Dpy-30 motif containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WQC3_LEIDO

TriTrypDb:

LdBPK_080900.1 , LdCL_080014400 , LDHU3_08.1250

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0034708	methyltransferase complex	4	11
GO:0035097	histone methyltransferase complex	3	11
GO:0044666	MLL3/4 complex	4	11
GO:0048188	Set1C/COMPASS complex	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WQC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQC3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0051568	histone H3-K4 methylation	7	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.648
CLV_C14_Caspase3-7	317	321	PF00656	0.598
CLV_C14_Caspase3-7	329	333	PF00656	0.685
CLV_NRD_NRD_1	161	163	PF00675	0.413
CLV_NRD_NRD_1	362	364	PF00675	0.351
CLV_NRD_NRD_1	45	47	PF00675	0.485
CLV_NRD_NRD_1	537	539	PF00675	0.462
CLV_NRD_NRD_1	54	56	PF00675	0.458
CLV_NRD_NRD_1	90	92	PF00675	0.422
CLV_PCSK_FUR_1	535	539	PF00082	0.482
CLV_PCSK_FUR_1	91	95	PF00082	0.455
CLV_PCSK_KEX2_1	161	163	PF00082	0.438
CLV_PCSK_KEX2_1	362	364	PF00082	0.351
CLV_PCSK_KEX2_1	53	55	PF00082	0.511
CLV_PCSK_KEX2_1	537	539	PF00082	0.524
CLV_PCSK_KEX2_1	93	95	PF00082	0.566
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.542
CLV_PCSK_PC7_1	89	95	PF00082	0.551
CLV_PCSK_SKI1_1	162	166	PF00082	0.377
CLV_PCSK_SKI1_1	169	173	PF00082	0.308
DEG_Kelch_Keap1_1	502	507	PF01344	0.612
DEG_Nend_UBRbox_2	1	3	PF02207	0.505
DEG_SCF_FBW7_1	268	275	PF00400	0.483
DOC_CYCLIN_RxL_1	166	173	PF00134	0.515
DOC_MAPK_gen_1	166	174	PF00069	0.334
DOC_MAPK_MEF2A_6	473	480	PF00069	0.552
DOC_MAPK_NFAT4_5	473	481	PF00069	0.558
DOC_PP1_RVXF_1	254	261	PF00149	0.334
DOC_PP2B_LxvP_1	172	175	PF13499	0.304
DOC_PP4_FxxP_1	353	356	PF00568	0.542
DOC_USP7_MATH_1	24	28	PF00917	0.448
DOC_USP7_MATH_1	274	278	PF00917	0.494
DOC_USP7_MATH_1	299	303	PF00917	0.378
DOC_WW_Pin1_4	228	233	PF00397	0.644
DOC_WW_Pin1_4	268	273	PF00397	0.386
LIG_14-3-3_CanoR_1	169	175	PF00244	0.436
LIG_14-3-3_CanoR_1	454	462	PF00244	0.337
LIG_BIR_III_4	509	513	PF00653	0.455
LIG_BIR_III_4	555	559	PF00653	0.522
LIG_BRCT_BRCA1_1	349	353	PF00533	0.640
LIG_eIF4E_1	32	38	PF01652	0.448
LIG_FHA_1	356	362	PF00498	0.497
LIG_FHA_1	368	374	PF00498	0.475
LIG_FHA_1	503	509	PF00498	0.572
LIG_FHA_2	320	326	PF00498	0.577
LIG_FHA_2	340	346	PF00498	0.542
LIG_FHA_2	413	419	PF00498	0.608
LIG_FHA_2	480	486	PF00498	0.637
LIG_GBD_Chelix_1	33	41	PF00786	0.248
LIG_LIR_Apic_2	350	356	PF02991	0.584
LIG_LIR_Gen_1	31	38	PF02991	0.448
LIG_LIR_Gen_1	447	458	PF02991	0.358
LIG_LIR_Gen_1	481	491	PF02991	0.618
LIG_LIR_Nem_3	31	35	PF02991	0.448
LIG_LIR_Nem_3	447	453	PF02991	0.357
LIG_LIR_Nem_3	481	486	PF02991	0.632
LIG_MYND_1	228	232	PF01753	0.645
LIG_NRBOX	262	268	PF00104	0.424
LIG_REV1ctd_RIR_1	162	170	PF16727	0.462
LIG_RPA_C_Fungi	49	61	PF08784	0.464
LIG_SH2_CRK	450	454	PF00017	0.321
LIG_SH2_NCK_1	104	108	PF00017	0.420
LIG_SH2_STAP1	387	391	PF00017	0.566
LIG_SH2_STAP1	543	547	PF00017	0.534
LIG_SH2_STAT5	254	257	PF00017	0.379
LIG_SH2_STAT5	265	268	PF00017	0.308
LIG_SH2_STAT5	32	35	PF00017	0.288
LIG_SH2_STAT5	387	390	PF00017	0.490
LIG_SH2_STAT5	5	8	PF00017	0.288
LIG_SH3_3	23	29	PF00018	0.288
LIG_SH3_3	331	337	PF00018	0.751
LIG_TRAF2_1	149	152	PF00917	0.514
LIG_TRAF2_1	208	211	PF00917	0.477
LIG_TRAF2_1	343	346	PF00917	0.631
LIG_TRAF2_1	557	560	PF00917	0.684
LIG_TRAF2_1	95	98	PF00917	0.431
LIG_TYR_ITIM	263	268	PF00017	0.406
LIG_TYR_ITIM	448	453	PF00017	0.364
LIG_UBA3_1	171	176	PF00899	0.362
LIG_WRC_WIRS_1	480	485	PF05994	0.564
MOD_CDK_SPK_2	268	273	PF00069	0.355
MOD_CK1_1	222	228	PF00069	0.714
MOD_CK2_1	273	279	PF00069	0.455
MOD_CK2_1	339	345	PF00069	0.738
MOD_CK2_1	479	485	PF00069	0.582
MOD_CK2_1	554	560	PF00069	0.620
MOD_GlcNHglycan	142	145	PF01048	0.647
MOD_GlcNHglycan	176	179	PF01048	0.466
MOD_GlcNHglycan	2	5	PF01048	0.288
MOD_GlcNHglycan	224	227	PF01048	0.592
MOD_GlcNHglycan	276	279	PF01048	0.517
MOD_GlcNHglycan	342	345	PF01048	0.698
MOD_GlcNHglycan	456	459	PF01048	0.331
MOD_GlcNHglycan	555	559	PF01048	0.571
MOD_GSK3_1	136	143	PF00069	0.663
MOD_GSK3_1	170	177	PF00069	0.452
MOD_GSK3_1	20	27	PF00069	0.417
MOD_GSK3_1	215	222	PF00069	0.551
MOD_GSK3_1	268	275	PF00069	0.394
MOD_N-GLC_1	268	273	PF02516	0.495
MOD_N-GLC_1	339	344	PF02516	0.544
MOD_NEK2_1	170	175	PF00069	0.424
MOD_NEK2_1	318	323	PF00069	0.537
MOD_PIKK_1	436	442	PF00454	0.416
MOD_PKA_2	140	146	PF00069	0.628
MOD_PKA_2	239	245	PF00069	0.594
MOD_Plk_1	197	203	PF00069	0.513
MOD_Plk_2-3	385	391	PF00069	0.565
MOD_Plk_4	285	291	PF00069	0.506
MOD_Plk_4	444	450	PF00069	0.379
MOD_ProDKin_1	228	234	PF00069	0.634
MOD_ProDKin_1	268	274	PF00069	0.389
MOD_SUMO_for_1	121	124	PF00179	0.503
MOD_SUMO_for_1	182	185	PF00179	0.369
MOD_SUMO_for_1	309	312	PF00179	0.511
MOD_SUMO_rev_2	43	48	PF00179	0.514
TRG_DiLeu_BaEn_1	110	115	PF01217	0.395
TRG_DiLeu_BaEn_4	503	509	PF01217	0.659
TRG_ENDOCYTIC_2	257	260	PF00928	0.337
TRG_ENDOCYTIC_2	265	268	PF00928	0.351
TRG_ENDOCYTIC_2	32	35	PF00928	0.288
TRG_ENDOCYTIC_2	450	453	PF00928	0.316
TRG_ER_diArg_1	192	195	PF00400	0.530
TRG_ER_diArg_1	361	363	PF00400	0.357
TRG_ER_diArg_1	53	55	PF00400	0.582
TRG_ER_diArg_1	537	540	PF00400	0.546
TRG_NLS_MonoCore_2	90	95	PF00514	0.363
TRG_NLS_MonoExtC_3	91	97	PF00514	0.428
TRG_NLS_MonoExtN_4	89	96	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H1	Leptomonas seymouri	63%	97%
A0A1X0NQN0	Trypanosomatidae	45%	93%
A0A422NJV4	Trypanosoma rangeli	39%	100%
A4H5E1	Leishmania braziliensis	82%	100%
A4HTN6	Leishmania infantum	100%	100%
C9ZPD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QI73	Leishmania major	94%	100%
V5BR17	Trypanosoma cruzi	41%	100%