Catalytic subunit of the vacuolar transporter chaperone 4, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQI7_LEIDO

TriTrypDb:

LdBPK_090430.1 , LdCL_090007500 , LDHU3_09.0320

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0020022	acidocalcisome	5	1
GO:0032991	protein-containing complex	1	1
GO:0033254	vacuolar transporter chaperone complex	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0101031	protein folding chaperone complex	3	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S7WQI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQI7

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006799	polyphosphate biosynthetic process	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.383
CLV_C14_Caspase3-7	808	812	PF00656	0.344
CLV_NRD_NRD_1	212	214	PF00675	0.168
CLV_NRD_NRD_1	275	277	PF00675	0.155
CLV_NRD_NRD_1	327	329	PF00675	0.155
CLV_NRD_NRD_1	355	357	PF00675	0.248
CLV_NRD_NRD_1	629	631	PF00675	0.294
CLV_NRD_NRD_1	63	65	PF00675	0.208
CLV_NRD_NRD_1	764	766	PF00675	0.235
CLV_NRD_NRD_1	769	771	PF00675	0.293

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C3	Leptomonas seymouri	82%	99%
A0A0S4J2S6	Bodo saltans	58%	100%
A0A0S4JCW1	Bodo saltans	26%	83%
A0A1X0NMU3	Trypanosomatidae	69%	100%
A0A422NDG2	Trypanosoma rangeli	68%	100%
A4H5J7	Leishmania braziliensis	88%	100%
A4HTX5	Leishmania infantum	100%	100%
D0A996	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AMM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P47075	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%

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