Ring finger domain/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQF3_LEIDO

TriTrypDb:

LdBPK_081001.1 , LdCL_080015600 , LDHU3_08.1440

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQF3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004842	ubiquitin-protein transferase activity	4	10
GO:0005488	binding	1	9
GO:0016740	transferase activity	2	10
GO:0019787	ubiquitin-like protein transferase activity	3	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0061630	ubiquitin protein ligase activity	5	10
GO:0061659	ubiquitin-like protein ligase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0008270	zinc ion binding	6	4
GO:0046914	transition metal ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.626
CLV_NRD_NRD_1	12	14	PF00675	0.544
CLV_NRD_NRD_1	185	187	PF00675	0.491
CLV_NRD_NRD_1	243	245	PF00675	0.504
CLV_NRD_NRD_1	264	266	PF00675	0.599
CLV_NRD_NRD_1	274	276	PF00675	0.472
CLV_NRD_NRD_1	311	313	PF00675	0.447
CLV_PCSK_FUR_1	9	13	PF00082	0.292
CLV_PCSK_KEX2_1	11	13	PF00082	0.478
CLV_PCSK_KEX2_1	185	187	PF00082	0.509
CLV_PCSK_KEX2_1	242	244	PF00082	0.559
CLV_PCSK_KEX2_1	264	266	PF00082	0.560
CLV_PCSK_KEX2_1	274	276	PF00082	0.482
CLV_PCSK_KEX2_1	97	99	PF00082	0.470
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.604
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.543
CLV_PCSK_SKI1_1	103	107	PF00082	0.482
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DOC_SPAK_OSR1_1	32	36	PF12202	0.399
DOC_USP7_MATH_1	132	136	PF00917	0.598
DOC_USP7_MATH_1	17	21	PF00917	0.478
DOC_USP7_MATH_1	207	211	PF00917	0.570
DOC_USP7_MATH_2	255	261	PF00917	0.397
DOC_USP7_UBL2_3	294	298	PF12436	0.316
LIG_14-3-3_CanoR_1	185	191	PF00244	0.533
LIG_14-3-3_CanoR_1	209	215	PF00244	0.446
LIG_BRCT_BRCA1_1	195	199	PF00533	0.492
LIG_Clathr_ClatBox_1	235	239	PF01394	0.439
LIG_FHA_1	109	115	PF00498	0.570
LIG_FHA_1	172	178	PF00498	0.382
LIG_FHA_1	209	215	PF00498	0.596
LIG_FHA_1	62	68	PF00498	0.368
LIG_FHA_2	323	329	PF00498	0.702
LIG_LIR_Gen_1	170	181	PF02991	0.440
LIG_LIR_Gen_1	230	238	PF02991	0.403
LIG_LIR_Gen_1	301	309	PF02991	0.303
LIG_LIR_Nem_3	170	176	PF02991	0.468
LIG_LIR_Nem_3	221	227	PF02991	0.497
LIG_LIR_Nem_3	230	235	PF02991	0.377
LIG_LIR_Nem_3	301	306	PF02991	0.303
LIG_NRBOX	64	70	PF00104	0.377
LIG_Pex14_1	299	303	PF04695	0.375
LIG_REV1ctd_RIR_1	69	77	PF16727	0.470
LIG_SH2_CRK	173	177	PF00017	0.432
LIG_SH2_GRB2like	85	88	PF00017	0.576
LIG_SH2_STAP1	173	177	PF00017	0.477
LIG_SH2_STAP1	232	236	PF00017	0.432
LIG_SH2_STAT5	173	176	PF00017	0.430
LIG_SH2_STAT5	181	184	PF00017	0.374
LIG_SH2_STAT5	188	191	PF00017	0.415
LIG_SH2_STAT5	258	261	PF00017	0.506
LIG_SH2_STAT5	85	88	PF00017	0.441
LIG_SH3_1	192	198	PF00018	0.435
LIG_SH3_3	192	198	PF00018	0.557
LIG_SH3_3	349	355	PF00018	0.562
LIG_SH3_4	330	337	PF00018	0.482
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.368
LIG_SUMO_SIM_par_1	233	239	PF11976	0.535
LIG_TYR_ITIM	222	227	PF00017	0.486
LIG_UBA3_1	235	242	PF00899	0.572
MOD_CK1_1	110	116	PF00069	0.545
MOD_CK1_1	15	21	PF00069	0.425
MOD_CK1_1	210	216	PF00069	0.617
MOD_CK1_1	301	307	PF00069	0.394
MOD_CK1_1	347	353	PF00069	0.581
MOD_CK2_1	148	154	PF00069	0.491
MOD_CK2_1	322	328	PF00069	0.691
MOD_GlcNHglycan	134	137	PF01048	0.578
MOD_GlcNHglycan	14	17	PF01048	0.447
MOD_GlcNHglycan	259	262	PF01048	0.480
MOD_GSK3_1	148	155	PF00069	0.508
MOD_GSK3_1	167	174	PF00069	0.565
MOD_GSK3_1	186	193	PF00069	0.297
MOD_GSK3_1	208	215	PF00069	0.638
MOD_GSK3_1	329	336	PF00069	0.728
MOD_GSK3_1	344	351	PF00069	0.576
MOD_GSK3_1	51	58	PF00069	0.406
MOD_N-GLC_1	171	176	PF02516	0.437
MOD_N-GLC_1	265	270	PF02516	0.422
MOD_N-GLC_1	43	48	PF02516	0.351
MOD_N-GLC_2	141	143	PF02516	0.441
MOD_N-GLC_2	280	282	PF02516	0.335
MOD_NEK2_1	190	195	PF00069	0.548
MOD_NEK2_1	199	204	PF00069	0.608
MOD_NEK2_1	276	281	PF00069	0.305
MOD_NEK2_1	333	338	PF00069	0.596
MOD_OFUCOSY	168	175	PF10250	0.393
MOD_OFUCOSY	262	269	PF10250	0.421
MOD_PIKK_1	213	219	PF00454	0.394
MOD_PIKK_1	317	323	PF00454	0.749
MOD_PIKK_1	55	61	PF00454	0.469
MOD_PK_1	348	354	PF00069	0.570
MOD_PKA_1	12	18	PF00069	0.477
MOD_PKA_2	12	18	PF00069	0.483
MOD_PKA_2	208	214	PF00069	0.516
MOD_Plk_1	171	177	PF00069	0.352
MOD_Plk_1	43	49	PF00069	0.516
MOD_Plk_4	63	69	PF00069	0.435
MOD_SUMO_rev_2	151	157	PF00179	0.509
MOD_SUMO_rev_2	322	332	PF00179	0.597
MOD_SUMO_rev_2	96	105	PF00179	0.520
TRG_DiLeu_BaEn_1	90	95	PF01217	0.418
TRG_DiLeu_BaEn_4	249	255	PF01217	0.561
TRG_ENDOCYTIC_2	173	176	PF00928	0.422
TRG_ENDOCYTIC_2	224	227	PF00928	0.466
TRG_ENDOCYTIC_2	232	235	PF00928	0.421
TRG_ER_diArg_1	243	245	PF00400	0.547
TRG_ER_diArg_1	273	275	PF00400	0.309
TRG_ER_diArg_1	9	12	PF00400	0.501
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H3	Leptomonas seymouri	43%	96%
A0A0S4KHN3	Bodo saltans	27%	67%
A0A1X0NP60	Trypanosomatidae	31%	79%
A4H5E8	Leishmania braziliensis	70%	100%
C9ZPE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	79%
E9ACQ5	Leishmania major	93%	100%
E9AG87	Leishmania infantum	98%	100%
E9AMH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%