Hydantoinase_A domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tuzin, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7WQC8_LEIDO

TriTrypDb:

LdBPK_080750.1 , LdCL_080013000 , LDHU3_08.1030

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.481
CLV_NRD_NRD_1	201	203	PF00675	0.479
CLV_NRD_NRD_1	255	257	PF00675	0.432
CLV_NRD_NRD_1	315	317	PF00675	0.546
CLV_NRD_NRD_1	324	326	PF00675	0.678
CLV_NRD_NRD_1	360	362	PF00675	0.638
CLV_NRD_NRD_1	373	375	PF00675	0.543
CLV_NRD_NRD_1	408	410	PF00675	0.714
CLV_NRD_NRD_1	414	416	PF00675	0.725
CLV_NRD_NRD_1	423	425	PF00675	0.626
CLV_NRD_NRD_1	5	7	PF00675	0.488
CLV_PCSK_FUR_1	3	7	PF00082	0.488
CLV_PCSK_FUR_1	371	375	PF00082	0.590
CLV_PCSK_FUR_1	412	416	PF00082	0.565
CLV_PCSK_KEX2_1	201	203	PF00082	0.479
CLV_PCSK_KEX2_1	216	218	PF00082	0.377
CLV_PCSK_KEX2_1	255	257	PF00082	0.432
CLV_PCSK_KEX2_1	297	299	PF00082	0.555
CLV_PCSK_KEX2_1	315	317	PF00082	0.601
CLV_PCSK_KEX2_1	324	326	PF00082	0.678
CLV_PCSK_KEX2_1	360	362	PF00082	0.638
CLV_PCSK_KEX2_1	373	375	PF00082	0.537
CLV_PCSK_KEX2_1	408	410	PF00082	0.723
CLV_PCSK_KEX2_1	414	416	PF00082	0.734
CLV_PCSK_KEX2_1	423	425	PF00082	0.617
CLV_PCSK_KEX2_1	5	7	PF00082	0.488
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.440
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.555
CLV_PCSK_PC7_1	293	299	PF00082	0.533
CLV_PCSK_PC7_1	404	410	PF00082	0.661
CLV_PCSK_SKI1_1	140	144	PF00082	0.444
CLV_PCSK_SKI1_1	208	212	PF00082	0.476
CLV_PCSK_SKI1_1	242	246	PF00082	0.376
CLV_PCSK_SKI1_1	278	282	PF00082	0.677
CLV_PCSK_SKI1_1	415	419	PF00082	0.568
DEG_APCC_DBOX_1	207	215	PF00400	0.432
DOC_CYCLIN_RxL_1	137	147	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.495
DOC_MAPK_gen_1	255	263	PF00069	0.442
DOC_MAPK_gen_1	293	301	PF00069	0.536
DOC_MAPK_gen_1	3	13	PF00069	0.485
DOC_MAPK_gen_1	324	333	PF00069	0.527
DOC_MAPK_MEF2A_6	5	13	PF00069	0.485
DOC_PP1_RVXF_1	240	246	PF00149	0.375
DOC_PP1_RVXF_1	295	302	PF00149	0.535
DOC_PP2B_LxvP_1	99	102	PF13499	0.510
DOC_USP7_MATH_1	266	270	PF00917	0.445
DOC_USP7_MATH_1	377	381	PF00917	0.602
DOC_USP7_MATH_1	79	83	PF00917	0.464
DOC_WW_Pin1_4	363	368	PF00397	0.577
DOC_WW_Pin1_4	373	378	PF00397	0.548
LIG_14-3-3_CanoR_1	179	188	PF00244	0.499
LIG_14-3-3_CanoR_1	276	281	PF00244	0.511
LIG_14-3-3_CanoR_1	286	292	PF00244	0.540
LIG_14-3-3_CanoR_1	298	308	PF00244	0.549
LIG_14-3-3_CanoR_1	3	13	PF00244	0.504
LIG_14-3-3_CanoR_1	318	327	PF00244	0.513
LIG_14-3-3_CanoR_1	379	383	PF00244	0.614
LIG_14-3-3_CanoR_1	423	427	PF00244	0.547
LIG_APCC_ABBA_1	109	114	PF00400	0.441
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BRCT_BRCA1_1	145	149	PF00533	0.503
LIG_FHA_1	139	145	PF00498	0.493
LIG_FHA_1	180	186	PF00498	0.493
LIG_FHA_1	258	264	PF00498	0.598
LIG_FHA_1	265	271	PF00498	0.639
LIG_FHA_1	363	369	PF00498	0.579
LIG_FHA_1	82	88	PF00498	0.495
LIG_GBD_Chelix_1	243	251	PF00786	0.399
LIG_SH2_CRK	139	143	PF00017	0.484
LIG_SH2_STAP1	62	66	PF00017	0.488
LIG_SH2_STAP1	92	96	PF00017	0.539
LIG_SH2_STAT5	12	15	PF00017	0.488
LIG_SH2_STAT5	121	124	PF00017	0.537
LIG_SH2_STAT5	65	68	PF00017	0.488
LIG_SH3_1	306	312	PF00018	0.531
LIG_SH3_3	148	154	PF00018	0.477
LIG_SH3_3	306	312	PF00018	0.531
LIG_SH3_3	382	388	PF00018	0.616
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.468
LIG_SUMO_SIM_par_1	101	106	PF11976	0.538
LIG_SUMO_SIM_par_1	140	147	PF11976	0.478
MOD_CDC14_SPxK_1	376	379	PF00782	0.596
MOD_CDK_SPxK_1	373	379	PF00069	0.594
MOD_CK1_1	24	30	PF00069	0.502
MOD_CK1_1	82	88	PF00069	0.462
MOD_CK2_1	166	172	PF00069	0.578
MOD_GlcNHglycan	122	125	PF01048	0.500
MOD_GlcNHglycan	145	149	PF01048	0.503
MOD_GlcNHglycan	230	233	PF01048	0.471
MOD_GlcNHglycan	234	237	PF01048	0.418
MOD_GlcNHglycan	264	267	PF01048	0.456
MOD_GlcNHglycan	29	32	PF01048	0.482
MOD_GlcNHglycan	37	40	PF01048	0.455
MOD_GlcNHglycan	72	75	PF01048	0.521
MOD_GSK3_1	224	231	PF00069	0.489
MOD_GSK3_1	262	269	PF00069	0.596
MOD_GSK3_1	300	307	PF00069	0.542
MOD_GSK3_1	373	380	PF00069	0.745
MOD_N-GLC_1	228	233	PF02516	0.432
MOD_NEK2_1	143	148	PF00069	0.484
MOD_NEK2_1	197	202	PF00069	0.487
MOD_NEK2_1	21	26	PF00069	0.476
MOD_NEK2_1	238	243	PF00069	0.400
MOD_NEK2_1	270	275	PF00069	0.487
MOD_NEK2_1	4	9	PF00069	0.509
MOD_NEK2_1	422	427	PF00069	0.586
MOD_NEK2_1	70	75	PF00069	0.526
MOD_PK_1	224	230	PF00069	0.453
MOD_PK_1	276	282	PF00069	0.483
MOD_PK_1	5	11	PF00069	0.483
MOD_PKA_1	5	11	PF00069	0.483
MOD_PKA_2	287	293	PF00069	0.538
MOD_PKA_2	378	384	PF00069	0.613
MOD_PKA_2	4	10	PF00069	0.495
MOD_PKB_1	3	11	PF00069	0.484
MOD_PKB_1	316	324	PF00069	0.578
MOD_Plk_4	154	160	PF00069	0.495
MOD_Plk_4	287	293	PF00069	0.553
MOD_Plk_4	82	88	PF00069	0.462
MOD_ProDKin_1	363	369	PF00069	0.579
MOD_ProDKin_1	373	379	PF00069	0.552
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.506
TRG_ENDOCYTIC_2	139	142	PF00928	0.487
TRG_ER_diArg_1	201	204	PF00400	0.474
TRG_ER_diArg_1	3	6	PF00400	0.488
TRG_ER_diArg_1	315	318	PF00400	0.598
TRG_ER_diArg_1	324	326	PF00400	0.669
TRG_ER_diArg_1	359	361	PF00400	0.647
TRG_ER_diArg_1	411	414	PF00400	0.723
TRG_ER_diArg_1	422	424	PF00400	0.663
TRG_NLS_Bipartite_1	201	219	PF00514	0.443
TRG_NLS_MonoExtC_3	214	220	PF00514	0.436
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HAZ9	Leishmania braziliensis	38%	69%
A4HTM2	Leishmania infantum	99%	100%