Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WQG6_LEIDO

TriTrypDb:

LdBPK_090020.1 , LdCL_090005100 , LDHU3_09.0030

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7WQG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQG6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0042273	ribosomal large subunit biogenesis	5	11
GO:0044085	cellular component biogenesis	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.604
CLV_C14_Caspase3-7	54	58	PF00656	0.295
CLV_NRD_NRD_1	127	129	PF00675	0.359
CLV_NRD_NRD_1	200	202	PF00675	0.376
CLV_NRD_NRD_1	218	220	PF00675	0.350
CLV_NRD_NRD_1	246	248	PF00675	0.445
CLV_NRD_NRD_1	281	283	PF00675	0.341
CLV_NRD_NRD_1	33	35	PF00675	0.359
CLV_NRD_NRD_1	366	368	PF00675	0.610
CLV_NRD_NRD_1	370	372	PF00675	0.583
CLV_PCSK_KEX2_1	200	202	PF00082	0.376
CLV_PCSK_KEX2_1	218	220	PF00082	0.350
CLV_PCSK_KEX2_1	246	248	PF00082	0.445
CLV_PCSK_KEX2_1	35	37	PF00082	0.345
CLV_PCSK_KEX2_1	366	368	PF00082	0.586
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.324
CLV_PCSK_PC7_1	196	202	PF00082	0.350
CLV_PCSK_PC7_1	214	220	PF00082	0.316
CLV_PCSK_SKI1_1	92	96	PF00082	0.447
DEG_SCF_FBW7_1	109	114	PF00400	0.352
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.354
DOC_MAPK_gen_1	160	169	PF00069	0.363
DOC_MAPK_gen_1	301	309	PF00069	0.310
DOC_MAPK_MEF2A_6	163	171	PF00069	0.487
DOC_MAPK_MEF2A_6	293	300	PF00069	0.455
DOC_PP2B_LxvP_1	167	170	PF13499	0.375
DOC_USP7_MATH_1	111	115	PF00917	0.443
DOC_USP7_MATH_1	362	366	PF00917	0.478
DOC_USP7_MATH_1	52	56	PF00917	0.436
DOC_USP7_UBL2_3	329	333	PF12436	0.505
DOC_USP7_UBL2_3	368	372	PF12436	0.594
DOC_WW_Pin1_4	107	112	PF00397	0.535
LIG_14-3-3_CanoR_1	218	224	PF00244	0.437
LIG_Actin_WH2_2	10	28	PF00022	0.478
LIG_BIR_II_1	1	5	PF00653	0.322
LIG_BRCT_BRCA1_1	111	115	PF00533	0.500
LIG_BRCT_BRCA1_1	49	53	PF00533	0.442
LIG_FHA_1	219	225	PF00498	0.374
LIG_FHA_1	289	295	PF00498	0.362
LIG_FHA_1	46	52	PF00498	0.343
LIG_FHA_1	7	13	PF00498	0.302
LIG_FHA_2	276	282	PF00498	0.462
LIG_FHA_2	3	9	PF00498	0.295
LIG_FHA_2	334	340	PF00498	0.523
LIG_IBAR_NPY_1	182	184	PF08397	0.453
LIG_IRF3_LxIS_1	59	66	PF10401	0.250
LIG_LIR_Gen_1	190	198	PF02991	0.298
LIG_LIR_Gen_1	339	349	PF02991	0.492
LIG_LIR_Gen_1	57	65	PF02991	0.245
LIG_LIR_Nem_3	168	174	PF02991	0.381
LIG_LIR_Nem_3	190	195	PF02991	0.299
LIG_LIR_Nem_3	320	325	PF02991	0.435
LIG_LIR_Nem_3	57	62	PF02991	0.245
LIG_SH2_CRK	192	196	PF00017	0.349
LIG_SH2_CRK	287	291	PF00017	0.332
LIG_SH2_NCK_1	145	149	PF00017	0.391
LIG_SH2_SRC	68	71	PF00017	0.301
LIG_SH2_STAT3	299	302	PF00017	0.334
LIG_SH2_STAT5	184	187	PF00017	0.331
LIG_SH2_STAT5	299	302	PF00017	0.405
LIG_SH2_STAT5	68	71	PF00017	0.378
LIG_SH3_3	149	155	PF00018	0.332
LIG_SH3_3	166	172	PF00018	0.400
LIG_SUMO_SIM_par_1	61	67	PF11976	0.342
LIG_SUMO_SIM_par_1	92	97	PF11976	0.410
LIG_TRAF2_1	151	154	PF00917	0.504
LIG_TRAF2_1	206	209	PF00917	0.370
LIG_TYR_ITSM	188	195	PF00017	0.287
MOD_CK1_1	103	109	PF00069	0.496
MOD_CK1_1	113	119	PF00069	0.511
MOD_CK1_1	18	24	PF00069	0.405
MOD_CK1_1	47	53	PF00069	0.342
MOD_CK2_1	25	31	PF00069	0.420
MOD_GlcNHglycan	115	118	PF01048	0.565
MOD_GlcNHglycan	20	23	PF01048	0.518
MOD_GlcNHglycan	235	239	PF01048	0.324
MOD_GlcNHglycan	322	325	PF01048	0.513
MOD_GSK3_1	107	114	PF00069	0.494
MOD_GSK3_1	17	24	PF00069	0.378
MOD_GSK3_1	2	9	PF00069	0.301
MOD_GSK3_1	358	365	PF00069	0.472
MOD_GSK3_1	47	54	PF00069	0.457
MOD_GSK3_1	99	106	PF00069	0.428
MOD_N-GLC_1	45	50	PF02516	0.401
MOD_NEK2_1	242	247	PF00069	0.332
MOD_NEK2_1	25	30	PF00069	0.371
MOD_NEK2_1	275	280	PF00069	0.450
MOD_NEK2_1	294	299	PF00069	0.321
MOD_NEK2_2	100	105	PF00069	0.332
MOD_NEK2_2	258	263	PF00069	0.330
MOD_PIKK_1	360	366	PF00454	0.478
MOD_PKA_1	218	224	PF00069	0.437
MOD_PKA_2	199	205	PF00069	0.382
MOD_PKA_2	218	224	PF00069	0.243
MOD_Plk_1	100	106	PF00069	0.376
MOD_Plk_4	100	106	PF00069	0.378
MOD_Plk_4	219	225	PF00069	0.319
MOD_Plk_4	294	300	PF00069	0.338
MOD_Plk_4	58	64	PF00069	0.303
MOD_Plk_4	84	90	PF00069	0.357
MOD_ProDKin_1	107	113	PF00069	0.533
MOD_SUMO_rev_2	350	357	PF00179	0.565
TRG_ENDOCYTIC_2	192	195	PF00928	0.353
TRG_ER_diArg_1	218	220	PF00400	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9A9	Leptomonas seymouri	79%	100%
A0A1X0NMW6	Trypanosomatidae	68%	100%
A0A422NE17	Trypanosoma rangeli	66%	100%
A4H5H7	Leishmania braziliensis	86%	100%
A4HTR8	Leishmania infantum	100%	100%
D0A977	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	96%
E9AMK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O94698	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	96%
Q4QI35	Leishmania major	92%	100%
Q58D06	Bos taurus	28%	97%
Q6CEC9	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	91%
Q6RFH5	Homo sapiens	28%	97%
Q8VCG3	Mus musculus	29%	97%
V5BIB3	Trypanosoma cruzi	64%	100%