Catalytic subunit of the vacuolar transporter chaperone 4, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQI7_LEIDO

TriTrypDb:

LdBPK_090430.1 , LdCL_090007500 , LDHU3_09.0320

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0020022	acidocalcisome	5	1
GO:0032991	protein-containing complex	1	1
GO:0033254	vacuolar transporter chaperone complex	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0101031	protein folding chaperone complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A0A3S7WQI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQI7

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006799	polyphosphate biosynthetic process	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.383
CLV_C14_Caspase3-7	808	812	PF00656	0.344
CLV_NRD_NRD_1	212	214	PF00675	0.168
CLV_NRD_NRD_1	275	277	PF00675	0.155
CLV_NRD_NRD_1	327	329	PF00675	0.155
CLV_NRD_NRD_1	355	357	PF00675	0.248
CLV_NRD_NRD_1	629	631	PF00675	0.294
CLV_NRD_NRD_1	63	65	PF00675	0.208
CLV_NRD_NRD_1	764	766	PF00675	0.235
CLV_NRD_NRD_1	769	771	PF00675	0.293
CLV_NRD_NRD_1	801	803	PF00675	0.539
CLV_PCSK_FUR_1	762	766	PF00082	0.162
CLV_PCSK_KEX2_1	105	107	PF00082	0.401
CLV_PCSK_KEX2_1	212	214	PF00082	0.189
CLV_PCSK_KEX2_1	275	277	PF00082	0.155
CLV_PCSK_KEX2_1	326	328	PF00082	0.155
CLV_PCSK_KEX2_1	354	356	PF00082	0.246
CLV_PCSK_KEX2_1	605	607	PF00082	0.368
CLV_PCSK_KEX2_1	629	631	PF00082	0.286
CLV_PCSK_KEX2_1	675	677	PF00082	0.340
CLV_PCSK_KEX2_1	764	766	PF00082	0.235
CLV_PCSK_KEX2_1	769	771	PF00082	0.293
CLV_PCSK_KEX2_1	801	803	PF00082	0.539
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.286
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.155
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.246
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.368
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.340
CLV_PCSK_PC7_1	323	329	PF00082	0.155
CLV_PCSK_PC7_1	765	771	PF00082	0.294
CLV_PCSK_SKI1_1	105	109	PF00082	0.272
CLV_PCSK_SKI1_1	213	217	PF00082	0.170
CLV_PCSK_SKI1_1	269	273	PF00082	0.171
CLV_PCSK_SKI1_1	28	32	PF00082	0.232
CLV_PCSK_SKI1_1	383	387	PF00082	0.161
CLV_PCSK_SKI1_1	392	396	PF00082	0.148
CLV_PCSK_SKI1_1	531	535	PF00082	0.371
CLV_PCSK_SKI1_1	675	679	PF00082	0.360
CLV_PCSK_SKI1_1	686	690	PF00082	0.142
CLV_PCSK_SKI1_1	717	721	PF00082	0.446
CLV_PCSK_SKI1_1	81	85	PF00082	0.357
CLV_PCSK_SKI1_1	92	96	PF00082	0.365
CLV_Separin_Metazoa	122	126	PF03568	0.382
DEG_APCC_KENBOX_2	34	38	PF00400	0.558
DEG_SPOP_SBC_1	585	589	PF00917	0.676
DOC_CKS1_1	41	46	PF01111	0.448
DOC_CYCLIN_RxL_1	101	111	PF00134	0.491
DOC_CYCLIN_RxL_1	714	724	PF00134	0.246
DOC_MAPK_gen_1	212	221	PF00069	0.383
DOC_MAPK_gen_1	245	254	PF00069	0.360
DOC_MAPK_gen_1	64	72	PF00069	0.404
DOC_MAPK_HePTP_8	501	513	PF00069	0.484
DOC_MAPK_MEF2A_6	230	237	PF00069	0.370
DOC_MAPK_MEF2A_6	504	513	PF00069	0.494
DOC_MAPK_MEF2A_6	65	74	PF00069	0.386
DOC_PP1_RVXF_1	529	535	PF00149	0.527
DOC_PP2B_LxvP_1	198	201	PF13499	0.545
DOC_PP2B_LxvP_1	719	722	PF13499	0.246
DOC_SPAK_OSR1_1	328	332	PF12202	0.404
DOC_USP7_MATH_1	204	208	PF00917	0.616
DOC_USP7_MATH_1	259	263	PF00917	0.362
DOC_USP7_MATH_1	365	369	PF00917	0.352
DOC_USP7_MATH_1	39	43	PF00917	0.493
DOC_USP7_MATH_1	576	580	PF00917	0.554
DOC_USP7_MATH_1	6	10	PF00917	0.447
DOC_USP7_MATH_1	654	658	PF00917	0.600
DOC_USP7_UBL2_3	101	105	PF12436	0.540
DOC_USP7_UBL2_3	241	245	PF12436	0.360
DOC_USP7_UBL2_3	678	682	PF12436	0.536
DOC_WW_Pin1_4	255	260	PF00397	0.362
DOC_WW_Pin1_4	40	45	PF00397	0.450
DOC_WW_Pin1_4	428	433	PF00397	0.383
DOC_WW_Pin1_4	726	731	PF00397	0.204
LIG_14-3-3_CanoR_1	130	140	PF00244	0.431
LIG_14-3-3_CanoR_1	184	192	PF00244	0.456
LIG_14-3-3_CanoR_1	212	216	PF00244	0.362
LIG_14-3-3_CanoR_1	412	420	PF00244	0.371
LIG_14-3-3_CanoR_1	504	511	PF00244	0.553
LIG_14-3-3_CanoR_1	563	569	PF00244	0.434
LIG_14-3-3_CanoR_1	92	97	PF00244	0.492
LIG_Actin_WH2_2	112	127	PF00022	0.395
LIG_Actin_WH2_2	370	385	PF00022	0.362
LIG_APCC_ABBA_1	312	317	PF00400	0.355
LIG_APCC_ABBA_1	639	644	PF00400	0.534
LIG_APCC_ABBAyCdc20_2	8	14	PF00400	0.436
LIG_BRCT_BRCA1_1	206	210	PF00533	0.518
LIG_BRCT_BRCA1_1	711	715	PF00533	0.297
LIG_BRCT_BRCA1_1	809	813	PF00533	0.317
LIG_BRCT_BRCA1_2	711	717	PF00533	0.297
LIG_EH1_1	225	233	PF00400	0.355
LIG_eIF4E_1	683	689	PF01652	0.460
LIG_FHA_1	132	138	PF00498	0.436
LIG_FHA_1	25	31	PF00498	0.438
LIG_FHA_1	484	490	PF00498	0.422
LIG_FHA_1	515	521	PF00498	0.521
LIG_FHA_1	539	545	PF00498	0.627
LIG_FHA_1	634	640	PF00498	0.543
LIG_FHA_1	645	651	PF00498	0.586
LIG_FHA_1	69	75	PF00498	0.386
LIG_FHA_1	738	744	PF00498	0.222
LIG_FHA_1	782	788	PF00498	0.187
LIG_FHA_2	200	206	PF00498	0.680
LIG_FHA_2	237	243	PF00498	0.355
LIG_FHA_2	292	298	PF00498	0.446
LIG_FHA_2	41	47	PF00498	0.442
LIG_FHA_2	425	431	PF00498	0.427
LIG_FHA_2	505	511	PF00498	0.573
LIG_FHA_2	591	597	PF00498	0.626
LIG_FHA_2	806	812	PF00498	0.263
LIG_FHA_2	82	88	PF00498	0.494
LIG_GBD_Chelix_1	115	123	PF00786	0.189
LIG_LIR_Gen_1	163	174	PF02991	0.418
LIG_LIR_Gen_1	179	189	PF02991	0.394
LIG_LIR_Gen_1	297	306	PF02991	0.356
LIG_LIR_Gen_1	45	56	PF02991	0.412
LIG_LIR_Gen_1	486	496	PF02991	0.415
LIG_LIR_Gen_1	555	565	PF02991	0.521
LIG_LIR_Gen_1	589	599	PF02991	0.531
LIG_LIR_Gen_1	734	744	PF02991	0.193
LIG_LIR_Gen_1	751	761	PF02991	0.134
LIG_LIR_Gen_1	781	789	PF02991	0.182
LIG_LIR_Gen_1	790	799	PF02991	0.174
LIG_LIR_Nem_3	155	160	PF02991	0.433
LIG_LIR_Nem_3	163	169	PF02991	0.408
LIG_LIR_Nem_3	172	178	PF02991	0.369
LIG_LIR_Nem_3	179	185	PF02991	0.395
LIG_LIR_Nem_3	297	302	PF02991	0.356
LIG_LIR_Nem_3	306	312	PF02991	0.357
LIG_LIR_Nem_3	364	369	PF02991	0.371
LIG_LIR_Nem_3	45	51	PF02991	0.421
LIG_LIR_Nem_3	555	560	PF02991	0.525
LIG_LIR_Nem_3	589	595	PF02991	0.529
LIG_LIR_Nem_3	635	640	PF02991	0.498
LIG_LIR_Nem_3	703	708	PF02991	0.297
LIG_LIR_Nem_3	734	739	PF02991	0.196
LIG_LIR_Nem_3	751	757	PF02991	0.141
LIG_LIR_Nem_3	781	785	PF02991	0.182
LIG_LIR_Nem_3	788	794	PF02991	0.174
LIG_LIR_Nem_3	9	15	PF02991	0.431
LIG_LYPXL_S_1	11	15	PF13949	0.225
LIG_LYPXL_SIV_4	437	445	PF13949	0.355
LIG_MYND_1	617	621	PF01753	0.536
LIG_PCNA_yPIPBox_3	168	180	PF02747	0.393
LIG_PDZ_Class_3	808	813	PF00595	0.260
LIG_Pex14_1	157	161	PF04695	0.516
LIG_Pex14_1	732	736	PF04695	0.162
LIG_Pex14_1	782	786	PF04695	0.267
LIG_PTB_Apo_2	264	271	PF02174	0.383
LIG_Rb_LxCxE_1	442	459	PF01857	0.355
LIG_RPA_C_Fungi	760	772	PF08784	0.321
LIG_SH2_CRK	147	151	PF00017	0.301
LIG_SH2_CRK	166	170	PF00017	0.241
LIG_SH2_CRK	182	186	PF00017	0.223
LIG_SH2_CRK	48	52	PF00017	0.248
LIG_SH2_CRK	557	561	PF00017	0.260
LIG_SH2_CRK	666	670	PF00017	0.478
LIG_SH2_CRK	754	758	PF00017	0.179
LIG_SH2_GRB2like	265	268	PF00017	0.238
LIG_SH2_NCK_1	166	170	PF00017	0.327
LIG_SH2_NCK_1	438	442	PF00017	0.170
LIG_SH2_NCK_1	557	561	PF00017	0.294
LIG_SH2_SRC	475	478	PF00017	0.179
LIG_SH2_SRC	754	757	PF00017	0.191
LIG_SH2_SRC	774	777	PF00017	0.242
LIG_SH2_STAP1	291	295	PF00017	0.238
LIG_SH2_STAP1	3	7	PF00017	0.412
LIG_SH2_STAP1	48	52	PF00017	0.375
LIG_SH2_STAP1	557	561	PF00017	0.276
LIG_SH2_STAP1	774	778	PF00017	0.342
LIG_SH2_STAT5	161	164	PF00017	0.347
LIG_SH2_STAT5	21	24	PF00017	0.244
LIG_SH2_STAT5	426	429	PF00017	0.221
LIG_SH2_STAT5	634	637	PF00017	0.351
LIG_SH2_STAT5	756	759	PF00017	0.191
LIG_SH2_STAT5	82	85	PF00017	0.302
LIG_SH3_1	230	236	PF00018	0.179
LIG_SH3_3	146	152	PF00018	0.307
LIG_SH3_3	230	236	PF00018	0.179
LIG_SH3_3	38	44	PF00018	0.319
LIG_SH3_3	774	780	PF00018	0.353
LIG_SH3_5	553	557	PF00018	0.338
LIG_Sin3_3	746	753	PF02671	0.147
LIG_SUMO_SIM_par_1	68	73	PF11976	0.236
LIG_TRAF2_1	170	173	PF00917	0.348
LIG_TRAF2_1	301	304	PF00917	0.179
LIG_TRAF2_1	358	361	PF00917	0.239
LIG_TRAF2_1	84	87	PF00917	0.366
LIG_TRFH_1	380	384	PF08558	0.179
LIG_TRFH_1	637	641	PF08558	0.406
LIG_TYR_ITIM	664	669	PF00017	0.488
LIG_TYR_ITIM	752	757	PF00017	0.176
LIG_TYR_ITIM	772	777	PF00017	0.273
LIG_TYR_ITSM	553	560	PF00017	0.326
LIG_UBA3_1	30	35	PF00899	0.288
LIG_WRC_WIRS_1	237	242	PF05994	0.191
LIG_WRC_WIRS_1	634	639	PF05994	0.435
MOD_CK1_1	199	205	PF00069	0.436
MOD_CK1_1	258	264	PF00069	0.185
MOD_CK1_1	406	412	PF00069	0.170
MOD_CK1_1	431	437	PF00069	0.209
MOD_CK1_1	487	493	PF00069	0.235
MOD_CK2_1	167	173	PF00069	0.235
MOD_CK2_1	199	205	PF00069	0.628
MOD_CK2_1	240	246	PF00069	0.247
MOD_CK2_1	291	297	PF00069	0.297
MOD_CK2_1	356	362	PF00069	0.209
MOD_CK2_1	40	46	PF00069	0.303
MOD_CK2_1	47	53	PF00069	0.249
MOD_CK2_1	504	510	PF00069	0.469
MOD_CK2_1	81	87	PF00069	0.353
MOD_Cter_Amidation	673	676	PF01082	0.419
MOD_GlcNHglycan	101	104	PF01048	0.480
MOD_GlcNHglycan	192	195	PF01048	0.389
MOD_GlcNHglycan	319	322	PF01048	0.179
MOD_GlcNHglycan	369	372	PF01048	0.140
MOD_GlcNHglycan	413	416	PF01048	0.202
MOD_GlcNHglycan	577	581	PF01048	0.527
MOD_GlcNHglycan	8	11	PF01048	0.305
MOD_GSK3_1	236	243	PF00069	0.179
MOD_GSK3_1	255	262	PF00069	0.179
MOD_GSK3_1	317	324	PF00069	0.179
MOD_GSK3_1	424	431	PF00069	0.238
MOD_GSK3_1	483	490	PF00069	0.242
MOD_GSK3_1	540	547	PF00069	0.509
MOD_GSK3_1	572	579	PF00069	0.459
MOD_GSK3_1	580	587	PF00069	0.486
MOD_GSK3_1	640	647	PF00069	0.546
MOD_GSK3_1	684	691	PF00069	0.170
MOD_GSK3_1	77	84	PF00069	0.268
MOD_GSK3_1	781	788	PF00069	0.159
MOD_GSK3_1	805	812	PF00069	0.379
MOD_GSK3_1	90	97	PF00069	0.369
MOD_N-GLC_1	356	361	PF02516	0.209
MOD_N-GLC_1	580	585	PF02516	0.437
MOD_N-GLC_1	644	649	PF02516	0.419
MOD_N-GLC_1	90	95	PF02516	0.402
MOD_NEK2_1	240	245	PF00069	0.179
MOD_NEK2_1	47	52	PF00069	0.255
MOD_NEK2_1	632	637	PF00069	0.617
MOD_NEK2_1	70	75	PF00069	0.350
MOD_NEK2_1	701	706	PF00069	0.274
MOD_NEK2_1	708	713	PF00069	0.195
MOD_NEK2_1	785	790	PF00069	0.175
MOD_NEK2_2	236	241	PF00069	0.179
MOD_NEK2_2	259	264	PF00069	0.179
MOD_NEK2_2	478	483	PF00069	0.179
MOD_NEK2_2	633	638	PF00069	0.412
MOD_NEK2_2	709	714	PF00069	0.274
MOD_PIKK_1	204	210	PF00454	0.400
MOD_PIKK_1	385	391	PF00454	0.170
MOD_PIKK_1	538	544	PF00454	0.440
MOD_PKA_2	190	196	PF00069	0.390
MOD_PKA_2	211	217	PF00069	0.185
MOD_PKA_2	403	409	PF00069	0.170
MOD_PKA_2	411	417	PF00069	0.170
MOD_PKA_2	424	430	PF00069	0.190
MOD_PKA_2	503	509	PF00069	0.336
MOD_PKB_1	287	295	PF00069	0.209
MOD_Plk_1	580	586	PF00069	0.443
MOD_Plk_1	90	96	PF00069	0.385
MOD_Plk_2-3	167	173	PF00069	0.332
MOD_Plk_4	259	265	PF00069	0.170
MOD_Plk_4	281	287	PF00069	0.170
MOD_Plk_4	342	348	PF00069	0.228
MOD_Plk_4	47	53	PF00069	0.258
MOD_Plk_4	478	484	PF00069	0.179
MOD_Plk_4	684	690	PF00069	0.170
MOD_Plk_4	778	784	PF00069	0.174
MOD_Plk_4	787	793	PF00069	0.165
MOD_ProDKin_1	255	261	PF00069	0.179
MOD_ProDKin_1	40	46	PF00069	0.303
MOD_ProDKin_1	428	434	PF00069	0.209
MOD_ProDKin_1	726	732	PF00069	0.238
MOD_SUMO_rev_2	17	27	PF00179	0.346
MOD_SUMO_rev_2	305	314	PF00179	0.174
MOD_SUMO_rev_2	375	385	PF00179	0.193
MOD_SUMO_rev_2	50	56	PF00179	0.227
MOD_SUMO_rev_2	596	603	PF00179	0.604
MOD_SUMO_rev_2	60	67	PF00179	0.202
MOD_SUMO_rev_2	648	657	PF00179	0.552
TRG_DiLeu_BaEn_1	281	286	PF01217	0.179
TRG_DiLeu_BaEn_2	121	127	PF01217	0.214
TRG_DiLeu_BaEn_2	334	340	PF01217	0.297
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.463
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.293
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.462
TRG_ENDOCYTIC_2	12	15	PF00928	0.256
TRG_ENDOCYTIC_2	147	150	PF00928	0.300
TRG_ENDOCYTIC_2	166	169	PF00928	0.241
TRG_ENDOCYTIC_2	182	185	PF00928	0.204
TRG_ENDOCYTIC_2	438	441	PF00928	0.190
TRG_ENDOCYTIC_2	48	51	PF00928	0.250
TRG_ENDOCYTIC_2	557	560	PF00928	0.371
TRG_ENDOCYTIC_2	561	564	PF00928	0.384
TRG_ENDOCYTIC_2	634	637	PF00928	0.351
TRG_ENDOCYTIC_2	666	669	PF00928	0.488
TRG_ENDOCYTIC_2	754	757	PF00928	0.170
TRG_ENDOCYTIC_2	774	777	PF00928	0.242
TRG_ENDOCYTIC_2	803	806	PF00928	0.273
TRG_ER_diArg_1	275	277	PF00400	0.170
TRG_ER_diArg_1	286	289	PF00400	0.170
TRG_ER_diArg_1	327	329	PF00400	0.170
TRG_ER_diArg_1	402	405	PF00400	0.158
TRG_ER_diArg_1	762	765	PF00400	0.179
TRG_ER_diArg_1	801	803	PF00400	0.428
TRG_NLS_MonoExtC_3	769	775	PF00514	0.342
TRG_NLS_MonoExtN_4	323	330	PF00514	0.170
TRG_NLS_MonoExtN_4	352	358	PF00514	0.297
TRG_NLS_MonoExtN_4	769	774	PF00514	0.346
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.193
TRG_Pf-PMV_PEXEL_1	566	571	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C3	Leptomonas seymouri	82%	99%
A0A0S4J2S6	Bodo saltans	58%	100%
A0A0S4JCW1	Bodo saltans	26%	83%
A0A1X0NMU3	Trypanosomatidae	69%	100%
A0A422NDG2	Trypanosoma rangeli	68%	100%
A4H5J7	Leishmania braziliensis	88%	100%
A4HTX5	Leishmania infantum	100%	100%
D0A996	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AMM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P47075	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P78810	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q4QI04	Leishmania major	97%	100%
V5BIC5	Trypanosoma cruzi	67%	100%