Suppressive immunomodulating factor, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

suppressive immunomodulating factor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQE7_LEIDO

TriTrypDb:

LdBPK_081050.1 , LdCL_080016100 , LDHU3_08.1500

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQE7

Function

Biological processes
Term	Name	Level	Count
GO:0001775	cell activation	2	1
GO:0002274	myeloid leukocyte activation	3	1
GO:0002376	immune system process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0042116	macrophage activation	4	1
GO:0045321	leukocyte activation	2	1
GO:0045428	regulation of nitric oxide biosynthetic process	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080164	regulation of nitric oxide metabolic process	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.728
CLV_C14_Caspase3-7	534	538	PF00656	0.569
CLV_NRD_NRD_1	539	541	PF00675	0.777
CLV_NRD_NRD_1	582	584	PF00675	0.742
CLV_NRD_NRD_1	735	737	PF00675	0.717
CLV_NRD_NRD_1	739	741	PF00675	0.683
CLV_NRD_NRD_1	743	745	PF00675	0.661
CLV_NRD_NRD_1	889	891	PF00675	0.677
CLV_NRD_NRD_1	99	101	PF00675	0.561
CLV_PCSK_KEX2_1	539	541	PF00082	0.770
CLV_PCSK_KEX2_1	567	569	PF00082	0.805
CLV_PCSK_KEX2_1	582	584	PF00082	0.490
CLV_PCSK_KEX2_1	723	725	PF00082	0.713
CLV_PCSK_KEX2_1	739	741	PF00082	0.567
CLV_PCSK_KEX2_1	789	791	PF00082	0.615
CLV_PCSK_KEX2_1	888	890	PF00082	0.669
CLV_PCSK_KEX2_1	99	101	PF00082	0.561
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.727
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.761
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.615
CLV_PCSK_SKI1_1	465	469	PF00082	0.801
CLV_PCSK_SKI1_1	575	579	PF00082	0.811
CLV_PCSK_SKI1_1	65	69	PF00082	0.416
CLV_PCSK_SKI1_1	723	727	PF00082	0.756
CLV_PCSK_SKI1_1	789	793	PF00082	0.619
CLV_PCSK_SKI1_1	869	873	PF00082	0.692
CLV_Separin_Metazoa	337	341	PF03568	0.494
DEG_APCC_DBOX_1	368	376	PF00400	0.504
DEG_APCC_DBOX_1	64	72	PF00400	0.441
DEG_COP1_1	639	648	PF00400	0.740
DEG_SCF_FBW7_1	904	911	PF00400	0.555
DEG_SCF_FBW7_2	457	464	PF00400	0.767
DEG_SPOP_SBC_1	174	178	PF00917	0.608
DOC_ANK_TNKS_1	157	164	PF00023	0.440
DOC_CDC14_PxL_1	83	91	PF14671	0.485
DOC_CKS1_1	496	501	PF01111	0.760
DOC_CKS1_1	905	910	PF01111	0.732
DOC_CYCLIN_RxL_1	720	729	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	179	182	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	933	939	PF00134	0.680
DOC_MAPK_MEF2A_6	223	230	PF00069	0.601
DOC_MAPK_MEF2A_6	723	732	PF00069	0.775
DOC_MAPK_NFAT4_5	223	231	PF00069	0.598
DOC_PP1_RVXF_1	873	879	PF00149	0.788
DOC_PP2B_LxvP_1	179	182	PF13499	0.546
DOC_PP2B_LxvP_1	239	242	PF13499	0.566
DOC_PP2B_LxvP_1	407	410	PF13499	0.839
DOC_PP2B_LxvP_1	549	552	PF13499	0.725
DOC_PP2B_LxvP_1	933	936	PF13499	0.686
DOC_PP2B_LxvP_1	937	940	PF13499	0.663
DOC_PP4_FxxP_1	905	908	PF00568	0.659
DOC_SPAK_OSR1_1	340	344	PF12202	0.506
DOC_USP7_MATH_1	170	174	PF00917	0.653
DOC_USP7_MATH_1	175	179	PF00917	0.569
DOC_USP7_MATH_1	305	309	PF00917	0.557
DOC_USP7_MATH_1	379	383	PF00917	0.702
DOC_USP7_MATH_1	506	510	PF00917	0.836
DOC_USP7_MATH_1	544	548	PF00917	0.814
DOC_USP7_MATH_1	558	562	PF00917	0.606
DOC_USP7_MATH_1	588	592	PF00917	0.771
DOC_USP7_MATH_1	607	611	PF00917	0.762
DOC_USP7_MATH_1	674	678	PF00917	0.609
DOC_USP7_MATH_1	834	838	PF00917	0.705
DOC_USP7_MATH_1	941	945	PF00917	0.625
DOC_USP7_UBL2_3	563	567	PF12436	0.735
DOC_WW_Pin1_4	275	280	PF00397	0.605
DOC_WW_Pin1_4	414	419	PF00397	0.806
DOC_WW_Pin1_4	457	462	PF00397	0.769
DOC_WW_Pin1_4	495	500	PF00397	0.838
DOC_WW_Pin1_4	554	559	PF00397	0.717
DOC_WW_Pin1_4	620	625	PF00397	0.731
DOC_WW_Pin1_4	693	698	PF00397	0.741
DOC_WW_Pin1_4	904	909	PF00397	0.657
LIG_14-3-3_CanoR_1	126	135	PF00244	0.480
LIG_14-3-3_CanoR_1	158	162	PF00244	0.652
LIG_14-3-3_CanoR_1	223	227	PF00244	0.480
LIG_14-3-3_CanoR_1	529	536	PF00244	0.635
LIG_14-3-3_CanoR_1	582	586	PF00244	0.798
LIG_14-3-3_CanoR_1	65	71	PF00244	0.430
LIG_14-3-3_CanoR_1	702	708	PF00244	0.582
LIG_14-3-3_CanoR_1	790	794	PF00244	0.613
LIG_14-3-3_CanoR_1	81	86	PF00244	0.426
LIG_BRCT_BRCA1_1	560	564	PF00533	0.718
LIG_deltaCOP1_diTrp_1	366	370	PF00928	0.500
LIG_EH1_1	719	727	PF00400	0.663
LIG_eIF4E_1	111	117	PF01652	0.451
LIG_EVH1_1	549	553	PF00568	0.826
LIG_EVH1_1	937	941	PF00568	0.639
LIG_FHA_1	10	16	PF00498	0.581
LIG_FHA_1	120	126	PF00498	0.479
LIG_FHA_1	149	155	PF00498	0.481
LIG_FHA_1	175	181	PF00498	0.606
LIG_FHA_1	223	229	PF00498	0.494
LIG_FHA_1	255	261	PF00498	0.492
LIG_FHA_1	314	320	PF00498	0.433
LIG_FHA_1	355	361	PF00498	0.441
LIG_FHA_1	452	458	PF00498	0.847
LIG_FHA_1	466	472	PF00498	0.602
LIG_FHA_1	496	502	PF00498	0.811
LIG_FHA_1	590	596	PF00498	0.649
LIG_FHA_1	683	689	PF00498	0.835
LIG_FHA_1	727	733	PF00498	0.709
LIG_FHA_1	781	787	PF00498	0.662
LIG_FHA_1	822	828	PF00498	0.657
LIG_FHA_1	911	917	PF00498	0.615
LIG_FHA_2	157	163	PF00498	0.571
LIG_FHA_2	3	9	PF00498	0.602
LIG_FHA_2	390	396	PF00498	0.854
LIG_FHA_2	532	538	PF00498	0.840
LIG_FHA_2	557	563	PF00498	0.741
LIG_FHA_2	582	588	PF00498	0.726
LIG_FHA_2	664	670	PF00498	0.690
LIG_FHA_2	67	73	PF00498	0.441
LIG_FHA_2	824	830	PF00498	0.655
LIG_FHA_2	925	931	PF00498	0.779
LIG_LIR_Apic_2	366	371	PF02991	0.502
LIG_LIR_Gen_1	829	838	PF02991	0.775
LIG_LIR_Gen_1	926	937	PF02991	0.682
LIG_LIR_LC3C_4	251	254	PF02991	0.462
LIG_LIR_LC3C_4	356	361	PF02991	0.468
LIG_LIR_Nem_3	207	213	PF02991	0.416
LIG_LIR_Nem_3	61	67	PF02991	0.432
LIG_LIR_Nem_3	799	803	PF02991	0.548
LIG_LIR_Nem_3	829	835	PF02991	0.668
LIG_LIR_Nem_3	870	876	PF02991	0.687
LIG_LIR_Nem_3	926	932	PF02991	0.681
LIG_PDZ_Class_1	941	946	PF00595	0.670
LIG_Pex14_1	165	169	PF04695	0.690
LIG_Rb_LxCxE_1	141	162	PF01857	0.479
LIG_SH2_CRK	210	214	PF00017	0.403
LIG_SH2_CRK	873	877	PF00017	0.687
LIG_SH2_GRB2like	111	114	PF00017	0.404
LIG_SH2_STAP1	107	111	PF00017	0.422
LIG_SH2_STAP1	326	330	PF00017	0.453
LIG_SH2_STAT3	825	828	PF00017	0.646
LIG_SH2_STAT5	144	147	PF00017	0.443
LIG_SH2_STAT5	313	316	PF00017	0.541
LIG_SH2_STAT5	438	441	PF00017	0.743
LIG_SH2_STAT5	70	73	PF00017	0.454
LIG_SH2_STAT5	825	828	PF00017	0.642
LIG_SH3_3	400	406	PF00018	0.725
LIG_SH3_3	407	413	PF00018	0.737
LIG_SH3_3	424	430	PF00018	0.563
LIG_SH3_3	547	553	PF00018	0.776
LIG_SH3_3	619	625	PF00018	0.672
LIG_SH3_3	768	774	PF00018	0.826
LIG_SH3_3	817	823	PF00018	0.707
LIG_SH3_3	858	864	PF00018	0.732
LIG_SH3_3	919	925	PF00018	0.676
LIG_SH3_3	935	941	PF00018	0.694
LIG_SH3_CIN85_PxpxPR_1	406	411	PF14604	0.759
LIG_SUMO_SIM_anti_2	320	327	PF11976	0.449
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.473
LIG_SUMO_SIM_anti_2	930	936	PF11976	0.688
LIG_SUMO_SIM_par_1	320	327	PF11976	0.454
LIG_SUMO_SIM_par_1	356	363	PF11976	0.473
LIG_TRAF2_1	591	594	PF00917	0.744
LIG_TRAF2_1	928	931	PF00917	0.669
LIG_TRFH_1	83	87	PF08558	0.450
LIG_TYR_ITIM	871	876	PF00017	0.788
LIG_UBA3_1	179	185	PF00899	0.523
LIG_WW_2	403	406	PF00397	0.818
MOD_CDK_SPxK_1	457	463	PF00069	0.769
MOD_CDK_SPxxK_3	414	421	PF00069	0.717
MOD_CK1_1	133	139	PF00069	0.455
MOD_CK1_1	173	179	PF00069	0.707
MOD_CK1_1	243	249	PF00069	0.701
MOD_CK1_1	258	264	PF00069	0.345
MOD_CK1_1	278	284	PF00069	0.644
MOD_CK1_1	504	510	PF00069	0.837
MOD_CK1_1	514	520	PF00069	0.678
MOD_CK1_1	623	629	PF00069	0.739
MOD_CK1_1	780	786	PF00069	0.680
MOD_CK2_1	156	162	PF00069	0.525
MOD_CK2_1	2	8	PF00069	0.615
MOD_CK2_1	379	385	PF00069	0.696
MOD_CK2_1	389	395	PF00069	0.681
MOD_CK2_1	488	494	PF00069	0.766
MOD_CK2_1	588	594	PF00069	0.737
MOD_CK2_1	602	608	PF00069	0.551
MOD_CK2_1	924	930	PF00069	0.779
MOD_GlcNHglycan	172	175	PF01048	0.697
MOD_GlcNHglycan	206	209	PF01048	0.454
MOD_GlcNHglycan	273	276	PF01048	0.775
MOD_GlcNHglycan	319	322	PF01048	0.446
MOD_GlcNHglycan	381	384	PF01048	0.684
MOD_GlcNHglycan	449	452	PF01048	0.821
MOD_GlcNHglycan	506	509	PF01048	0.786
MOD_GlcNHglycan	513	516	PF01048	0.726
MOD_GlcNHglycan	604	607	PF01048	0.698
MOD_GlcNHglycan	608	612	PF01048	0.695
MOD_GlcNHglycan	639	643	PF01048	0.822
MOD_GlcNHglycan	836	839	PF01048	0.628
MOD_GlcNHglycan	852	855	PF01048	0.667
MOD_GSK3_1	105	112	PF00069	0.415
MOD_GSK3_1	148	155	PF00069	0.472
MOD_GSK3_1	169	176	PF00069	0.723
MOD_GSK3_1	254	261	PF00069	0.461
MOD_GSK3_1	271	278	PF00069	0.652
MOD_GSK3_1	313	320	PF00069	0.336
MOD_GSK3_1	441	448	PF00069	0.774
MOD_GSK3_1	453	460	PF00069	0.683
MOD_GSK3_1	497	504	PF00069	0.850
MOD_GSK3_1	554	561	PF00069	0.761
MOD_GSK3_1	607	614	PF00069	0.717
MOD_GSK3_1	620	627	PF00069	0.653
MOD_GSK3_1	689	696	PF00069	0.717
MOD_GSK3_1	698	705	PF00069	0.723
MOD_GSK3_1	81	88	PF00069	0.457
MOD_GSK3_1	904	911	PF00069	0.630
MOD_N-GLC_1	354	359	PF02516	0.479
MOD_N-GLC_1	530	535	PF02516	0.782
MOD_N-GLC_1	751	756	PF02516	0.723
MOD_N-GLC_1	780	785	PF02516	0.676
MOD_NEK2_1	105	110	PF00069	0.450
MOD_NEK2_1	188	193	PF00069	0.453
MOD_NEK2_1	237	242	PF00069	0.520
MOD_NEK2_1	248	253	PF00069	0.490
MOD_NEK2_1	359	364	PF00069	0.466
MOD_NEK2_1	56	61	PF00069	0.454
MOD_NEK2_1	638	643	PF00069	0.822
MOD_NEK2_1	66	71	PF00069	0.349
MOD_NEK2_1	682	687	PF00069	0.657
MOD_NEK2_1	76	81	PF00069	0.405
MOD_NEK2_1	777	782	PF00069	0.670
MOD_NEK2_1	903	908	PF00069	0.767
MOD_NEK2_2	506	511	PF00069	0.777
MOD_NEK2_2	689	694	PF00069	0.575
MOD_PIKK_1	436	442	PF00454	0.841
MOD_PIKK_1	769	775	PF00454	0.751
MOD_PIKK_1	90	96	PF00454	0.509
MOD_PKA_1	789	795	PF00069	0.718
MOD_PKA_2	133	139	PF00069	0.441
MOD_PKA_2	157	163	PF00069	0.546
MOD_PKA_2	222	228	PF00069	0.478
MOD_PKA_2	258	264	PF00069	0.456
MOD_PKA_2	268	274	PF00069	0.648
MOD_PKA_2	28	34	PF00069	0.515
MOD_PKA_2	581	587	PF00069	0.811
MOD_PKA_2	682	688	PF00069	0.706
MOD_PKA_2	789	795	PF00069	0.718
MOD_PKA_2	847	853	PF00069	0.741
MOD_PKB_1	463	471	PF00069	0.837
MOD_Plk_1	189	195	PF00069	0.533
MOD_Plk_1	354	360	PF00069	0.467
MOD_Plk_1	419	425	PF00069	0.824
MOD_Plk_1	434	440	PF00069	0.652
MOD_Plk_1	445	451	PF00069	0.724
MOD_Plk_1	452	458	PF00069	0.745
MOD_Plk_1	76	82	PF00069	0.405
MOD_Plk_1	869	875	PF00069	0.691
MOD_Plk_2-3	389	395	PF00069	0.855
MOD_Plk_2-3	441	447	PF00069	0.746
MOD_Plk_2-3	589	595	PF00069	0.746
MOD_Plk_4	133	139	PF00069	0.409
MOD_Plk_4	152	158	PF00069	0.301
MOD_Plk_4	175	181	PF00069	0.629
MOD_Plk_4	189	195	PF00069	0.382
MOD_Plk_4	243	249	PF00069	0.595
MOD_Plk_4	28	34	PF00069	0.510
MOD_Plk_4	354	360	PF00069	0.447
MOD_Plk_4	66	72	PF00069	0.392
MOD_Plk_4	85	91	PF00069	0.468
MOD_Plk_4	911	917	PF00069	0.689
MOD_ProDKin_1	275	281	PF00069	0.603
MOD_ProDKin_1	414	420	PF00069	0.808
MOD_ProDKin_1	457	463	PF00069	0.769
MOD_ProDKin_1	495	501	PF00069	0.839
MOD_ProDKin_1	554	560	PF00069	0.719
MOD_ProDKin_1	620	626	PF00069	0.730
MOD_ProDKin_1	693	699	PF00069	0.741
MOD_ProDKin_1	904	910	PF00069	0.656
MOD_SUMO_rev_2	782	791	PF00179	0.642
TRG_DiLeu_BaEn_1	930	935	PF01217	0.686
TRG_DiLeu_BaEn_2	62	68	PF01217	0.476
TRG_DiLeu_BaEn_4	930	936	PF01217	0.688
TRG_DiLeu_BaLyEn_6	721	726	PF01217	0.748
TRG_ENDOCYTIC_2	210	213	PF00928	0.409
TRG_ENDOCYTIC_2	873	876	PF00928	0.686
TRG_ER_diArg_1	739	741	PF00400	0.705
TRG_ER_diArg_1	888	890	PF00400	0.779
TRG_ER_diArg_1	99	101	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.746
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP7	Leptomonas seymouri	50%	100%
A4H5F2	Leishmania braziliensis	78%	100%
A4HTP7	Leishmania infantum	100%	100%
E9AMI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QI55	Leishmania major	93%	100%