Dimethylargininase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dimethylargininase

Gene product:

amidinotransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQF2_LEIDO

TriTrypDb:

LdBPK_081220.1 , LdCL_080017400 , LdCL_080018100 , LDHU3_08.1640 , LDHU3_08.1730

Length:

286

Annotations

Annotations by Jardim et al.

Amino acid metabolism, arginine deiminase amidinotransferase, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WQF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQF2

Function

Biological processes
Term	Name	Level	Count
GO:0000052	citrulline metabolic process	5	2
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006525	arginine metabolic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009064	glutamine family amino acid metabolic process	5	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019222	regulation of metabolic process	3	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0045428	regulation of nitric oxide biosynthetic process	6	2
GO:0045429	positive regulation of nitric oxide biosynthetic process	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080164	regulation of nitric oxide metabolic process	5	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1904407	positive regulation of nitric oxide metabolic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016403	dimethylargininase activity	5	8
GO:0016740	transferase activity	2	3
GO:0016787	hydrolase activity	2	8
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	8
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4	8
GO:0005488	binding	1	2
GO:0016597	amino acid binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043177	organic acid binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.382
CLV_NRD_NRD_1	35	37	PF00675	0.484
CLV_NRD_NRD_1	94	96	PF00675	0.463
CLV_PCSK_KEX2_1	94	96	PF00082	0.463
CLV_PCSK_SKI1_1	133	137	PF00082	0.408
CLV_PCSK_SKI1_1	200	204	PF00082	0.511
DOC_CDC14_PxL_1	58	66	PF14671	0.408
DOC_MAPK_gen_1	36	45	PF00069	0.484
DOC_USP7_MATH_1	10	14	PF00917	0.523
DOC_USP7_MATH_1	272	276	PF00917	0.558
DOC_WW_Pin1_4	185	190	PF00397	0.503
LIG_14-3-3_CanoR_1	230	239	PF00244	0.585
LIG_14-3-3_CanoR_1	27	33	PF00244	0.454
LIG_Actin_WH2_2	159	176	PF00022	0.463
LIG_APCC_ABBA_1	43	48	PF00400	0.454
LIG_BRCT_BRCA1_1	198	202	PF00533	0.633
LIG_CaM_IQ_9	160	176	PF13499	0.422
LIG_FHA_1	17	23	PF00498	0.467
LIG_FHA_1	182	188	PF00498	0.446
LIG_FHA_1	257	263	PF00498	0.561
LIG_FHA_1	27	33	PF00498	0.288
LIG_FHA_1	80	86	PF00498	0.521
LIG_FHA_2	21	27	PF00498	0.487
LIG_FHA_2	232	238	PF00498	0.584
LIG_LIR_Apic_2	188	194	PF02991	0.542
LIG_LIR_Gen_1	145	155	PF02991	0.408
LIG_LIR_Nem_3	132	137	PF02991	0.441
LIG_LIR_Nem_3	199	205	PF02991	0.512
LIG_PDZ_Class_2	281	286	PF00595	0.533
LIG_PTB_Apo_2	128	135	PF02174	0.463
LIG_PTB_Phospho_1	128	134	PF10480	0.463
LIG_Rb_LxCxE_1	19	33	PF01857	0.536
LIG_SH2_PTP2	134	137	PF00017	0.463
LIG_SH2_PTP2	42	45	PF00017	0.454
LIG_SH2_STAP1	54	58	PF00017	0.521
LIG_SH2_STAT5	128	131	PF00017	0.460
LIG_SH2_STAT5	134	137	PF00017	0.466
LIG_SH2_STAT5	154	157	PF00017	0.463
LIG_SH2_STAT5	42	45	PF00017	0.398
LIG_SH3_2	89	94	PF14604	0.463
LIG_SH3_3	86	92	PF00018	0.463
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.524
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.551
LIG_SUMO_SIM_par_1	181	188	PF11976	0.427
LIG_SUMO_SIM_par_1	203	209	PF11976	0.548
LIG_SUMO_SIM_par_1	28	33	PF11976	0.484
LIG_TRAF2_1	249	252	PF00917	0.557
LIG_WRC_WIRS_1	217	222	PF05994	0.523
MOD_CDK_SPK_2	185	190	PF00069	0.503
MOD_CK1_1	140	146	PF00069	0.408
MOD_CK1_1	181	187	PF00069	0.465
MOD_CK1_1	280	286	PF00069	0.526
MOD_CK2_1	10	16	PF00069	0.595
MOD_CK2_1	143	149	PF00069	0.473
MOD_CK2_1	20	26	PF00069	0.326
MOD_CK2_1	231	237	PF00069	0.582
MOD_CK2_1	240	246	PF00069	0.452
MOD_GlcNHglycan	12	15	PF01048	0.485
MOD_GlcNHglycan	145	148	PF01048	0.521
MOD_GlcNHglycan	220	223	PF01048	0.555
MOD_GSK3_1	16	23	PF00069	0.505
MOD_GSK3_1	181	188	PF00069	0.427
MOD_N-GLC_1	143	148	PF02516	0.521
MOD_N-GLC_2	81	83	PF02516	0.463
MOD_NEK2_1	180	185	PF00069	0.476
MOD_PKA_2	256	262	PF00069	0.562
MOD_PKA_2	26	32	PF00069	0.484
MOD_Plk_1	181	187	PF00069	0.499
MOD_Plk_1	20	26	PF00069	0.479
MOD_Plk_1	74	80	PF00069	0.521
MOD_Plk_2-3	117	123	PF00069	0.408
MOD_Plk_4	175	181	PF00069	0.422
MOD_Plk_4	2	8	PF00069	0.547
MOD_Plk_4	277	283	PF00069	0.436
MOD_Plk_4	67	73	PF00069	0.408
MOD_Plk_4	74	80	PF00069	0.408
MOD_ProDKin_1	185	191	PF00069	0.504
MOD_SUMO_for_1	270	273	PF00179	0.464
TRG_DiLeu_BaEn_1	182	187	PF01217	0.501
TRG_ENDOCYTIC_2	134	137	PF00928	0.463
TRG_ENDOCYTIC_2	148	151	PF00928	0.463
TRG_ENDOCYTIC_2	42	45	PF00928	0.398
TRG_ER_diArg_1	94	96	PF00400	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6E5	Leptomonas seymouri	74%	100%
A0A0S4J9U5	Bodo saltans	46%	97%
E9AG92	Leishmania infantum	100%	100%
E9AMJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O08557	Rattus norvegicus	28%	100%
O34497	Bacillus subtilis (strain 168)	25%	100%
O94760	Homo sapiens	28%	100%
Q4QI38	Leishmania major	95%	100%
Q4QI44	Leishmania major	95%	100%
Q9CWS0	Mus musculus	28%	100%
Q9I4E3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	30%	100%
Q9X7M4	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	31%	100%
Q9Y8N2	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	32%	100%