LeishMANIAdb
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Amastin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amastin-like protein
Gene product:
amastin-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7WQC1_LEIDO
TriTrypDb:
LdBPK_080780.1 , LdCL_080013100 , LDHU3_08.1040
Length:
193

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 9
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 12, no: 203
NetGPI no yes: 0, no: 215
Cellular components
Term Name Level Count
GO:0016020 membrane 2 192
GO:0110165 cellular anatomical entity 1 192

Expansion

Sequence features

A0A3S7WQC1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQC1

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016485 protein processing 5 1
GO:0016540 protein autoprocessing 6 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004175 endopeptidase activity 4 1
GO:0004197 cysteine-type endopeptidase activity 5 1
GO:0008233 peptidase activity 3 1
GO:0008234 cysteine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 176 180 PF00656 0.560
CLV_NRD_NRD_1 72 74 PF00675 0.484
CLV_PCSK_KEX2_1 72 74 PF00082 0.494
DEG_MDM2_SWIB_1 105 112 PF02201 0.511
DEG_SCF_TRCP1_1 179 185 PF00400 0.555
DOC_CKS1_1 23 28 PF01111 0.351
DOC_MAPK_MEF2A_6 108 116 PF00069 0.575
DOC_MAPK_MEF2A_6 37 46 PF00069 0.348
DOC_MAPK_MEF2A_6 4 13 PF00069 0.543
DOC_MAPK_NFAT4_5 4 12 PF00069 0.424
DOC_PP1_RVXF_1 70 77 PF00149 0.265
DOC_PP2B_LxvP_1 171 174 PF13499 0.697
DOC_USP7_MATH_1 142 146 PF00917 0.322
DOC_USP7_MATH_1 182 186 PF00917 0.580
DOC_WW_Pin1_4 22 27 PF00397 0.353
DOC_WW_Pin1_4 38 43 PF00397 0.279
LIG_14-3-3_CanoR_1 143 150 PF00244 0.424
LIG_14-3-3_CanoR_1 183 187 PF00244 0.630
LIG_14-3-3_CanoR_1 77 83 PF00244 0.298
LIG_BIR_II_1 1 5 PF00653 0.717
LIG_BRCT_BRCA1_1 144 148 PF00533 0.211
LIG_eIF4E_1 134 140 PF01652 0.199
LIG_FHA_1 111 117 PF00498 0.360
LIG_FHA_1 119 125 PF00498 0.388
LIG_FHA_1 39 45 PF00498 0.282
LIG_FHA_2 174 180 PF00498 0.694
LIG_FHA_2 23 29 PF00498 0.394
LIG_FHA_2 54 60 PF00498 0.326
LIG_GBD_Chelix_1 88 96 PF00786 0.373
LIG_LIR_Gen_1 167 177 PF02991 0.374
LIG_LIR_Gen_1 51 62 PF02991 0.361
LIG_LIR_Nem_3 149 155 PF02991 0.363
LIG_LIR_Nem_3 167 173 PF02991 0.387
LIG_LIR_Nem_3 59 65 PF02991 0.309
LIG_PALB2_WD40_1 165 173 PF16756 0.194
LIG_Pex14_2 105 109 PF04695 0.527
LIG_Pex14_2 148 152 PF04695 0.374
LIG_Pex14_2 15 19 PF04695 0.254
LIG_Pex14_2 94 98 PF04695 0.363
LIG_REV1ctd_RIR_1 103 112 PF16727 0.402
LIG_SH2_STAP1 54 58 PF00017 0.290
LIG_SH2_STAP1 62 66 PF00017 0.296
LIG_SH2_STAT5 10 13 PF00017 0.460
LIG_SH3_3 20 26 PF00018 0.348
LIG_SUMO_SIM_anti_2 81 86 PF11976 0.338
LIG_SUMO_SIM_par_1 19 25 PF11976 0.321
LIG_TRAF2_1 61 64 PF00917 0.204
LIG_TYR_ITIM 60 65 PF00017 0.201
MOD_CK2_1 58 64 PF00069 0.457
MOD_GlcNHglycan 179 182 PF01048 0.488
MOD_GSK3_1 173 180 PF00069 0.481
MOD_GSK3_1 38 45 PF00069 0.328
MOD_N-GLC_1 67 72 PF02516 0.377
MOD_NEK2_2 53 58 PF00069 0.298
MOD_PIKK_1 184 190 PF00454 0.464
MOD_PKA_2 142 148 PF00069 0.530
MOD_PKA_2 182 188 PF00069 0.608
MOD_Plk_1 58 64 PF00069 0.440
MOD_Plk_4 42 48 PF00069 0.363
MOD_Plk_4 53 59 PF00069 0.357
MOD_ProDKin_1 22 28 PF00069 0.353
MOD_ProDKin_1 38 44 PF00069 0.313
TRG_ENDOCYTIC_2 10 13 PF00928 0.431
TRG_ENDOCYTIC_2 54 57 PF00928 0.326
TRG_ENDOCYTIC_2 62 65 PF00928 0.328
TRG_ER_diArg_1 72 74 PF00400 0.393

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2C4 Leptomonas seymouri 32% 100%
A0A0N0P547 Leptomonas seymouri 46% 100%
A0A0N0P6P9 Leptomonas seymouri 23% 84%
A0A0N0P993 Leptomonas seymouri 25% 86%
A0A0N1HWY5 Leptomonas seymouri 27% 99%
A0A0N1PAD5 Leptomonas seymouri 21% 77%
A0A0N1PDH0 Leptomonas seymouri 42% 96%
A0A1X0NQ58 Trypanosomatidae 30% 100%
A0A1X0NUH1 Trypanosomatidae 29% 85%
A0A1X0NVN5 Trypanosomatidae 28% 100%
A0A1X0NVT7 Trypanosomatidae 31% 100%
A0A1X0P2R3 Trypanosomatidae 28% 91%
A0A1X0P988 Trypanosomatidae 43% 100%
A0A381MTA7 Leishmania infantum 47% 99%
A0A381MTB8 Leishmania infantum 46% 99%
A0A381MTC7 Leishmania infantum 46% 100%
A0A381MTN2 Leishmania infantum 43% 100%
A0A381MVY0 Leishmania infantum 48% 97%
A0A3Q8ID16 Leishmania donovani 28% 100%
A0A3Q8IE85 Leishmania donovani 57% 100%
A0A3Q8IEC2 Leishmania donovani 45% 100%
A0A3Q8IEI1 Leishmania donovani 47% 99%
A0A3Q8IF65 Leishmania donovani 45% 100%
A0A3Q8IFB9 Leishmania donovani 35% 100%
A0A3Q8IFH7 Leishmania donovani 46% 100%
A0A3Q8IH65 Leishmania donovani 45% 99%
A0A3Q8IHN2 Leishmania donovani 48% 100%
A0A3Q8IHW7 Leishmania donovani 53% 100%
A0A3Q8IHZ6 Leishmania donovani 49% 100%
A0A3Q8IIH1 Leishmania donovani 46% 99%
A0A3Q8IL03 Leishmania donovani 46% 99%
A0A3Q8IMR4 Leishmania donovani 26% 98%
A0A3Q8IUK8 Leishmania donovani 45% 99%
A0A3Q8IUR5 Leishmania donovani 43% 100%
A0A3S5H662 Leishmania donovani 47% 100%
A0A3S5H663 Leishmania donovani 47% 100%
A0A3S5H665 Leishmania donovani 48% 100%
A0A3S5H666 Leishmania donovani 48% 100%
A0A3S5H667 Leishmania donovani 48% 100%
A0A3S5H7D2 Leishmania donovani 31% 100%
A0A3S5H7L2 Leishmania donovani 49% 100%
A0A3S5H7V9 Leishmania donovani 45% 100%
A0A3S5H7W2 Leishmania donovani 28% 99%
A0A3S5H7W6 Leishmania donovani 41% 100%
A0A3S7WQA0 Leishmania donovani 48% 100%
A0A3S7WQA8 Leishmania donovani 70% 100%
A0A3S7X2E6 Leishmania donovani 48% 100%
A0A3S7X357 Leishmania donovani 24% 87%
A0A3S7X453 Leishmania donovani 44% 98%
A0A3S7X472 Leishmania donovani 43% 97%
A0A3S7X7E5 Leishmania donovani 51% 77%
A0A3S7X7M4 Leishmania donovani 53% 91%
A0A3S7X7U1 Leishmania donovani 47% 92%
A0A3S7X7U4 Leishmania donovani 51% 75%
A0A3S7X7W2 Leishmania donovani 41% 92%
A0A3S7X7Y0 Leishmania donovani 47% 99%
A4H595 Leishmania braziliensis 45% 100%
A4H596 Leishmania braziliensis 45% 100%
A4H597 Leishmania braziliensis 46% 100%
A4H5D1 Leishmania braziliensis 45% 100%
A4H5D2 Leishmania braziliensis 43% 100%
A4H5G0 Leishmania braziliensis 50% 97%
A4H5G4 Leishmania braziliensis 39% 100%
A4H5G6 Leishmania braziliensis 38% 100%
A4H5G7 Leishmania braziliensis 45% 100%
A4H5G9 Leishmania braziliensis 56% 100%
A4H5H0 Leishmania braziliensis 56% 100%
A4H5H1 Leishmania braziliensis 57% 100%
A4H5H2 Leishmania braziliensis 56% 100%
A4H5H3 Leishmania braziliensis 40% 100%
A4H6C8 Leishmania braziliensis 56% 100%
A4H7D7 Leishmania braziliensis 43% 100%
A4H9E8 Leishmania braziliensis 49% 100%
A4H9E9 Leishmania braziliensis 45% 100%
A4HAJ4 Leishmania braziliensis 49% 100%
A4HAJ5 Leishmania braziliensis 40% 100%
A4HAJ6 Leishmania braziliensis 45% 100%
A4HAL1 Leishmania braziliensis 45% 100%
A4HAL2 Leishmania braziliensis 29% 99%
A4HAM2 Leishmania braziliensis 43% 99%
A4HAM4 Leishmania braziliensis 44% 99%
A4HAR1 Leishmania braziliensis 45% 100%
A4HAZ8 Leishmania braziliensis 49% 100%
A4HB00 Leishmania braziliensis 42% 100%
A4HB02 Leishmania braziliensis 42% 98%
A4HB47 Leishmania braziliensis 38% 100%
A4HBJ0 Leishmania braziliensis 46% 100%
A4HBJ1 Leishmania braziliensis 44% 99%
A4HBJ2 Leishmania braziliensis 51% 100%
A4HDI2 Leishmania braziliensis 23% 95%
A4HDI3 Leishmania braziliensis 30% 100%
A4HDI4 Leishmania braziliensis 27% 99%
A4HDL3 Leishmania braziliensis 28% 100%
A4HDL4 Leishmania braziliensis 27% 99%
A4HI41 Leishmania braziliensis 22% 100%
A4HTM3 Leishmania infantum 91% 100%
A4HTM4 Leishmania infantum 70% 100%
A4HTM5 Leishmania infantum 70% 100%
A4I0W3 Leishmania infantum 25% 98%
A4I0W4 Leishmania infantum 31% 100%
A4I0W5 Leishmania infantum 28% 100%
A4I4J2 Leishmania infantum 47% 100%
A4I4J3 Leishmania infantum 45% 100%
A4I5B9 Leishmania infantum 24% 100%
A4I6E5 Leishmania infantum 43% 100%
A4I9Q4 Leishmania infantum 51% 100%
A4I9R4 Leishmania infantum 28% 99%
A4I9R5 Leishmania infantum 35% 100%
A4I9R7 Leishmania infantum 57% 100%
A4I9W8 Leishmania infantum 51% 100%
A4I9X0 Leishmania infantum 40% 100%
A4IA59 Leishmania infantum 43% 100%
A4IAL7 Leishmania infantum 52% 100%
A4IAM1 Leishmania infantum 47% 99%
A4IAM2 Leishmania infantum 47% 100%
C6K3X9 Leptomonas seymouri 26% 100%
E8NHC3 Leishmania infantum 47% 100%
E8NHD3 Leishmania infantum 49% 100%
E8NHD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E8NHD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E8NHE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E8NHF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E8NHF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 99%
E8NHF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E8NHG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E8NHH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E8NHI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E8NHK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E8NHK9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHL7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E8NHL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E8NHM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E8NHM3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E8NHM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 98%
E8NHM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E8NHP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E8NHQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E8NHR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E8NHR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E8NHS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E9AG81 Leishmania infantum 47% 100%
E9AG82 Leishmania infantum 47% 100%
E9AG83 Leishmania infantum 47% 100%
E9AG85 Leishmania infantum 47% 100%
E9AHI9 Leishmania infantum 48% 100%
E9AHT2 Leishmania infantum 51% 100%
E9AME9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
E9AMF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AMF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9AMF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AMF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AMF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AMF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AMF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AMF8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
E9AMF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 99%
E9ASP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AWW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 95%
E9AWW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AWW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 99%
E9AWX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 96%
E9B0L5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B0L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B1J3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9B1J4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9B1J5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9B4L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9B4R7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B4R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B4R9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B4S0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 99%
E9B4Y3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
Q4Q1U9 Leishmania major 45% 99%
Q4Q305 Leishmania major 47% 99%
Q4Q309 Leishmania major 45% 100%
Q4Q313 Leishmania major 47% 99%
Q4Q317 Leishmania major 45% 100%
Q4Q325 Leishmania major 49% 100%
Q4Q327 Leishmania major 44% 99%
Q4Q329 Leishmania major 47% 99%
Q4Q333 Leishmania major 47% 99%
Q4Q335 Leishmania major 48% 99%
Q4Q337 Leishmania major 45% 99%
Q4Q339 Leishmania major 47% 99%
Q4Q341 Leishmania major 51% 99%
Q4Q397 Leishmania major 56% 74%
Q4Q3A7 Leishmania major 28% 99%
Q4Q3A8 Leishmania major 35% 100%
Q4Q3A9 Leishmania major 51% 100%
Q4Q3F7 Leishmania major 51% 100%
Q4Q6L8 Leishmania major 42% 100%
Q4Q7L6 Leishmania major 23% 100%
Q4Q7L7 Leishmania major 22% 100%
Q4Q7L8 Leishmania major 22% 100%
Q4QAK4 Leishmania major 26% 95%
Q4QAK5 Leishmania major 29% 100%
Q4QAK6 Leishmania major 33% 100%
Q4QAK7 Leishmania major 26% 95%
Q4QI84 Leishmania major 70% 100%
Q4QI85 Leishmania major 73% 100%
Q4QI86 Leishmania major 74% 100%
Q4QI87 Leishmania major 82% 100%
Q4QI88 Leishmania major 68% 100%
Q4QI92 Leishmania major 44% 100%
Q4QI93 Leishmania major 44% 100%
Q4QI95 Leishmania major 43% 100%
Q4QI97 Leishmania major 44% 100%
Q4QIA0 Leishmania major 42% 100%
Q4QIA1 Leishmania major 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS