT5	82	85	PF00017	0.510
LIG_SH3_3	23	29	PF00018	0.608
LIG_SxIP_EBH_1	83	92	PF03271	0.494
LIG_TRFH_1	19	23	PF08558	0.677
MOD_CDC14_SPxK_1	107	110	PF00782	0.467
MOD_CDC14_SPxK_1	22	25	PF00782	0.611
MOD_CDK_SPxK_1	104	110	PF00069	0.468
MOD_CDK_SPxK_1	19	25	PF00069	0.614
MOD_CK1_1	102	108	PF00069	0.573
MOD_CK2_1	25	31	PF00069	0.599
MOD_CK2_1	92	98	PF00069	0.567
MOD_Cter_Amidation	6	9	PF01082	0.494
MOD_DYRK1A_RPxSP_1	25	29	PF00069	0.650
MOD_GlcNHglycan	111	114	PF01048	0.820
MOD_GSK3_1	109	116	PF00069	0.571
MOD_GSK3_1	21	28	PF00069	0.634
MOD_GSK3_1	57	64	PF00069	0.391
MOD_GSK3_1	81	88	PF00069	0.501
MOD_GSK3_1	99	106	PF00069	0.574
MOD_NEK2_1	109	114	PF00069	0.621
MOD_NEK2_1	74	79	PF00069	0.526
MOD_PKA_2	109	115	PF00069	0.530
MOD_PKA_2	12	18	PF00069	0.624
MOD_PKA_2	91	97	PF00069	0.563
MOD_Plk_1	57	63	PF00069	0.392
MOD_Plk_4	74	80	PF00069	0.510
MOD_ProDKin_1	19	25	PF00069	0.614
MOD_ProDKin_1	99	105	PF00069	0.549
TRG_ENDOCYTIC_2	63	66	PF00928	0.404
TRG_ENDOCYTIC_2	82	85	PF00928	0.445
TRG_ER_diArg_1	34	36	PF00400	0.654
TRG_ER_diArg_1	66	69	PF00400	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B9	Leptomonas seymouri	61%	100%
A4H5J4	Leishmania braziliensis	73%	100%
A4HTT7	Leishmania infantum	98%	100%
D0A994	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AML8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QI07	Leishmania major	88%	100%
V5BIJ0	Trypanosoma cruzi	45%	100%