LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WQI9_LEIDO
TriTrypDb:
LdBPK_090130.1 , LdCL_090006200 , LDHU3_09.0180
Length:
221

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A0A3S7WQI9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQI9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 107 111 PF00656 0.600
CLV_C14_Caspase3-7 41 45 PF00656 0.594
CLV_C14_Caspase3-7 88 92 PF00656 0.549
CLV_NRD_NRD_1 131 133 PF00675 0.354
CLV_NRD_NRD_1 204 206 PF00675 0.531
CLV_NRD_NRD_1 209 211 PF00675 0.529
CLV_NRD_NRD_1 22 24 PF00675 0.515
CLV_NRD_NRD_1 68 70 PF00675 0.343
CLV_PCSK_FUR_1 20 24 PF00082 0.377
CLV_PCSK_KEX2_1 123 125 PF00082 0.337
CLV_PCSK_KEX2_1 131 133 PF00082 0.325
CLV_PCSK_KEX2_1 206 208 PF00082 0.535
CLV_PCSK_KEX2_1 22 24 PF00082 0.515
CLV_PCSK_KEX2_1 68 70 PF00082 0.332
CLV_PCSK_PC1ET2_1 123 125 PF00082 0.408
CLV_PCSK_PC1ET2_1 206 208 PF00082 0.604
CLV_PCSK_SKI1_1 104 108 PF00082 0.410
CLV_PCSK_SKI1_1 120 124 PF00082 0.342
CLV_PCSK_SKI1_1 23 27 PF00082 0.476
CLV_PCSK_SKI1_1 68 72 PF00082 0.421
DEG_SPOP_SBC_1 37 41 PF00917 0.673
DOC_CKS1_1 114 119 PF01111 0.576
DOC_CYCLIN_RxL_1 64 75 PF00134 0.613
DOC_MAPK_gen_1 184 192 PF00069 0.371
DOC_MAPK_MEF2A_6 184 192 PF00069 0.329
DOC_PP2B_LxvP_1 188 191 PF13499 0.349
DOC_USP7_MATH_1 31 35 PF00917 0.737
DOC_USP7_MATH_1 37 41 PF00917 0.563
DOC_USP7_MATH_1 62 66 PF00917 0.553
DOC_USP7_MATH_1 8 12 PF00917 0.703
DOC_USP7_UBL2_3 211 215 PF12436 0.356
DOC_WW_Pin1_4 113 118 PF00397 0.673
LIG_14-3-3_CanoR_1 10 18 PF00244 0.715
LIG_14-3-3_CanoR_1 184 189 PF00244 0.354
LIG_14-3-3_CanoR_1 20 26 PF00244 0.740
LIG_Actin_WH2_2 59 74 PF00022 0.533
LIG_APCC_ABBA_1 100 105 PF00400 0.507
LIG_BIR_II_1 1 5 PF00653 0.611
LIG_eIF4E_1 133 139 PF01652 0.578
LIG_FHA_1 185 191 PF00498 0.353
LIG_FHA_1 92 98 PF00498 0.587
LIG_FHA_2 105 111 PF00498 0.602
LIG_FHA_2 39 45 PF00498 0.641
LIG_GBD_Chelix_1 151 159 PF00786 0.331
LIG_LIR_Nem_3 116 121 PF02991 0.552
LIG_LIR_Nem_3 162 168 PF02991 0.344
LIG_LIR_Nem_3 182 188 PF02991 0.264
LIG_LIR_Nem_3 65 70 PF02991 0.517
LIG_NRBOX 154 160 PF00104 0.411
LIG_SH2_CRK 185 189 PF00017 0.371
LIG_SH2_CRK 67 71 PF00017 0.505
LIG_SH2_STAP1 134 138 PF00017 0.558
LIG_SH2_STAT5 157 160 PF00017 0.300
LIG_TRAF2_1 73 76 PF00917 0.615
MOD_CDK_SPxxK_3 113 120 PF00069 0.498
MOD_CK1_1 137 143 PF00069 0.349
MOD_CK1_1 36 42 PF00069 0.740
MOD_CK1_1 6 12 PF00069 0.607
MOD_GlcNHglycan 1 4 PF01048 0.523
MOD_GlcNHglycan 11 14 PF01048 0.479
MOD_GlcNHglycan 35 38 PF01048 0.653
MOD_GlcNHglycan 41 44 PF01048 0.530
MOD_GlcNHglycan 56 60 PF01048 0.486
MOD_GSK3_1 105 112 PF00069 0.361
MOD_GSK3_1 31 38 PF00069 0.662
MOD_GSK3_1 85 92 PF00069 0.487
MOD_NEK2_1 159 164 PF00069 0.451
MOD_NEK2_1 35 40 PF00069 0.687
MOD_NEK2_1 55 60 PF00069 0.499
MOD_NEK2_1 89 94 PF00069 0.471
MOD_NEK2_2 62 67 PF00069 0.356
MOD_PK_1 186 192 PF00069 0.421
MOD_PKA_2 21 27 PF00069 0.547
MOD_PKA_2 9 15 PF00069 0.661
MOD_PKB_1 184 192 PF00069 0.423
MOD_Plk_1 104 110 PF00069 0.384
MOD_Plk_2-3 105 111 PF00069 0.381
MOD_Plk_4 62 68 PF00069 0.372
MOD_ProDKin_1 113 119 PF00069 0.607
TRG_DiLeu_BaLyEn_6 66 71 PF01217 0.510
TRG_DiLeu_BaLyEn_6 95 100 PF01217 0.377
TRG_ENDOCYTIC_2 157 160 PF00928 0.311
TRG_ENDOCYTIC_2 185 188 PF00928 0.456
TRG_ENDOCYTIC_2 67 70 PF00928 0.385
TRG_ER_diArg_1 131 133 PF00400 0.449
TRG_ER_diArg_1 145 148 PF00400 0.504
TRG_ER_diArg_1 20 23 PF00400 0.612
TRG_ER_diArg_1 67 69 PF00400 0.396
TRG_NES_CRM1_1 91 105 PF08389 0.316
TRG_NLS_MonoExtN_4 120 127 PF00514 0.408
TRG_Pf-PMV_PEXEL_1 207 212 PF00026 0.555
TRG_Pf-PMV_PEXEL_1 46 51 PF00026 0.564

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCG1 Leptomonas seymouri 75% 100%
A0A0S4JU75 Bodo saltans 33% 100%
A0A1X0NNG1 Trypanosomatidae 48% 100%
A0A422NED0 Trypanosoma rangeli 43% 100%
A4H5I8 Leishmania braziliensis 90% 100%
A4HTS9 Leishmania infantum 100% 100%
D0A990 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AML2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QI24 Leishmania major 93% 100%
V5B321 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS