SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WQB3_LEIDO

TriTrypDb:

LdBPK_080810.1 , LdCL_080013400 , LDHU3_08.1150

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WQB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WQB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.539
CLV_NRD_NRD_1	131	133	PF00675	0.425
CLV_NRD_NRD_1	142	144	PF00675	0.406
CLV_NRD_NRD_1	233	235	PF00675	0.403
CLV_NRD_NRD_1	29	31	PF00675	0.387
CLV_NRD_NRD_1	35	37	PF00675	0.415
CLV_PCSK_FUR_1	179	183	PF00082	0.373
CLV_PCSK_KEX2_1	131	133	PF00082	0.414
CLV_PCSK_KEX2_1	142	144	PF00082	0.389
CLV_PCSK_KEX2_1	181	183	PF00082	0.366
CLV_PCSK_KEX2_1	222	224	PF00082	0.412
CLV_PCSK_KEX2_1	232	234	PF00082	0.440
CLV_PCSK_KEX2_1	29	31	PF00082	0.587
CLV_PCSK_KEX2_1	325	327	PF00082	0.589
CLV_PCSK_KEX2_1	35	37	PF00082	0.415
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.366
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.392
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.381
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.557
CLV_PCSK_SKI1_1	132	136	PF00082	0.413
CLV_PCSK_SKI1_1	409	413	PF00082	0.541
DEG_Nend_UBRbox_3	1	3	PF02207	0.596
DOC_CYCLIN_RxL_1	255	265	PF00134	0.382
DOC_PP4_MxPP_1	388	391	PF00568	0.550
DOC_USP7_MATH_1	149	153	PF00917	0.435
DOC_USP7_MATH_1	311	315	PF00917	0.583
DOC_USP7_MATH_1	347	351	PF00917	0.564
DOC_USP7_MATH_1	364	368	PF00917	0.652
DOC_USP7_MATH_1	379	383	PF00917	0.567
DOC_USP7_MATH_1	384	388	PF00917	0.542
DOC_USP7_MATH_2	123	129	PF00917	0.441
DOC_USP7_UBL2_3	201	205	PF12436	0.420
DOC_USP7_UBL2_3	214	218	PF12436	0.422
DOC_USP7_UBL2_3	228	232	PF12436	0.382
DOC_USP7_UBL2_3	315	319	PF12436	0.566
LIG_14-3-3_CanoR_1	132	138	PF00244	0.416
LIG_14-3-3_CanoR_1	409	414	PF00244	0.630
LIG_Actin_WH2_2	158	175	PF00022	0.416
LIG_FHA_1	295	301	PF00498	0.457
LIG_FHA_2	134	140	PF00498	0.411
LIG_FHA_2	331	337	PF00498	0.536
LIG_FHA_2	381	387	PF00498	0.594
LIG_FHA_2	403	409	PF00498	0.557
LIG_FHA_2	410	416	PF00498	0.542
LIG_FHA_2	92	98	PF00498	0.550
LIG_IBAR_NPY_1	90	92	PF08397	0.568
LIG_LIR_Gen_1	290	299	PF02991	0.461
LIG_LIR_Gen_1	60	69	PF02991	0.423
LIG_LIR_Nem_3	187	192	PF02991	0.502
LIG_LIR_Nem_3	20	25	PF02991	0.473
LIG_LIR_Nem_3	224	230	PF02991	0.434
LIG_LIR_Nem_3	240	244	PF02991	0.493
LIG_LIR_Nem_3	290	294	PF02991	0.476
LIG_LIR_Nem_3	60	65	PF02991	0.393
LIG_MYND_3	166	170	PF01753	0.405
LIG_PCNA_PIPBox_1	338	347	PF02747	0.583
LIG_Pex14_2	237	241	PF04695	0.400
LIG_PTB_Apo_2	260	267	PF02174	0.398
LIG_PTB_Phospho_1	260	266	PF10480	0.395
LIG_SH2_CRK	291	295	PF00017	0.455
LIG_SH2_NCK_1	62	66	PF00017	0.375
LIG_SH2_STAP1	113	117	PF00017	0.564
LIG_SH2_STAP1	375	379	PF00017	0.641
LIG_SH2_STAT3	100	103	PF00017	0.537
LIG_SH2_STAT3	266	269	PF00017	0.366
LIG_SH2_STAT3	345	348	PF00017	0.571
LIG_SH2_STAT5	203	206	PF00017	0.410
LIG_SH2_STAT5	219	222	PF00017	0.407
LIG_SH2_STAT5	230	233	PF00017	0.334
LIG_SH2_STAT5	259	262	PF00017	0.401
LIG_SH2_STAT5	266	269	PF00017	0.410
LIG_SH3_3	388	394	PF00018	0.622
LIG_SH3_3	77	83	PF00018	0.561
LIG_SUMO_SIM_par_1	296	301	PF11976	0.452
LIG_UBA3_1	165	173	PF00899	0.397
LIG_UBA3_1	52	56	PF00899	0.460
MOD_CK1_1	116	122	PF00069	0.504
MOD_CK1_1	14	20	PF00069	0.521
MOD_CK1_1	350	356	PF00069	0.586
MOD_CK2_1	133	139	PF00069	0.459
MOD_CK2_1	171	177	PF00069	0.507
MOD_CK2_1	364	370	PF00069	0.580
MOD_CK2_1	380	386	PF00069	0.630
MOD_CK2_1	409	415	PF00069	0.641
MOD_CK2_1	57	63	PF00069	0.407
MOD_GlcNHglycan	364	367	PF01048	0.606
MOD_GlcNHglycan	59	62	PF01048	0.385
MOD_GSK3_1	113	120	PF00069	0.519
MOD_GSK3_1	290	297	PF00069	0.475
MOD_GSK3_1	311	318	PF00069	0.618
MOD_GSK3_1	347	354	PF00069	0.601
MOD_GSK3_1	358	365	PF00069	0.690
MOD_GSK3_1	380	387	PF00069	0.620
MOD_LATS_1	313	319	PF00433	0.589
MOD_LATS_1	378	384	PF00433	0.571
MOD_N-GLC_1	17	22	PF02516	0.508
MOD_N-GLC_1	237	242	PF02516	0.381
MOD_NEK2_1	133	138	PF00069	0.409
MOD_NEK2_1	237	242	PF00069	0.346
MOD_NEK2_1	294	299	PF00069	0.464
MOD_NEK2_1	369	374	PF00069	0.623
MOD_NEK2_1	72	77	PF00069	0.544
MOD_PIKK_1	125	131	PF00454	0.412
MOD_PIKK_1	99	105	PF00454	0.579
MOD_PKA_1	217	223	PF00069	0.385
MOD_Plk_1	17	23	PF00069	0.496
MOD_Plk_1	237	243	PF00069	0.372
MOD_Plk_1	369	375	PF00069	0.582
MOD_Plk_1	70	76	PF00069	0.463
MOD_Plk_2-3	371	377	PF00069	0.618
MOD_Plk_4	294	300	PF00069	0.470
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.414
TRG_ENDOCYTIC_2	259	262	PF00928	0.412
TRG_ENDOCYTIC_2	291	294	PF00928	0.464
TRG_ENDOCYTIC_2	62	65	PF00928	0.382
TRG_ER_diArg_1	130	132	PF00400	0.419
TRG_ER_diArg_1	142	144	PF00400	0.388
TRG_ER_diArg_1	29	31	PF00400	0.409
TRG_ER_diArg_1	34	36	PF00400	0.390
TRG_ER_diArg_1	404	407	PF00400	0.558
TRG_NLS_MonoExtC_3	204	209	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	68%	96%
A0A3Q8IIE7	Leishmania donovani	25%	100%
A4H6C6	Leishmania braziliensis	77%	100%
A4HTM7	Leishmania infantum	100%	100%
E9AHL0	Leishmania infantum	25%	100%
E9AMG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4Q6I6	Leishmania major	22%	100%
Q4QI82	Leishmania major	93%	100%